Laurence HECQUET

Documents

Identifiants chercheurs

laurence-hecquet
0000-0003-2971-5686

Présentation

Publications

	Synthesis of Deoxysugars from Aliphatic α‐Ketoacids and Aldoses Catalyzed by Thermostable Transketolase Variants from Geobacillus stearothermophilus Nazim Ocal , Giuseppe Arbia , Aurélie Lagarde , Muriel Joly , Samantha Gittings Advanced Synthesis and Catalysis, 2022, ⟨10.1002/adsc.202201190⟩ Article dans une revue hal-03918083v1
	Cleavage of Aliphatic α-Hydroxy Ketones by Evolved Transketolase from Geobacillus stearothermophilus Hubert Casajus , Aurélie Lagarde , Lionel Nauton , Nazim Ocal , Martin Leremboure ACS Catalysis, 2022, 12, pp.3566-3576. ⟨10.1021/acscatal.1c05140⟩ Article dans une revue hal-03607757v1
	QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle Lionel Nauton , Laurence Hecquet , Vincent Théry Journal of Chemical Information and Modeling, 2021, ⟨10.1021/acs.jcim.1c00190⟩ Article dans une revue hal-03286397v1
	Convergent in situ Generation of Both Transketolase Substrates via Transaminase and Aldolase Reactions for Sequential One‐Pot, Three‐Step Cascade Synthesis of Ketoses Marion Lorillière , Christine Guérard‐hélaine , Thierry Gefflaut , Wolf‐dieter Fessner , Pere Clapés ChemCatChem, 2020, 12 (3), pp.812-817. ⟨10.1002/cctc.201901756⟩ Article dans une revue hal-02991624v1
	d -Serine as a Key Building Block: Enzymatic Process Development and Smart Applications within the Cascade Enzymatic Concept Nazim Ocal , Mélanie L’enfant , Franck Charmantray , Loredano Pollegioni , Juliette Martin Organic Process Research and Development, 2020, 24 (5), pp.769-775. ⟨10.1021/acs.oprd.0c00024⟩ Article dans une revue hal-02995483v1
	Enzymatic Synthesis of Aliphatic Acyloins through Thermostable Transketolase Catalyzed-Reaction Hubert Casajus , Aurélie Lagarde , Martin Leremboure , Thomas De Dios Miguel , Lionel Nauton ChemCatChem, 2020, ⟨10.1002/cctc.202001160⟩ Article dans une revue hal-02995504v1
	One‐Pot Cascade Synthesis of (3 S )‐Hydroxyketones Catalyzed by Transketolase via Hydroxypyruvate Generated in Situ from d ‐Serine by d ‐Amino Acid Oxidase Mélanie L’enfant , Felipe Bruna , Marion Lorillière , Nazim Ocal , Wolf‐dieter Fessner Advanced Synthesis and Catalysis, 2019, 361, pp.2550-2558. ⟨10.1002/adsc.201900109⟩ Article dans une revue hal-02195016v1
	Evolved Thermostable Transketolase for Stereoselective Two-Carbon Elongation of Non-Phosphorylated Aldoses to Naturally Rare Ketoses Marion Lorillière , Romain Dumoulin , Mélanie L’enfant , Agnès Rambourdin , Vincent Thery ACS Catalysis, 2019, 9 (6), pp.4754-4763. ⟨10.1021/acscatal.9b01339⟩ Article dans une revue hal-02195534v1
	Innovative Electrochemical Screening Allows Transketolase Inhibitors to Be Identified Chloé Aymard , Matilte Halma , Arnaud Comte , Christine Mousty , Vanessa Prevot Analytical Chemistry, 2018, 90 (15), pp.9241 - 9248. ⟨10.1021/acs.analchem.8b01752⟩ Article dans une revue hal-01878842v1
	Engineering a thermostable transketolase for arylated substrates. Thangavelu Saravanan , Marie-Luise Reif , Dong Yi , Marion Lorillière , Franck Charmantray Green Chemistry, 2017, 19, pp.481-489. ⟨10.1039/C6GC02017H⟩ Article dans une revue hal-01541467v1
	High-throughput electrochemical screening assay for free and immobilized oxidases: electrochemiluminescence and intermittent pulse amperometry. Chloé Aymard , Celia Bonaventura , Robert Henkens , Christine Mousty , Laurence Hecquet ChemElectroChem, 2017, 4, pp.957-966. ⟨10.1002/celc.201600647⟩ Article dans une revue hal-01546189v1
	Second-generation engineering of a thermostable transketolase (TKGst) for aliphatic aldehyde acceptors with either improved or reversed stereoselectivity. Chaoqiang Zhou , Thangavelu Saravanan , Marion Lorillière , Dongzhi Wei , Franck Charmantray ChemBioChem, 2017, 18, pp.455-459. ⟨10.1002/cbic.201600609⟩ Article dans une revue hal-01543229v1
	One-pot, two-step cascade synthesis of naturally rare L-$erythro$ (3S,4S) ketoses by coupling thermostable transaminase and transketolase. Marion Lorillière , Maxime De Sousa , Felipe Bruna , Egon Heuson , Thierry Gefflaut Green Chemistry, 2017, 19, pp.425-435. ⟨10.1039/C6GC02015A⟩ Article dans une revue hal-01540859v1
	Instant one-pot preparation of functional layered double hydroxides (LDHs) via a continuous hydrothermal approach Oana Pascu , Samuel Marre , Bastien Cacciuttolo , Ghina Ali , Laurence Hecquet ChemNanoMat, 2017, 3 (9), pp.614-619. ⟨10.1002/cnma.201700125⟩ Article dans une revue hal-01656067v1
