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82

Curriculum vitae of Laurent Goffart


Scientific Landmarks

"Block diagrams of oculomotor organization serve as a compact description of system behavior but seldom have much bearing on the way in which the real system, composed of nerve and muscle, actually operates. The models thus do not contribute much to the neurophysiology (or neurology) of eye movements and incur the danger of suggesting that there actually are segregated portions of the nervous system which perform the differentiation, integration and other operations indicated in the boxes of the diagrams" (David A Robinson)

"A humble approach is the one that lets the brain be investigated in its own grandeur instead of reducing it into a flat shadow" (Andras Pellionisz)

"All measurements, from the most intuitive to the most advanced, rest on the observation of spatio-temporal coincidences" (Moritz Schlick)

"What we see externally is only the result of the physico-chemical excitations of the inner environment; this is where the physiologist must establish the real determinism of vital functions" (Claude Bernard)

Education and training

2020: Aix-Marseille University, Habilitation to supervise research in Neuroscience

2016: Aix-Marseille University, Master degree in History and philosophy of fundamental sciences

1996: University Claude Bernard Lyon I, PhD degree in Neuroscience

1992: University Claude Bernard Lyon I, Master degree in Neuroscience

1991: University of Sciences and Technologies of Lille I, Mastery in Physiology

1990: University of Human Sciences, Letters and Arts, Lille III, Mastery in Experimental Psychology

Academic path

My scientific engagement starts in 1983 with the discovery of the kantian conceptions of space (S), time (T) and knowledge acquisition. During an initial training within the domain of psychological sciences, I was sensitized by the Piagetian constructivism and Thom's catastroph theory. However, once I learned the neurophysiological observations that Schiller & Stryker (1972) made in the superior colliculus, I decided to focus on the saccadic orienting reaction and on its intrinsic morphogenesis within the brain networks. My first experience of scientific research then started with Dr Jacques Honoré (CNRS) in the Laboratory of Psychophysiology (headed by Prof. Jean-Marie Coquery) at the University of Lille 1. After obtaining a mastery in Physiology, I joined the laboratory Vision & Motricité (INSERM U94, headed by Prof. Marc Jeannerod) in order to learn the techniques of animal experimentation. Although I was initially engaged by Dr Denis Pélisson (CNRS) to test the role of the nucleus prepositus hypoglossi in the feedback control of eye-head gaze shifts in the cat, the discovery of the article of Pellionisz & Llinas (1982) re-oriented my investigations toward the understanding of the cerebellar control of gaze accuracy. The spectacular results that we obtained in the cat after reversible inactivation of the caudal fastigial nucleus led me to wonder whether they would also hold in human patients suffering from cerebellar ataxia. Therefore, after a short training to cerebellar electrophysiology with Drs Albert Fuchs and Farrel Ric Robinson in the Department of Physiology and Biophysics at the University of Washington, I decided to continue my physiological investigations in the macaque monkey. After three years of post-doctoral training in the laboratory of Dr David Sparks (University of Pennsylvania and Baylor College of Medicine), I returned to France to set up, ex nihilo but with the crucial support of my previous American mentor, a research laboratory for the neurophysiological study of gaze visual orientation in the macaque monkey. Then, with my first doctoral collaborator, Dr Julie Quinet, we took on the toughest challenge : studying the cerebellar control of gaze orientation in macaque monkeys tested with the head completely free to move ...

On-going research

MULTI-EQUILIBRIUM AND TRANSITIONS :

Neurophysiology of gaze orientation and visuomotor presence

How do activities of interconnected microscopic elements (neurons) enable a macroscopic organism to reach a visual object located in its external physical world ? How do we relate neuronal activities with kinematic or dynamic (force) measurements, which are quantifications made within mediums of different scales, temporalities and complexity orders ? Do flows of cerebral activity engender "space" and "time" frames similar to those used by kinematics when it formalizes the movement of a body in the extracorporeal world ?

