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Co-authors

Number of documents

62

TOUTAIN Jérôme, CNRS Enginner


Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales
ISTCT - UMR 6030 - CNRS, CEA, Université de Caen

GIP CYCERON
Campus Jules Horowitz
Bd Henri Becquerel
BP 5229
14074 CAEN Cedex 5

Tél : 02.31.47.02.63.
Mail : toutain@cyceron.fr

Missions :

Animal physiology of stroke and brain oncology

Multimodal (PET and MRI) acquisition and data analysis of brain deseases imaging

Radio and hadron therapies on animal

Competent personne of radioprotection (PCR)

 


Journal articles29 documents

  • Aurélien Corroyer-Dulmont, Valable Samuel, Jade Fantin, Laurent Chatre, Jérôme Toutain, et al.. Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy. Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-90662-0⟩. ⟨hal-03244249⟩
  • Samuel Valable, Aurélie Gérault, Gaelle Lambert, Marine Leblond, Clement Anfray, et al.. Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes. Cancers, MDPI, 2020, 12 (8), pp.2019. ⟨10.3390/cancers12082019⟩. ⟨hal-02912590⟩
  • Coralie Le Deroff, Elodie A. Pérès, Xavier Ledoux, Toutain Jérôme, Anne-Marie Frelin-Labalme. In vivo surface dosimetry with a scintillating fiber dosimeter in preclinical image‐guided radiotherapy. Medical Physics, American Association of Physicists in Medicine, 2020, 47 (1), pp.234-241. ⟨10.1002/mp.13903⟩. ⟨hal-02363478⟩
  • Clement Anfray, Sarah Komaty, Aurélien Corroyer-Dulmont, Moussa Zaarour, Charly Hélaine, et al.. Nanosized zeolites as a gas delivery platform in a glioblastoma model. Biomaterials, Elsevier, 2020, 257, pp.120249. ⟨10.1016/j.biomaterials.2020.120249⟩. ⟨hal-02912573⟩
  • Elodie A. Pérès, Toutain Jérôme, Louis-Paul Paty, Didier Divoux, Méziane Ibazizène, et al.. 64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study. EJNMMI Research, SpringerOpen, 2019, 9 (114), ⟨10.1186/s13550-019-0586-6⟩. ⟨hal-02409461⟩
  • Aurélien Corroyer-Dulmont, Samuel Valable, Nadia Falzone, Anne-Marie Frelin-Labalme, Ole Tietz, et al.. VCAM-1 Targeted Alpha-Particle Therapy for Early Brain Metastases. Neuro-Oncology, Oxford University Press (OUP), 2019, 22 (3), pp.357-368. ⟨10.1093/neuonc/noz169⟩. ⟨hal-02346582⟩
  • Narinée Hovhannisyan, Fabien Fillesoye, Stéphane Guillouet, Méziane Ibazizene, Jérôme Toutain, et al.. [ 18 F]Fludarabine-PET as a promising tool for differentiating CNS lymphoma and glioblastoma: Comparative analysis with [ 18 F]FDG in human xenograft models. Theranostics, Ivyspring International Publisher, 2018, 8 (16), pp.4563-4573. ⟨10.7150/thno.26754⟩. ⟨hal-02006576⟩
  • Rozenn Le Gal, Myriam Bernaudin, Jérôme Toutain, Omar Touzani. Assessment of behavioural deficits following ischaemic stroke in the marmoset. Behavioural Brain Research, Elsevier, 2018, 352, pp.151-160. ⟨10.1016/j.bbr.2017.07.042⟩. ⟨hal-01994459⟩
  • Yacine Khelif, Jérôme Toutain, Marie-Sophie Quittet, Sandrine Chantepie, Xavier Laffray, et al.. A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke. Theranostics, Ivyspring International Publisher, 2018, 8 (21), pp.5814-5827. ⟨10.7150/thno.28252⟩. ⟨hal-02018014⟩
  • Marine Maud Desgeorges, Xavier Devillard, Jérôme Toutain, Josiane Castells, Didier Divoux, et al.. Pharmacological inhibition of myostatin improves skeletal muscle mass and function in a mouse model of stroke. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.14000. ⟨10.1038/s41598-017-13912-0⟩. ⟨hal-02043512⟩
  • S Valable, A Corroyer-Dulmont, A Chakhoyan, L Durand, J Toutain, et al.. Imaging of brain oxygenation with magnetic resonance imaging : A validation with positron emission tomography in the healthy and tumoural brain.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2017, 37 (7), pp.2584-2597. ⟨10.1177/0271678X16671965⟩. ⟨hal-01575065⟩
  • A Chakhoyan, A Corroyer-Dulmont, M.M. Leblond, A Gérault, J Toutain, et al.. Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2017, 37 (6), pp.2270-2282. ⟨10.1177/0271678X16663947⟩. ⟨hal-01575557⟩
  • M Médoc, M Dhilly, L Matesic, J Toutain, Am Krause-Heuer, et al.. In vivo evaluation of radiofluorinated caspases-3/7 inhibitors as radiotracers for apoptosis imaging and comparison with [18F]-ML-10 in a stroke model in the rat. Molecular Imaging and Biology, Springer Verlag, 2016, 18, pp.117-128. ⟨10.1007/s11307-015-0865-1⟩. ⟨hal-01538309⟩
