PENG Ling

Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, et al.. Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1773. ⟨10.1038/s41467-020-15644-8⟩. ⟨hal-02551996⟩

Bo Hu, Liping Zhong, Yuhuang Weng, Ling Peng, Yuanyuan Huang, et al.. Therapeutic siRNA: state of the art. Signal Transduction and Targeted Therapy, Nature.com, 2020. ⟨hal-02879322⟩

Ling Ding, Zhenbin Lyu, Aura Tintaru, Erik Laurini, Domenico Marson, et al.. A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging. Chemical Communications, Royal Society of Chemistry, 2020, 56 (2), pp.301-304. ⟨10.1039/c9cc07750b⟩. ⟨hal-02480314⟩

Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, et al.. Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy. Chemical Communications, Royal Society of Chemistry, 2020, ⟨10.1039/d0cc04660d⟩. ⟨hal-02912892⟩

Wenjun Lan, Patricia Santofimia, Yi Xia, Zhengwei Zhou, Can Huang, et al.. Targeting NUPR1 with the Small Compound ZZW-115 Is an Efficient Strategy to Treat Hepatocellular Carcinoma. Cancer Letters, Elsevier, 2020. ⟨hal-02879351⟩

Wenjun Lan, Patricia Santofimia-Castano, Mirna Swayden, Yi Xia, Zhengwei Zhou, et al.. ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. JCI Insight, American Society for Clinical Investigation, 2020. ⟨hal-02942467⟩

Kai-Wen Huang, Vikash Reebye, Katherine Czysz, Simona Ciriello, Stephanie Dorman, et al.. Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile. Molecular Therapy - Nucleic Acids, Nature Publishing Group, 2020, 19, pp.361-370. ⟨10.1016/j.omtn.2019.10.044⟩. ⟨hal-02480317⟩

Ling Ding, Zhenbin Lyu, Beatrice Louis, Aura Tintaru, Erik Laurini, et al.. Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study. Small, Wiley-VCH Verlag, 2020, pp.2003290. ⟨10.1002/smll.202003290⟩. ⟨hal-02925669⟩

Z. Lyu, L. Ding, A.Y.T. Huang, L. Kao, L. Peng. Poly(amidoamine) dendrimers: covalent and supramolecular synthesis. Materials Today Chemistry, Elsevier, 2019, 13, pp.34-48. ⟨10.1016/j.mtchem.2019.04.004⟩. ⟨hal-02140381⟩

Patricia Santofimia-Castaño, Yi Xia, Ling Peng, Adrián Velázquez-Campoy, Olga Abián, et al.. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells, MDPI, 2019, 8 (11), pp.1453. ⟨10.3390/cells8111453⟩. ⟨hal-02480322⟩

Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, et al.. Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm. Molecular & Cellular Oncology, Taylor et Francis, 2019, pp.1-3. ⟨10.1080/23723556.2019.1612678⟩. ⟨hal-02140372⟩

Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, et al.. Targeting intrinsically disordered proteins involved in cancer. Cellular and Molecular Life Sciences, Springer Verlag, 2019, ⟨10.1007/s00018-019-03347-3⟩. ⟨hal-02491357⟩

Aleksandra Ellert-Miklaszewska, Natalia Ochocka, Marta Maleszewska, Ling Ding, Erik Laurini, et al.. Efficient and Innocuous Delivery of siRNA to Microglia using an Amphiphilic Dendrimer Nanovector. Nanomedicine, Future Medicine, In press. ⟨hal-02166653⟩

Zhengwei Zhou, Biyao Luo, Xi Liu, Mimi Chen, Wenjun Lan, et al.. Flavonoid-Alkylphospholipid Conjugates Elicit Dual Inhibition of Cancer Cell Growth and Lipid Accumulation. Journal of the Chemical Society, Chemical Communications, Royal Society of Chemistry, In press. ⟨hal-02166662⟩

Patricia Santofimia-Castaño, Yi Xia, Wenjun Lan, Zhengwei Zhou, Can Huang, et al.. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. Journal of Clinical Investigation, American Society for Clinical Investigation, 2019, ⟨10.1172/JCI127223⟩. ⟨hal-02140363⟩

Cheng-Cai Zhang, Cong-Zhao Zhou, Robert Burnap, Ling Peng. Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria. Trends in Plant Science, Elsevier, 2018, 23 (12), pp.1116-1130. ⟨hal-01952249⟩

