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48

Lise Musset


Pharmaceutical doctor (Université de Reims 2002) and Doctor of Sciences (Université Paris-Descartes 2006), Lise Musset has been studying the mechanisms of resistance to antimalarial drugs and their evolution for 15 years. Since her arrival in French Guiana, she develops projects related to the Amazonian territory. Her team identified a phenomenon of natural reversion of resistance to chloroquine in French Guiana, seven years after the withdrawal of this molecule (Pelleau et al., 2015, PNAS) and characterized the selection of artemisinin resistance in Guyana (Mathieu et al., 2020, eLife). Her areas of interest relate to i) understanding the mechanisms of resistance, ii) identifying the associated genetic factors, iii) developing or evaluating new diagnostic methods, and iv) understanding the transmission of malaria in French Guiana. These projects benefit on extensive experience in genetics and cell biology and aim to enhance malaria control and elimination in the region.


Journal articles47 documents

  • Maylis Douine, Yann Lambert, Lise Musset, Helene Hiwat, Liana Reis Blume, et al.. Malaria in Gold Miners in the Guianas and the Amazon: Current Knowledge and Challenges. Current tropical medicine reports, 2020, 7 (2), pp.37-47. ⟨10.1007/s40475-020-00202-5⟩. ⟨hal-02862894⟩
  • M. Thellier, F. Simard, Lise Musset, M. Cot, G. Velut, et al.. Changes in malaria epidemiology in France and worldwide, 2000–2015. Médecine et Maladies Infectieuses, Elsevier Masson, 2020, 50 (2), pp.99-112. ⟨10.1016/j.medmal.2019.06.002⟩. ⟨hal-02507727⟩
  • Luana Mathieu, Horace Cox, Angela Early, Sachel Mok, Yassamine Lazrek, et al.. Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance.. eLife, eLife Sciences Publication, 2020, 12, pp.e51015. ⟨10.7554/eLife.51015⟩. ⟨hal-02862736⟩
  • Virginie Rougeron, Eric Elguero, Céline Arnathau, Beatriz Acuña Hidalgo, Patrick Durand, et al.. Human Plasmodium vivax diversity, population structure and evolutionary origin. PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (3), pp.e0008072. ⟨10.1371/journal.pntd.0008072⟩. ⟨pasteur-02567249⟩
  • Raphael Saldanha, Emilie Mosnier, Christovam Barcellos, Aurel Carbunar, Christophe Charron, et al.. Contributing to Elimination of Cross-Border Malaria Through a Standardized Solution for Case Surveillance, Data Sharing, and Data Interpretation: Development of a Cross-Border Monitoring System. JMIR Public Health and Surveillance, JMIR Publications, 2020, 6 (3), pp.e15409. ⟨10.2196/15409⟩. ⟨hal-02928782⟩
  • Emilie Mosnier, Isabelle Dusfour, Guillaume Lacour, Raphael Saldanha, Amandine Guidez, et al.. Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil. BMC Infectious Diseases, BioMed Central, 2020, 20, pp.373. ⟨10.1186/s12879-020-05086-4⟩. ⟨hal-02682286⟩
  • Emilie Mosnier, Emmanuel Roux, Claire Cropet, Yassamine Lazrek, Olivier Moriceau, et al.. Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana–Brazil): Associated Factors and Spatial Distribution. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2020, 102 (1), pp.130-141. ⟨10.4269/ajtmh.19-0378⟩. ⟨hal-02397337⟩
  • Lise Musset, Christophe Heugas, Richard Naldjinan, Denis Blanchet, Pascal Houzé, et al.. Emergence of Plasmodium vivax Resistance to Chloroquine in French Guiana. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2019, 63 (11), ⟨10.1128/AAC.02116-18⟩. ⟨pasteur-02567258⟩
  • Maylis Douine, Alice Sanna, Muriel Galindo, Lise Musset, Vincent Pommier de Santi, et al.. Malakit: an innovative pilot project to self‑diagnose and self‑treat malaria among illegal gold miners in the Guiana Shield. Malaria Journal, BioMed Central, 2018, 17, pp.158. ⟨10.1186/s12936-018-2306-5⟩. ⟨inserm-01819736⟩
