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Synthesis and Fluorescence of (E)‐3‐Aryl‐2‐(5‐aryl‐4H‐1,2,4‐triazol‐3‐yl) Acrylonitriles

Lazhar Zribi , Lhassane Ismaili , Luís Vieira‐ferreira , Isabel Ferreira‐machado , José Marco‐contelles , et al.
ChemistrySelect, 2021, 6 (25), pp.6360-6364. ⟨10.1002/slct.202100571⟩
Article dans une revue hal-03654566v1
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Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases of classes A, B and D

Eugénie Romero , Saoussen Oueslati , Mohamed Benchekroun , Agathe D’hollander , Sandrine Ventre , et al.
2020
Pré-publication, Document de travail hal-02998861v1
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Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D)

Eugénie Romero , Saoussen Oueslati , Mohamed Benchekroun , Agathe C.A. D’hollander , Sandrine Ventre , et al.
European Journal of Medicinal Chemistry, 2021, 219, ⟨10.1016/j.ejmech.2021.113418⟩
Article dans une revue hal-03227989v1

Chiral discrimination of phenoxypropionic acid herbicide enantiomers on teicoplanin phase: methanol dependence and eluent pH consideration.

Yves-Claude Guillaume , Lhassane Ismaili , Tong-Than Truong , Laurence Nicod , Joelle Millet , et al.
Talanta, 2002, 58 (5), pp.951-959
Article dans une revue hal-00502818v1

Chromenones as Multineurotargeting Inhibitors of Human Enzymes

Carina Lemke , Joscha Christmann , Jiafei Yin , José Alonso , Estefanía Serrano , et al.
ACS Omega, 2019, 4 (26), pp.22161-22168. ⟨10.1021/acsomega.9b03409⟩
Article dans une revue hal-03654629v1
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Base-Mediated Generation of Ketenimines from Ynamides: Direct Access to Azetidinimines by an Imino Staudinger Synthesis

Eugénie Romero , Corinne Minard , Mohamed Benchekroun , Sandrine Ventre , Pascal ́ Retailleau , et al.
Chemistry - A European Journal, 2017, 23 (53), pp.12991-12994. ⟨10.1002/chem.201702545⟩
Article dans une revue hal-02307210v1
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Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Rim Malek , Alexey Simakov , Audrey Davis , Maciej Maj , Paul Bernard , et al.
Molecules, 2023, 28 (1), pp.71. ⟨10.3390/molecules28010071⟩
Article dans une revue hal-03969932v1

New highly fluorescent hybrids (benz)imidazol-2-aminonicotinonitrile and -2-aminoisophthalonitrile: synthesis, characterization, fluorescence study, and theoretical calculations

Houssem Boulebd , Lhassane Ismaili , Abderrahim Khatyr , Abdelghani May , Ali Belfaitah
Chemical Monthly = Monatshefte für Chemie, 2018, ⟨10.1007/s00706-018-2141-y⟩
Article dans une revue hal-01713387v1

Synthesis of (±)‐ cis ‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1 H ‐benzo[ f ]chromene‐2‐carbonitriles and (±)‐ trans ‐4‐Aryl‐2‐oxo‐3,4‐dihydro‐2 H ‐benzo[ h ]chromene‐3‐carbonitriles

Kamar Mkaouar , Isabel Iriepa , Daniel Diez‐iriepa , José Marco‐contelles , Lhassane Ismaili , et al.
ChemistrySelect, 2019, 4 (44), pp.12902-12905. ⟨10.1002/slct.201903982⟩
Article dans une revue hal-03654637v1

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

Irene Pachón-Angona , Bernard Refouvelet , Rudolf Andrýs , Helène Martin , Vincent Luzet , et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.479-489. ⟨10.1080/14756366.2018.1545766⟩
Article dans une revue hal-03654661v1

Synthesis, characterization, theoretical studies, ADMET and drug-Likeness analysis: Electrochemical and biological activities of metal complexes of 3-(2-hydroxybenzoyl)-2H-chromen-2-one

Drifa Belkhir-Talbi , Malika Makhloufi-Chebli , Souhila Terrachet-Bouaziz , Djamila Hikem-Oukacha , Naima Ghemmit , et al.
Journal of Molecular Structure, 2019, 1179, pp.495-505. ⟨10.1016/j.molstruc.2018.11.035⟩
Article dans une revue hal-03654668v1

New (benz)imidazolopyridino tacrines as nonhepatotoxic, cholinesterase inhibitors for Alzheimer disease

Houssem Boulebd , Lhassane Ismaili , Helene Martin , Alexandre Bonet , Mourad Chioua , et al.
Future Medicinal Chemistry, 2017, 9 (8), pp.723-729. ⟨10.4155/fmc-2017-0019⟩
Article dans une revue hal-03654691v1

Design, Synthesis and Biological Evaluation of Potent Antioxidant 1-(2,5-Dimethoxybenzyl)-4-arylpiperazines and N -Azolyl Substituted 2-(4-Arylpiperazin-1-yl)

Haythem Saadeh , Mohammad Khasawneh , Abdelouahid Samadi , Ismail El-Haty , Grzegorz Satała , et al.
ChemistrySelect, 2017, 2 (13), pp.3854-3859. ⟨10.1002/slct.201700397⟩
Article dans une revue hal-03654696v1

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy

Imen Dakhlaoui , Emna Maalej , Helene Martin , Aurélia Lucht , Isabel Iriepa , et al.
ChemistrySelect, 2021, 6 (37), pp.9975-9980. ⟨10.1002/slct.202102363⟩
Article dans une revue hal-03654529v1

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy

Lazhar Zribi , Irene Pachòn-Angona , Òscar Bautista-Aguilera , Daniel Diez-Iriepa , José Marco-Contelles , et al.
Molecules, 2020, 25 (14), pp.3190. ⟨10.3390/molecules25143190⟩
Article dans une revue hal-03654594v1

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy

José Marco-Contelles , Mercedes Unzeta , Irene Bolea , Gerard Esteban , Rona Ramsay , et al.
Frontiers in Neuroscience, 2016, 10, ⟨10.3389/fnins.2016.00294⟩
Article dans une revue hal-03654719v1

Concentration of sodium ion as the determining factor for the association of dansyl amino acids with the teicoplanin molecule in reversed-phase liquid chromatography.

