PENG Ling

Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, et al.. Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1773. ⟨10.1038/s41467-020-15644-8⟩. ⟨hal-02551996⟩

Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam Dey, Jingjie Tang, et al.. Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells. Nature Protocols, Nature Publishing Group, 2020, ⟨10.1038/s41596-020-00418-9⟩. ⟨hal-03041303⟩

Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, et al.. Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy. Chemical Communications, Royal Society of Chemistry, 2020, 56 (69), pp.10014-10017. ⟨10.1039/d0cc04660d⟩. ⟨hal-02992738⟩

Kai-Wen Huang, Vikash Reebye, Katherine Czysz, Simona Ciriello, Stephanie Dorman, et al.. Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile. Molecular Therapy - Nucleic Acids, Nature Publishing Group, 2020, 19, pp.361 - 370. ⟨10.1016/j.omtn.2019.10.044⟩. ⟨hal-02992731⟩

Bo Hu, Liping Zhong, Yuhua Weng, Ling Peng, Yuanyu Huang, et al.. Therapeutic siRNA: state of the art. Signal Transduction and Targeted Therapy, Nature.com, 2020, 5 (1), ⟨10.1038/s41392-020-0207-x⟩. ⟨hal-02992725⟩

Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, et al.. ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. JCI Insight, American Society for Clinical Investigation, 2020, 5 (18), ⟨10.1172/jci.insight.138117⟩. ⟨hal-02992672⟩

Yanhua Zhang, Yun Lin, Qianqian Hou, Xi Liu, Sabrina Pricl, et al.. Novel Aryltriazole Acyclic C-Azanucleosides as Anticancer Candidates. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, ⟨10.1039/d0ob02164d⟩. ⟨hal-03041312⟩

Wenjun Lan, Patricia Santofimia-Castaño, Yi Xia, Zhengwei Zhou, Can Huang, et al.. Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma. Cancer Letters, Elsevier, 2020, 486, pp.8-17. ⟨10.1016/j.canlet.2020.04.024⟩. ⟨hal-02994552⟩

Ling Ding, Zhenbin Lyu, Beatrice Louis, Aura Tintaru, Erik Laurini, et al.. Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study. Small, Wiley-VCH Verlag, 2020, 16 (2), pp.301-304. ⟨10.1002/smll.202003290⟩. ⟨hal-02992689⟩

Dinesh Dhumal, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, et al.. An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile. Nano Research, Springer, 2020, ⟨10.1007/s12274-020-3216-8⟩. ⟨hal-03041310⟩

Ling Ding, Zhenbin Lyu, Aura Tintaru, Erik Laurini, Domenico Marson, et al.. A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging. Chemical Communications, Royal Society of Chemistry, 2020, 56 (2), pp.301-304. ⟨10.1039/c9cc07750b⟩. ⟨hal-02480314⟩

Zhenbin Lyu, Ling Ding, Aura Tintaru, Ling Peng. Self-assembling supramolecular dendrimers for biomedical applications: lessons learned from poly(amidoamine) dendrimers. Accounts of Chemical Research, American Chemical Society, 2020, ⟨10.1021/acs.accounts.0c00589⟩. ⟨hal-03041818⟩

Aleksandra Ellert-Miklaszewska, Natalia Ochocka, Marta Maleszewska, Ling Ding, Erik Laurini, et al.. Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector. Nanomedicine, Future Medicine, 2019, 14 (18), pp.2441 - 2458. ⟨10.2217/nnm-2019-0176⟩. ⟨hal-02992806⟩

Zhengwei Zhou, Biyao Luo, Xi Liu, Mimi Chen, Wenjun Lan, et al.. Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation. Chemical Communications, Royal Society of Chemistry, 2019, 55 (61), pp.8919 - 8922. ⟨10.1039/c9cc04084f⟩. ⟨hal-02992833⟩

Patricia Santofimia-Castaño, Yi Xia, Wenjun Lan, Zhengwei Zhou, Can Huang, et al.. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. Journal of Clinical Investigation, American Society for Clinical Investigation, 2019, 129 (6), pp.2500 - 2513. ⟨10.1172/jci127223⟩. ⟨hal-02992816⟩

