Lionel Nauton

Documents

Publications

	QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle Lionel Nauton , Laurence Hecquet , Vincent Théry Journal of Chemical Information and Modeling, 2021, ⟨10.1021/acs.jcim.1c00190⟩ Article dans une revue hal-03286397v1
	Pyruvate Aldolases Catalyze Cross-Aldol Reactions between Ketones: Highly Selective Access to Multi-Functionalized Tertiary Alcohols Victor Laurent , Léa Gourbeyre , Alexandre Uzel , Virgil Hélaine , Lionel Nauton ACS Catalysis, 2020, 10 (4), pp.2538-2543. ⟨10.1021/acscatal.9b05512⟩ Article dans une revue hal-02907546v1
	Enzymatic Synthesis of Aliphatic Acyloins through Thermostable Transketolase Catalyzed-Reaction Hubert Casajus , Aurélie Lagarde , Martin Leremboure , Thomas De Dios Miguel , Lionel Nauton ChemCatChem, 2020, ⟨10.1002/cctc.202001160⟩ Article dans une revue hal-02995504v1
	Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest Nahida Mokhtari Brikci-Nigassa , Lionel Nauton , Pascale Moreau , Olivier Mongin , Raphael E Duval Bioorganic Chemistry, 2020, 94, pp.103347. ⟨10.1016/j.bioorg.2019.103347⟩ Article dans une revue hal-02404054v1
	Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia Alexia Visseq , Amélie Descheemaeker , Nicolas Pinto-Pardo , Lionel Nauton , Vincent Thery European Journal of Medicinal Chemistry, 2020, 187, pp.111917. ⟨10.1016/j.ejmech.2019.111917⟩ Article dans une revue hal-02444268v1
	4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition Laurent Gavara , Federica Verdirosa , Alice Legru , Paola Sandra Mercuri , Lionel Nauton Biomolecules, 2020, 10 (8), pp.1094. ⟨10.3390/biom10081094⟩ Article dans une revue hal-02997710v1
	Evolved Thermostable Transketolase for Stereoselective Two-Carbon Elongation of Non-Phosphorylated Aldoses to Naturally Rare Ketoses Marion Lorillière , Romain Dumoulin , Mélanie L’enfant , Agnès Rambourdin , Vincent Thery ACS Catalysis, 2019, 9 (6), pp.4754-4763. ⟨10.1021/acscatal.9b01339⟩ Article dans une revue hal-02195534v1
	Diastereoselective Synthesis of 2,6-Disubstituted-1,2,3,6-Tetrahydropyridines through a Palladium-Catalyzed Intramolecular Allylic Amination Alexia Visseq , Thibaut Boibessot , Lionel Nauton , Vincent Thery , Fabrice Anizon European Journal of Organic Chemistry, 2019, 2019 (47), pp.7686-7702. ⟨10.1002/ejoc.201901520⟩ Article dans une revue hal-02444228v1
	Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies Waël Zeinyeh , Yannick Esvan , Béatrice Josselin , Blandine Baratte , Stéphane Bach Bioorganic and Medicinal Chemistry, 2019, 27 (10), pp.2083-2089. ⟨10.1016/j.bmc.2019.04.005⟩ Article dans une revue hal-02164744v1
	Achiral Hydroxypyruvaldehyde Phosphate as a Platform for Multi-Aldolases Cascade Synthesis of Diuloses and for a Quadruple Acetaldehyde Addition Catalyzed by 2-Deoxyribose-5-Phosphate Aldolases Victor Laurent , Virgil Hélaine , Carine Vergne-Vaxelaire , Lionel Nauton , Mounir Traïkia ACS Catalysis, 2019, 9 (10), pp.9508-9512. ⟨10.1021/acscatal.9b02668⟩ Article dans une revue hal-02329545v1
	NC α‐ gem ‐dimethylated peptoid side chains: A novel approach for structural control and peptide sequence mimetics Radhe Shyam , Lionel Nauton , Gaetano Angelici , Olivier Roy , Claude Taillefumier Biopolymers, 2019, 110, pp.e23273. ⟨10.1002/bip.23273⟩ Article dans une revue hal-02194898v1