	Donor promiscuity of a thermostable transketolase engineered by directed evolution-Efficient complementation of DXS activity. Thangavelu Saravanan , Sébastian Junker , Michael Kickstein , Sascha Hein , Marie-Kristin Link Angewandte Chemie International Edition, 2017, 56, pp.5358-5362. ⟨10.1002/anie.201701169⟩ Article dans une revue hal-01540844v1
	Transketolase-Aldolase Symbiosis for the Stereoselective Preparation of Aldoses and Ketoses of Biological Interest Christine Guérard-Hélaine , Maxime De sousa lopes moreira , Nadia Touisni , Laurence Hecquet , Marielle Lemaire Advanced Synthesis and Catalysis, 2017, 359 (12), pp.2061 - 2065. ⟨10.1002/adsc.201700209⟩ Article dans une revue hal-01654769v1
	Thiamine biosensor based on oxidative trapping of enzyme-substrate intermediate. Matilte Halma , Bastien Doumèche , Laurence Hecquet , Vanessa Prévot , Christine Mousty Biosensors and Bioelectronics, 2017, 87, pp.850-857. ⟨10.1016/j.bios.2016.09.049⟩ Article dans une revue hal-01546142v1
	Insights into the Thiamine Diphosphate Enzyme Activation Mechanism: Computational Model for Transketolase Using a Quantum Mechanical/Molecular Mechanical Method. Lionel Nauton , Virgil Hélaine , Vincent Théry , Laurence Hecquet Biochemistry, 2016, 55, pp.2144-2152. ⟨10.1021/acs.biochem.5b00787⟩ Article dans une revue hal-01323789v1
	Droplet millifluidics for kinetic study of transketolase. A. Pinsolle , F. Charmantray , L. Hecquet , F. Sarrazin Biomicrofluidics, 2016, 10, pp.064103. ⟨10.1063/1.4966619⟩ Article dans une revue hal-01479103v1
	Substrate cycling based fluorometric assay for dihydroxyacetone phosphate. B. Légeret , L. Hecquet , F. Charmantray Journal of Molecular Catalysis B: Enzymatic, 2015, 114, pp.13-18. ⟨10.1016/j.molcatb.2014.07.005⟩ Article dans une revue hal-01206687v1
	A thermostable transketolase evolved for aliphatic aldehyde acceptors. Dong Yi , Thangavelu Saravanan , Titu Devamani , Franck Charmantray , Laurence Hecquet Chemical Communications, 2015, 51, pp.480-483. ⟨10.1039/C4CC08436E⟩ Article dans une revue hal-01207844v1
	Chiral polyol synthesis catalyzed by a thermostable Transketolase immobilized on Layered Double Hydroxides in Ionic liquids. Ghina Ali , Thomas Moreau , Claude Forano , Christine Mousty , Vanessa Prevot ChemCatChem, 2015, 7, pp.3163-3170. ⟨10.1002/cctc.201500524⟩ Article dans une revue hal-01213647v1
	Engineering a Thermostable Transketolase for Unnatural Conversion of (2S)-Hydroxyaldehyde. Juliane Abdoul-Zabar , Marion Lorillière , Dong Yi , Thangavelu Saravanan , Titu Devamani Advanced Synthesis and Catalysis, 2015, 357, pp.1715-1720. ⟨10.1002/adsc.201500207⟩ Article dans une revue hal-01206477v1
	Galactose Oxidase/Prussian Blue Based Biosensors. Franck Charmantray , Nadia Touisni , Laurence Hecquet , Thierry Noguer , Christine Mousty Electroanalysis, 2015, 27, pp.1341-1344. ⟨10.1002/elan.201400720⟩ Article dans une revue hal-01213418v1
	An efficient amperometric transketolase assay:Towards inhibitor screening Nadia Touisni , Franck Charmantray , Virgil Hélaine , Laurence Hecquet , Christine Mousty Biosensors and Bioelectronics, 2014, 62, pp.90-96. ⟨10.1016/j.bios.2014.06.019⟩ Article dans une revue hal-01077362v1
	Optimized immobilization of Transketolase from E. coli in MgAl-Layered Double Hydroxides. Nadia Touisni , Franck Charmantray , Virgil Hélaine , Claude Forano , Laurence Hecquet Colloids and Surfaces B: Biointerfaces, 2013, 112, pp.452-459 Article dans une revue hal-00948890v1
	Amperometric Biosensor Based on Galactose Oxidase Immobilized in Clay Matrix. Franck Charmantray , Nadia Touisni , Laurence Hecquet , Christine Mousty Electroanalysis, 2013, 25, pp.630-635 Article dans une revue hal-00799835v1
	Thermostable Transketolase from Geobacillus stearothermophilus: Characterization and Catalytic Properties Juliane Abdoul-Zabar , Isabelle Sorel , Virgil Hélaine , Franck Charmantray , Titu Devamani Advanced Synthesis and Catalysis, 2013, 355, pp.116-128 Article dans une revue hal-00790248v1
	Synthesis of specially designed probes to broaden transketolase scope Grégory Simon , T. Eljezi , Bertrand Legeret , Franck Charmantray , José A. Castillo ChemCatChem, 2013, 5, pp.784-795 Article dans une revue hal-00803221v1
	One-pot Cascade Reactions using Fructose-6-phosphate Aldolase: Efficient Synthesis of d-Arabinose-5-phosphate, D-Fructose-6-phosphate and Analogues Israel Sanchez-Moreno , Virgil Hélaine , Nicolas Poupard , Franck Charmantray , Bertrand Legeret Advanced Synthesis and Catalysis, 2012, 354 (9), pp.1725-1730. ⟨10.1002/adsc.201200150⟩ Article dans une revue hal-00714763v1