In agreement with the doubts expressed by Pellionisz & Llinas (1982) on such an isomorphism, our work first contributed to characterize the neural networks that endow primates and felines with the ability to direct their gaze and head towards the place where a visual object is located (static or in motion), and then to propose a radically new viewpoint, strictly neurophysiological. According to this theory, the orienting movements of the eyes and the head are the physical (measurable) expression of intracerebral processes that consist in re-establishing balances between sensorimotor channels whose activities are mutually opposed. In the medium of cerebral functioning, there is no coding of the kinematic parameters to search for within the firing rate of neurons and the previous assertions to the contrary are not free from major shortcomings. The static orientation of gaze (and head) is the outcome of multiple and simultaneous equilibria (multi-equilibrium) of commands that cancel each other out. From the visual activities to the recruitment of premotor neurons responsible for the horizontal and vertical components of saccadic (fast) and slow movements, no movement is initiated as long as the recruited channels convey commands that counterbalance each other. While a saccade is the behavioral (kinematic and dynamic) expression of intrinsic processes that restore the multi-equilibrium, a slow eye movement is the behavioral outcome of a sustained (and adjusted) imbalance between activities carried by visuomotor channels involved in generating "glissades".

During the course of Evolution, most animals were faced with the necessity to cope with a dynamic environment. In the world peculiar to each species (Umwelt), the most significant events happen when things (animal or not, predator, prey, congener or else) move or when they move themselves. Endowed with a sensitivity and a reactivity to motion, the animals managed to interact with the objects of the external world, their interactions consisting of establishing contacts and links around zones of less instabilities. The sensitivity does not resume to the passive contemplation (or assimilation) of a streaming landscape ; it is a "combative" engagement, the opportunity for creating spatiotemporally local links, for creating accompaniments, i.e., an oriented relation to objects.

Our investigations are aimed at characterizing the neurophysiology of this relationship, dynamic and spatial, that an animal establishes with objects of its visual environment, using the gaze orientation of the monkey as an experimental probe but also as a model for comprehending human neurological disorders. Aware of the stratification of measured phenomenon, We defend the following theoretical viewpoint: the zones of visuomotor interaction are multiple equilibria and the movements (saccadic or slow) are their restoration or maintenance with dynamics which are determined by the intrinsic properties of recruited sensorimotor channels. By not postulating that neural communication processes (intrinsic to the brain) are comparable to human communication modes (conventional), we want to see whether this strictly neurophysiological approach leads to an impasse or rather to the discovery of necessary conditions, and then to identify which ones.

The appearance of an event in the peripheral visual field triggers a transition, a rapid orienting gaze shift (saccade) at the end of which the image of the object becomes more or less well projected onto the retinal area endowed of the greatest visual acuity (the fovea). Thus, brought within the central visual field, the target involves a larger number of neurons. The resulting equilibrium corresponds to a bilateral cerebral activity whose fluctuations in the superior colliculus are proposed to be the origin of those microsaccades observed during visual fixation. We have shown that the symmetry of this unstable equilibrium involves the oculomotor cerebellum through the two caudal fastigial nuclei. We have also characterized how the neurons of these nuclei intervene in the restoration (saccade) of the equilibrium broken by any asymmetrical visual stimulus.

The foveal capture (foveation) also applies to targets that are moving. In this case, for the capture to be accurate, the brain activity might develop signals that correspond to what would be called the "current spatiotemporal coordinates" of the targeted object. Our works suggest that these signals correspond in the best case (as a boundary) to its here-and-now (hic-et-nunc) location. How is this physically local and "sharp" representation neurally possible with regard to the multiple delays of neuronal conduction, the divergence of anatomical connections and the resulting distributed encoding of a visual object in the brain ? What then is the neurophysiological structure of this thing that the classical measurements reduce to the time-point (x,y,z,t) ?

Notions of prediction or internal model of the trajectory are used by some colleagues. But do these notions denote anything in neurophysiological language ?  Instead, our experimental results lead to consider attempts to synchronize with the present and current situation. The repetition of this visuomotor presence (engagements) yields a dynamic mnemonic "trace" which, in the physical world corresponds to the trajectory, but in the brain activity appears to be a recruitment of resources (more neurons and more spikes). We do neither use the notion of prediction because it postulates a notion (the future) which is a cultural concept, likely meaningless at the neuronal level if it is imaginary. Actually, when we examine the activity of collicular neurons during interceptive saccades, we discover a "horizon", a border that does not expand beyond the locus/time of capture. In order to aim at understanding how a memorized experience is being actualized within the action, we prefer to avoid notions linked to prevision or gamble, and to focus on the construction of sensorimotor schemes that generate accurate action, i.e., efficient for the survival of the macroscopic organism.