Z. Lyu, L. Ding, A.Y.T. Huang, L. Kao, Ling Peng. Poly(amidoamine) dendrimers: covalent and supramolecular synthesis. Materials Today Chemistry, Elsevier, 2019, 13, pp.34-48. ⟨10.1016/j.mtchem.2019.04.004⟩. ⟨hal-02140381⟩

Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, et al.. Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm. Molecular & Cellular Oncology, Taylor et Francis, 2019, pp.1-3. ⟨10.1080/23723556.2019.1612678⟩. ⟨hal-02140372⟩

Patricia Santofimia-Castaño, Yi Xia, Ling Peng, Adrián Velázquez-Campoy, Olga Abián, et al.. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells, MDPI, 2019, 8 (11), pp.1453. ⟨10.3390/cells8111453⟩. ⟨hal-02480322⟩

Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, et al.. Targeting intrinsically disordered proteins involved in cancer. Cellular and Molecular Life Sciences, Springer Verlag, 2019, ⟨10.1007/s00018-019-03347-3⟩. ⟨hal-02491357⟩

Wenjun Lan, Benjamin Bian, Yi Xia, Samir Dou, Odile Gayet, et al.. E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments. Scientific Reports, Nature Publishing Group, 2018, 8, pp.8330. ⟨10.1038/s41598-018-26613-z⟩. ⟨hal-01947725⟩

Ling Peng, F. Chen, Z.-W. Hong, J.-F. Zheng, Laure Fillaud, et al.. Precise tuning of single molecule conductance in an electrochemical environment. Nanoscale, Royal Society of Chemistry, 2018, 10 (15), pp.7026 - 7032. ⟨10.1039/c8nr00625c⟩. ⟨hal-01792394⟩

Jing Ma, Shashwati Kala, Susan Yung, Tak Mao Chan, Yu Cao, et al.. Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery. Molecular Therapy, Nature Publishing Group, 2018, 26 (1), pp.70 - 83. ⟨10.1016/j.ymthe.2017.11.006⟩. ⟨hal-02992967v2⟩

Jing Ma, Shashwati Kala, Susan Yung, Tak Mao Chan, Yu Cao, et al.. Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery. Molecular Therapy, Nature Publishing Group, 2018, 26 (1), pp.70-83. ⟨10.1016/j.ymthe.2017.11.006⟩. ⟨hal-01952271⟩

Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Yu, et al.. A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy. Journal of the American Chemical Society, American Chemical Society, 2018, 140 (47), pp.16264-16274. ⟨10.1021/jacs.8b10021⟩. ⟨hal-01948490⟩

Ling Ding, Zhenbin Lyu, Dinesh Dhumal, Chai-Lin Kao, Monique Bernard, et al.. Dendrimer-based magnetic resonance imaging agents for brain cancer. Science China Materials, Springer, 2018, 61 (11), pp.1420-1443. ⟨hal-01952251⟩

Zhengwei Zhou, Mei Cong, Mengyao Li, Aura Tintaru, Jia Li, et al.. Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates. Chemical Communications, Royal Society of Chemistry, 2018, 54 (47), pp.5956-5959. ⟨10.1039/c8cc01221k⟩. ⟨hal-01952259⟩

Cheng-Cai Zhang, Cong-Zhao Zhou, Robert Burnap, Ling Peng. Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria. Trends in Plant Science, Elsevier, 2018, 23 (12), pp.1116-1130. ⟨hal-01952249⟩

Cheng-Cai Zhang, Cong-Zhao Zhou, Robert Burnap, Ling Peng. Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria. Trends in Plant Science, Elsevier, 2018, 23 (12), pp.1116 - 1130. ⟨10.1016/j.tplants.2018.09.008⟩. ⟨hal-02992919⟩

Ling Ding, Zhenbin Lyu, Dinesh Dhumal, Chai-Lin Kao, Monique Bernard, et al.. Dendrimer-based magnetic resonance imaging agents for brain cancer. Science China Materials, Springer, 2018, 61 (11), pp.1420 - 1443. ⟨10.1007/s40843-018-9323-6⟩. ⟨hal-02992931⟩

Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, et al.. A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy. Journal of the American Chemical Society, American Chemical Society, 2018, 140 (47), pp.16264-16274. ⟨10.1021/jacs.8b10021⟩. ⟨hal-02992903⟩

Philippe Garrigue, Jingjie Tang, Ling Ding, Ahlem Bouhlel, Aura Tintaru, et al.. Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2018, 115 (45), pp.11454-11459. ⟨10.1073/pnas.1812938115⟩. ⟨hal-01947788⟩

Zhengwei Zhou, Mei Cong, Mengyao Li, Aura Tintaru, Jia Li, et al.. Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates. Chemical Communications, Royal Society of Chemistry, 2018, 54 (47), pp.5956 - 5959. ⟨10.1039/c8cc01221k⟩. ⟨hal-02992951⟩

Zhenbin Lyu, Ling Peng. Potent drugless dendrimers. Nature Biomedical Engineering, Nature Publishing Group, 2017, 1 (9), pp.686 - 688. ⟨10.1038/s41551-017-0136-3⟩. ⟨hal-01783444⟩

Mimi Chen, Zhengwei Zhou, Yaxiong Suo, Mengyao Li, Jianhua Yao, et al.. Acyclonucleosides bearing coplanar arylethynyltriazole nucleobases: synthesis, structural analysis, and biological evaluation. New Journal of Chemistry, Royal Society of Chemistry, 2017, 41 (16), pp.8509-8519. ⟨hal-01962989⟩

Yu Cao, Xiaoxuan Liu, Ling Peng. Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing. Frontiers of Chemical Science and Engineering, Higher Education Press; Springer, 2017, 11 (4), pp.663 - 675. ⟨10.1007/s11705-017-1623-5⟩. ⟨hal-01962995⟩

Qi Cui, Su Yang, Peng Ye, E. Tian, Guoqiang Sun, et al.. Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis. Nature Communications, Nature Publishing Group, 2016, 7, pp.10637. ⟨10.1038/ncomms10637⟩. ⟨hal-01452670⟩

Xiaoxuan Liu, Yang Wang, Chao Chen, Aura Tintaru, Yu Cao, et al.. A Fluorinated Bola-Amphiphilic Dendrimer for On-Demand Delivery of siRNA, via Specific Response to Reactive Oxygen Species. Advanced Functional Materials, Wiley, 2016, 26 (47), pp.8594-8603. ⟨10.1002/adfm.201604192⟩. ⟨hal-01459079⟩

Chao Chen, Paola Posocco, Xiaoxuan Liu, Qiang Cheng, Erik Laurini, et al.. Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing. Small, Wiley-VCH Verlag, 2016, 12 (27), pp.3667-3676. ⟨10.1002/smll.201503866⟩. ⟨hal-01459075⟩

Vikash Reebye, Kai-Wen Huang, Katherine Czysz, Simona Ciriello, Stehpanie Dorman, et al.. Hepatocellular Nuclear Factor 4 alpha (HNF-4 alpha) activation by saRNA rescues dyslipidemia and promotes favorable metabolic profile in a high fat diet (HFD) fed rat model.. Hepatology, Wiley-Blackwell, 2016, 63 (1 SUPP), pp.794A. ⟨10.1002/hep.28799⟩. ⟨hal-01452675⟩

Samuel Hinman, Charles Ruiz, Yu Cao, Meghann Ma, Jingjie Tang, et al.. Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2016, 9 (1), pp.1029 - 1035. ⟨10.1021/acsami.6b11556⟩. ⟨hal-01783435⟩

Xue Zhang, Na Li, L. Liu, Gaochen Gu, Chao Li, et al.. Robust Sierpiński triangle fractals on symmetry-mismatched Ag(100). Chemical Communications, Royal Society of Chemistry, 2016, 52 (69), pp.10578-10581. ⟨10.1039/c6cc04879j⟩. ⟨hal-01766330⟩

Aura Tintaru, Rémi Ungaro, Xiaoxiuan Liu, Chao Chen, Laurent Giordano, et al.. Structural characterization of new defective molecules in poly(amidoamide)dendrimers by combining mass spectrometry and nuclear magnetic resonance. Analytica Chimica Acta, Elsevier Masson, 2015, 853, pp.451-459. ⟨10.1016/j.aca.2014.10.048⟩. ⟨hal-01128946⟩