	A pH-Based High-Throughput Assay for Transketolase: Fingerprinting of Substrate Tolerance and Quantitative Kinetics Dong Yi , Titu Devamani , Juliane Abdoul-Zabar , Franck Charmantray , Virgil Hélaine ChemBioChem, 2012, 13, pp.2290-2300 Article dans une revue hal-00787216v1
	Enzymatic and organocatalyzed asymmetric aldolization reactions for the synthesis of thiosugar scaffolds Johan Fanton , Flora Camps Bres , José A. Castillo , Christine Guérard-Hélaine , Marielle Lemaire European Journal of Organic Chemistry, 2012, pp.203-210 Article dans une revue hal-00663434v1
	Efficient immobilization of yeast transketolase on layered double hydroxides and application for ketose synthesis Karima Benaissi , Virgil Hélaine , Vanessa Prevot , Claude Forano , Laurence Hecquet Advanced Synthesis and Catalysis, 2011, 353, pp.1497-1509 Article dans une revue hal-00603696v1
	Electrochemical detection of transketolase activity using a tyrosinase biosensor Marta Sanchez-Paniagua Lopez , Franck Charmantray , Virgil Hélaine , Laurence Hecquet , Christine Mousty Biosensors and Bioelectronics, 2010, 26, pp.139-143. ⟨10.1016/j.bios.2010.05.023⟩ Article dans une revue hal-00530536v1
	A mutant D-fructose-6-Phosphate Aldolase (Ala129Ser) with improved affinity towards dihydroxyacetone for the synthesis of polyhydroxylated compounds José A. Castillo , Christine Guérard-Hélaine , Mariana Gutierrez , Xavier Garrabou , Martine Sancelme Advanced Synthesis and Catalysis, 2010, 352, pp.1039-1046. ⟨10.1002/adsc.200900772⟩ Article dans une revue hal-00492855v1
	Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs Grégory Simon , Madeleine Bouzon , Franck Charmantray , Virgil Hélaine , Bertrand Legeret Bioorganic and Medicinal Chemistry Letters, 2009, 19, pp.3767-3770. ⟨10.1016/j.bmcl.2009.04.111⟩ Article dans une revue hal-00413292v1
	Fluorogenic substrates for the screening assay of transketolase through beta-elimination of umbelliferone-development, scope and limitations? Franck Charmantray , Bertrand Legeret , Virgil Hélaine , Laurence Hecquet Journal of Biotechnology, 2009, 145, pp.359-366 Article dans une revue hal-00455188v1
	Preparative scale enzymatic synthesis of D-sedoheptulose-7-phosphate from β-hydroxypyruvate and D-ribose-5-phosphate Franck Charmantray , Virgil Hélaine , Bertrand Legeret , Laurence Hecquet Journal of Molecular Catalysis B: Enzymatic, 2009, 57, pp.6-9 Article dans une revue hal-00366191v1
	Chemoenzymatic synthesis of L-tyrosine derivative for a transketolase assay Franck Charmantray , Virgil Hélaine , Angelika Lasikova , Bertrand Legeret , Laurence Hecquet Tetrahedron Letters, 2008, 49, pp.3229-3233 Article dans une revue hal-00275587v1
	An efficient chemoenzymatic route to dihydroxyacetone phosphate from glycidol for the in situ aldoalse-mediated synthesis of monosaccharides Franck Charmantray , Philippe Dellis , Soth Samreth , Laurence Hecquet Tetrahedron Letters, 2006, 47, pp.3261-3263. ⟨10.1016/j.tetlet.2006.03.036⟩ Article dans une revue hal-00022357v1
	Chemoenzymatic synthesis of 5-thio-D-xylopyranose. Franck Charmantray , Philippe Dellis , Virgil Hélaine , Soth Samreth , Laurence Hecquet European Journal of Organic Chemistry, 2006, pp.5526-5532. ⟨10.1002/ejoc.200600627⟩ Article dans une revue hal-00121152v1
	Synthesis of stereochemical probes for new fluorogenic assays for yeast transketolase variants. Aurélie Sevestre , Franck Charmantray , Virgil Hélaine , Angelika Lasikova , Laurence Hecquet Tetrahedron, 2006, 62, pp.3969-3976. ⟨10.1016/j.tet.2006.02.033⟩ Article dans une revue hal-00022356v1
	Improved straightforward chemical synthesis of dihydroxyacetone phosphate through enzymatic desymmetrization of 2,2-dimethoxypropane-1,3-diol Franck Charmantray , Lahssen El Blidi , Thierry Gefflaut , Laurence Hecquet , Jean Bolte Journal of Organic Chemistry, 2004, 69, pp.9310-9312. ⟨10.1021/jo048697k⟩ Article dans une revue hal-00136047v1
	Slow-binding inhibition of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase Rémi Braga , Laurence Hecquet , Casimir Blonski Bioorganic and Medicinal Chemistry, 2004, 12, pp.2965-2972. ⟨10.1016/j.bmc.2004.03.039⟩ Article dans une revue hal-00136361v1
	A fluorogenic assay for transketolase from Saccharomyces cerevisiae A. Sevestre , Viviane Helaine , G. Guyot , C. Martin , Laurence Hecquet Tetrahedron Letters, 2003, 44 (4), pp.827-830. ⟨10.1016/S0040-4039(02)02634-5⟩ Article dans une revue hal-02680071v1