Using transient and local perturbation techniques (pharmacological inactivation, microstimulation), we aim at defining the neuro-functional organization that enables us to generate actions which are spatiotemporally adapted to the on-going external conditions, on the basis of an afferent neuronal dynamics and a mnemonic dynamics built upon the past experience but actualized in the on-going action. We want to understand how this is made possible, neurophysiologically speaking, i.e., to identify the channels and flows of neuronal activity which are hidden behind these multiple shortcuts, often vague and sterile, like internal model, etc., taking care also of avoiding any teleological argument, even refuting them because the nervous system is not a "machine" akin to most of those invented by homo faber.

This research is primarily performed in the non-human primate (macaque monkey) in order to identify the underlying neurophysiology and promote the neurology of sensorimotor disorders. Efforts have also been developed to extend it to other animal varieties such as the insect (link), in collaboration with Drs Y. Yamawaki and T. Carle (Kyushu University, Japan), with the aim to define more fundamentally, with neurobiological terms, the visuomotor presence, i.e., the locus and the instant of sensorimotor interaction which, once again, must not be considered as a point but as a dynamical multi-equilibrium.

 

 

 


Journal articles43 documents

  • Nicolas Orlando-Dessaints, Laurent Goffart. Initiating the tracking of a target moving across the central visual field: a study in macaque monkey. Journal of Vision, Association for Research in Vision and Ophthalmology, 2021, 21 (9), pp.2676. ⟨10.1167/jov.21.9.2676⟩. ⟨hal-03432635⟩
  • Clara Bourrelly, Julie Quinet, Laurent Goffart. Bilateral control of interceptive saccades: evidence from the ipsipulsion of vertical saccades after caudal fastigial inactivation. Journal of Neurophysiology, American Physiological Society, 2021, Control of movement, 125 (6), pp.2068-2083. ⟨10.1152/jn.00037.2021⟩. ⟨hal-03168070v2⟩
  • Julie Quinet, Laurent Goffart. Are tracking eye movements driven by an internal model of target motion ?. Journal of Vision, Association for Research in Vision and Ophthalmology, 2021, 21 (9), pp.1839. ⟨10.1167/jov.21.9.1839⟩. ⟨hal-03432632⟩
  • Ziad M Hafed, Laurent Goffart. Gaze direction as equilibrium: more evidence from spatial and temporal aspects of small-saccade triggering in the rhesus macaque monkey. Journal of Neurophysiology, American Physiological Society, 2019, pp.10.1152/jn.00588.2019. ⟨10.1152/jn.00588.2019⟩. ⟨hal-02392063⟩
  • Jean-Charles Quinton, L. Goffart. A unified dynamic neural field model of goal directed eye-movements. Connection Science, Taylor & Francis, 2018, Embodied Neuronal Mechanisms in Adaptive Behaviour, 30 (1), pp.20-52. ⟨10.1080/09540091.2017.1351421⟩. ⟨hal-01637024⟩
  • Clara Bourrelly, Julie Quinet, Laurent Goffart. Pursuit disorder and saccade dysmetria after caudal fastigial inactivation in the monkey. Journal of Neurophysiology, American Physiological Society, 2018, 120 (4), pp.1640-1654. ⟨10.1152/jn.00278.2018⟩. ⟨hal-02328776⟩