Zhengwei Zhou, Mei Cong, Mengyao Li, Aura Tintaru, Jia Li, et al.. Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates. Chemical Communications, Royal Society of Chemistry, 2018, 54 (47), pp.5956-5959. ⟨10.1039/c8cc01221k⟩. ⟨hal-01952259⟩

Jing Ma, Shashwati Kala, Susan Yung, Tak Mao Chan, Yu Cao, et al.. Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery. Molecular Therapy, Nature Publishing Group, 2018, 26 (1), pp.70-83. ⟨10.1016/j.ymthe.2017.11.006⟩. ⟨hal-01952271⟩

Ling Ding, Zhenbin Lyu, Dinesh Dhumal, Chai-Lin Kao, Monique Bernard, et al.. Dendrimer-based magnetic resonance imaging agents for brain cancer. Science China Materials, Springer, 2018, 61 (11), pp.1420-1443. ⟨hal-01952251⟩

Philippe Garrigue, Jingjie Tang, Ling Ding, Ahlem Bouhlel, Aura Tintaru, et al.. Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2018, 115 (45), pp.11454-11459. ⟨10.1073/pnas.1812938115⟩. ⟨hal-01947788⟩

L. Peng, F. Chen, Z.-W. Hong, J.-F. Zheng, Laure Fillaud, et al.. Precise tuning of single molecule conductance in an electrochemical environment. Nanoscale, Royal Society of Chemistry, 2018, 10 (15), pp.7026 - 7032. ⟨10.1039/c8nr00625c⟩. ⟨hal-01792394⟩

Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Yu, et al.. A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy. Journal of the American Chemical Society, American Chemical Society, 2018, 140 (47), pp.16264-16274. ⟨10.1021/jacs.8b10021⟩. ⟨hal-01948490⟩

Mimi Chen, Zhengwei Zhou, Yaxiong Suo, Mengyao Li, Jianhua Yao, et al.. Acyclonucleosides bearing coplanar arylethynyltriazole nucleobases: synthesis, structural analysis, and biological evaluation. New Journal of Chemistry, Royal Society of Chemistry, 2017, 41 (16), pp.8509-8519. ⟨hal-01962989⟩

Qi Cui, Su Yang, Peng Ye, E. Tian, Guoqiang Sun, et al.. Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis. Nature Communications, Nature Publishing Group, 2016, 7, pp.10637. ⟨10.1038/ncomms10637⟩. ⟨hal-01452670⟩

Chao Chen, Paola Posocco, Xiaoxuan Liu, Qiang Cheng, Erik Laurini, et al.. Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing. Small, Wiley-VCH Verlag, 2016, 12 (27), pp.3667-3676. ⟨10.1002/smll.201503866⟩. ⟨hal-01459075⟩

Vikash Reebye, Kai-Wen Huang, Katherine Czysz, Simona Ciriello, Stehpanie Dorman, et al.. Hepatocellular Nuclear Factor 4 alpha (HNF-4 alpha) activation by saRNA rescues dyslipidemia and promotes favorable metabolic profile in a high fat diet (HFD) fed rat model.. Hepatology, Wiley-Blackwell, 2016, 63 (1 SUPP), pp.794A. ⟨10.1002/hep.28799⟩. ⟨hal-01452675⟩

Xiaoxuan Liu, Yang Wang, Chao Chen, Aura Tintaru, Yu Cao, et al.. A Fluorinated Bola-Amphiphilic Dendrimer for On-Demand Delivery of siRNA, via Specific Response to Reactive Oxygen Species. Advanced Functional Materials, Wiley, 2016, 26 (47), pp.8594-8603. ⟨10.1002/adfm.201604192⟩. ⟨hal-01459079⟩

G. Tang, M. Cong, Y. Xia, G. Quélever, Y. Fan, et al.. Pd-catalyzed oxidative C-H alkenylation: an effective method for synthesizing arylvinyltriazole nucleosides. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2015, 13, pp.110-114. ⟨hal-01128969⟩