	Topologically Diverse Shapes Accessible by Modular Design of Arylopeptoid Macrocycles Thomas Hjelmgaard , Lionel Nauton , Francesco de Riccardis , Laurent Jouffret , Sophie Faure Organic Letters, 2018, 20 (1), pp.268 - 271. ⟨10.1021/acs.orglett.7b03660⟩ Article dans une revue hal-01705225v1
	Synthesis of Branched-Chain Sugars with a DHAP-Dependent Aldolase: Ketones are Electrophile Substrates of Rhamnulose-1- phosphate Aldolases Victor Laurent , Ekaterina Darii , Angelina Aujon , Marine Debacker , Jean-Louis Petit Angewandte Chemie International Edition, 2018, 57 (19), pp.5467 - 5471. ⟨10.1002/anie.201712851⟩ Article dans une revue hal-02323732v1
	A catalytic intramolecular nitrene insertion into a copper(I)–N-heterocyclic carbene bond yielding fused nitrogen heterocycles. Kévin Fauché , Lionel Nauton , Laurent Jouffret , Federico Cisnetti , Arnaud Gautier Chemical Communications, 2017, 53, pp.2402-2405. ⟨10.1039/C6CC09160A⟩ Article dans une revue hal-01546151v1
	1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases Laurent Sevaille , Laurent Gavara , Carine Bebrone , Filomena De luca , Lionel Nauton ChemMedChem, 2017, 12 (12), pp.972-985. ⟨10.1002/cmdc.201700186⟩ Article dans une revue hal-02923462v1
	Insights into the Thiamine Diphosphate Enzyme Activation Mechanism: Computational Model for Transketolase Using a Quantum Mechanical/Molecular Mechanical Method. Lionel Nauton , Virgil Hélaine , Vincent Théry , Laurence Hecquet Biochemistry, 2016, 55, pp.2144-2152. ⟨10.1021/acs.biochem.5b00787⟩ Article dans une revue hal-01323789v1
	Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c. Yannick J. Esvan , Francis Giraud , Elisabeth Pereira , Virginie Suchaud , Lionel Nauton Bioorganic and Medicinal Chemistry, 2016, 24, pp.3116-3124. ⟨10.1016/j.bmc.2016.05.032⟩ Article dans une revue hal-01367761v1
	Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co–crystal structure. Yannick J. Esvan , Wael Zeinyeh , Thibaut Boibessot , Lionel Nauton , Vincent Théry European Journal of Medicinal Chemistry, 2016, 118, pp.170-177. ⟨10.1016/j.ejmech.2016.04.004⟩ Article dans une revue hal-01308803v1
	Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives. Wael Zeinyeh , Yannick J. Esvan , Lionel Nauton , Nadège Loaëc , Laurent Meijer Bioorganic and Medicinal Chemistry Letters, 2016, 26, pp.4327-4329. ⟨10.1016/j.bmcl.2016.07.032⟩ Article dans une revue hal-01367659v1
	Water-Soluble Gold–N-Heterocyclic Carbene Complexes for the Catalytic Homogeneous Acid- and Silver-Free Hydration of Hydrophilic Alkynes. Houssein Ibrahim , Pierre De frémont , Pierre Braunstein , Vincent Théry , Lionel Nauton Advanced Synthesis and Catalysis, 2015, 357, pp.3893-3900. ⟨10.1002/adsc.201500729⟩ Article dans une revue hal-01264762v1
	Engineering a Thermostable Transketolase for Unnatural Conversion of (2S)-Hydroxyaldehyde. Juliane Abdoul-Zabar , Marion Lorillière , Dong Yi , Thangavelu Saravanan , Titu Devamani Advanced Synthesis and Catalysis, 2015, 357, pp.1715-1720. ⟨10.1002/adsc.201500207⟩ Article dans une revue hal-01206477v1
	Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition Virginie Suchaud , Laurent Gavara , Francis Giraud , Lionel Nauton , Vincent Théry Bioorganic and Medicinal Chemistry, 2014, 22, pp.4704-4710. ⟨10.1016/j.bmc.2014.07.011⟩ Article dans une revue hal-01077451v1
	New N-1,N-10 bridged pyrrolo[2,3-a]carbazole-3-carbaldehyde: synthesis and biological activities. Francis Giraud , Marion Bourhis , Lionel Nauton , Vincent Théry , Lars Herfindal Bioorganic Chemistry, 2014, 57, pp.108-115. ⟨10.1016/j.bioorg.2014.09.004⟩ Article dans une revue hal-01077457v1
	New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin. Pascale Moreau , Lyubov G. Dezhenkova , Fabrice Anizon , Lionel Nauton , Vincent Thery Anti-Cancer Agents in Medicinal Chemistry, 2014, 14, pp.1228-1236. ⟨10.2174/1871520614666140825124456⟩ Article dans une revue hal-01077420v1
	Macrocyclic arylopeptoids - a novel type of cyclic N-alkylated aromatic oligoamides forming nanotubular assemblies. Thomas Hjelmgaard , Olivier Roy , Lionel Nauton , Malika El-Ghozzi , Daniel Avignant Chemical Communications, 2014, 50, pp.3564-3567. ⟨10.1039/C4CC00821A⟩ Article dans une revue hal-00987596v1
	Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors. Laurent Gavara , Virginie Suchaud , Lionel Nauton , Vincent Théry , Fabrice Anizon Bioorganic and Medicinal Chemistry Letters, 2013, 23 (8), pp.2298-2301. ⟨10.1016/j.bmcl.2013.02.074⟩ Article dans une revue hal-01089114v1
	Are Cu(I)-mesoionic NHC carbenes associated with nitrogen additives the best Cu-carbene catalysts for the azide-alkyne click reaction in solution? A case study. Stephan Hohloch , Biprajit Sarkar , Lionel Nauton , Federico Cisnetti , Arnaud Gautier Tetrahedron Letters, 2013, 54, pp.1808-1812 Article dans une revue hal-00812528v1
	Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors. Virginie Suchaud , Laurent Gavara , Emmanuelle Saugues , Lionel Nauton , Vincent Théry Bioorganic and Medicinal Chemistry, 2013, 21 (14), pp.4102-4111. ⟨10.1016/j.bmc.2013.05.011⟩ Article dans une revue hal-01089084v1
	Luminogenic "Clickable" Lanthanide Complexes for Protein Labeling. Nicolas Candelon , Niculina D. Hădade , Mihaela Matache , Jean-Louis Canet , Federico Cisnetti Chemical Communications, 2013, 49, pp.9206-9208 Article dans une revue hal-00950489v1
	Synthesis, characterization, X-ray structure, DNA cleavage and cytotoxic activities of palladium(II) complexes of 4-phenyl-3-thiosemicarbazide and triphenylphosphine. Fillipe Vieira Rocha , Carolina Valério Barra , Antonio Eduardo Mauro , Iracilda Z. Carlos , Lionel Nauton European Journal of Inorganic Chemistry, 2013, pp.4499-4505 Article dans une revue hal-00948885v1
	Structure-Based Design of PDZ Ligands as Inhibitors of 5-HT2A Receptor/PSD-95 PDZ1 Domain Interaction Possessing Anti-hyperalgesic Activity Alexandre Vogrig , Liam Dorr , Naoual Bouzidi , Benjamin Boucherle , Anne-Sophie Wattiez ACS Chemical Biology, 2013, 8, pp.2209-2216. ⟨10.1021/cb400308u⟩ Article dans une revue hal-00948867v1
	Clicked europium dipicolinate complexes for protein X-ray structure determination Romain Talon , Lionel Nauton , Jean-Louis Canet , Richard Kahn , Eric Girard Chemical Communications, 2012, 48, pp.11886-11888 Article dans une revue hal-00787224v1
	Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors. Francis Giraud , Rufine Akué-Gédu , Lionel Nauton , Nicolas Candelon , Eric Debiton European Journal of Medicinal Chemistry, 2012, 56, pp.225-236 Article dans une revue hal-00786353v1
	Access to functionalised silver(I) and gold(I) N-heterocyclic carbenes by [2+3] dipolar cycloadditions. Audrey Hospital , Clémentine Gibard , Christelle Gaulier , Lionel Nauton , Vincent Thery Dalton Transactions, 2012, 41, pp.6803-6812 Article dans une revue hal-00711788v1
	FSAB: A new fructose-6-phosphate aldolase from Escherichia coli. Cloning, over-expression and comparative kinetic characterization with FSAA Israel Sanchez-Moreno , Lionel Nauton , Vincent Théry , Agnès Pinet , Jean-Louis Petit Journal of Molecular Catalysis B: Enzymatic, 2012, 84, pp.9-14 Article dans une revue hal-00786230v1
	A platinum Chugaev carbene complex as a potent anticancer agent Georges Alves , Laurent Morel , Malika El-Ghozzi , Daniel Avignant , Bertrand Legeret Chemical Communications, 2011, 47, pp.7830-7832 Article dans une revue hal-00609652v1
	Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives. Francis Giraud , Georges Alves , Eric Debiton , Lionel Nauton , Vincent Thery Journal of Medicinal Chemistry, 2011, 54, pp.4474-4489 Article dans une revue hal-00609607v1
	Synthesis and molecular modelling study of new trimeric quinoline derivatives Emmanuelle Saugues , Lionel Nauton , Vincent Thery , Fabrice Anizon , Pascale Moreau Bioorganic Chemistry, 2011, 39, pp.143-150 Article dans une revue hal-00625030v1
	Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles Rufine Akué-Gédu , Lionel Nauton , Vincent Thery , Jenny Bain , Philip Cohen Bioorganic and Medicinal Chemistry, 2010, 18, pp.6865-6873 Article dans une revue hal-00530591v1
	Aromatic Nitrogen Donors for Efficient Copper(I)-NHC CuAAC under reductant-free conditions. Marie-Laure Teyssot , Lionel Nauton , Jean-Louis Canet , Federico Cisnetti , Aurélien Chevry European Journal of Organic Chemistry, 2010, pp.3507-3515. ⟨10.1002/ejoc.201000046⟩ Article dans une revue hal-00492922v1
	Click Chelators – The Behavior of Platinum and Palladium Complexes in the Presence of Guanosine and DNA Aurélien Chevry , Marie-Laure Teyssot , Aurélie Maisonial , Pascale Lemoine , Bernard Viossat European Journal of Inorganic Chemistry, 2010, 22, pp.3513-3519. ⟨10.1002/ejic.201000183⟩ Article dans une revue hal-00530546v1
	Structural insights into the design of inhbitors for the L1 metallo-ß-lactamase from Stenotrophomonas maltophilia Lionel Nauton , Richard Kahn , G. Garau , Jean-François Hernandez , Otto Dideberg Journal of Molecular Biology, 2008, 1, pp.257-269. ⟨10.1016/j.jmb.2007.10.036⟩ Article dans une revue hal-00341669v1
	X-ray spectroscopy and X-ray diffraction at wavelengths near the K-absorption edge of phosphorus. Valérie Biou , Peter Bösecke , Jean Marie Bois , Gérard Brandolin , Richard Kahn Journal of Synchrotron Radiation, 2005, 12 (Pt 4), pp.402-9. ⟨10.1107/S0909049505009222⟩ Article dans une revue hal-00376039v1

	Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles Fabrice Anizon , Rufine Akué-Gédu , Lionel Nauton , Vincent Thery , J. Bain 17th European Symposium on Organic Chemistry, Hersonissos (Grèce), 10-15 juillet 2011, Jul 2011, Hersonissos, Greece Communication dans un congrès hal-00609939v1
	Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives Pascale Moreau , Francis Giraud , Elisabeth Pereira , Fabrice Anizon , Georges Alves 17th European Symposium on Organic Chemistry, Jul 2011, Hersonissos, Greece Communication dans un congrès hal-00609975v1
	Edifices glycoconjugués multivalents. Antigènes Tn – béta-Peptides Marielle Barra , Olivier Roy , Lionel Nauton , Claude Taillefumier SyCOCAL VI, Symposium de Chimie Organique en Centre-Auvergne-Limousin, Sep 2008, La Bourboule, France Communication dans un congrès hal-00323171v1

Lionel Nauton

Publications

QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle

Pyruvate Aldolases Catalyze Cross-Aldol Reactions between Ketones: Highly Selective Access to Multi-Functionalized Tertiary Alcohols

Enzymatic Synthesis of Aliphatic Acyloins through Thermostable Transketolase Catalyzed-Reaction

Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest

Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia

4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition

Evolved Thermostable Transketolase for Stereoselective Two-Carbon Elongation of Non-Phosphorylated Aldoses to Naturally Rare Ketoses

Diastereoselective Synthesis of 2,6-Disubstituted-1,2,3,6-Tetrahydropyridines through a Palladium-Catalyzed Intramolecular Allylic Amination

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies

Achiral Hydroxypyruvaldehyde Phosphate as a Platform for Multi-Aldolases Cascade Synthesis of Diuloses and for a Quadruple Acetaldehyde Addition Catalyzed by 2-Deoxyribose-5-Phosphate Aldolases

NC α‐ gem ‐dimethylated peptoid side chains: A novel approach for structural control and peptide sequence mimetics

Topologically Diverse Shapes Accessible by Modular Design of Arylopeptoid Macrocycles

Synthesis of Branched-Chain Sugars with a DHAP-Dependent Aldolase: Ketones are Electrophile Substrates of Rhamnulose-1- phosphate Aldolases

A catalytic intramolecular nitrene insertion into a copper(I)–N-heterocyclic carbene bond yielding fused nitrogen heterocycles.

1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases

Insights into the Thiamine Diphosphate Enzyme Activation Mechanism: Computational Model for Transketolase Using a Quantum Mechanical/Molecular Mechanical Method.

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co–crystal structure.

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives.

Water-Soluble Gold–N-Heterocyclic Carbene Complexes for the Catalytic Homogeneous Acid- and Silver-Free Hydration of Hydrophilic Alkynes.

Engineering a Thermostable Transketolase for Unnatural Conversion of (2S)-Hydroxyaldehyde.

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

New N-1,N-10 bridged pyrrolo[2,3-a]carbazole-3-carbaldehyde: synthesis and biological activities.

New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin.

Macrocyclic arylopeptoids - a novel type of cyclic N-alkylated aromatic oligoamides forming nanotubular assemblies.

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

Are Cu(I)-mesoionic NHC carbenes associated with nitrogen additives the best Cu-carbene catalysts for the azide-alkyne click reaction in solution? A case study.

Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors.

Luminogenic "Clickable" Lanthanide Complexes for Protein Labeling.

Synthesis, characterization, X-ray structure, DNA cleavage and cytotoxic activities of palladium(II) complexes of 4-phenyl-3-thiosemicarbazide and triphenylphosphine.

Structure-Based Design of PDZ Ligands as Inhibitors of 5-HT2A Receptor/PSD-95 PDZ1 Domain Interaction Possessing Anti-hyperalgesic Activity

Clicked europium dipicolinate complexes for protein X-ray structure determination

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Access to functionalised silver(I) and gold(I) N-heterocyclic carbenes by [2+3] dipolar cycloadditions.

FSAB: A new fructose-6-phosphate aldolase from Escherichia coli. Cloning, over-expression and comparative kinetic characterization with FSAA

A platinum Chugaev carbene complex as a potent anticancer agent

Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives.

Synthesis and molecular modelling study of new trimeric quinoline derivatives

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

Aromatic Nitrogen Donors for Efficient Copper(I)-NHC CuAAC under reductant-free conditions.

Click Chelators – The Behavior of Platinum and Palladium Complexes in the Presence of Guanosine and DNA

Structural insights into the design of inhbitors for the L1 metallo-ß-lactamase from Stenotrophomonas maltophilia

X-ray spectroscopy and X-ray diffraction at wavelengths near the K-absorption edge of phosphorus.

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives

Edifices glycoconjugués multivalents. Antigènes Tn – béta-Peptides