T. Wei, C. Chen, J. Liu, C. Liu, A. M. Posocco, et al.. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2015, 112 (10), pp.2978-2983. ⟨hal-01131206⟩

X. Liu, C. Liu, J. Zhou, C. Chen, F. Qu, et al.. Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrime. Nanoscale, Royal Society of Chemistry, 2015, 7, pp.3867-3875. ⟨hal-01130071⟩

G. Tang, M. Cong, Y. Xia, G. Quélever, Y. Fan, et al.. Pd-catalyzed oxidative C-H alkenylation: an effective method for synthesizing arylvinyltriazole nucleosides. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2015, 13, pp.110-114. ⟨hal-01128969⟩

M. Cong, Y. Xia, J. Tang, L. Borge, G. Quéléver, et al.. Microwave promoted C-O coupling for synthesizing O-aryloxytriazole nucleoside analogues. New Journal of Chemistry, Royal Society of Chemistry, 2015, 39, pp.3889-3893. ⟨hal-01149759⟩

M. Hao, C. Liu, Ling Peng, J. Li, W. Lu, et al.. Shape separation of gold nanoparticles using a pH-responsive amphiphilic dendrimer according to their shape anisotropy distinction. Journal of Colloid and Interface Science, Elsevier, 2015, 437, pp.311-315. ⟨hal-01128932⟩

Y. Zhao, F. Chen, Y. Pan, Z. Li, X. Xue, et al.. Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2015, 7, pp.19295-19305. ⟨hal-01222099⟩

Aura Tintaru, Christophe Chendo, Qi Wang, Stéphane Viel, Gilles Quéléver, et al.. Conformational sensitivity of conjugated poly(ethylene oxide)-poly(amidoamine) molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study. Analytica Chimica Acta, Elsevier Masson, 2014, 808, pp.163--174. ⟨10.1016/j.aca.2013.08.030⟩. ⟨hal-01460547⟩

M.F. Ottaviani, M. Cangiotti, A. Fattori, C. Coppola, P. Posocco, et al.. Copper(II) binding to structurally flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2014, 16, pp.685-694. ⟨hal-00919576⟩

Y. Fn, M. Cong, Ling Peng. Mixed ligand catalyst: a powerful tool in transition metal-catalyzed cross-coupling reactions. Chemistry - A European Journal, Wiley-VCH Verlag, 2014, 20, pp.2698-2702. ⟨hal-00975063⟩

A. Tintaru, C. Chendo, Qiang Wang, S. Viel, G. Quelever, et al.. Conformational sensibility of PEO-PAMAM hybrid molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study. Analytica Chimica Acta, Elsevier Masson, 2014, 808, pp.163-174. ⟨hal-00975038⟩

M. Cong, Y. Fan, J-M. Raimundo, J. Tang, Ling Peng. Pd(dba)2 vs Pd2(dba)3 : An in-depth comparison of catalytic reactivity and mechanism via mixed-ligand promoted C-N and C-S coupling reactions. Organic Letters, American Chemical Society, 2014, 16, pp.4074-4077. ⟨hal-01067963⟩

Y. Wang, Z. Assaf, X. Liu, F. Ziarelli, A. Latifi, et al.. A 'click' chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (33), pp.6470-6475. ⟨10.1039/c4ob01005a⟩. ⟨hal-01067964⟩

C. Liu, X. Liu, P. Rocchi, F. Qu, J. Iovanna, et al.. An arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo. Bioconjugate Chemistry, American Chemical Society, 2014, 25, pp.521-532. ⟨hal-00975157⟩

X. Liu, C. Liu, C.V. Catapano, Ling Peng, J. Zhou, et al.. Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics. Biotechnology Advances, Elsevier, 2014, 32, pp.844-852. ⟨hal-01021095⟩

S. Kala, A.S.C. Mak, X. Liu, P. Posoxxo, S. Pricl, et al.. Combination of dendrimer nanovector mediated small interfering RNA delivery to target Akt with clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer. Journal of Medicinal Chemistry, American Chemical Society, 2014, 57, pp.2634-2642. ⟨hal-00992909⟩