	Extending the reaction toolbox for C-C bond formation and cleavage: biocatalytic applications of Transketolases. Laurence Hecquet Symposium on Molecular Evolution and Biocatalysis: When Chemistry goes Green (Webinar), Dec 2020, Vitry-sur-Seine, France Communication dans un congrès hal-03132988v1
	Evolved thermostable Transketolase for the valorization of vegetable oils. H. Casajus , T. de Dios Miguel , E. Métay , N. Duguet , W.-D. Fessner International Symposium on Green Chemistry, ISGC 2019, May 2019, La Rochelle, France Communication dans un congrès hal-02282426v1
	Application d'un biocapteur à tyrosinase à la détection ampérométrique de l'activité de la transcétolase Christine Mousty , M. Sanchez-Paniagua Lopez , Franck Charmantray , Virgil Hélaine , Laurence Hecquet XIIème colloque du Groupe Français de Bioélectrochimie, May 2010, Lacanau, France Communication dans un congrès hal-00506410v1
	Electrochemical detection of transketolase activity using a tyrosinase biosensor M. Sanchez-Paniague Lope , Franck Charmantray , Virgil Hélaine , Laurence Hecquet , Christine Mousty 61st Annual Meeting of the International Society of electrochemistry, Sep 2010, Nice, France Communication dans un congrès hal-00493347v1
	Amperometric determination of protected tyrosine at a tyrosinase biosensor: application to TK activity detection M. Sanchez-Paniagua Lopez , Franck Charmantray , Virgil Hélaine , Laurence Hecquet , Christine Mousty 13th International Conference on Electroanalysis (ESEAC), Jun 2010, Gijon, Spain Communication dans un congrès hal-00506458v1
	Immobilisation de la transcétolase dans des matrices Hydroxydes Doubles Lamellaires Karima Benaissi , Franck Charmantray , Virgil Hélaine , Vanessa Prevot , Laurence Hecquet 23ème colloque du Club Bioconversion en Synthèse Organique, CBSO 2010, May 2010, Royat, France Communication dans un congrès hal-00493301v1
	Synthèse de sondes pour le développement d'un test de sélection de la transcétolase de levure Virgil Hélaine , Grégory Simon , Franck Charmantray , M. Bouzon , P. Marlière 13èmes Rencontres de Chimie Organique et Biologique (RECOB 13), Mar 2010, Aussois, France Communication dans un congrès hal-00493325v1
	Layered Double Hydroxides as supports for Transletolase applications Karima Benaissi , M. Sanchez-Paniagua Lopez , Franck Charmantray , Virgil Hélaine , Vanessa Prevot COST Castcat Meeting, Sep 2010, Vilnius, Lithuania Communication dans un congrès hal-00531745v1
	Amperometric determination of protected Tyrosine at a Tyrosinase biosensor: application to TK activity detection M. Sanchez-Paniagua Lope , Franck Charmantray , Virgil Hélaine , Laurence Hecquet , Christine Mousty 23ème colloque du Club Bioconversion en Synthèse Organique, CBSO 2010, May 2010, Royat, France Communication dans un congrès hal-00493339v1
	Synthèse de sondes pour le développement d'un test de sélection de la transcétolase de levure Virgil Hélaine , Grégory Simon , Franck Charmantray , M. Bouzon , P. Marlière 23ème colloque du Club Bioconversion en Synthèse Organique, CBSO 2010, May 2010, Royat, France Communication dans un congrès hal-00493296v1
	Synthèse biocatalysée de monosaccharides d'intérêt biologique par formation stéréospécifique de liaison C-C. Johan Fanton , Franck Charmantray , Laurence Hecquet GLUCIDOC 2009, Oct 2009, Autrans, France Communication dans un congrès hal-00493264v1
	Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs Grégory Simon , M. Bouzon , Franck Charmantray , Virgil Hélaine , Bertrand Legeret Biotrans 2009, Jul 2009, Bern, Switzerland Communication dans un congrès hal-00387978v1
	Transketolase, aldolases and organocatalysis, complementary tools for ketose synthesis Laurence Hecquet , Grégory Simon , Franck Charmantray , Virgil Hélaine , Bertrand Legeret Colloque Action COST CM0701-CASCAT "Working group 4", Mar 2009, Darmstadt, Germany Communication dans un congrès hal-00383315v1
	Transketolase engineering - Development of enzymatic assays Grégory Simon , Franck Charmantray , Virgil Hélaine , Bertrand Legeret , M. Bouzon Action COST CM0701 "Kick-off Workshop", Sep 2008, Côme, Italy Communication dans un congrès hal-00345618v1
	Formation stéréospécifique de liaison C-C : applications de la transcétolase pour la synthèse d'analogues de cétoses Laurence Hecquet Université d'Amiens, Apr 2008, France Communication dans un congrès hal-00246524v1
	Transketolase engineering. The development of a selection assay in E. coli Grégory Simon , Franck Charmantray , Virgil Hélaine , Bertrand Legeret , M. Bouzon CBSO 2008, 22ème Colloque du Club Bioconversions en Synthèse Organique, Jun 2008, Bussang, France Communication dans un congrès hal-00286258v1
	Study of the fructose-6-phosphate aldolase substrate specificity Franck Charmantray , Estelle Gallienne , Thierry Gefflaut , Laurence Hecquet , Marielle Lemaire CBSO 2008, 22ème Colloque du Club Bioconversions en Synthèse Organique, Jun 2008, Bussang, France Communication dans un congrès hal-00286261v1