Lhassane Ismaili , Tong Than Truong , Claire André , Mireille Thomassin , Jean-Louis Mozer , et al.
Journal of AOAC INTERNATIONAL, 2003, 86 (2), pp.222-228
Article dans une revue hal-00502666v1

New highly fluorescent hybrids (benz)imidazol-2-aminonicotinonitrile and -2-aminoisophthalonitrile: synthesis, characterization, fluorescence study, and theoretical calculations

Houssem Boulebd , Lhassane Ismaili , Abderrahim Khatyr , Abdelghani May , Ali Belfaitah
Chemical Monthly = Monatshefte für Chemie, 2018, 149 (6), pp.1125-1136. ⟨10.1007/s00706-018-2141-y⟩
Article dans une revue hal-03654681v1

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

Lhassane Ismaili , Bernard Refouvelet , Mohamed Benchekroun , Simone Brogi , Margherita Brindisi , et al.
Progress in Neurobiology, 2017, 151, pp.4-34. ⟨10.1016/j.pneurobio.2015.12.003⟩
Article dans une revue hal-03654698v1

Donepezil–ferulic acid hybrids as anti-Alzheimer drugs

Mohamed Benchekroun , Lhassane Ismaili , M. Pudlo , Vincent Luzet , Tijani Gharbi , et al.
Future Medicinal Chemistry, 2015, 7 (1), pp.15-21. ⟨10.4155/fmc.14.148⟩
Article dans une revue hal-03407863v1

Automated Synthesis of New Quinoxalinetacrines

Óscar Bautista‐aguilera , Lhassane Ismaili , Mourad Chioua , Isabel Iriepa , Marìa Ángeles Martinez‐grau , et al.
ChemistrySelect, 2020, 5 (21), pp.6491-6493. ⟨10.1002/slct.202001593⟩
Article dans une revue hal-03654605v1

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

Irene Pachòn Angona , Solene Daniel , Helene Martin , Alexandre Bonet , Artur Wnorowski , et al.
Molecules, 2020, 25 (6), pp.1329. ⟨10.3390/molecules25061329⟩
Article dans une revue hal-03654614v1

Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy

Youssef Dgachi , Olga Sokolov , Vincent Luzet , Justyna Godyń , Dawid Panek , et al.
European Journal of Medicinal Chemistry, 2017, 126, pp.576-589. ⟨10.1016/j.ejmech.2016.11.050⟩
Article dans une revue hal-03654693v1

Triazine-human serum albumin association: thermodynamic approach and sodium effect.

Lhassane Ismaili , Claire André , Laurence Nicod , Tong Thanh Truong , Joëlle Millet , et al.
Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2002, 780 (2), pp.467-74
Article dans une revue hal-00492643v1
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Synthèse multicomposants et évaluation pharmacologique de nouveaux adduits de Ugi et de Passerini pour le traitement de la maladie d'Alzheimer

Mohamed Benchekroun
Médecine humaine et pathologie. Université de Franche-Comté, 2014. Français. ⟨NNT : 2014BESA3007⟩
Thèse tel-01164372v1

Synthesis of new Hantzsch adducts showing Ca 2+ channel blockade capacity, cholinesterase inhibition and antioxidant power

Irene Pachón-Angona , Maciej Maj , Artur Wnorowski , Helene Martin , Krzysztof Jóźwiak , et al.
Future Medicinal Chemistry, 2021, 13 (20), pp.1717-1729. ⟨10.4155/fmc-2021-0176⟩
Article dans une revue hal-03654559v1

Transition-metal complexes of N,N′-di(4-bromophenyl)-4-hydroxycoumarin-3-carboximidamide: synthesis, characterization, biological activities, ADMET and drug-likeness analysis

Drifa Belkhir-Talbi , Naima Ghemmit-Doulache , Souhila Terrachet-Bouaziz , Malika Makhloufi-Chebli , Amal Rabahi , et al.
Inorganic Chemistry Communications, 2021, 127, pp.108509. ⟨10.1016/j.inoche.2021.108509⟩
Article dans une revue hal-03654571v1

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy

Óscar Bautista-Aguilera , Lhassane Ismaili , Mourad Chioua , Rudolf Andrys , Monika Schmidt , et al.
International Journal of Molecular Sciences, 2020, 21 (11), pp.3913. ⟨10.3390/ijms21113913⟩
Article dans une revue hal-03654611v1

Propargylamine-derived multi-target directed ligands for Alzheimer’s disease therapy

Maria Do Carmo Carreiras , Lhassane Ismaili , José Marco-Contelles
Bioorganic and Medicinal Chemistry Letters, 2020, 30 (3), pp.126880. ⟨10.1016/j.bmcl.2019.126880⟩
Article dans une revue hal-03654620v1

Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease

Mourad Chioua , Eleonora Buzzi , Ignacio Moraleda , Isabel Iriepa , Maciej Maj , et al.
European Journal of Medicinal Chemistry, 2018, 155, pp.839-846. ⟨10.1016/j.ejmech.2018.06.044⟩
Article dans une revue hal-03654670v1