Y. Wang, X. Liu, E. Laurini, P. Posocco, F. Ziarelli, et al.. Mimicking 2-oxoglutaric acid signaling function using molecular probes: insights from structural and functional investigations. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12, pp.4723-4729. ⟨hal-01021094⟩

V. Reebye, P. Sætrom, P.J. Mintz, K. Wen Huang, V. Lin, et al.. A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. Hepatology, Wiley-Blackwell, 2014, 59 (1), pp.216-227. ⟨10.1002/hep.26669⟩. ⟨hal-00975037⟩

Han Chen, Stéphane Viel, Fabio Ziarelli, Ling Peng. F-19 NMR: a valuable tool for studying biological events. Chemical Society Reviews, Royal Society of Chemistry, 2013, 42 (20), pp.7971--7982. ⟨10.1039/c3cs60129c⟩. ⟨hal-01460447⟩

Y-F. Chen, Z. Dong, Y. Xia, J. Tang, Ling Peng, et al.. Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer. Cancer Science, Wiley Open Access, 2013, 104 (12), pp.1683-1689. ⟨10.1111/cas.12277⟩. ⟨hal-00919578⟩

P. Posocco, X. Liu, E. Laurini, D. Marson, C. Chen, et al.. Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing. Molecular Pharmaceutics, American Chemical Society, 2013, 10, pp.3262-3273. ⟨hal-00914727⟩

M. Cong, Y. Fan, J-L. Raimundo, Y. Xia, Yehan Liu, et al.. C-S coupling using a mixed-ligand Pd catalyst: a highly effective strategy for synthesizing arylthio-substituted heterocycles. Chemistry - A European Journal, Wiley-VCH Verlag, 2013, 19, pp.17267-17272. ⟨hal-00919577⟩

H. Chen, S. Viel, F. Ziarelli, Ling Peng. 19F NMR: a valuable tool for studying biological events. Chemical Society Reviews, Royal Society of Chemistry, 2013, 42, pp.7971-82. ⟨10.1039/c3cs60129c⟩. ⟨hal-00914745⟩

A. Tintaru, S. Pricl, L. Denbigh, X. Liu, Ling Peng, et al.. Conformational changes of small PAMAM dendrimers as a function of their charge state: a combined electrospray mass spectrometry, traveling-wave ion mobility and molecular modeling study. International Journal of Mass Spectrometry, Elsevier, 2013, 354-355, pp.235-241. ⟨hal-00919568⟩

Y. Xia, K. Sengupta, A. Maggiani, F. Qu, Ling Peng. A bola-phospholipid containing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2013, 11, pp.5000-5005. ⟨hal-00914728⟩

Y. Xia, Ling Peng. Photoactivatable lipid probes to study biomembranes using photoaffinity labeling. Chemical Reviews, American Chemical Society, 2013, 113, pp.7880-7929. ⟨hal-00914750⟩

X. Liu, Y. Wang, E. Laurini, P. Posocco, H. Chen, et al.. Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function. Organic Letters, American Chemical Society, 2013, 15, pp.4664-4665. ⟨hal-00914747⟩

Fabio Ziarelli, Ling Peng, Cheng-Cai Zhang, Stéphane Viel. High resolution magic angle spinning NMR to investigate ligand-receptor binding events for mass-limited samples in liquids. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2012, 59, pp.13--17. ⟨10.1016/j.jpba.2011.10.006⟩. ⟨hal-01460455⟩

Yi Xia, Stéphane Viel, Yang Wang, Fabio Ziarelli, Erik Laurini, et al.. Rationalizing the F...S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid. Chemical Communications, Royal Society of Chemistry, 2012, 48 (36), pp.4284--4286. ⟨10.1039/c2cc18147a⟩. ⟨hal-01460422⟩

T. Yu, X. Liu, A-L. Bolcato-Bellemin, Y. Wang, C. Liu, et al.. An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51, pp.8478-8484. ⟨hal-00773462⟩

Y. Fan, X. Xia, J. Tang, F. Ziarelli, F. Qu, et al.. An efficient mixed-ligand Pd catalytic system to promote C-N coupling for the synthesis of N-arylaminotriazole nucleosides. Chemistry - A European Journal, Wiley-VCH Verlag, 2012, 18, pp.2221-2225. ⟨hal-00696853⟩

