Laurent Soulère MCF INSA

Laurent Soulère, Thibaut Barbier, Yves Queneau. Docking-based virtual screening studies aiming at the covalent inhibition of SARS-CoV-2 MPro by targeting the cysteine 145. Computational Biology and Chemistry, Elsevier, 2021, 92, pp.107463. ⟨10.1016/j.compbiolchem.2021.107463⟩. ⟨hal-03243702⟩

Qiang Zhang, Si-Zhe Li, Yves Queneau, Laurent Soulère. Synthesis of new 1,4‐ and 1,5‐disubstituted N ‐ethyl acetate and N ‐α‐butyro‐γ‐lactone alkylimidazole derivatives as N ‐acylhomoserine lactone analogs. Journal of Heterocyclic Chemistry, Wiley, In press, ⟨10.1002/jhet.4356⟩. ⟨hal-03378482⟩

Qiang Zhang, Sizhe Li, Maha Hachicha, Mohamed Boukraa, Laurent Soulère, et al.. Heterocyclic Chemistry Applied to the Design of N-Acyl Homoserine Lactone Analogues as Bacterial Quorum Sensing Signals Mimics. Molecules, MDPI, 2021, 26 (17), pp.5135. ⟨10.3390/molecules26175135⟩. ⟨hal-03378442⟩

Qiang Zhang, Erwann Jeanneau, Yves Queneau, Laurent Soulère. (2R)- and (2S)- 2-hydroxy Hexanoyl and Octanoyl-l-Homoserine Lactones: new highly potent Quorum Sensing modulators with opposite activities. Bioorganic Chemistry, Elsevier, 2020, pp.104307. ⟨10.1016/j.bioorg.2020.104307⟩. ⟨hal-02952061⟩

Zhang Qiang, Yves Queneau, Laurent Soulère. Biological Evaluation and Docking Studies of New Carbamate, Thiocarbamate, and Hydrazide Analogues of Acyl Homoserine Lactones as Vibrio fischeri-Quorum Sensing Modulators. Biomolecules, MDPI, 2020, 10 (3), pp.455. ⟨10.3390/biom10030455⟩. ⟨hal-02883805⟩

Zhang Qiang, Si-Zhe Li, Mohammed Ahmar, Laurent Soulère, Yves Queneau. Esters of Glucose-2-Phosphate: Occurrence and Chemistry. Molecules, MDPI, 2020, 25 (12), pp.2829. ⟨10.3390/molecules25122829⟩. ⟨hal-02883902⟩

Nans Florens, Catherine Calzada, Sandrine Lemoine, Marie Boulet, Nicolas Guillot, et al.. CKD Increases Carbonylation of HDL and Is Associated with Impaired Antiaggregant Properties. Journal of the American Society of Nephrology, American Society of Nephrology, 2020, 31 (7), pp.1462-1477. ⟨10.1681/ASN.2019111205⟩. ⟨hal-03046430⟩

Laurent Soulère, Yves Queneau. Conformational and docking studies of acyl homoserine lactones as a robust method to investigate bioactive conformations. Computational Biology and Chemistry, Elsevier, 2019, 79, pp.48-54. ⟨10.1016/j.compbiolchem.2019.01.006⟩. ⟨hal-02110869⟩

Si-Zhe Li, Armelle Vigouroux, Mohammed Ahmar, Abbas El Sahili, Laurent Soulere, et al.. Synthesis of a non-natural glucose-2-phosphate ester able to dupe the acc system of Agrobacterium fabrum. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (5), pp.1090--1096. ⟨10.1039/c8ob03086c⟩. ⟨hal-02173130⟩

Si-Zhe Li, Rui Xu, Mohammed Ahmar, Catherine Goux-Henry, Yves Queneau, et al.. Influence of the d/l configuration of N-acyl-homoserine lactones (AHLs) and analogues on their Lux-R dependent quorum sensing activity. Bioorganic Chemistry, Elsevier, 2018, 77, pp.215-222. ⟨10.1016/j.bioorg.2018.01.005⟩. ⟨hal-02110506⟩

