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Lise Musset

Lise Musset, Research director at Institut Pasteur de la Guyane
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Présentation

*Pharmaceutical doctor (Université de Reims 2002) and Doctor of Sciences (Université Paris-Descartes 2006), Lise Musset has been studying the mechanisms of resistance to antimalarial drugs and their evolution for 15 years. Since her arrival in French Guiana, she develops projects related to the Amazonian territory. Her team identified a phenomenon of natural reversion of resistance to chloroquine in French Guiana, seven years after the withdrawal of this molecule (Pelleau et al., 2015, PNAS) and characterized the selection of artemisinin resistance in Guyana (Mathieu et al., 2020, eLife). Her areas of interest relate to i) understanding the mechanisms of resistance, ii) identifying the associated genetic factors, iii) developing or evaluating new diagnostic methods, and iv) understanding the transmission of malaria in French Guiana. These projects benefit on extensive experience in genetics and cell biology and aim to enhance malaria control and elimination in the region.*

Publications

"Humans"
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Mortality from malaria in France, 2005 to 2014

Eric Kendjo , Marc Thellier , Harold Noël , Stéphane Jauréguiberry , Alexandra Septfons
Eurosurveillance, 2020, 25 (36), pp.1900579. ⟨10.2807/1560-7917.ES.2020.25.36.1900579⟩
Article dans une revue hal-03429595v1
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Human Plasmodium vivax diversity, population structure and evolutionary origin

Virginie Rougeron , Eric Elguero , Céline Arnathau , Beatriz Acuña Hidalgo , Durand Patrick
PLoS Neglected Tropical Diseases, 2020, 14 (3), pp.e0008072. ⟨10.1371/journal.pntd.0008072⟩
Article dans une revue pasteur-02567249v1
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A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.

Didier Ménard , Nimol Khim , Johann Beghain , Ayola A Adegnika , Mohammad Shafiul-Alam
New England Journal of Medicine, 2016, 374 (25), pp.2453-64. ⟨10.1056/NEJMoa1513137⟩
Article dans une revue pasteur-01336483v1
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COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data.

Kevin Galinsky , Clarissa Valim , Arielle Salmier , Benoit de Thoisy , Lise Musset
Malaria Journal, 2015, 14 (4), ⟨10.1186/1475-2875-14-4⟩
Article dans une revue pasteur-01109705v1
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Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.

Stéphane Pelleau , Eli L Moss , Satish K Dhingra , Béatrice Volney , Jessica Casteras
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩
Article dans une revue hal-01229321v1

Patterns of selection on Plasmodium falciparum erythrocyte-binding antigens after the colonization of the New World.

Erhan Yalcindag , Virginie Rougeron , Eric Elguero , Céline Arnathau , Durand Patrick
Molecular Ecology Notes, 2014, 23 (8), pp.1979-93. ⟨10.1111/mec.12696⟩
Article dans une revue pasteur-01109668v1
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Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strains.

Didier Menard , Ernest R Chan , Christophe Benedet , Arsène Ratsimbasoa , Saorin Kim
PLoS Neglected Tropical Diseases, 2013, 7 (11), pp.e2489. ⟨10.1371/journal.pntd.0002489⟩
Article dans une revue pasteur-01109627v1
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Investigation of a sudden malaria outbreak in the isolated Amazonian village of Saul, French Guiana, January-April 2009.

Franck Berger , Claude Flamand , Lise Musset , Félix Djossou , Jacques Rosine
American Journal of Tropical Medicine and Hygiene, 2012, 86 (4), pp.591-7. ⟨10.4269/ajtmh.2012.11-0582⟩
Article dans une revue pasteur-00705561v1

Multiple independent introductions of Plasmodium falciparum in South America.

Erhan Yalcindag , Eric Elguero , Céline Arnathau , Durand Patrick , Jean Akiana
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (2), pp.511-6. ⟨10.1073/pnas.1119058109⟩
Article dans une revue pasteur-00705564v1
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Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

Stephanie G Valderramos , Juan-Carlos Valderramos , Lise Musset , Lisa A Purcell , Odile Mercereau-Puijalon
PLoS Pathogens, 2010, 6 (5), pp.e1000887. ⟨10.1371/journal.ppat.1000887⟩
Article dans une revue pasteur-00577266v1

Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.

Lise Musset , Jacques Le Bras , Jérôme Clain
Molecular Biology and Evolution, 2007, 24 (8), pp.1582-5. ⟨10.1093/molbev/msm087⟩
Article dans une revue pasteur-00577268v1

Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.

Lise Musset , Bruno Pradines , Daniel Parzy , Rémy Durand , Patricia Bigot
Journal of Antimicrobial Chemotherapy, 2006, 57 (1), pp.110-5. ⟨10.1093/jac/dki420⟩
Article dans une revue hal-00577270v1

Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.

Lise Musset , Olivier Bouchaud , Sophie Matheron , Laurent Massias , Jacques Le Bras
Microbes and Infection, 2006, 8 (11), pp.2599-604. ⟨10.1016/j.micinf.2006.07.011⟩
Article dans une revue pasteur-00577269v1