F. Ziarelli, Ling Peng, C-C. Zhang, S. Viel. HR-MAS NMR to investigate protein-ligand binding events in mass-limited samples. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2012, 59, pp.13-17. ⟨hal-00696830⟩

Y. Xia, P. Rocchi, J. Iovanna, Ling Peng. Targeting heat shock response pathway to treat pancreatic cancer. Drug Discovery Today, Elsevier, 2012, 17, pp.35-43. ⟨hal-00696836⟩

M-F. Lang, S. Yang, C. Zhao, G. Sun, K. Murai, et al.. Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells. PLoS ONE, Public Library of Science, 2012, 7 (4), pp.e36248. ⟨hal-00698900⟩

Y. Xia, Yehan Liu, P. Rocchi, M. Wang, Y. Fan, et al.. Targeting heat shock factor I with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer. Cancer Letters, Elsevier, 2012, 318, pp.145-153. ⟨hal-00697518⟩

X. Liu, C. Liu, E. Laurini, P. Posocco, S. Pricl, et al.. Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer. Molecular Pharmaceutics, American Chemical Society, 2012, 9 (3), pp.470-481. ⟨hal-00697517⟩

Y. Wang, G. Quélever, Ling Peng. The seemingly trivial yet challenging synthesis of poly(aminoester) dendrimers. Current Medicinal Chemistry, Bentham Science Publishers, 2012, 19, pp.5011. ⟨hal-00773476⟩

Y. Xia, M. Wang, O. Demaria, J. Tang, P. Rocchi, et al.. A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity. Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (11), pp.5642-5646. ⟨10.1021/jm300534u⟩. ⟨hal-00724325⟩

X. Liu, P. Rocchi, Ling Peng. Dendrimers as non-viral vectors for siRNA delivery. New Journal of Chemistry, Royal Society of Chemistry, 2012, 36, pp.256-263. ⟨hal-00696854⟩

X. Liu, J. Wu, M. Yamine, J. Zhou, P. Posocco, et al.. Rationally designed structurally flexible PAMAM dendrimers as efficient vectors for DNA transfection in vitro and in vivo to mouse thymus. Bioconjugate Chemistry, American Chemical Society, 2011, 22, pp.2461-2473. ⟨hal-00696835⟩

M. Wang, R. Zhu, Z. Fan, Y. Fu, L. Feng, et al.. Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2011, 21, pp.354-357. ⟨hal-00566384⟩

M. Katsogiannou, Ling Peng, C. Catapano, P. Rocchi. Active-Targeted Nanotherapy Strategies for Prostate Cancer. Current Cancer Drug Targets, Bentham Science Publishers, 2011, 11, pp.954-965. ⟨hal-00696828⟩

X.J. Liu, H. Chen, E. Laurini, Y. Wang, V. Dal Col, et al.. 2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria. Organic Letters, American Chemical Society, 2011, 13 (11), pp.2924-2927. ⟨10.1021/ol2009544⟩. ⟨hal-00624846⟩

A. Tintaru, C. Chendo, V. Monnier, C. Bouillon, G. Quelever, et al.. Electrospray tandem mass spectrometry of poly(amino)ester dendrimers: dissociation rules and structural characterization of defective molecules. International Journal of Mass Spectrometry, Elsevier, 2011, 308, pp.56-64. ⟨10.1016/j.ijms.2011.07.021⟩. ⟨hal-00696829⟩

J. Zhou, P. Neff, X. Liu, J. Zhang, H. Li, et al.. Systemic administration of dendrimer-siRNA complexes efficiently suppresses HIV-1 infection. Molecular Therapy, Nature Publishing Group, 2011, 19, pp.2228-2238. ⟨hal-00696834⟩

Y. Xia, F. Qu, A. Maggiani, K. Sengupta, C. Liu, et al.. Photoactivatable phospholipids bearing tetrafluorophenylazido chromophores exhibit unprecedented protonation state - dependent 19F-NMR signals. Organic Letters, American Chemical Society, 2011, 13, pp.4248-4251. ⟨hal-00624856⟩

