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Lise Musset

Lise Musset, Research director at Institut Pasteur de la Guyane
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Présentation

*Pharmaceutical doctor (Université de Reims 2002) and Doctor of Sciences (Université Paris-Descartes 2006), Lise Musset has been studying the mechanisms of resistance to antimalarial drugs and their evolution for 15 years. Since her arrival in French Guiana, she develops projects related to the Amazonian territory. Her team identified a phenomenon of natural reversion of resistance to chloroquine in French Guiana, seven years after the withdrawal of this molecule (Pelleau et al., 2015, PNAS) and characterized the selection of artemisinin resistance in Guyana (Mathieu et al., 2020, eLife). Her areas of interest relate to i) understanding the mechanisms of resistance, ii) identifying the associated genetic factors, iii) developing or evaluating new diagnostic methods, and iv) understanding the transmission of malaria in French Guiana. These projects benefit on extensive experience in genetics and cell biology and aim to enhance malaria control and elimination in the region.*

Publications

"Drug Resistance"
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A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.

Didier Ménard , Nimol Khim , Johann Beghain , Ayola A Adegnika , Mohammad Shafiul-Alam
New England Journal of Medicine, 2016, 374 (25), pp.2453-64. ⟨10.1056/NEJMoa1513137⟩
Article dans une revue pasteur-01336483v1
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Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

Stephanie G Valderramos , Juan-Carlos Valderramos , Lise Musset , Lisa A Purcell , Odile Mercereau-Puijalon
PLoS Pathogens, 2010, 6 (5), pp.e1000887. ⟨10.1371/journal.ppat.1000887⟩
Article dans une revue pasteur-00577266v1

High prevalence and fixation of Plasmodium vivax dhfr/dhps mutations related to sulfadoxine/pyrimethamine resistance in French Guiana.

Céline Barnadas , Lise Musset , Eric Legrand , Magali Tichit , Sébastien Briolant
American Journal of Tropical Medicine and Hygiene, 2009, 81 (1), pp.19-22. ⟨10.4269/ajtmh.2009.81.19⟩
Article dans une revue pasteur-00577267v1

Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.

Lise Musset , Jacques Le Bras , Jérôme Clain
Molecular Biology and Evolution, 2007, 24 (8), pp.1582-5. ⟨10.1093/molbev/msm087⟩
Article dans une revue pasteur-00577268v1

Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.

Lise Musset , Bruno Pradines , Daniel Parzy , Rémy Durand , Patricia Bigot
Journal of Antimicrobial Chemotherapy, 2006, 57 (1), pp.110-5. ⟨10.1093/jac/dki420⟩
Article dans une revue hal-00577270v1

Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.

Lise Musset , Olivier Bouchaud , Sophie Matheron , Laurent Massias , Jacques Le Bras
Microbes and Infection, 2006, 8 (11), pp.2599-604. ⟨10.1016/j.micinf.2006.07.011⟩
Article dans une revue pasteur-00577269v1