Laurent Soulère, Pascaline M. Alix, Marine L. Croze, Christophe Soulage. Identification of novel antilipogenic agents targeting fatty acid biosynthesis through structure-based virtual screening. Chemical Biology and Drug Design, Wiley, 2018, 92 (1), pp.1366-1372. ⟨10.1111/cbdd.13202⟩. ⟨hal-01847387⟩

Christophe Soulage, Laura Puig, Laurent Soulère, Bader Zarrouki, Michel Guichardant, et al.. Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation. Diabetologia, Springer Verlag, 2018, 61 (3), pp.688-699. ⟨10.1007/s00125-017-4528-4⟩. ⟨hal-02110460⟩

Almudena Gonzalez-Mula, Julien Lang, Catherine Grandclément, Delphine Naquin, Mohammed Ahmar, et al.. Lifestyle of the biotroph Agrobacterium tumefaciens in the ecological niche constructed on its host plant. New Phytologist, Wiley, 2018, 219 (1), pp.350-362. ⟨10.1111/nph.15164⟩. ⟨hal-02110550⟩

Seyhan Ulusoy, Sevil Senkardes, Inci Coskun, Gulgun Bosgelmez-T|naz, Laurent Soulère, et al.. Quorum Sensing Inhibitor Activities of Celecoxib Derivatives in Pseudomonas aeruginosa. Letters in Drug Design & Discovery, 2017, 14 (5), pp.613-618. ⟨10.2174/1570180814666161121120719⟩. ⟨hal-02193031⟩

S. Li, J. Wawrzyniak, Y. Queneau, L. Soulère. 2-Substituted Aniline as a Simple Scaffold for LuxR-Regulated QS Modulation. Molecules, MDPI, 2017, 22 (12), pp.E2090. ⟨10.3390/molecules22122090⟩. ⟨hal-02001353⟩

Zonglong Yang, Rui Xu, Fahima Ali-Rachedi, Stéphane Chambert, Nuno Xavier, et al.. Liquid crystalline glycosteroids and acyl steroid glycosides (ASG). Liquid Crystals, Taylor & Francis, 2017, pp.1-19. ⟨10.1080/02678292.2017.1346211⟩. ⟨hal-02193065⟩

Laurent Soulère, Christophe Soulage. Exploring docking methods for virtual screening: application to the identification of neuraminidase and Ftsz potential inhibitors. Molecular Simulation, Taylor & Francis, 2017, 43 (8), pp.656-663. ⟨10.1080/08927022.2017.1290234⟩. ⟨hal-01600438⟩

Meddy El Alaoui, L. Soulere, A. Noiriel, F. Popowycz, A. Khatib, et al.. A continuous spectrophotometric assay that distinguishes between phospholipase A1 and A2 activities. Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2016, 57 (8), pp.1589-1597. ⟨10.1194/jlr.D065961⟩. ⟨hal-01477286⟩

Sigde Mamani, Danielle Moinier, Yann Denis, L. Soulère, Y. Queneau, et al.. Insights into the Quorum Sensing Regulon of the Acidophilic Acidithiobacillus ferrooxidans Revealed by Transcriptomic in the Presence of an Acyl Homoserine Lactone Superagonist Analog. Frontiers in Microbiology, Frontiers Media, 2016, 7, pp.1365. ⟨10.3389/fmicb.2016.01365⟩. ⟨hal-01440758⟩

S.L. Li, M. Ahmar, Y. Queneau, L. Soulère. A convenient method for phosphorylation using trially phosphate. Tetrahedron Letters, Elsevier, 2015, 56 (32), pp.4694-4696. ⟨10.1016/j.tetlet.2015.06.030⟩. ⟨hal-01478940⟩