Xiaoxuan Liu, Jiangyu Wu, Miriam Yammine, Jiehua Zhou, Paola Posocco, et al.. Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus. Bioconjugate Chemistry, American Chemical Society, 2011, 22 (12), pp.2461--2473. ⟨10.1021/bc200275g⟩. ⟨hal-01460316⟩

Y. Xia, F. Qu, Ling Peng. Triazole Nucleoside Derivatives Bearing Aryl Functionalities on the Nucleobases Show Antiviral and Anticancer Activity. Mini Reviews in Medicinal Chemistry / Mini-Reviews in Medicinal Chemistry, 2010, 10 (9), pp.806-821. ⟨hal-00524518⟩

M.H. Wang, Y. Xia, Y.T. Fan, P. Rocchi, F.Q. Qu, et al.. A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20 (20), pp.5979-5983. ⟨10.1016/j.bmcl.2010.08.093⟩. ⟨hal-00566366⟩

M. Wang, Y. Xia, F. Qu, Ling Peng. Novel triazole nucleoside analogs with anticancer activity. Chinese Journal of Medicinal Chemistry, 2010, 20 (5), pp.362. ⟨hal-00566382⟩

Yehan Liu, Y. Xia, W. Li, M. Cong, A. Maggiani, et al.. S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20 (12), pp.3610-3613. ⟨hal-00523863⟩

C. Bouillon, A. Tintaru, V. Monnier, L. Charles, G. Quelever, et al.. Synthesis of Poly(amino)ester Dendrimers via Active Cyanomethyl Ester Intermediates. Journal of Organic Chemistry, American Chemical Society, 2010, 75, pp.8685-8688. ⟨hal-00566380⟩

Yehan Liu, Y. Xia, Y. Fan, A. Maggiani, P. Rocchi, et al.. N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20, pp.2503-2507. ⟨hal-00476527⟩

Y. Fan, Y. Xia, J. Tang, P. Rocchi, F. Qu, et al.. Ligand-Mediated Highly Effective and Selective C-N Coupling for Synthesizing Bioactive N-Aryltriazole Acyclonucleosides. Organic Letters, American Chemical Society, 2010, 12 (24), pp.5712-5715. ⟨hal-00566383⟩

A. Tintaru, V. Monnier, C. Bouillon, R. Giordanengo, Ling Peng, et al.. Structural characterization of poly(amino)ester dendrimers and related impurities by electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry, Wiley, 2010, 24, pp.2207-2216. ⟨hal-00566381⟩

A. Specht, S. Loudwig, Ling Peng, M. Goeldner. Complexing photolabile cholinergic ligands with synthetic and biological receptors: a dynamic survey. Journal of Inclusion Phenomena and Macrocyclic Chemistry, Springer Verlag, 2009, 65, pp.157-163. ⟨hal-00440700⟩

Y. Xia, Yehan Liu, J. Wan, M. Wang, P. Rocchi, et al.. Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer. Journal of Medicinal Chemistry, American Chemical Society, 2009, 52 (19), pp.6083-6096. ⟨10.1021/jm900960v⟩. ⟨hal-00440701⟩

C. Bouillon, G. Quéléver, Ling Peng. Efficient synthesis of esters containing tertiary amine functionalities via active cyanomethyl ester intermediates. Tetrahedron Letters, Elsevier, 2009, 50 (30), pp.4346-4349. ⟨hal-00413539⟩

X. Liu, P. Rocci, F. Qu, S. Zheng, Z. Liang, et al.. PAMAM dendrimer mediated siRNA delivery to target heat-shock protein 27 and produce potent antiproliferation effect on prostate cancer PC-3 cells. ChemMedChem, Wiley-VCH Verlag, 2009, 4, pp.1302-1310. ⟨hal-00440698⟩

W. Li, Y. Fan, P. Rocchi, R. Zhu, F. Qu, et al.. Cu-mediated Selective N-arylation of Aminotriazole Acyclonucleosides. Helvetica Chimica Acta, Wiley, 2009, 92, pp.1503-1513. ⟨hal-00440699⟩