	Ingéniérie de la transcétolase. Mise au point d'un test de sélection dans E. coli Grégory Simon , Franck Charmantray , Laurence Hecquet , Virgil Hélaine , M. Bouzon 12èmes REncontres de Chimie Organique Biologique – RECOB 12, Mar 2008, France Communication dans un congrès hal-00246509v1
	New donor substrates for yeast transketolase Grégory Simon , Franck Charmantray , Virgil Hélaine , Laurence Hecquet 8th International Symposium on Biocatalysis and Biotransformations BIOTRANS 2007, Jul 2007, Oviedo, Spain Communication dans un congrès hal-00165448v1
	Synthèse de précurseurs d'acides aminés pour la mise au point d'un test de selection de transcétolases mutées Grégory Simon , Franck Charmantray , Virgil Hélaine , Laurence Hecquet Colloque "Chimie écocompatible" programme interdisciplinaire du CNRS, Dec 2007, Lyon, France Communication dans un congrès hal-00193716v1
	Les enzymes, outils pour le chimiste organicien Laurence Hecquet Colloque "Chimie écocompatible" programme interdisciplinaire du CNRS, Dec 2007, Lyon, France Communication dans un congrès hal-00193711v1
	Study of fluorogenic assay for yeast transketolase Franck Charmantray , Virgil Hélaine , Bertrand Legeret , Laurence Hecquet 8th International Symposium on Biocatalysis and Biotransformations BIOTRANS 2007, Jul 2007, Oviedo, Spain Communication dans un congrès hal-00165446v1
	From inexpensive glycidol to 5-thio-D-xylopyranose Franck Charmantray , Laurence Hecquet 11èmes REcontres de Chimie Organique et Biologique (RECOB 11), 2006, Aussois, France Communication dans un congrès hal-00022027v1
	Enzymes catalysing C-C bond making in sugar chemistry towards new biocatalysts by in vitro evolution. Franck Charmantray , Virgil Hélaine , Laurence Hecquet Biocat 2006, Sep 2006, Hambourg, Germany Communication dans un congrès hal-00124221v1
	From inexpensive glycidol to 5-thio-D-xylopyranose. Franck Charmantray , Laurence Hecquet , P. Dellis , S. Samreth CBSO, 2006, Ax les Thermes, France Communication dans un congrès hal-00021262v1
	Chemoenzymatic synthesis of monosaccharides and analogues by stereoselective C6C bond formation Laurence Hecquet Working Group D25 "New Biotransformations using enzymes and catalytic antibodies" Synthesis of monosccahrides by C-C bond formation, Sep 2006, Stockholm, Sweden Communication dans un congrès hal-00136911v1
	From inexpensive glycidol to 5-thio-D-xylopyranose. Franck Charmantray , Laurence Hecquet , Virgil Hélaine , Patrick Dellis , Soth Samreth Biocat 2006, Sep 2006, Hambourg, Germany Communication dans un congrès hal-00124216v1
	A new chemoenzymatic route to dihydroxyacetone phosphate from glycidol for the in situ aldolase-mediated synthesis of monosaccharides Franck Charmantray , Laurence Hecquet , Patrick Dellis , Soth Samreth MECP06 Multi-step Enzyme catalysed Processes, 2006, Gratz, Austria Communication dans un congrès hal-00022376v1
	New Biotransformations using enzymes and catalytic antibodies Laurence Hecquet New Biotransformations using enzymes and catalytic antibodies, 2005, Delft, Netherlands Communication dans un congrès hal-00022362v1
	New selection and screening assays for in vitro evolved transketolase from Saccharomyces cerevisiae A. Sevestre , A. Lasikova , Franck Charmantray , V. Hélaine , L. Hecquet 7th International Symposium on Biocatalysis and Biotransformations, Biotrans 2005, Jul 2005, Delft, Netherlands Communication dans un congrès hal-00128046v1
	In vitro evolution on transketolase from Saccharomyces cerevisiae A Sevestre , Viviane Helaine , Christine Martin , Laurence Hecquet Colloque Bioconversions et synthèses organiques (CBSO), 2004, Obernai, France. pp.Inconnu Communication dans un congrès hal-02828037v1
	Syntheses of monosaccharides analogs used in screening test of transketolase mutants Angelika Lasikova , Aurélie Sevestre , Virgil Hélaine , Laurence Hecquet Franco-German Symposium : Bioconversions and Organic Synthesis, May 2004, Obernai, France Communication dans un congrès hal-00138630v1
	Directed evolution on transketolase for obtaining new monosaccharides Virgil Hélaine , Aurélie Sevestre , Angelika Lasikova , Laurence Hecquet European Research Council's Chemistry Committees (CERC3) young chemists'workshops, Mar 2004, Erlangen, Germany Communication dans un congrès hal-00136979v1
	In vitro evolution on transketolase from Saccharomyces cerevisiae Aurélie Sevestre , Virgil Hélaine , C. Martin , Laurence Hecquet Franco-German Symposium : Bioconversions and Organic Synthesis, May 2004, Obernai, France Communication dans un congrès hal-00137321v1
	Nouvelle synthèse chimique du dihydroxyacétone phosphate : substrat de la D-fructose-1,6-diphosphate aldolase Franck Charmantray , Thierry Gefflaut , Marielle Lemaire , Laurence Hecquet , Jean Bolte 10èmes REncontres de Chimie Organique Biologique (RECOB 10), Mar 2004, Aussois, France Communication dans un congrès hal-00137390v1
	Ingénierie d'une enzyme : la transcétolase de Saccharomyces cerevisiae. Mise au point d'un test de selection Aurélie Sevestre , Virgil Hélaine , C. Martin , Laurence Hecquet 10èmes REncontres de Chimie Organique Biologique (RECOB 10), Mar 2004, Aussois, France Communication dans un congrès hal-00137395v1