Quang Huy Lê, Meddy El Alaoui, Evelyne Véricel, Bérénice Ségrestin, Laurent Soulère, et al.. Glycoxidized HDL, HDL enriched with oxidized phospholipids and HDL from diabetic patients inhibit platelet function. Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2015, 100 (5), pp.1-10. ⟨10.1210/jc.2014-4214⟩. ⟨inserm-01134619⟩

Abbas El Sahili, Si-Zhe Li, Julien Lang, Cornelia Virus, Sara Planamente, et al.. A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens. PLoS Pathogens, Public Library of Science, 2015, 11 (8), pp.e1005071. ⟨10.1371/journal.ppat.1005071⟩. ⟨hal-01430779⟩

Meddy El Alauoui, Alexandre Noiriel, Laurent Soulère, Lucie Grand, Yves Queneau, et al.. Development of a high-throughput assay for measuring phospholipase A activity using synthetic 1,2-a-eleostearoyl-sn-glycero-3-phosphocholine coated on microtiter plates.. Analytical Chemistry, American Chemical Society, 2014, 86 (21), pp.10576-83. ⟨10.1021/ac502096v⟩. ⟨hal-01141494⟩

Mohamad Sabbah, Maud Bernollin, Alain Doutheau, Laurent Soulère, Yves Queneau. A new route towards fimbrolide analogues: importance of the exomethylene motif in LuxR dependent quorum sensing inhibition. MedChemComm, Royal Society of Chemistry, 2013, 4 (2), pp.363-366. ⟨10.1039/C2MD20298K⟩. ⟨hal-02194528⟩

Alex González, Sören Bellenberg, Sigde Mamani, Lina Ruiz, Alex Echeverría, et al.. AHL signaling molecules with a large acyl chain enhance biofilm formation on sulfur and metal sulfides by the bioleaching bacterium Acidithiobacillus ferrooxidans.. Applied Microbiology and Biotechnology, Springer Verlag, 2013, 97 (8), pp.3729-37. ⟨10.1007/s00253-012-4229-3⟩. ⟨hal-00919253⟩

Mohamad Sabbah, Maud Bernollin, Alain Doutheau, Laurent Soulère, Yves Queneau. A new route towards fimbrolide analogues : importance of the exomethylene motif in LuxR dependent quorum sensing inhibition. MedChemComm, Royal Society of Chemistry, 2013, 4, pp.363-366. ⟨10.1039/c2md20298k⟩. ⟨hal-01146328⟩

Yannick Raoul Des Essarts, Mohamad Sabbah, Arnaud Comte, Laurent Soulère, Yves Queneau, et al.. N,N'-alkylated Imidazolium-derivatives act as quorum-sensing inhibitors targeting the Pectobacterium atrosepticum-induced symptoms on potato tubers.. International Journal of Molecular Sciences, MDPI, 2013, 14 (10), pp.19976-19986. ⟨10.3390/ijms141019976⟩. ⟨hal-00919246⟩

Amélie Beury-Cirou, Mélanie Tannières, Corinne Minard, Laurent Soulère, Tsiry Rasamiravaka, et al.. At a supra-physiological concentration, human sexual hormones act as quorum-sensing inhibitors.. PLoS ONE, Public Library of Science, 2013, 8 (12), pp.e83564. ⟨10.1371/journal.pone.0083564⟩. ⟨hal-00949341⟩

Mohamad Sabbah, Fanny Fontaine, Lucie Grand, Mohamed Boukraa, Mohamed L Efrit, et al.. Synthesis and biological evaluation of new N-acyl-homoserine-lactone analogues, based on triazole and tetrazole scaffolds, acting as LuxR-dependent quorum sensing modulators.. Bioorganic and Medicinal Chemistry, Elsevier, 2012, 20 (15), pp.4727-36. ⟨10.1016/j.bmc.2012.06.007⟩. ⟨hal-00919262⟩