  • Laurent Goffart, Clara Bourrelly, Jean-Charles Quinton. Neurophysiology of visually guided eye movements: critical review and alternative viewpoint. Journal of Neurophysiology, American Physiological Society, 2018, 120 (6), pp.3234-3245. ⟨10.1152/jn.00402.2018⟩. ⟨hal-01966558⟩
  • Clara Bourrelly, Julie Quinet, Laurent Goffart. The caudal fastigial nucleus and the steering of saccades toward a moving visual target. Journal of Neurophysiology, American Physiological Society, 2018, 120 (2), pp.421-438. ⟨10.1152/jn.00141.2018⟩. ⟨hal-02328770⟩
  • Richard Krauzlis, Laurent Goffart, Ziad Hafed. Neuronal control of fixation and fixational eye movements. Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2017, 372 (1718), pp.20160205. ⟨10.1098/rstb.2016.0205⟩. ⟨hal-02498711⟩
  • Laurent Goffart, Aaron Cecala, Neeraj Gandhi. The superior colliculus and the steering of saccades toward a moving visual target. Journal of Neurophysiology, American Physiological Society, 2017, 118 (5), pp.2890-2901. ⟨10.1152/jn.00506.2017⟩. ⟨hal-02328781⟩
  • Laurent Goffart. Parallel and continuous visuomotor processing of simultaneously moving targets. Journal of Vision, Association for Research in Vision and Ophthalmology, 2017, 17 (10), pp.901. ⟨10.1167/17.10.901⟩. ⟨hal-03432638⟩
  • Laurent Goffart, Aaron Cecala, Neeraj Gandhi. Does the saccade-related burst in the superior colliculus convey commands related to the future location of a moving target ?. Journal of Vision, Association for Research in Vision and Ophthalmology, 2016, 16 (12), pp.98. ⟨10.1167/16.12.98⟩. ⟨hal-03432641⟩
  • Clara Bourrelly, Julie Quinet, Patrick Cavanagh, Laurent Goffart. Learning the trajectory of a moving visual target and evolution of its tracking in the monkey. Journal of Neurophysiology, American Physiological Society, 2016, 116 (6), pp.2739 - 2751. ⟨10.1152/jn.00519.2016⟩. ⟨hal-01427801⟩
  • Wahiba Taouali, Laurent Goffart, Frédéric Alexandre, Nicolas P. Rougier. A parsimonious computational model of visual target position encoding in the superior colliculus. Biological Cybernetics (Modeling), Springer Verlag, 2015, 109 (4-5), ⟨10.1007/s00422-015-0660-8⟩. ⟨hal-01201785⟩
  • Clara Bourrelly, Julie Quinet, Laurent Goffart. Evolution of the oculomotor tracking with an accelerating or decelerating target. Journal of Vision, Association for Research in Vision and Ophthalmology, 2015, 15 (12), pp.1016. ⟨10.1167/15.12.1016⟩. ⟨hal-02328814⟩
  • Julie Quinet, Laurent Goffart. Does the Brain Extrapolate the Position of a Transient Moving Target?. Journal of Neuroscience, Society for Neuroscience, 2015, 35 (34), pp.11780 - 11790. ⟨10.1523/JNEUROSCI.1212-15.2015⟩. ⟨hal-01427775⟩
  • Julie Quinet, Laurent Goffart. Cerebellar control of saccade dynamics: contribution of the fastigial oculomotor region. Journal of Neurophysiology, American Physiological Society, 2015, 113 (9), pp.3323 - 3336. ⟨10.1152/jn.01021.2014⟩. ⟨hal-01427782⟩
  • Laurent Goffart, Julie Quinet, Clara Bourrelly. Foveating a moving target, here-and-now. Journal of Vision, Association for Research in Vision and Ophthalmology, 2014, 14 (10), pp.495-495. ⟨10.1167/14.10.495⟩. ⟨hal-02328817⟩