	Ingénierie d'une protéine: la transketolase de Saccharomyces cerevisiae A Sevestre , Viviane Helaine , Christine Martin , Laurence Hecquet Rencontres de Chimie Organique Biologique (RECOB), 2004, Aussois, France. pp.Inconnu, 2004 Poster de conférence hal-02830132v1
	A fluorogenic assay for transketolase A Sevestre , Viviane Helaine , G Guyot , Christine Martin , Laurence Hecquet Biotrans 2003, 2003, Olomouc, Czech Republic. pp.Inconnu, 2003 Poster de conférence hal-02830487v1

	Chemoenzymatic synthesis of 5-thio-D-xylopyranose Franck Charmantray , P. Dellis , Virgil Hélaine , S. Samreth , Laurence Hecquet Practical Methods for Biocatalysis and Biotransformations, Publisher John Wiley. Eds. Dr John Whittall and Dr Peter W. Sutton, pp.218-225, 2010 Chapitre d'ouvrage hal-00443817v1
	Enzymes catalysing C-C bond formation for the synthesis of monosaccharide analogs Laurence Hecquet , Virgil Hélaine , Franck Charmantray , Marielle Lemaire Modern Biocatalysis : stereoselective and Environmentally Friendly Reactions, Edited by W. D. Fessner and T. Anthonsen. Publisher John Wiley, pp.287-297, 2008 Chapitre d'ouvrage hal-00377184v1
	Enzymes as tools for the stereospecific carbon-carbon bonds formation in monosaccharides and analogs synthesis. Jean Bolte , Virgil Hélaine , Laurence Hecquet , Marielle Lemaire Enzyme Technology, Eds, Asiatech Pub, Inc., pp.157-173, 2005 Chapitre d'ouvrage hal-00124262v1