  • Maylis Douine, Lise Musset, Florine Corlin, Stéphane Pelleau, Yassamine Lazrek, et al.. Paludisme et orpaillage illégal en Guyane : un enjeu majeur de santé publique. Bulletin Epidémiologique Hebdomadaire - BEH, Saint-Maurice (Val de Marne) : Institut de veille sanitaire, 2017, 6, pp.102-114. ⟨inserm-01491193⟩
  • Louis-Jérôme Leba, Jean Popovici, Yannick Estevez, Stéphane Pelleau, Eric Legrand, et al.. Antiplasmodial activities of dyes against Plasmodium falciparum asexual and sexual stages: Contrasted uptakes of triarylmethanes Brilliant green, Green S (E142), and Patent Blue V (E131) by erythrocytes. International journal for parasitology. Drugs and drug resistance, Elsevier, 2017, 7 (3), pp.314 - 320. ⟨10.1016/j.ijpddr.2017.07.002⟩. ⟨pasteur-01614675⟩
  • M. Douine, Y Lazrek, D. Blanchet, S. Pelleau, R Chanlin, et al.. Predictors of antimalarial self-medication in illegal gold miners in French Guiana: a pathway towards artemisinin resistance.. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2017, Epub ahead of print. ⟨10.1093/jac/dkx343⟩. ⟨inserm-01622957⟩
  • Maylis Douine, Emilie Mosnier, Quentin Le Hingrat, Charlotte Charpentier, Florine Corlin, et al.. Illegal gold miners in French Guiana: a neglected population with poor health. BMC Public Health, BioMed Central, 2017, 18 (1), pp.23. ⟨10.1016/S0140-6736(10)62169-1⟩. ⟨inserm-01566314⟩
  • Virginie Rougeron, Kathryn Tiedje, Donald S Chen, Thomas S Rask, Dionicia Gamboa, et al.. Evolutionary structure of Plasmodium falciparum major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance. BMC Evolutionary Biology, BioMed Central, In press, pp.1-15. ⟨10.1002/ece3.3425⟩. ⟨pasteur-01621487⟩
  • Reyaud Rahman, Maria Jesus Sanchez Martin, Shamdeo Persaud, Nicolas Ceron, Dwayne Kellman, et al.. Continued Sensitivity of Plasmodium falciparum to Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles.. Open Forum Infect Dis, Oxford Academic, 2016, 4 (3), pp.ofw185. ⟨10.1093/ofid/ofw185⟩. ⟨hal-02862961⟩
  • Stanislaw Gabryszewski, Charin Modchang, Lise Musset, Thanat Chookajorn, David Fidock. Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum. Molecular Biology and Evolution, Oxford University Press (OUP), 2016, 33 (6), pp.1554-1570. ⟨10.1093/molbev/msw037⟩. ⟨hal-02862965⟩
  • Stella Chenet, Sheila Akinyi Okoth, Curtis Huber, Javin Chandrabose, Naomi Lucchi, et al.. Independent Emergence of the Plasmodium falciparum Kelch Propeller Domain Mutant Allele C580Y in Guyana. Journal of Infectious Diseases, Oxford University Press (OUP), 2016, 213 (9), pp.1472-1475. ⟨10.1093/infdis/jiv752⟩. ⟨hal-02862975⟩
  • Emilie Faway, Lise Musset, Stéphane Pelleau, Béatrice Volney, Jessica Casteras, et al.. Plasmodium vivax multidrug resistance-1 gene polymorphism in French Guiana. Malaria Journal, BioMed Central, 2016, 15 (1), pp.540. ⟨10.1186/s12936-016-1595-9⟩. ⟨pasteur-01400964⟩
  • Margarete Do Socorro Mendonça Gomes, José Luiz Fernandes Vieira, Gustavo Capatti Cassiano, Lise Musset, Eric Legrand, et al.. EVALUATION OF CIRCUMSPOROZOITE PROTEIN OF Plasmodium vivax TO ESTIMATE ITS PREVALENCE IN OIAPOQUE , AMAPÁ STATE, BRAZIL, BORDERING FRENCH GUIANA. Revista do Instituto de Medicina Tropical de São Paulo, Instituto de Medicina Tropical, 2016, 58, pp.72. ⟨10.1590/S1678-9946201658072⟩. ⟨pasteur-01372566⟩
  • Maylis Douine, Lise Musset, Florine Corlin, Stéphane Pelleau, Jérémie Pasquier, et al.. Prevalence of Plasmodium spp.in illegal gold miners in French Guiana in 2015: a hidden but critical malaria reservoir. Malaria Journal, BioMed Central, 2016, 15, pp.315. ⟨10.1186/s12936-016-1367-6⟩. ⟨hal-01346800⟩
  • Mathieu Nacher, Sebastien Briolant, Vincent Pommier Santi, Félix Djossou, Nicolas Barthes, et al.. Malaria Hyperendemicity and Risk for Artemisinin Resistance among ă Illegal Gold Miners, French Guiana. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, 22 (5), pp.903-906. ⟨10.3201/eid2205.151957⟩. ⟨hal-01467560⟩
