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Creating analogues of the anti-tumor polyketide stambomycins by genetic engineering and allied approaches

 Li Su , Hotel L , Christophe Jacob , Kira J Weissman , Bertrand Aigle
2018, 2018, Nancy, France
Poster de conférence hal-03016980v1

The structural biology of modular polyketide synthases: insights and implications for synthetic biology

 Kira J Weissman , Jack Davison , Jonathan Dorival , Thibault Annaval , Fanny Risser , et al.
3rd European Conference on Natural Products, 2018, Frankfurt, Germany
Communication dans un congrès hal-02956684v1

Probing interactions in fungal PKS

 Kira J Weissman
Chemistry & biology, 2013, 20 (9), pp.1089-91. ⟨10.1016/j.chembio1.2013.09.001⟩
Article dans une revue hal-01467279v1

Modular Oxime Formation by a trans‐AT Polyketide Synthase

 Hannah Minas , Romain François , Franziska Hemmerling , Amy Fraley , Cora Dieterich , et al.
Angewandte Chemie International Edition, 2023, 62 (34), pp.e202304481. ⟨10.1002/anie.202304481⟩
Article dans une revue hal-04307564v1

Function of polyketide synthases from the SAXS structure of a complete module

 Jack Davison , Jonathan Dorival , Hery Rabeharindranto , Hortense Mazon , Benjamin Chagot , et al.
Acta Crystallographica Section A : Foundations and Advances [2014-..], 2014, 70 (a1), pp.C407 - C407. ⟨10.1107/S2053273314095928⟩
Article dans une revue hal-01653555v1

Successes, surprises and pitfalls in modular polyketide synthase engineering

 Kira J. Weissman , Li Su , Laurence Hôtel , Cédric Paris , Clara Chepkirui , et al.
2nd International Conference on Biomolecules and the Bioeconomy, Nov 2021, Nancy, France
Communication dans un congrès hal-03525292v1

Engineering of a polyketide synthase leads to 'low-fat' stambomycins

 Li Su , Laurence Hôtel , Cédric Paris , Christophe Jacob , Bertrand Aigle , et al.
Journées francophones d'actinobactéries (ACTINO 2020), Dec 2020, On-line, France
Communication dans un congrès hal-03525244v1

The structural biology of modular polyketide synthases: insights and implications for synthetic biology

 Kira J. Weissman , Jonathan Dorival , Thibault Annaval , Fanny Risser , Sabrina Collin , et al.
European Workshop on Natural Product Biosynthesis, Jun 2017, Gif-sur-Yvete, France
Communication dans un congrès hal-01736000v1

The use of Saccharomyces cerevisiae as a toolbox for understanding how polyketide synthases function

 Christophe Jacob , Jean-Malo Massicard , Sabrina Collin , Kira J. Weissman
13th International conference "Levures, modèles et outils", Sep 2018, Rheinau, Switzerland
Communication dans un congrès hal-02070073v1

Genome mining: accessing Nature’s natural product diversity

 Kira J Weissman
Biomolecules: Research & Development, Markets and Acceptability, 2019, Palma de Majorca, Spain
Communication dans un congrès hal-03016889v1

Characterization of Intersubunit Communication in the Virginiamycin trans-AT Polyketide Synthase

 Jonathan Dorival , Thibault Annaval , Fanny Risser , Sabrina Collin , Pierre Roblin , et al.
Directing Biosynthesis V, Mar 2017, Warwick, United Kingdom
Poster de conférence hal-01735993v1

Polyketide stereocontrol: a study in chemical biology

 Kira J. Weissman
Beilstein Journal of Organic Chemistry, 2017, 13, pp.348 - 371. ⟨10.3762/bjoc.13.39⟩
Article dans une revue hal-01671019v1

The structural biology of biosynthetic megaenzymes

 Kira J Weissman
Nature Chemical Biology, 2015, 11 (9), pp.660 - 670. ⟨10.1038/NCHEMBIO.1883⟩
Article dans une revue hal-01474060v1
Image document

Editorial overview: Macromolecular assemblies: Assembly, dynamics and control of activity

 Timm Maier , Kira J. Weissman
Current Opinion in Structural Biology, 2018, 49, pp.vi-vii. ⟨10.1016/j.sbi.2018.04.001⟩
Article dans une revue hal-02956617v1

Generation of analogues of stambomycins by genetic engineering and allied approaches

 Li Su , Laurence Hôtel , Cédric Paris , Christophe Jacob , Bertrand Aigle , et al.
15. Congrès National de la SFM (Société Française de Microbiologie), Oct 2019, Paris, France
Communication dans un congrès hal-03666910v1