Laurence HECQUET

Présentation

Publications

Synthesis of Deoxysugars from Aliphatic α‐Ketoacids and Aldoses Catalyzed by Thermostable Transketolase Variants from Geobacillus stearothermophilus

Cleavage of Aliphatic α-Hydroxy Ketones by Evolved Transketolase from Geobacillus stearothermophilus

QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle

Convergent in situ Generation of Both Transketolase Substrates via Transaminase and Aldolase Reactions for Sequential One‐Pot, Three‐Step Cascade Synthesis of Ketoses

d -Serine as a Key Building Block: Enzymatic Process Development and Smart Applications within the Cascade Enzymatic Concept

Enzymatic Synthesis of Aliphatic Acyloins through Thermostable Transketolase Catalyzed-Reaction

One‐Pot Cascade Synthesis of (3 S )‐Hydroxyketones Catalyzed by Transketolase via Hydroxypyruvate Generated in Situ from d ‐Serine by d ‐Amino Acid Oxidase

Evolved Thermostable Transketolase for Stereoselective Two-Carbon Elongation of Non-Phosphorylated Aldoses to Naturally Rare Ketoses

Innovative Electrochemical Screening Allows Transketolase Inhibitors to Be Identified

Engineering a thermostable transketolase for arylated substrates.

High-throughput electrochemical screening assay for free and immobilized oxidases: electrochemiluminescence and intermittent pulse amperometry.

Second-generation engineering of a thermostable transketolase (TKGst) for aliphatic aldehyde acceptors with either improved or reversed stereoselectivity.

One-pot, two-step cascade synthesis of naturally rare L-$erythro$ (3S,4S) ketoses by coupling thermostable transaminase and transketolase.

Instant one-pot preparation of functional layered double hydroxides (LDHs) via a continuous hydrothermal approach

Donor promiscuity of a thermostable transketolase engineered by directed evolution-Efficient complementation of DXS activity.

Transketolase-Aldolase Symbiosis for the Stereoselective Preparation of Aldoses and Ketoses of Biological Interest

Thiamine biosensor based on oxidative trapping of enzyme-substrate intermediate.

Insights into the Thiamine Diphosphate Enzyme Activation Mechanism: Computational Model for Transketolase Using a Quantum Mechanical/Molecular Mechanical Method.

Droplet millifluidics for kinetic study of transketolase.

Substrate cycling based fluorometric assay for dihydroxyacetone phosphate.

A thermostable transketolase evolved for aliphatic aldehyde acceptors.

Chiral polyol synthesis catalyzed by a thermostable Transketolase immobilized on Layered Double Hydroxides in Ionic liquids.

Engineering a Thermostable Transketolase for Unnatural Conversion of (2S)-Hydroxyaldehyde.