  • Vincent Pommier de Santi, Felix Djossou, Nicolas Barthes, Herve Bogreau, Georges Hyvert, et al.. Malaria Hyperendemicity and Risk for Artemisinin Resistance among Illegal Gold Miners, French Guiana.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, 22 (5), pp.903-6. ⟨10.3201/eid2205.151957.⟩. ⟨pasteur-01305106⟩
  • Didier Ménard, Nimol Khim, Johann Beghain, Ayola A Adegnika, Mohammad Shafiul-Alam, et al.. A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.. New England Journal of Medicine, Massachusetts Medical Society, 2016, 374 (25), pp.2453-64. ⟨10.1056/NEJMoa1513137⟩. ⟨pasteur-01336483⟩
  • Stanislaw Gabryszewski, Satish Dhingra, Jill Combrinck, Ian Lewis, Paul Callaghan, et al.. Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4- Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology. PLoS Pathogens, Public Library of Science, 2016, 12 (11), pp.e1005976. ⟨10.1371/journal.ppat.1005976⟩. ⟨hal-02862933⟩
  • Mary Lynn Baniecki, Aubrey L Faust, Stephen F Schaffner, Daniel J Park, Kevin Galinsky, et al.. Development of a Single Nucleotide Polymorphism Barcode to Genotype Plasmodium vivax Infections.. PLoS Neglected Tropical Diseases, Public Library of Science, 2015, 9 (3), pp.e0003539. ⟨10.1371/journal.pntd.0003539⟩. ⟨pasteur-01133539⟩
  • Marie Mura, Sébastien Briolant, Damien Donato, Béatrice Volney, Stéphane Pelleau, et al.. Absence of correlation between ex vivo susceptibility to doxycycline and pfteQ–pfmdt gene polymorphism in French Guiana. Malaria Journal, BioMed Central, 2015, 14 (1), pp.286. ⟨10.1186/s12936-015-0788-y⟩. ⟨pasteur-01182758⟩
  • Margarete Do Socorro M Gomes, José Luiz F Vieira, Ricardo L D Machado, Mathieu Nacher, Aurélia Stefani, et al.. Efficacy in the treatment of malaria by Plasmodium vivax in Oiapoque, Brazil, on the border with French Guiana: the importance of control over external factors.. Malaria Journal, BioMed Central, 2015, 14 (1), pp.402. ⟨10.1186/s12936-015-0925-7⟩. ⟨pasteur-01229355⟩
  • Marine Ginouves, Vincent Veron, Lise Musset, Eric Legrand, Aurélia Stefani, et al.. Frequency and distribution of mixed Plasmodium falciparum-vivax infections in French Guiana between 2000 and 2008.. Malaria Journal, BioMed Central, 2015, 14 (1), pp.446. ⟨10.1186/s12936-015-0971-1⟩. ⟨pasteur-01229359⟩
  • Louis-Jérôme Leba, Lise Musset, Stéphane Pelleau, Yannick Estevez, Caroline Birer, et al.. Use of Plasmodium falciparum culture-adapted field isolates for in vitro exflagellation-blocking assay.. Malaria Journal, BioMed Central, 2015, 14, pp.234. ⟨10.1186/s12936-015-0752-x⟩. ⟨pasteur-01182753⟩
  • Stéphane Pelleau, Eli L Moss, Satish K Dhingra, Béatrice Volney, Jessica Casteras, et al.. Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩. ⟨pasteur-01229321⟩
  • Kevin Galinsky, Clarissa Valim, Arielle Salmier, Benoit de Thoisy, Lise Musset, et al.. COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data.. Malaria Journal, BioMed Central, 2015, 14 (4), ⟨10.1186/1475-2875-14-4⟩. ⟨pasteur-01109705⟩
  • Nimol Khim, Voahangy Andrianaranjaka, Jean Popovici, Saorin Kim, Arsene Ratsimbasoa, et al.. Effects of mefloquine use on Plasmodium vivax multidrug resistance.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2014, 20 (10), pp.1637-44. ⟨10.3201/eid2010.140411⟩. ⟨pasteur-01109696⟩
  • Lise Musset, Stéphane Pelleau, Romain Girod, Vanessa Ardillon, Luisiane Carvalho, et al.. Malaria on the Guiana Shield: a review of the situation in French Guiana.. Memorias do Instituto Oswaldo Cruz, 2014, 109 (5), pp.525. ⟨10.1590/0074-0276140031⟩. ⟨pasteur-01109689⟩
  • Gilles Cottrell, Lise Musset, Véronique Hubert, Jacques Le Bras, Jérôme Clain. Emergence of Resistance to Atovaquone-Proguanil in Malaria Parasites: Insights From Computational Modeling and Clinical Case Reports. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2014, 58 (8), pp.4504-4514. ⟨10.1128/AAC.02550-13⟩. ⟨hal-02862980⟩
