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laurent Micouin

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Présentation

MICOUIN Laurent CNRS Research Director first class, UMR 8601 Paris Descartes Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques 45, rue des Saints Pères, 75006 Paris, France Phone + (33) 1 42 86 20 40, Fax + (33) 1 42 86 83 87 e-mail : laurent.micouin@parisdescartes.fr Born on March 6th 1968, Clermont Ferrand, France Academic and Professional Background : 2014- CNRS Research Director, first class (UMR 8601, University Paris Descartes) 2012-2014 CNRS Research Director, second class (UMR 8601, University Paris Descartes) 2005-2012 CNRS Research Director, second class (UMR 8638, University Paris Descartes) 2000-2005 CNRS Associate Scientist, first class (UMR 8638, University Paris Descartes) 2000 Habilitation, University Paris Descartes, Paris, France 1996-2000 CNRS Associate Scientist, second class (UMR 8638, University Paris Descartes) 1995- 1996 Post-Doctoral Fellow, University Marburg, Germany (with Prof. P.Knochel) 1992-1995 PhD in Chemistry, University Paris 5 (with Prof. J.-C. Quirion and Prof. H.-P. Husson) 1990-1992 Research Assistant, Institut Malardé, French Polynesia 1990 Master in Chemistry, University Paris 6 (With Prof. P. Cresson) 1990 Engineer in Chemistry, ENSCP (Chemistry National School), Paris. **Scientific Record:** 96 publications, 8 patents, book chapters, 1 book co-editor (Patai), 66 invited conferences or seminars **Scientific interests** \- Diversity-oriented synthesis of bioactive compounds or tools for biological investigations. \- New chemical methods for the fragment-based synthesis of RNA binders \- New synthetic methods for the preparation of organoaluminum reagents **Official capacities** 2019- 2016- 2015-2018 2012-2018 2011- 2013 2010- 2012 Director of UMR 8601 Member of the CNRS national Committee (section 16). CNRS Deputy director of UMR 8601 Head of the Doctoral School 563 MTCI "Medecines, Toxicology, Chemistry, Imaging), board member of several doctoral schools. CNRS Scientific Officer (chargé de mission), National Chemistry Institute, CNRS Deputy director of UMR 8638 **Honors and awards** 2007 Invited Professor (Puebla University, Mexico) 2005 French Chemical Society Acros prize 1996 Roussel (PhD) prize of Paris 5 University 1995 Alexander Von Humboldt post-doctoral fellowship

Publications

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Monitoring of reversible boronic acid–diol interactions by fluorine NMR spectroscopy in aqueous media

Laura Iannazzo , Erica Benedetti , Marjorie Catala , Mélanie Etheve-Quelquejeu , Carine Tisné
Organic & Biomolecular Chemistry, 2015, 13 (33), pp.8817-8821. ⟨10.1039/c5ob01362c⟩
Article dans une revue hal-03544508v1

Fragment-based design of small RNA binders: promising developments and contribution of NMR.

Roba Moumné , Marjorie Catala , Valéry Larue , Laurent Micouin , Carine Tisné
Biochimie, 2012, 94 (7), pp.1607-1619. ⟨10.1016/j.biochi.2012.02.002⟩
Article dans une revue hal-00692356v1

Investigation of RNA-Ligand Interactions by (19) F NMR Spectroscopy Using Fluorinated Probes.

Thomas Lombès , Roba Moumné , Valéry Larue , Elise Prost , Marjorie Catala
Angewandte Chemie International Edition, 2012, 51 (38), pp.9530-9534. ⟨10.1002/anie.201204083⟩
Article dans une revue hal-00724894v1

Tether influence on the binding properties of tRNALys3 ligands designed by a fragment-based approach.

Roba Moumné , Valéry Larue , Bili Seijo , Thomas Lecourt , Laurent Micouin
Organic & Biomolecular Chemistry, 2010, 8 (5), pp.1154-9. ⟨10.1039/b921232a⟩
Article dans une revue hal-00596199v1

Fluorinated diaminocyclopentanes as chiral sensitive NMR probes of RNA structure.

Roba Moumné , Morgane Pasco , Elise Prost , Thomas Lecourt , Laurent Micouin
Journal of the American Chemical Society, 2010, 132 (38), pp.13111-3. ⟨10.1021/ja1037885⟩
Article dans une revue hal-00614591v1
Image document

NMR-guided fragment-based approach for the design of tRNA(Lys3) ligands.

Florence Chung , Carine Tisné , Thomas Lecourt , Frédéric Dardel , Laurent Micouin
Angewandte Chemie International Edition, 2007, 46 (24), pp.4489-91. ⟨10.1002/anie.200605201⟩
Article dans une revue hal-00218344v1