  • C. Bourrelly, J. Quinet, Laurent Goffart. Unsupervised dynamic morphing of a spatiotemporal visual event during its oculomotor tracking. Journal of Vision, Association for Research in Vision and Ophthalmology, 2014, 14 (10), pp.492-492. ⟨10.1167/14.10.492⟩. ⟨hal-02328811⟩
  • Guillaume S. Masson, Laurent Goffart. Fixate and stabilize: shall the twain meet?. Nature Neuroscience, Nature Publishing Group, 2013, 16 (6), pp.663-664. ⟨10.1038/nn.3411⟩. ⟨hal-02387886⟩
  • Laurent Goffart, Ziad M Hafed, Richard J Krauzlis. Visual Fixation as Equilibrium: Evidence from Superior Colliculus Inactivation. Journal of Neuroscience, Society for Neuroscience, 2012, 32 (31), pp.10627 - 10636. ⟨10.1523/jneurosci.0696-12.2012⟩. ⟨hal-01427763⟩
  • Jerome Fleuriet, Laurent Goffart. Saccadic Interception of a Moving Visual Target after a Spatiotemporal Perturbation. Journal of Neuroscience, Society for Neuroscience, 2011, 32 (2), pp.452 - 461. ⟨10.1523/JNEUROSCI.3896-11.2012⟩. ⟨hal-01427769⟩
  • Jerome Fleuriet, S. Hugues, L. Perrinet, Laurent Goffart. Saccadic Foveation of a Moving Visual Target in the Rhesus Monkey. Journal of Neurophysiology, American Physiological Society, 2011, 105 (2), pp.883 - 895. ⟨10.1152/jn.00622.2010⟩. ⟨hal-01427790⟩
  • Lorenzo Guerrasio, Julie Quinet, Ulrich Buttner, Laurent Goffart. Fastigial Oculomotor Region and the Control of Foveation During Fixation. Journal of Neurophysiology, American Physiological Society, 2010, 103 (4), pp.1988 - 2001. ⟨10.1152/jn.00771.2009⟩. ⟨hal-01427834⟩
  • Ziad M Hafed, Laurent Goffart, Richard J Krauzlis. A Neural Mechanism for Microsaccade Generation in the Primate Superior Colliculus. Science, American Association for the Advancement of Science (AAAS), 2009, 323 (5916), pp.940 - 943. ⟨10.1126/science.1166112⟩. ⟨hal-01427860⟩
  • Julie Quinet, Laurent Goffart. Electrical Microstimulation of the Fastigial Oculomotor Region in the Head-Unrestrained Monkey. Journal of Neurophysiology, American Physiological Society, 2009, 102 (1), pp.320 - 336. ⟨10.1152/jn.90716.2008⟩. ⟨hal-01427878⟩
  • Ziad M Hafed, Laurent Goffart, Richard J Krauzlis. Superior Colliculus Inactivation Causes Stable Offsets in Eye Position during Tracking. Journal of Neuroscience, Society for Neuroscience, 2008, ⟨10.1523/JNEUROSCI.1317-08.2008⟩. ⟨hal-01427871⟩
  • Julie Quinet, Laurent Goffart. Head-Unrestrained Gaze Shifts After Muscimol Injection in the Caudal Fastigial Nucleus of the Monkey. Journal of Neurophysiology, American Physiological Society, 2007, 98 (6), pp.3269 - 3283. ⟨10.1152/jn.00741.2007⟩. ⟨hal-01427887⟩
  • Laurent Goffart, Julie Quinet, Frédéric Chavane, Guillaume S. Masson. Influence of background illumination on fixation and visually guided saccades in the rhesus monkey. Vision Research, Elsevier, 2006, 46 (1-2), pp.149 - 162. ⟨10.1016/j.visres.2005.07.026⟩. ⟨hal-01427899⟩
  • Julie Quinet, Laurent Goffart. Saccade Dysmetria in Head-Unrestrained Gaze Shifts After Muscimol Inactivation of the Caudal Fastigial Nucleus in the Monkey. Journal of Neurophysiology, American Physiological Society, 2005, 93 (4), pp.2343 - 2349. ⟨10.1152/jn.00705.2004⟩. ⟨hal-01427909⟩
  • Laurent Goffart, Longtang Chen, David Sparks. Deficits in Saccades and Fixation During Muscimol Inactivation of the Caudal Fastigial Nucleus in the Rhesus Monkey. Journal of Neurophysiology, American Physiological Society, 2004, 92 (6), pp.3351-3367. ⟨10.1152/jn.01199.2003⟩. ⟨hal-03719083⟩