Galactose Oxidase/Prussian Blue Based Biosensors.

An efficient amperometric transketolase assay:Towards inhibitor screening

Optimized immobilization of Transketolase from E. coli in MgAl-Layered Double Hydroxides.

Amperometric Biosensor Based on Galactose Oxidase Immobilized in Clay Matrix.

Thermostable Transketolase from Geobacillus stearothermophilus: Characterization and Catalytic Properties

Synthesis of specially designed probes to broaden transketolase scope

One-pot Cascade Reactions using Fructose-6-phosphate Aldolase: Efficient Synthesis of d-Arabinose-5-phosphate, D-Fructose-6-phosphate and Analogues

A pH-Based High-Throughput Assay for Transketolase: Fingerprinting of Substrate Tolerance and Quantitative Kinetics

Enzymatic and organocatalyzed asymmetric aldolization reactions for the synthesis of thiosugar scaffolds

Efficient immobilization of yeast transketolase on layered double hydroxides and application for ketose synthesis

Electrochemical detection of transketolase activity using a tyrosinase biosensor

A mutant D-fructose-6-Phosphate Aldolase (Ala129Ser) with improved affinity towards dihydroxyacetone for the synthesis of polyhydroxylated compounds

Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs

Fluorogenic substrates for the screening assay of transketolase through beta-elimination of umbelliferone-development, scope and limitations?

Preparative scale enzymatic synthesis of D-sedoheptulose-7-phosphate from β-hydroxypyruvate and D-ribose-5-phosphate

Chemoenzymatic synthesis of L-tyrosine derivative for a transketolase assay

An efficient chemoenzymatic route to dihydroxyacetone phosphate from glycidol for the in situ aldoalse-mediated synthesis of monosaccharides

Chemoenzymatic synthesis of 5-thio-D-xylopyranose.

Synthesis of stereochemical probes for new fluorogenic assays for yeast transketolase variants.

Improved straightforward chemical synthesis of dihydroxyacetone phosphate through enzymatic desymmetrization of 2,2-dimethoxypropane-1,3-diol

Slow-binding inhibition of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase

A fluorogenic assay for transketolase from Saccharomyces cerevisiae

Extending the reaction toolbox for C-C bond formation and cleavage: biocatalytic applications of Transketolases.

Evolved thermostable Transketolase for the valorization of vegetable oils.

Application d'un biocapteur à tyrosinase à la détection ampérométrique de l'activité de la transcétolase

Electrochemical detection of transketolase activity using a tyrosinase biosensor

Amperometric determination of protected tyrosine at a tyrosinase biosensor: application to TK activity detection

Immobilisation de la transcétolase dans des matrices Hydroxydes Doubles Lamellaires

Synthèse de sondes pour le développement d'un test de sélection de la transcétolase de levure

Layered Double Hydroxides as supports for Transletolase applications

Amperometric determination of protected Tyrosine at a Tyrosinase biosensor: application to TK activity detection

Synthèse de sondes pour le développement d'un test de sélection de la transcétolase de levure

Synthèse biocatalysée de monosaccharides d'intérêt biologique par formation stéréospécifique de liaison C-C.

Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs

Transketolase, aldolases and organocatalysis, complementary tools for ketose synthesis

Transketolase engineering - Development of enzymatic assays

Formation stéréospécifique de liaison C-C : applications de la transcétolase pour la synthèse d'analogues de cétoses

Transketolase engineering. The development of a selection assay in E. coli

Study of the fructose-6-phosphate aldolase substrate specificity

Ingéniérie de la transcétolase. Mise au point d'un test de sélection dans E. coli

New donor substrates for yeast transketolase

Synthèse de précurseurs d'acides aminés pour la mise au point d'un test de selection de transcétolases mutées

Les enzymes, outils pour le chimiste organicien

Study of fluorogenic assay for yeast transketolase

From inexpensive glycidol to 5-thio-D-xylopyranose

Enzymes catalysing C-C bond making in sugar chemistry towards new biocatalysts by in vitro evolution.

From inexpensive glycidol to 5-thio-D-xylopyranose.

Chemoenzymatic synthesis of monosaccharides and analogues by stereoselective C6C bond formation

From inexpensive glycidol to 5-thio-D-xylopyranose.

A new chemoenzymatic route to dihydroxyacetone phosphate from glycidol for the in situ aldolase-mediated synthesis of monosaccharides

New Biotransformations using enzymes and catalytic antibodies

New selection and screening assays for in vitro evolved transketolase from Saccharomyces cerevisiae

In vitro evolution on transketolase from Saccharomyces cerevisiae

Syntheses of monosaccharides analogs used in screening test of transketolase mutants