Aura Tintaru, Rémi Ungaro, Xiaoxiuan Liu, Chao Chen, Laurent Giordano, et al.. Structural characterization of new defective molecules in poly(amidoamide)dendrimers by combining mass spectrometry and nuclear magnetic resonance. Analytica Chimica Acta, Elsevier Masson, 2015, 853, pp.451-459. ⟨10.1016/j.aca.2014.10.048⟩. ⟨hal-01128946⟩

Y. Zhao, F. Chen, Y. Pan, Z. Li, X. Xue, et al.. Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2015, 7, pp.19295-19305. ⟨hal-01222099⟩

T. Wei, C. Chen, J. Liu, C. Liu, A. M. Posocco, et al.. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2015, 112 (10), pp.2978-2983. ⟨hal-01131206⟩

M. Hao, C. Liu, L. Peng, J. Li, W. Lu, et al.. Shape separation of gold nanoparticles using a pH-responsive amphiphilic dendrimer according to their shape anisotropy distinction. Journal of Colloid and Interface Science, Elsevier, 2015, 437, pp.311-315. ⟨hal-01128932⟩

M. Cong, Y. Xia, J. Tang, L. Borge, G. Quéléver, et al.. Microwave promoted C-O coupling for synthesizing O-aryloxytriazole nucleoside analogues. New Journal of Chemistry, Royal Society of Chemistry, 2015, 39, pp.3889-3893. ⟨hal-01149759⟩

X. Liu, C. Liu, J. Zhou, C. Chen, F. Qu, et al.. Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrime. Nanoscale, Royal Society of Chemistry, 2015, 7, pp.3867-3875. ⟨hal-01130071⟩

S. Kala, A.S.C. Mak, X. Liu, P. Posoxxo, S. Pricl, et al.. Combination of dendrimer nanovector mediated small interfering RNA delivery to target Akt with clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer. Journal of Medicinal Chemistry, American Chemical Society, 2014, 57, pp.2634-2642. ⟨hal-00992909⟩

M. Cong, Y. Fan, J-M. Raimundo, J. Tang, L. Peng. Pd(dba)2 vs Pd2(dba)3 : An in-depth comparison of catalytic reactivity and mechanism via mixed-ligand promoted C-N and C-S coupling reactions. Organic Letters, American Chemical Society, 2014, 16, pp.4074-4077. ⟨hal-01067963⟩

Y. Wang, Z. Assaf, X. Liu, F. Ziarelli, A. Latifi, et al.. A 'click' chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (33), pp.6470-6475. ⟨10.1039/c4ob01005a⟩. ⟨hal-01067964⟩

Y. Wang, X. Liu, E. Laurini, P. Posocco, F. Ziarelli, et al.. Mimicking 2-oxoglutaric acid signaling function using molecular probes: insights from structural and functional investigations. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12, pp.4723-4729. ⟨hal-01021094⟩

M.F. Ottaviani, M. Cangiotti, A. Fattori, C. Coppola, P. Posocco, et al.. Copper(II) binding to structurally flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2014, 16, pp.685-694. ⟨hal-00919576⟩

Y. Fn, M. Cong, L. Peng. Mixed ligand catalyst: a powerful tool in transition metal-catalyzed cross-coupling reactions. Chemistry - A European Journal, Wiley-VCH Verlag, 2014, 20, pp.2698-2702. ⟨hal-00975063⟩

X. Liu, C. Liu, C.V. Catapano, L. Peng, J. Zhou, et al.. Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics. Biotechnology Advances, Elsevier, 2014, 32, pp.844-852. ⟨hal-01021095⟩

Aura Tintaru, Christophe Chendo, Qi Wang, Stéphane Viel, Gilles Quéléver, et al.. Conformational sensitivity of conjugated poly(ethylene oxide)-poly(amidoamine) molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study. Analytica Chimica Acta, Elsevier Masson, 2014, 808, pp.163--174. ⟨10.1016/j.aca.2013.08.030⟩. ⟨hal-01460547⟩

C. Liu, X. Liu, P. Rocchi, F. Qu, J. Iovanna, et al.. An arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo. Bioconjugate Chemistry, American Chemical Society, 2014, 25, pp.521-532. ⟨hal-00975157⟩

A. Tintaru, C. Chendo, Qiang Wang, S. Viel, G. Quelever, et al.. Conformational sensibility of PEO-PAMAM hybrid molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study. Analytica Chimica Acta, Elsevier Masson, 2014, 808, pp.163-174. ⟨hal-00975038⟩