  • Julie Quinet, Laurent Goffart. Influence of head restraint on visually triggered saccades in the Rhesus monkey. Annals of the New York Academy of Sciences, Wiley, 2003, 1004 (1), pp.404-408. ⟨10.1111/j.1749-6632.2003.tb00248.x⟩. ⟨hal-02875224⟩
  • Denis Pélisson, Laurent Goffart, Alain Guillaume, Julie Quinet. Visuo-motor deficits induced by fastigial nucleus inactivation. The Cerebellum, Springer, 2003, 2 (1), pp.71-76. ⟨10.1080/14734220310015629⟩. ⟨hal-02498732⟩
  • Laurent Goffart, Longtang Chen, David Sparks. Saccade Dysmetria during Functional Perturbation of the Caudal Fastigial Nucleus in the Monkey. Annals of the New York Academy of Sciences, Wiley, 2003, 1004 (1), pp.220-228. ⟨10.1196/annals.1303.019⟩. ⟨hal-02328816⟩
  • A Guillaume, Laurent Goffart, J H Courjon, D Pelisson. Altered visuo-motor behavior during inactivation of the caudal fastigial nucleus in the cat.. Experimental Brain Research, Springer Verlag, 2000, pp.457-63. ⟨10.1007/s002210000359⟩. ⟨hal-01432075⟩
  • Laurent Goffart, D Pélisson. Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. I. Gaze dysmetria.. Journal of Neurophysiology, American Physiological Society, 1998, pp.1942-58. ⟨10.1152/jn.1998.79.4.1942⟩. ⟨hal-01427960⟩
  • Laurent Goffart, D Pélisson, A Guillaume. Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. II. Dynamics and eye-head coupling.. Journal of Neurophysiology, American Physiological Society, 1998, pp.1959-76. ⟨10.1152/jn.1998.79.4.1959⟩. ⟨hal-01427962⟩
  • Denis Pélisson, Laurent Goffart, Alain Guillaume. Contribution of the rostral fastigial nucleus to the control of orienting gaze shifts in the head-unrestrained cat.. Journal of Neurophysiology, American Physiological Society, 1998, pp.1180-96. ⟨10.1152/jn.1998.80.3.1180⟩. ⟨hal-01427956⟩
  • Laurent Goffart, Alain Guillaume, Denis Pélisson. Compensation for gaze perturbation during inactivation of the caudal fastigial nucleus in the head-unrestrained cat.. Journal of Neurophysiology, American Physiological Society, 1998, pp.1552-7. ⟨10.1152/jn.1998.80.3.1552⟩. ⟨hal-01427943⟩
  • Laurent Goffart, D Pélisson. Changes in initiation of orienting gaze shifts after muscimol inactivation of the caudal fastigial nucleus in the cat.. The Journal of Physiology, Wiley, 1997, pp.657-71. ⟨10.1111/j.1469-7793.1997.657bg.x⟩. ⟨hal-01427969⟩
  • Denis Pélisson, Laurent Goffart, Daniel Guitton. On-line compensation of gaze shifts perturbed by micro-stimulation of the superior colliculus in the cat with unrestrained head. Experimental Brain Research, Springer Verlag, 1995, 106 (2), ⟨10.1007/BF00241115⟩. ⟨hal-01427973⟩
  • Laurent Goffart, D Pelisson. Cerebellar contribution to the spatial encoding of orienting gaze shifts in the head-free cat.. Journal of Neurophysiology, American Physiological Society, 1994, pp.2547-50. ⟨10.1152/jn.1994.72.5.2547⟩. ⟨hal-01427965⟩
  • G. Vanni-Mercier, D. Pelisson, L. Goffart, K. Sakai, M. Jouvet. Eye Saccade Dynamics During Paradoxical Sleep in the Cat. European Journal of Neuroscience, Wiley, 1994, 6 (8), pp.1298 - 1306. ⟨10.1111/j.1460-9568.1994.tb00320.x⟩. ⟨hal-01432717⟩