J. Wan, Y. Xia, Yehan Liu, M. Wang, P. Rocchi, et al.. Discovery of novel arylethynyltriazole Ribonucleosides with selective and effective antiviral and anti-proliferative activity. Journal of Medicinal Chemistry, American Chemical Society, 2009, 52, pp.1144-1155. ⟨hal-00386951⟩

R. Zhu, M. Wang, Y. Xia, F. Qu, J. Neyts, et al.. Arylethynyltriazole Acyclonucleosides Inhibit Hepatitis C Virus Replication. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2008, 18, pp.3321-3327. ⟨hal-00303813⟩

W. Li, Y. Xia, Z. Fan, F. Qu, Q. Wu, et al.. Bitriazolyl Acyclonucleosides with Antiviral Activity against Tobacco Mosaic Virus. Tetrahedron Letters, Elsevier, 2008, 49, pp.2804-2809. ⟨hal-00303814⟩

Krittalak Chakrabandhu, Zoltán Hérincs, Sébastien Huault, Britta Dost, Ling Peng, et al.. Palmitoylation is required for efficient Fas cell death signaling.. EMBO Journal, EMBO Press, 2007, 26 (1), pp.209-20. ⟨10.1038/sj.emboj.7601456⟩. ⟨hal-00165458⟩

Y. Xia, W. Li, F. Qu, Z. Fan, X. Liu, et al.. Synthesis of Bitriazolyl Nucleosides and Unexpectedly Different Reactivity of Azidotriazole Nucleoside Isomers in Huisgen Reaction. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2007, 5, pp.1695-1701. ⟨hal-00303626⟩

Z. Herincs, K. Chakrabandhu, B. Dost, Ling Peng, F. Conchonaud, et al.. Palmitoylation is Required for Fas to Trigger Cell Death Signaling. EMBO Journal, EMBO Press, 2007, 26, pp.209-220. ⟨hal-00303625⟩

R. Zhu, F. Qu, G. Quelever, Ling Peng. Direct Synthesis of 5-Aryltriazole Acyclonucleosides via Suzuki Coupling in Aqueous Solution. Tetrahedron Letters, Elsevier, 2007, 48, pp.2389-2393. ⟨hal-00303627⟩

R. Giordanengo, M. Mazarin, J. Wu, Ling Peng, L. Charles. Propagation of structural deviation of poly(amido)amine fan-shape dendrimers (generations 0 to 3) characterized by MALDI and electrospray mass spectrometry. International Journal of Mass Spectrometry, Elsevier, 2007, 266 (1-3), pp.62-75. ⟨10.1016/j.ijms.2007.07.002⟩. ⟨hal-00303628⟩

X.-C. Shen, J. Zhou, X. Liu, J. Wu, F. Qu, et al.. Importance of Size to Charge Ratio in Construction of Stable and Uniform Nanoscale RNA/dendrimer Complexes. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2007, 5, pp.3674-3681. ⟨hal-00303629⟩

J. Zhou, J. Wu, N. Hafdi, J.-P. Behr, P. Erbacher, et al.. PAMAM dendrimers for efficient siRNA delivery and potent gene silencing. Chemical Communications, Royal Society of Chemistry, 2006, pp.2362-2364. ⟨10.1039/B601381C⟩. ⟨hal-00130018⟩

J. Zhou, J. Wu, X.X. Liu, F. Qu, M. Xiao, et al.. Cooperative binding and self-assembling behavior of cationic low-molecular-weight dendrons with RNA molecules. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2006, 4(3), pp.581-585. ⟨hal-00067894⟩

C.-C. Zhang, S. Laurent, S. Sakr, Ling Peng, S. Bédu. Heterocyst differentition and pattern formation in cyanobacteria: a chorus of signals. Molecular Microbiology, Wiley, 2006, 59(2), pp.367-375. ⟨hal-00067898⟩

A. Specht, F. Ziarelli, P. Bernard, M. Goeldner, Ling Peng. Para-Sulfonated Calixarenes Used as Synthetic Receptors for Complexing Photolabile Cholinergic Ligand. Helvetica Chimica Acta, Wiley, 2005, 88 (10), pp.2641-2653. ⟨10.1002/hlca.200590205⟩. ⟨hal-00129989⟩