  • Erhan Yalcindag, Virginie Rougeron, Eric Elguero, Céline Arnathau, Patrick Durand, et al.. Patterns of selection on Plasmodium falciparum erythrocyte-binding antigens after the colonization of the New World.. Molecular Ecology Notes, Wiley-Blackwell, 2014, 23 (8), pp.1979-93. ⟨10.1111/mec.12696⟩. ⟨pasteur-01109668⟩
  • Didier Menard, Ernest R Chan, Christophe Benedet, Arsène Ratsimbasoa, Saorin Kim, et al.. Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strains.. PLoS Neglected Tropical Diseases, Public Library of Science, 2013, 7 (11), pp.e2489. ⟨10.1371/journal.pntd.0002489⟩. ⟨pasteur-01109627⟩
  • Mélanie Trouvay, Georges Palazon, Franck Berger, Béatrice Volney, Denis Blanchet, et al.. High performance of histidine-rich protein 2 based rapid diagnostic tests in French Guiana are explained by the absence of pfhrp2 gene deletion in P. falciparum.. PLoS ONE, Public Library of Science, 2013, 8 (9), pp.e74269. ⟨10.1371/journal.pone.0074269⟩. ⟨pasteur-01109596⟩
  • Charles J Woodrow, Sabina Dahlström, Richard Cooksey, Jennifer A Flegg, Hervé Le Nagard, et al.. High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 57 (7), pp.3121-30. ⟨10.1128/AAC.02350-12⟩. ⟨pasteur-00861904⟩
  • Aurélia Stefani, Isabelle Dusfour, Ana Paula Corrêa, Manoel Cruz, Nadine Dessay, et al.. Land cover, land use and malaria in the Amazon: a systematic literature review of studies using remotely sensed data.. Malaria Journal, BioMed Central, 2013, 12 (1), pp.192. ⟨10.1186/1475-2875-12-192⟩. ⟨inserm-00834790⟩
  • Erhan Yalcindag, Eric Elguero, Céline Arnathau, Patrick Durand, Jean Akiana, et al.. Multiple independent introductions of Plasmodium falciparum in South America.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2012, 109 (2), pp.511-6. ⟨10.1073/pnas.1119058109⟩. ⟨pasteur-00705564⟩
  • Eric Legrand, Joséphine Yrinesi, Marie-Thérèse Ekala, Julie Péneau, Béatrice Volney, et al.. Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2012, 56 (3), pp.1382-9. ⟨10.1128/AAC.05280-11⟩. ⟨pasteur-00705562⟩
  • Franck Berger, Claude Flamand, Lise Musset, Félix Djossou, Jacques Rosine, et al.. Investigation of a sudden malaria outbreak in the isolated Amazonian village of Saul, French Guiana, January-April 2009.. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2012, 86 (4), pp.591-7. ⟨10.4269/ajtmh.2012.11-0582⟩. ⟨pasteur-00705561⟩
  • Stephanie G Valderramos, Juan-Carlos Valderramos, Lise Musset, Lisa A Purcell, Odile Mercereau-Puijalon, et al.. Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.. PLoS Pathogens, Public Library of Science, 2010, 6 (5), pp.e1000887. ⟨10.1371/journal.ppat.1000887⟩. ⟨pasteur-00577266⟩
  • Céline Barnadas, Lise Musset, Eric Legrand, Magali Tichit, Sébastien Briolant, et al.. High prevalence and fixation of Plasmodium vivax dhfr/dhps mutations related to sulfadoxine/pyrimethamine resistance in French Guiana.. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2009, 81 (1), pp.19-22. ⟨10.4269/ajtmh.2009.81.19⟩. ⟨pasteur-00577267⟩
  • Lise Musset, Jacques Le Bras, Jérôme Clain. Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.. Molecular Biology and Evolution, Oxford University Press (OUP), 2007, 24 (8), pp.1582-5. ⟨10.1093/molbev/msm087⟩. ⟨pasteur-00577268⟩
  • Lise Musset, Olivier Bouchaud, Sophie Matheron, Laurent Massias, Jacques Le Bras. Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.. Microbes and Infection, Elsevier, 2006, 8 (11), pp.2599-604. ⟨10.1016/j.micinf.2006.07.011⟩. ⟨pasteur-00577269⟩
  • Lise Musset, Bruno Pradines, Daniel Parzy, Rémy Durand, Patricia Bigot, et al.. Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2006, 57 (1), pp.110-5. ⟨10.1093/jac/dki420⟩. ⟨pasteur-00577270⟩

Theses1 document

  • Lise Musset. Contribution à l'étude de la résistance
    de Plasmodium falciparum à l'atovaquone-proguanil. Médicaments. Université René Descartes - Paris V, 2006. Français. ⟨tel-00130030⟩