Conference papers20 documents

  • Laurent Goffart. Are kinematic parameters embedded within the brain activity while an accurate movement is being achieved?. Journée Complexité-Désordre, Jean-Claude Levy, Jan 2020, Paris, France. ⟨hal-03652212⟩
  • Laurent Goffart. Neural processes underlying the foveation and tracking of a moving visual target. Bilateral symposium in Neuroscience (Aix-Marseille University & University of Tübingen), Oct 2019, Marseille, France. ⟨hal-03654895⟩
  • Laurent Goffart, Clara Bourrelly, Julie Quinet. Cerebellar control of saccades by the size of the active population in the caudal fastigial nucleus. European Conference on Eye Movements, 2019, Alicante, Spain. ⟨hal-03652182⟩
  • Laurent Goffart. La cinématique est-elle en-corporée dans le cerveau?. Journée d'étude "Embodiment", Pierre Leger (CGGG), Marie-Charlotte Cuartero (LPL) et Ana Zappa (LPL), May 2019, Aix-en-Provence, France. ⟨hal-03652188⟩
  • Laurent Goffart. Does the brain perform arithmetical computations with neurally embedded kinematic parameters?. Meeting of the GDR Vision, Oct 2019, Marseille, France. ⟨hal-03652194⟩
  • Laurent Goffart, Clara Bourrelly. Neurophysiologie de la locosynchronisation visuomotrice. Journées Complexité - Désordre (Jean-Claude Lévy), Jan 2018, Paris, France. ⟨hal-03652221⟩
  • Laurent Goffart. Neural processes underlying the accurate foveation and tracking of a visual target. Kolloquium der Abteilung Allgemeine Psychologie/ Current Topics in Perception and Cognition, Prof. Karl Gegenfurtner, Oct 2018, Giessen, Germany. ⟨hal-02074886⟩
  • Laurent Goffart. Entre les mesures comportementales et le milieu de fonctionnement intracérébral : réflexions sur le dynamisme visuomoteur. Journée d'étude sur la mesure, Igor LY, Jun 2017, Marseille, France. ⟨hal-03655871⟩
  • Laurent Goffart. Contribution à la recherche de la structure spatiotemporelle sous-jacente au dynamisme visuo-oculomoteur. Complexité et désordre, Jean-Claude Lévy, Jan 2017, Paris, France. ⟨hal-01432728⟩
  • Laurent Goffart. Cerebellar control of saccades by the size of the active population in the caudal fastigial nucleus. A scientific meeting on eye movements to honor David A Robinson, May 2017, Baltimore, United States. ⟨hal-01699079⟩
  • Laurent Goffart. De sa représentation spatio-temporellement distribuée dans le cerveau à la capture ici-et-maintenant d’un objet visuel en mouvement. Complexité / désordre : adaptation, localisation, dynamique, Jean-Claude Lévy, Jan 2016, Paris, France. ⟨hal-01432726⟩
  • Jean-Charles Quinton, Laurent Goffart. A neural field model of the dynamics of goal-directed eye movements. Colloque BioComp, Oct 2016, Lyon, France. ⟨hal-01839803⟩
  • Laurent Goffart. Cerebellar mechanisms for orienting toward the location where a target is : lessons from perturbing the output of the midline cerebellum. Cerebellum and eye movements, Jun 2013, Paris, France. ⟨hal-03673887⟩
  • Laurent Goffart, Jerome Fleuriet. Hic-Et-Nunc (Here-and-Now) Encoding of a Moving Target for its Saccadic Foveation. Asia Pacific Conference on Vision, Jul 2012, Incheon, South Korea. pp.741 - 741, ⟨10.1068/if741⟩. ⟨hal-01440264⟩
  • Laurent Goffart. Cerebellar mechanisms for orienting the fovea toward a visual target. European Conference on Eye Movements 2011, Aug 2011, Marseille, France. ⟨hal-03673767⟩
  • Laurent Goffart. The shape of the orienting reaction and its neural representations . 1st international workshop on the shapes of brain dynamics, Complex systems institute, Jun 2010, Paris, France. ⟨hal-01440272⟩
  • Laurent Goffart. The fastigial oculomotor region and the cerebellar control of gaze orientation. "Neural control of eye, head and limb movements", satellite meeting of the Barany Society meeting for honoring Dr Yoshikazu Shinoda, Mar 2008, Kyoto, Japan. ⟨hal-03673243⟩
  • Laurent Goffart. Neural mechanisms for orienting the fovea toward a visual target. Primate Neurobiology, First Annual Meeting 2008, Feb 2008, Tübingen, Germany. ⟨hal-03673249⟩
  • Laurent Goffart. The caudal fastigial nucleus and the control of gaze orientation : lessons from perturbation experiments in the cat and monkey. “Neural mechanisms of oculomotor and vestibular functions”, meeting in honor of Dr Albert Fuchs, Oct 2008, Medford, Oregon, United States. ⟨hal-03673241⟩
  • Laurent Goffart, Julie Quinet. Coupling between the Horizontal and Vertical Saccade Generators after Inactivation of the Caudal Fastigial Nucleus in the Monkey. Symposium 10: Vertical eye movements XXV Bárány Society Meeting 2008, Mar 2008, Kyoto, Japan. ⟨hal-03673247⟩

