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laurent Micouin

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Présentation

MICOUIN Laurent CNRS Research Director first class, UMR 8601 Paris Descartes Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques 45, rue des Saints Pères, 75006 Paris, France Phone + (33) 1 42 86 20 40, Fax + (33) 1 42 86 83 87 e-mail : laurent.micouin@parisdescartes.fr Born on March 6th 1968, Clermont Ferrand, France Academic and Professional Background : 2014- CNRS Research Director, first class (UMR 8601, University Paris Descartes) 2012-2014 CNRS Research Director, second class (UMR 8601, University Paris Descartes) 2005-2012 CNRS Research Director, second class (UMR 8638, University Paris Descartes) 2000-2005 CNRS Associate Scientist, first class (UMR 8638, University Paris Descartes) 2000 Habilitation, University Paris Descartes, Paris, France 1996-2000 CNRS Associate Scientist, second class (UMR 8638, University Paris Descartes) 1995- 1996 Post-Doctoral Fellow, University Marburg, Germany (with Prof. P.Knochel) 1992-1995 PhD in Chemistry, University Paris 5 (with Prof. J.-C. Quirion and Prof. H.-P. Husson) 1990-1992 Research Assistant, Institut Malardé, French Polynesia 1990 Master in Chemistry, University Paris 6 (With Prof. P. Cresson) 1990 Engineer in Chemistry, ENSCP (Chemistry National School), Paris. **Scientific Record:** 96 publications, 8 patents, book chapters, 1 book co-editor (Patai), 66 invited conferences or seminars **Scientific interests** \- Diversity-oriented synthesis of bioactive compounds or tools for biological investigations. \- New chemical methods for the fragment-based synthesis of RNA binders \- New synthetic methods for the preparation of organoaluminum reagents **Official capacities** 2019- 2016- 2015-2018 2012-2018 2011- 2013 2010- 2012 Director of UMR 8601 Member of the CNRS national Committee (section 16). CNRS Deputy director of UMR 8601 Head of the Doctoral School 563 MTCI "Medecines, Toxicology, Chemistry, Imaging), board member of several doctoral schools. CNRS Scientific Officer (chargé de mission), National Chemistry Institute, CNRS Deputy director of UMR 8638 **Honors and awards** 2007 Invited Professor (Puebla University, Mexico) 2005 French Chemical Society Acros prize 1996 Roussel (PhD) prize of Paris 5 University 1995 Alexander Von Humboldt post-doctoral fellowship

Publications

erica-benedetti
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Compact CPL emitters based on a [2.2]paracyclophane scaffold: recent developments and future perspectives

Simon Felder , Marie-Leonie Delcourt , Damian Contant , Rafael Rodríguez , Ludovic Favereau
Journal of Materials Chemistry C, 2023, 11, pp.2053-2062. ⟨10.1039/d2tc04885j⟩
Article dans une revue hal-04011240v1
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Intramolecular Buchwald–Hartwig N -arylation of bicyclic hydrazines: practical access to spiro[indoline-2,3′-piperidines]

Claire Fleurisson , Nessrine Graidia , Yann Foricher , Erica Benedetti , Laurent Micouin
Organic & Biomolecular Chemistry, 2023, 21 (17), pp.3542-3546. ⟨10.1039/D3OB00406F⟩
Article dans une revue hal-04267385v1
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Light-Driven Reductive Cleavage of Sulfonamides Promoted by Thiourea Organophotosensitizers

Jules Brom , Antoine Maruani , Laurent Micouin , Erica Benedetti
Journal of Organic Chemistry, 2023, 88 (9), pp.5923-5935. ⟨10.1021/acs.joc.3c00296⟩
Article dans une revue hal-04267371v1
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Planar Chiral Analogues of PRODAN Based on a [2.2]Paracyclophane Scaffold: Synthesis and Photophysical Studies

Simon Felder , Marie-Leonie Delcourt , Manon H. E. Bousquet , Denis Jacquemin , Rafael Rodriguez
Journal of Organic Chemistry, 2022, 87 (1), pp.147-158. ⟨10.1021/acs.joc.1c02071⟩
Article dans une revue hal-03512519v1
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Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping

Simon Felder , Corinne Sagné , Erica Benedetti , Laurent Micouin
ACS Chemical Biology, 2022, 17 (11), pp.3069-3076. ⟨10.1021/acschembio.2c00171⟩
Article dans une revue hal-04035021v1
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Enantiopure planar chiral [2.2]paracyclophanes: Synthesis and applications in asymmetric organocatalysis

Simon Felder , Shiqi Wu , Jules Brom , Laurent Micouin , Erica Benedetti
Chirality, 2021, 33 (9), pp.506-527. ⟨10.1002/chir.23335⟩
Article dans une revue hal-03366196v1
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Para‐Functionalization of N‐Substituted 4‐amino[2.2]paracyclophanes by Regioselective Formylation

Simon Felder , Laurent Micouin , Erica Benedetti
European Journal of Organic Chemistry, 2021, pp.4015. ⟨10.1002/ejoc.202100288⟩
Article dans une revue hal-03297447v1
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Tuning the excited state properties of [2.2]paracyclophane-based antennas to ensure efficient sensitization of lanthanide ions or singlet oxygen generation

Shiqi Wu , Laura Abad Galán , Margaux Roux , François Riobé , Boris Le Guennic
Inorganic Chemistry, 2021, 60 (60), pp.21. ⟨10.1021/acs.inorgchem.1c01986⟩
Article dans une revue hal-03407500v1
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Cyclic cis-1,3-Diamines Derived from Bicyclic Hydrazines: Synthesis and Applications

Claire Fleurisson , Erica Benedetti , Laurent Micouin
Article dans une revue hal-03003668v1

Highly Enantioselective Asymmetric Transfer Hydrogenation: A Practical and Scalable Method To Efficiently Access Planar Chiral [2.2]Paracyclophanes

Marie-Leonie Delcourt , Simon Felder , Serge Turcaud , Corina Pollok , Christian Merten
Journal of Organic Chemistry, 2019, ⟨10.1021/acs.joc.9b00372⟩
Article dans une revue hal-02113386v1
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3D Coumarin Systems Based on [2.2]Paracyclophane Synthesis, Spectroscopic Characterization, and Chiroptical Properties

Marie-Leonie Delcourt , Corentin Reynaud , Serge Turcaud , Ludovic Favereau , Jeanne Crassous
Journal of Organic Chemistry, 2019, 84 (2), pp.888-899. ⟨10.1021/acs.joc.8b02773⟩
Article dans une revue hal-02049506v1
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Highly Enantioselective Desymmetrization of Centrosymmetric pseudo - para -Diformyl[2.2]paracyclophane via Asymmetric Transfer Hydrogenation

Marie-Leonie Delcourt , Simon Felder , Erica Benedetti , Laurent Micouin
ACS Catalysis, 2018, 8 (7), pp.6612-6616. ⟨10.1021/acscatal.8b01872⟩
Article dans une revue hal-02113395v1
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Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents

Riccardo Piccardi , Serge Turcaud , Erica Benedetti , Laurent Micouin
Synthesis: Journal of Synthetic Organic Chemistry, 2018, 51 (01), pp.97-106. ⟨10.1055/s-0037-1610392⟩
Article dans une revue hal-02113388v1

Continuous Flow Synthesis of Dimethylalkynylaluminum Reagents

Riccardo Piccardi , Anaïs Coffinet , Erica Benedetti , Serge Turcaud , Laurent Micouin
Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48 (19), pp.3272-3278. ⟨10.1055/s-0035-1561484⟩
Article dans une revue hal-02134269v1