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Laurent Delbreilh

Dr. Laurent DELBREILH Associate Professor in the University of Rouen since September 2006 Section CNU : 28 Physics Researcher in Physics Researcher in GPM laboratory, UMR CNRS 6634, Co-Coordinator of « Physics Mention » Licence at the University of Rouen. Coordinator of Material Science specialty 3rd year Licence at University of Rouen Member of l’Association Française de Calorimétrie et d'Analyse Thermique (AFCAT) et de l’International Committee of Thermal Analysis and Calorimetry (ICTAC) depuis 2008. Education 2016 : “Habilitation à Diriger la Recherche” HDR 2004 : PhD. Of the University of Toulouse (F) in Polymer Physics Current Position Since 2016: Maître de Conférences HDR/ Associate Professor in the Physics research Department of the University of Rouen. Since 2014 : Visiting Adjunct Research Professor at the Mechanical and Materials Engineering department at University of Nebraska Lincoln (UNL) USA 2006/2016 : Maitre de conférences/Assistant Professor in the Physics research Department of the University of Rouen 2004/2006 : Assistant in the Physics research Department of the University of Rouen. Supervision Activities 50 Students in Master Degree 11 Students in PhD Thesis Scientific Activities: My research activities mainly concern the field of the physics of glasses, physics of disordered matter and more particularly the physics of polymers and nowadays of biopolymers. I work more specifically on the study of dynamics in amorphous phases, mainly in polymers but also for other glass formers. The various works that I have implemented, or in which I have participated, are at the intersection of two issues: - A more fundamental theme which aims to understand the physical mechanisms and the laws of behavior for glass-forming liquids below and above the glass transition temperature. - A theme with a more "materials" approach aimed at studying the impact of modifications of amorphous phases, in a physicochemical manner. This produces different relaxation environments. The principle of the environment is seen here in the broad sense since under this term we can group together: - microstructures in the case of semi-crystalline polymers - geometric confinement - fillers or nano-fillers in the case of composites - additives - nano-texturing ... These two approaches are most often interconnected in my work since the fundamental understanding of relaxation phenomena in amorphous "model" materials allows a more precise reading of the phenomena observed during an application on more complex materials.
19
Documents

Présentation

Domaines de recherche

Matière Molle [cond-mat.soft] Science des matériaux [cond-mat.mtrl-sci] Physique [physics] Matériaux

Publications

gerard-coquerel

Enhancement of the Physical and Chemical Stability of Amorphous Drug–Polymer Mixtures via Cryogenic Comilling

Michela Romanini , Marta Lorente , Benjamin Schammé , Laurent Delbreilh , Valérie Dupray
Macromolecules, 2018, 51 (22), pp.9382-9392. ⟨10.1021/acs.macromol.8b01271⟩
Article dans une revue hal-02048482v1

Vitrification of two active pharmaceutical ingredients by fast scanning calorimetry: From structural relaxation to nucleation phenomena

Xavier Monnier , Quentin Viel , Benjamin Schammé , Samuel Petit , Laurent Delbreilh
International Journal of Pharmaceutics, 2018, 536 (1), pp.426 - 433. ⟨10.1016/j.ijpharm.2017.12.013⟩
Article dans une revue hal-01857176v1

Investigation of Drug–Excipient Interactions in Biclotymol Amorphous Solid Dispersions

Benjamin Schammé , Nicolas Couvrat , Vincent Tognetti , Laurent Delbreilh , Valérie Dupray
Molecular Pharmaceutics, 2018, 15 (3), pp.1112-1125. ⟨10.1021/acs.molpharmaceut.7b00993⟩
Article dans une revue hal-01857154v1

Molecular Mobility of an Amorphous Chiral Pharmaceutical Compound: Impact of Chirality and Chemical Purity

Quentin Viel , Laurent Delbreilh , Gérard Coquerel , Samuel Petit , Eric Dargent
Journal of Physical Chemistry B, 2017, 121 (32), pp.7729 - 7740. ⟨10.1021/acs.jpcb.7b05667⟩
Article dans une revue hal-01927923v1

Insights on the Physical State Reached by an Active Pharmaceutical Ingredient upon High-Energy Milling

Benjamin Schammé , Xavier Monnier , Nicolas Couvrat , Laurent Delbreilh , Valérie Dupray
Journal of Physical Chemistry B, 2017, 121 (19), pp.5142 - 5150. ⟨10.1021/acs.jpcb.7b02247⟩
Article dans une revue hal-01766057v1

Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol

Benjamin Schammé , Nicolas Couvrat , Pascal Malpeli , Emeline Dudognon , Laurent Delbreilh
International Journal of Pharmaceutics, 2016, 499 (1-2), pp.67 - 73. ⟨10.1016/j.ijpharm.2015.12.032⟩
Article dans une revue hal-01928396v1

Molecular Relaxations in Supercooled Liquid and Glassy States of Amorphous Quinidine: Dielectric Spectroscopy and Density Functional Theory Approaches

Benjamin Schammé , Mélanie Mignot , Nicolas Couvrat , Vincent Tognetti , Laurent Joubert
Journal of Physical Chemistry B, 2016, 120 (30), pp.7579-7592. ⟨10.1021/acs.jpcb.6b04242⟩
Article dans une revue hal-01928417v1

Crystallization kinetics and molecular mobility of an amorphous active pharmaceutical ingredient: A case study with Biclotymol

Benjamin Schammé , Nicolas Couvrat , Pascal Malpeli , Laurent Delbreilh , Valérie Dupray
International Journal of Pharmaceutics, 2015, 490 (1-2), pp.248 - 257. ⟨10.1016/j.ijpharm.2015.05.036⟩
Article dans une revue hal-01928832v1

Thermal growth of organic supramolecular crystals with screw dislocations

Alexandre Dhotel , Laurent Delbreilh , Boulos Youssef , Jinyue Jiang , Gérard Coquerel
Journal of Thermal Analysis and Calorimetry, 2013, 112 (1), pp.301 - 305. ⟨10.1007/s10973-012-2827-z⟩
Article dans une revue hal-01930173v1

Transformation of an active pharmaceutical ingredient upon high-energy milling: a case study with Biclotymol

B. Schammé , N. Couvrat , P. Malpelli , E. Dudognon , L. Delbreilh
Colloque Francophone de Cristallisation et de Précipitation Industrielles (CRISTAL-8), May 2016, Rouen, France
Communication dans un congrès hal-01939501v1

Transformation d’un principe actif sous broyage haute-énergie : cas du Biclotymol

Benjamin Schammé , Nicolas Couvrat , Pascal Malpeli , Emeline Dudognon , Laurent Delbreilh
CRISTAL 8 (Cristallisation et précipitation industrielles), May 2016, Rouen, France
Communication dans un congrès hal-02468844v1

Role of molecular mobility and fragility on physical stability of two amorphous pharmaceuticals in the supercooled and glassy states

B. Schammé , L. Delbreilh , V. Dupray , E. Dargent , G. Coquerel
PolyChar 23, May 2015, Nebraska, United States
Communication dans un congrès hal-01940511v1

Thermal and physical stability of amorphous Biclotymol

B. Schammé , L. Delbreilh , N. Couvrat , V. Dupray , G. Coquerel
Condensed Matter 2014 (25th Conference of the Condensed Matter Division), Aug 2014, Paris, France
Communication dans un congrès hal-01941049v1

Behavior of Biclotymol: from high-energy milling to supercooled melt

B. Schammé , N. Couvrat , P. Malpeli , L. Delbreilh , V. Dupray
BIWIC (21st International Workshop on Industrial Crystallization), Sep 2014, Rouen, France
Communication dans un congrès hal-01941095v1

7.Effects of milling on polymorphism of biclotymol

B. Schammé , V. Dupray , L. Delbreihl , G. Coquerel
XXXX èmes JEEP (Joint European days on Equilibrium between Phases), Mar 2014, Lyon, France
Communication dans un congrès hal-01940890v1

Order-Disorder Transition Investigated by Temperature Resolved Second Harmonic Generation (TR-SHG)

S. Clevers , Céline Rougeot , M. Sanselme , F. Taulelle , C. Martineau
Journées CNRS Cristech, Oct 2014, Autrans, France
Communication dans un congrès hal-01941131v1

Molecular mobility, crystallization kinetics and physical stability of amorphous Biclotymol

B. Schammé , N. Couvrat , L. Delbreilh , V. Dupray , E. Dargent
Condensed Matter 2014 (25th Conference of the Condensed Matter Division), Aug 2014, Paris, France
Communication dans un congrès hal-01941046v1

Order-Disorder transitions: investigations in a series of triazole ketones

S. Clevers , Céline Rougeot , M. Sanselme , V. Dupray , F. Taulelle
CGOM-11 (Crystal Growth of Organic Molecules), Jun 2014, Kyoto, Japan
Communication dans un congrès hal-01941027v1

Crystallization and phase transitions of Biclotymol polymorphs

B. Schammé , L. Delbreilh , V. Dupray , G. Coquerel
JCAT (Journées de Calorimétrie et d’Analyse Thermique), May 2014, Rouen, France
Communication dans un congrès hal-01940951v1