Polyketides: applications in therapy and agriculture, development of new analogues using synthetic biology

 Kira J. Weissman
2018
Autre publication scientifique hal-03525977v1

Deciphering the structures of trans-AT polyketide synthase megaenzymes

 Kira J. Weissman
2016
Autre publication scientifique hal-03526010v1
Image document

Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

 Li Su , Laurence Hôtel , Cédric Paris , Clara Chepkirui , Alexander Brachmann , et al.
Nature Communications, 2022, 13 (1), pp.515. ⟨10.1038/s41467-022-27955-z⟩
Article dans une revue hal-03544763v1
Image document

Towards improved understanding of intersubunit interactions in modular polyketide biosynthesis: Docking in the enacyloxin IIa polyketide synthase

 Fanny Risser , Sabrina Collin , Raphael dos Santos-Morais , Arnaud Gruez , Benjamin Chagot , et al.
Journal of Structural Biology, 2020, 212 (1), pp.107581. ⟨10.1016/j.jsb.2020.107581⟩
Article dans une revue hal-02926190v1

Structure-function relationships in modular PKSs and their application to genetic engineering

 Kira J. Weissman
2020
Autre publication scientifique hal-03525856v1

Bacterial Type I Polyketide Synthases

 Kira J. Weissman
Comprehensive Natural Products III - Third edition, 1, Elsevier, pp.4-46, 2020, 978-0-08-102691-5. ⟨10.1016/B978-0-12-409547-2.14644-X⟩
Chapitre d'ouvrage hal-02956621v1
Image document

Manipulating polyketide stereochemistry by exchange of polyketide synthase modules

 Jean-Malo Massicard , Claire Soligot , Kira J. Weissman , Christophe Jacob
Chemical Communications, 2020, 56, pp.12749-12752. ⟨10.1039/D0CC05068G⟩
Article dans une revue hal-02937132v1

Structural characterization of the unusual lankacidin-producing polyketide synthase megaenzymes

 Dorota Jakubczyk , Sabrina Collin , Jonathan Dorival , Benjamin Chagot , Arnaud Gruez , et al.
Enzymes, biocatalysis and chemical biology: the new frontiers EMBO conference, 2018, Pavia, Italy
Poster de conférence hal-03016971v1

Decrypting structure-function relationships in modular PKSs

 Kira J Weissman , Jack Davison , Jonathan Dorival , Thibault Annaval , Fanny Risser , et al.
From mutases to megasynthases: celebrating the career of Professor Peter Leadlay. Retirement symposium for Prof. Peter Leadlay., 2018, Cambridge, United Kingdom
Communication dans un congrès hal-03016899v1

Insights into the function of trans-acyl transferase polyketide synthases from the SAXS structure of a complete module

 Jack Davison , Jonathan Dorival , Hery Rabeharindranto , Hortense Mazon , Benjamin Chagot , et al.
Chemical Science, 2014, 5 (8), pp.3081-3095. ⟨10.1039/c3sc53511h⟩
Article dans une revue hal-01453210v1

The structural biology of modular polyketide synthases: insights and implications for synthetic biology

 Kira J. Weissman
2018
Autre publication scientifique hal-03525954v1
Image document

Characterization of Intersubunit Communication in the Virginiamycin trans-Acyl Transferase Polyketide Synthase

 Jonathan Dorival , Thibault Annaval , Fanny Risser , Sabrina Collin , Pierre Roblin , et al.
Journal of the American Chemical Society, 2016, 138 (12), pp.4155-4167. ⟨10.1021/jacs.5b13372⟩
Article dans une revue hal-01452317v1

Engineering of a polyketide synthase leads to ring-contracted stambomycins

 Li Su , Laurence Hôtel , Cédric Paris , Clara Chepkirui , Alexander Brachmann , et al.
VAAM workshop 2021: Biology of Bacterial Producing Natural Products, Sep 2021, Saabrucken, Germany
Communication dans un congrès hal-03666909v1

Deciphering Nature's molecular scale assembly lines

 Kira J. Weissman
2020
Autre publication scientifique hal-03525913v1

Structure-function relationships in modular PKSs and their application to genetic engineering

 Kira J Weissman , Fanny Risser , Jean-Malo Massicard , Sabrina Collin , Raphael dos Santos Morais , et al.
MegaSyn Symposium, 2020, Bad Nauheim, Germany
Communication dans un congrès hal-02956682v1
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