V. Reebye, P. Sætrom, P.J. Mintz, K. Wen Huang, V. Lin, et al.. A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. Hepatology, Wiley-Blackwell, 2014, 59 (1), pp.216-227. ⟨10.1002/hep.26669⟩. ⟨hal-00975037⟩

Y. Xia, K. Sengupta, A. Maggiani, F. Qu, L. Peng. A bola-phospholipid containing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2013, 11, pp.5000-5005. ⟨hal-00914728⟩

Y-F. Chen, Z. Dong, Y. Xia, J. Tang, L. Peng, et al.. Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer. Cancer Science, Wiley Open Access, 2013, 104 (12), pp.1683-1689. ⟨10.1111/cas.12277⟩. ⟨hal-00919578⟩

Y. Xia, L. Peng. Photoactivatable lipid probes to study biomembranes using photoaffinity labeling. Chemical Reviews, American Chemical Society, 2013, 113, pp.7880-7929. ⟨hal-00914750⟩

H. Chen, S. Viel, F. Ziarelli, L. Peng. 19F NMR: a valuable tool for studying biological events. Chemical Society Reviews, Royal Society of Chemistry, 2013, 42, pp.7971-82. ⟨10.1039/c3cs60129c⟩. ⟨hal-00914745⟩

Han Chen, Stéphane Viel, Fabio Ziarelli, Ling Peng. F-19 NMR: a valuable tool for studying biological events. Chemical Society Reviews, Royal Society of Chemistry, 2013, 42 (20), pp.7971--7982. ⟨10.1039/c3cs60129c⟩. ⟨hal-01460447⟩

M. Cong, Y. Fan, J-L. Raimundo, Y. Xia, Yehan Liu, et al.. C-S coupling using a mixed-ligand Pd catalyst: a highly effective strategy for synthesizing arylthio-substituted heterocycles. Chemistry - A European Journal, Wiley-VCH Verlag, 2013, 19, pp.17267-17272. ⟨hal-00919577⟩

X. Liu, Y. Wang, E. Laurini, P. Posocco, H. Chen, et al.. Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function. Organic Letters, American Chemical Society, 2013, 15, pp.4664-4665. ⟨hal-00914747⟩

A. Tintaru, S. Pricl, L. Denbigh, X. Liu, L. Peng, et al.. Conformational changes of small PAMAM dendrimers as a function of their charge state: a combined electrospray mass spectrometry, traveling-wave ion mobility and molecular modeling study. International Journal of Mass Spectrometry, Elsevier, 2013, 354-355, pp.235-241. ⟨hal-00919568⟩

P. Posocco, X. Liu, E. Laurini, D. Marson, C. Chen, et al.. Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing. Molecular Pharmaceutics, American Chemical Society, 2013, 10, pp.3262-3273. ⟨hal-00914727⟩

Y. Xia, M. Wang, O. Demaria, J. Tang, P. Rocchi, et al.. A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity. Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (11), pp.5642-5646. ⟨10.1021/jm300534u⟩. ⟨hal-00724325⟩

F. Ziarelli, L. Peng, C-C. Zhang, S. Viel. HR-MAS NMR to investigate protein-ligand binding events in mass-limited samples. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2012, 59, pp.13-17. ⟨hal-00696830⟩

Fabio Ziarelli, Ling Peng, Cheng-Cai Zhang, Stéphane Viel. High resolution magic angle spinning NMR to investigate ligand-receptor binding events for mass-limited samples in liquids. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2012, 59, pp.13--17. ⟨10.1016/j.jpba.2011.10.006⟩. ⟨hal-01460455⟩

Y. Xia, Yehan Liu, P. Rocchi, M. Wang, Y. Fan, et al.. Targeting heat shock factor I with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer. Cancer Letters, Elsevier, 2012, 318, pp.145-153. ⟨hal-00697518⟩

Yi Xia, Stéphane Viel, Yang Wang, Fabio Ziarelli, Erik Laurini, et al.. Rationalizing the F center dot center dot center dot S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid. Chemical Communications, Royal Society of Chemistry, 2012, 48 (36), pp.4284--4286. ⟨10.1039/c2cc18147a⟩. ⟨hal-01460422⟩