Poster communications8 documents

  • Laurent Goffart. Cerebellar control of gaze orientation toward visual targets: studies in the non-human primate. Cerebellum-Striatum-Hippocampus network: bridging the gap between basic science and clinical research, Mar 2019, Paris, France. ⟨hal-02073990⟩
  • Laurent Goffart, Clara Bourrelly, Julie Quinet. Cerebellar control of visually-guided eye movements by the bilateral mass of activity in the caudal fastigial nuclei. Meeting of the GDR Neural Net, Dec 2019, Bordeaux, France. ⟨hal-03652206⟩
  • Laurent Goffart. Sensorimotor transformation: lessons from the neurophysiological study of visually-guided eye movements. Meeting of the GDR Neural Net, Dec 2019, Bordeaux, France. ⟨hal-03652208⟩
  • Jean-Charles Quinton, Laurent Goffart. Active Neural Field model of goal directed eye-movements. Grenoble Workshop on Models and Analysis of Eye Movements, Jun 2018, Grenoble, France. ⟨hal-01839369⟩
  • Laurent Goffart. Critical revision of the neurophysiology of tracking eye movements. GDR conference NeuralNet 2018, Dec 2018, Paris, France. ⟨hal-03654901⟩
  • Laurent Goffart, Julie Quinet, Clara Bourrelly. Cerebellar control of saccades by the size of the active population in the caudal fastigial nucleus. Society for Neuroscience Meeting, Nov 2017, Washington DC, United States. ⟨hal-03654905⟩
  • Laurent Goffart. Parallel processing for the generation of saccades to simultaneously moving centrifugal targets. Society for Neuroscience Meeting 2016, Nov 2016, San Diego, United States. http://www.abstractsonline.com/pp8/#!/4071/presentation/26132. ⟨hal-01402661⟩
  • Laurent Goffart. On the utility of neural perturbation experiments for identifying the neural components of an integrated system.. Multiscale analysis of neural systems: taking the challenge SERIOUSLY, Feb 2010, Gif-sur-Yvette, France. ⟨hal-01440282⟩

Book sections5 documents

  • Laurent Goffart. Kinematics and the neurophysiological study of visually-guided eye movements. Mathematical modelling in motor neuroscience: State of the art and translation to the clinic, 2019, ⟨10.1016/bs.pbr.2019.03.027⟩. ⟨hal-02109608⟩
  • Laurent Goffart. De la représentation cérébrale spatio-temporellement distribuée à la capture ici et maintenant d'un objet visuel en mouvement. L'avenir de la complexité et du désordre, 2018. ⟨hal-02296340⟩
  • Laurent Goffart, Clara Bourrelly, Julie Quinet. Synchronizing the tracking eye movements with the motion of a visual target: Basic neural processes. Temporal Sampling and Representation Updating, pp.243-268, 2017, ⟨10.1016/bs.pbr.2017.07.009⟩. ⟨hal-02328789⟩
  • Laurent Goffart. Saccadic Eye Movements: Basic Neural Processes. Reference Module in Neuroscience and Biobehavioral Psychology, 2017, Sensorimotor systems, ⟨10.1016/B978-0-12-809324-5.02576-1⟩. ⟨hal-01427818⟩
  • Denis Pélisson, Laurent Goffart, Alain Guillaume. Control of saccadic eye movements and combined eye/head gaze shifts by the medio-posterior cerebellum. Neural Control of Space Coding and Action Production, pp.69-89, 2003, ⟨10.1016/S0079-6123(03)42007-4⟩. ⟨hal-02498724⟩

Other publications4 documents

  • Laurent Goffart. Brain processes for foveating a visual target here-and-now: seminar at the Brain Research Institute at University of California, Los Angeles (visit of Dr Michele Basso's lab). 2016. ⟨hal-01402663⟩
  • Laurent Goffart. Brain processes for foveating a visual target here-and-now: séminaire. 2014. ⟨halshs-01066504⟩
  • Laurent Goffart. Brain mechanisms for foveating a visual target here-and-now (i.e., where it is and when it is there). 2013. ⟨hal-03674126⟩
  • Laurent Goffart. Structure and function : in search for the (neuro)biological foundations of visuomotor space. Seminar at the Laboratoire de Neurosciences Intégratives et Adaptatives, Marseille, France, 2010. ⟨hal-03663058⟩

Preprints, Working Papers, ...1 document

  • Laurent Goffart. Neurophysiology of gaze orientation: Core neuronal networks. 2022. ⟨hal-03541980⟩

Habilitation à diriger des recherches1 document

  • Laurent Goffart. Itinéraire pour une contribution de la Neurophysiologie de l'orientation du regard à la recherche des conditions de possibilité de l'intuition spatiale. Psychologie et comportements. Aix-Marseille Université (AMU), 2020. ⟨tel-02968991v2⟩