J. Pillon N., L. Croze M., E. Vella R., L. Soulère, M. Lagarde, et al.. The lipid peroxidation by-product 4-hydroxy-2-Nonenal (4-HNE) induces insulin resistance in skeletal. Endocrinology, Endocrine Society, 2012, 153 (5), pp.2099-2111. ⟨10.1210/en.2011-1957⟩. ⟨hal-01555917⟩

Mohamed Boukraa, Mohamad Sabbah, Laurent Soulère, Mohamed L El Efrit, Yves Queneau, et al.. AHL-dependent quorum sensing inhibition: synthesis and biological evaluation of α-(N-alkyl-carboxamide)-γ-butyrolactones and α-(N-alkyl-sulfonamide)-γ-butyrolactones.. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2011, 21 (22), pp.6876-9. ⟨10.1016/j.bmcl.2011.09.010⟩. ⟨hal-00695861⟩

Ann M Stevens, Y. Queneau, L. Soulère, Susanne von Bodman, A. Doutheau. Mechanisms and synthetic modulators of AHL-dependent gene regulation.. Chemical Reviews, American Chemical Society, 2011, 111 (1), pp.4-27. ⟨10.1021/cr100064s⟩. ⟨hal-00695865⟩

Mohamad Sabbah, Laurent Soulère, Sylvie Reverchon, Y. Queneau, Alain Doutheau. LuxR dependent quorum sensing inhibition by N,N'-disubstituted imidazolium salts.. Bioorganic and Medicinal Chemistry, Elsevier, 2011, 19 (16), pp.4868-75. ⟨10.1016/j.bmc.2011.06.075⟩. ⟨hal-00695863⟩

Nicolas Pillon, Roxane E. Vella, Laurent Soulère, Michel Becchi, Michel Lagarde, et al.. Structural and Functional Changes in Human Insulin Induced by the Lipid Peroxidation Byproducts 4-Hydroxy-2-nonenal and 4-Hydroxy-2-hexenal. Chemical Research in Toxicology, American Chemical Society, 2011, 24 (5), pp.752 - 762. ⟨10.1021/tx200084d⟩. ⟨hal-02650408⟩

Laurent Soulère, Mohamad Sabbah, Fanny Fontaine, Yves Queneau, Alain Doutheau. LuxR-dependent quorum sensing: computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones.. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20 (15), pp.4355-8. ⟨10.1016/j.bmcl.2010.06.081⟩. ⟨hal-00695871⟩

Annabel Simon-Levert, Christophe Menniti, Laurent Soulère, Anne-Marie Genevière, Chantal Barthomeuf, et al.. Marine natural meroterpenes: synthesis and antiproliferative activity. Marine drugs, MDPI, 2010, 8 (2), pp.347-358. ⟨10.3390/md8020347⟩. ⟨hal-02190465⟩

Nicolas J Pillon, Laurent Soulère, Roxane E Vella, Marine Croze, Bertrand R Caré, et al.. Quantitative structure-activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells. Chemico-Biological Interactions, Elsevier, 2010, 188 (1), pp.171-80. ⟨10.1016/j.cbi.2010.06.015⟩. ⟨hal-00759515⟩

Laurent Soulère, Julien Bernard. Rational design, solid phase synthesis and evaluation of cationic ferrocenoyl peptide bioconjugates as potential antioxidant enzyme mimics. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2009, 19 (4), pp.1173-1176. ⟨hal-00374569⟩

M. Frezza, L. Soulere, S. Reverchon, N. Guiliani, C. Jerez, et al.. Synthetic homoserine lactone-derived sulfonylureas as inhibitors of Vibrio fischeri quorum sensing regulator. Bioorganic and Medicinal Chemistry, Elsevier, 2008, 16 (7), pp.3550-6. ⟨10.1016/j.bmc.2008.02.023⟩. ⟨hal-01997035⟩