Y. Xia, S. Viel, Y. Wang, F. Ziarelli, E. Laurini, et al.. Rationalizing the F...S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid. Chemical Communications, Royal Society of Chemistry, 2012, 48 (36), pp.4284-4286. ⟨hal-00697532⟩

Y. Fan, X. Xia, J. Tang, F. Ziarelli, F. Qu, et al.. An efficient mixed-ligand Pd catalytic system to promote C-N coupling for the synthesis of N-arylaminotriazole nucleosides. Chemistry - A European Journal, Wiley-VCH Verlag, 2012, 18, pp.2221-2225. ⟨hal-00696853⟩

M-F. Lang, S. Yang, C. Zhao, G. Sun, K. Murai, et al.. Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells. PLoS ONE, Public Library of Science, 2012, 7 (4), pp.e36248. ⟨hal-00698900⟩

X. Liu, P. Rocchi, L. Peng. Dendrimers as non-viral vectors for siRNA delivery. New Journal of Chemistry, Royal Society of Chemistry, 2012, 36, pp.256-263. ⟨hal-00696854⟩

Y. Wang, G. Quélever, L. Peng. The seemingly trivial yet challenging synthesis of poly(aminoester) dendrimers. Current Medicinal Chemistry, Bentham Science Publishers, 2012, 19, pp.5011. ⟨hal-00773476⟩

Y. Xia, P. Rocchi, J. Iovanna, L. Peng. Targeting heat shock response pathway to treat pancreatic cancer. Drug Discovery Today, Elsevier, 2012, 17, pp.35-43. ⟨hal-00696836⟩

X. Liu, C. Liu, E. Laurini, P. Posocco, S. Pricl, et al.. Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer. Molecular Pharmaceutics, American Chemical Society, 2012, 9 (3), pp.470-481. ⟨hal-00697517⟩

T. Yu, X. Liu, A-L. Bolcato-Bellemin, Y. Wang, C. Liu, et al.. An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51, pp.8478-8484. ⟨hal-00773462⟩

Y. Xia, F. Qu, A. Maggiani, K. Sengupta, C. Liu, et al.. Photoactivatable phospholipids bearing tetrafluorophenylazido chromophores exhibit unprecedented protonation state - dependent 19F-NMR signals. Organic Letters, American Chemical Society, 2011, 13, pp.4248-4251. ⟨hal-00624856⟩

X.J. Liu, H. Chen, E. Laurini, Y. Wang, V. Dal Col, et al.. 2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria. Organic Letters, American Chemical Society, 2011, 13 (11), pp.2924-2927. ⟨10.1021/ol2009544⟩. ⟨hal-00624846⟩

X. Liu, J. Wu, M. Yamine, J. Zhou, P. Posocco, et al.. Rationally designed structurally flexible PAMAM dendrimers as efficient vectors for DNA transfection in vitro and in vivo to mouse thymus. Bioconjugate Chemistry, American Chemical Society, 2011, 22, pp.2461-2473. ⟨hal-00696835⟩

M. Wang, R. Zhu, Z. Fan, Y. Fu, L. Feng, et al.. Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2011, 21, pp.354-357. ⟨hal-00566384⟩

Xiaoxuan Liu, Jiangyu Wu, Miriam Yammine, Jiehua Zhou, Paola Posocco, et al.. Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus. Bioconjugate Chemistry, American Chemical Society, 2011, 22 (12), pp.2461--2473. ⟨10.1021/bc200275g⟩. ⟨hal-01460316⟩

M. Katsogiannou, L. Peng, C. Catapano, P. Rocchi. Active-Targeted Nanotherapy Strategies for Prostate Cancer. Current Cancer Drug Targets, Bentham Science Publishers, 2011, 11, pp.954-965. ⟨hal-00696828⟩

A. Tintaru, C. Chendo, V. Monnier, C. Bouillon, G. Quelever, et al.. Electrospray tandem mass spectrometry of poly(amino)ester dendrimers: dissociation rules and structural characterization of defective molecules. International Journal of Mass Spectrometry, Elsevier, 2011, 308, pp.56-64. ⟨10.1016/j.ijms.2011.07.021⟩. ⟨hal-00696829⟩