J. Estephane, J. Dauvergne, L. Soulere, S. Reverchon, Y. Queneau, et al.. N-Acyl-3-amino-5H-furanone derivatives as new inhibitors of LuxR-dependent quorum sensing: Synthesis, biological evaluation and binding mode study. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2008, 18 (15), pp.4321-4. ⟨hal-01997033⟩

Marine Frezza, Laurent Soulère, Damien Balestrino, Michel Gohar, Christian Deshayes, et al.. Ac2-DPD, the bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD) is a convenient stable precursor of bacterial quorum sensing autoinducer AI-2.. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (5), pp.1428-31. ⟨10.1016/j.bmcl.2006.11.076⟩. ⟨hal-00164190⟩

M. Frezza, L. Soulere, D. Balestrino, Y. Queneau, C. Forestier, et al.. Bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD): a convenient stable precursor of quorum sensing autoinducer AI-2. Biorg.Med.Chem.Lett., 2007, pp.1428-1431. ⟨hal-00139413⟩

M. Frezza, D. Balestrino, L. Soulère, S. Reverchon-Pescheux, Y. Queneau, et al.. Synthesis and biological evaluation of the trifluoromethyl analog of (4S)-4,5-dihydroxy-2,3-pentanedione (DPD). European Journal of Organic Chemistry, Wiley-VCH Verlag, 2006, pp.4731-4736. ⟨hal-00144011⟩

J.-P. Steghens, K. Arab, A. Rossary, L. Soulère. Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. British Journal of Nutrition, Cambridge University Press (CUP), 2006, 96 (96), pp.811-819. ⟨hal-00144012⟩

M. Frezza, S. Castang, J. Estephane, L. Soulere, C. Deshayes, et al.. Synthesis and biological evaluation of homoserine lactone derived ureas as antagonists of bacterial quorum sensing. Bioorganic and Medicinal Chemistry, Elsevier, 2006, 14 (14), pp.4781-91. ⟨hal-01997034⟩

Marine Frezza, Laurent Soulère, Yves Queneau, Alain Doutheau. Baylis-Hillmann route to (R,S) 4,5-dihydroxy-2,3-pentanedione (DPD) and analogs. Tetrahedron Letters, Elsevier, 2004, 46, pp.6495-6498. ⟨hal-00015820⟩

Nans Florens, Yi Dan, Laurent Soulère, Laurent Juillard, Christophe Soulage. Using binding competitors on albumin to promote the removal of protein-bound uremic toxins in hemodialysis: proof of concept and screening of candidates. Annual Meeting of French Society of Pharmacology and Therapeutics, and INSERM Clinical Research Centers (CIC) Meeting, Jun 2019, Lyon, France. Wiley, Fundamental and Clinical Pharmacology, 33, 106 p., 2019, Abstracts of the Annual Meeting of French Society of Pharmacology and Therapeutics, and INSERM Clinical Research Centers (CIC) Meeting. ⟨hal-02737249⟩

Meddy El Alaoui, Laurent Soulère, Alexandre Noiriel, Priscila Sutto-Ortiz, Lucie Grand, et al.. A Continuous and Sensitive Spectrophotometric Assay for Lipase and Phospholipase A Activities using α-Eleostearic Acid-containing Substrates. Lipases and phospholipases, Methods and, Protocols. G. Sandoval, Ed. Methods in Molecular Biology, Springer, pp.119-128, 2018. ⟨hal-02285369⟩

Zhuo Yang, R. Xu, S. Chambert, L. Soulère, M. Ahmar, et al.. Carbohydrate steroid hybrid architectures : the viewpoint of amphiphilicity and self-organisation. A.Pilar RAUTER, Thisbe K LINDHORST and Yves QUENEAU. Specialist Periodical Reports, Carbohydrate Chemistry, Chemical and Biological Approaches,, 4, pp.274-312, 2017, ⟨10.1039/9781782626657-00274⟩. ⟨hal-01477305⟩