J. Zhou, P. Neff, X. Liu, J. Zhang, H. Li, et al.. Systemic administration of dendrimer-siRNA complexes efficiently suppresses HIV-1 infection. Molecular Therapy, Nature Publishing Group, 2011, 19, pp.2228-2238. ⟨hal-00696834⟩

Y. Xia, F. Qu, L. Peng. Triazole Nucleoside Derivatives Bearing Aryl Functionalities on the Nucleobases Show Antiviral and Anticancer Activity. Mini Reviews in Medicinal Chemistry / Mini-Reviews in Medicinal Chemistry, 2010, 10 (9), pp.806-821. ⟨hal-00524518⟩

Y. Fan, Y. Xia, J. Tang, P. Rocchi, F. Qu, et al.. Ligand-Mediated Highly Effective and Selective C-N Coupling for Synthesizing Bioactive N-Aryltriazole Acyclonucleosides. Organic Letters, American Chemical Society, 2010, 12 (24), pp.5712-5715. ⟨hal-00566383⟩

C. Bouillon, A. Tintaru, V. Monnier, L. Charles, G. Quelever, et al.. Synthesis of Poly(amino)ester Dendrimers via Active Cyanomethyl Ester Intermediates. Journal of Organic Chemistry, American Chemical Society, 2010, 75, pp.8685-8688. ⟨hal-00566380⟩

M. Wang, Y. Xia, F. Qu, L. Peng. Novel triazole nucleoside analogs with anticancer activity. Chinese Journal of Medicinal Chemistry, 2010, 20 (5), pp.362. ⟨hal-00566382⟩

M.H. Wang, Y. Xia, Y.T. Fan, P. Rocchi, F.Q. Qu, et al.. A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20 (20), pp.5979-5983. ⟨10.1016/j.bmcl.2010.08.093⟩. ⟨hal-00566366⟩

Yehan Liu, Y. Xia, W. Li, M. Cong, A. Maggiani, et al.. S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20 (12), pp.3610-3613. ⟨hal-00523863⟩

Yehan Liu, Y. Xia, Y. Fan, A. Maggiani, P. Rocchi, et al.. N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20, pp.2503-2507. ⟨hal-00476527⟩

A. Tintaru, V. Monnier, C. Bouillon, R. Giordanengo, L. Peng, et al.. Structural characterization of poly(amino)ester dendrimers and related impurities by electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry, Wiley, 2010, 24, pp.2207-2216. ⟨hal-00566381⟩

J. Wan, Y. Xia, Yehan Liu, M. Wang, P. Rocchi, et al.. Discovery of novel arylethynyltriazole Ribonucleosides with selective and effective antiviral and anti-proliferative activity. Journal of Medicinal Chemistry, American Chemical Society, 2009, 52, pp.1144-1155. ⟨hal-00386951⟩

X. Liu, P. Rocci, F. Qu, S. Zheng, Z. Liang, et al.. PAMAM dendrimer mediated siRNA delivery to target heat-shock protein 27 and produce potent antiproliferation effect on prostate cancer PC-3 cells. ChemMedChem, Wiley-VCH Verlag, 2009, 4, pp.1302-1310. ⟨hal-00440698⟩

Y. Xia, Yehan Liu, J. Wan, M. Wang, P. Rocchi, et al.. Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer. Journal of Medicinal Chemistry, American Chemical Society, 2009, 52 (19), pp.6083-6096. ⟨10.1021/jm900960v⟩. ⟨hal-00440701⟩

C. Bouillon, G. Quéléver, L. Peng. Efficient synthesis of esters containing tertiary amine functionalities via active cyanomethyl ester intermediates. Tetrahedron Letters, Elsevier, 2009, 50 (30), pp.4346-4349. ⟨hal-00413539⟩

A. Specht, S. Loudwig, L. Peng, M. Goeldner. Complexing photolabile cholinergic ligands with synthetic and biological receptors: a dynamic survey. Journal of Inclusion Phenomena and Macrocyclic Chemistry, Springer Verlag, 2009, 65, pp.157-163. ⟨hal-00440700⟩

W. Li, Y. Fan, P. Rocchi, R. Zhu, F. Qu, et al.. Cu-mediated Selective N-arylation of Aminotriazole Acyclonucleosides. Helvetica Chimica Acta, Wiley, 2009, 92, pp.1503-1513. ⟨hal-00440699⟩

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