  • A Corroyer-Dulmont, Elodie A. Pérès, An Gérault, A Savina, F Bouquet, et al.. Multimodal imaging based on MRI and PET reveals [(18)F]FLT PET as a specific and early indicator of treatment efficacy in a preclinical model of recurrent glioblastoma. European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2016, 43 (4), pp.682-694. ⟨10.1007/s00259-015-3225-0⟩. ⟨hal-01575614⟩
  • Ms Quittet, O Touzani, L Sindji, J Cayon, F Fillesoye, et al.. Effects of mesenchymal stem cell therapy, in association with pharmacologically active microcarriers releasing VEGF, in an ischaemic stroke model in the rat.. Acta Biomaterialia, Elsevier, 2015, pp.77-88. ⟨10.1016/j.actbio.2014.12.017⟩. ⟨hal-01577870⟩
  • Al Letourneur, S Roussel, M Bernaudin, F Fillesoye, J Toutain, et al.. Chronic arterial hypertension impedes glioma growth: a multiparametric MRI study in the rat.. Hypertension Research, Nature Publishing Group, 2015, 38 ((11)), pp.723-32. ⟨10.1038/hr.2015.66⟩. ⟨hal-01587404⟩
  • Marine Maud Desgeorges, Xavier Devillard, Jérôme Toutain, Didier Divoux, Josiane Castells, et al.. Molecular mechanisms of skeletal muscle atrophy in a mouse model of cerebral ischemia. Stroke, American Heart Association, 2015, 46 (6), pp.1673-80. ⟨10.1161/STROKEAHA.114.008574⟩. ⟨hal-01585137⟩
  • Elodie A. Pérès, An Gérault, S Valable, S Roussel, J Toutain, et al.. Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget, Impact journals, 2015, 6 (4), pp.2101-19. ⟨10.18632/oncotarget.2937⟩. ⟨hal-01576268⟩
  • Aurélien Corroyer-Dulmont, Elodie A. Pérès, Edwige Petit, Lucile Durand, Léna Marteau, et al.. Noninvasive assessment of hypoxia with 3-[18F]-fluoro-1-(2-nitro-1-imidazolyl)-2-propanol ([18F]-FMISO): a PET study in two experimental models of human glioma. Biological Chemistry, De Gruyter, 2013, 394 (4), ⟨10.1515/hsz-2012-0318⟩. ⟨hal-01660598⟩
  • Aurélien Corroyer-Dulmont, Elodie A. Pérès, Edwige Petit, Jean-Sébastien Guillamo, Nathalie Varoqueaux, et al.. Detection of glioblastoma response to temozolomide combined with bevacizumab based on µMRI and µPET imaging reveals [18F]-fluoro-l-thymidine as an early and robust predictive marker for treatment efficacy. Neuro-Oncology, Oxford University Press (OUP), 2013, 15 (1), pp.41 - 56. ⟨10.1093/neuonc/nos260⟩. ⟨hal-01655989⟩
  • Annelise Letourneur, Thomas Freret, Simon Roussel, Michel Boulouard, Didier Divoux, et al.. Maternal hypertension during pregnancy modifies the response of the immature brain to hypoxia-ischemia: sequential MRI and behavioral investigations.. Experimental Neurology, Elsevier, 2012, 233 (1), pp.264-72. ⟨10.1016/j.expneurol.2011.10.014⟩. ⟨hal-00862822⟩
  • Claire Leconte, Emmanuelle Tixier, Thomas Freret, Jérôme Toutain, Romaric Saulnier, et al.. Delayed hypoxic postconditioning protects against cerebral ischemia in the mouse.. Stroke, American Heart Association, 2009, 40 (10), pp.3349-55. ⟨10.1161/STROKEAHA.109.557314⟩. ⟨hal-00863295⟩
  • Valentine Bouet, Michel Boulouard, Jérôme Toutain, Didier Divoux, Myriam Bernaudin, et al.. The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice.. Nature Protocols, Nature Publishing Group, 2009, 4 (10), pp.1560-4. ⟨10.1038/nprot.2009.125⟩. ⟨hal-00863258⟩
  • Thomas Freret, Valentine Bouet, Jérôme Toutain, Romaric Saulnier, Palma Pro-Sistiaga, et al.. Intraluminal thread model of focal stroke in the non-human primate. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2008, 28 (4), pp.786-96. ⟨10.1038/sj.jcbfm.9600575⟩. ⟨hal-00863332⟩
  • Elise Esneault, Emilie Pacary, Dauphou Eddi, Thomas Freret, Emmanuelle Tixier, et al.. Combined therapeutic strategy using erythropoietin and mesenchymal stem cells potentiates neurogenesis after transient focal cerebral ischemia in rats.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2008, 28 (9), pp.1552-63. ⟨10.1038/jcbfm.2008.40⟩. ⟨hal-00863330⟩
  • Valentine BouËt, Thomas Freret, Jérôme Toutain, Didier Divoux, Michel Boulouard, et al.. Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse.. Experimental Neurology, Elsevier, 2007, 203 (2), pp.555-67. ⟨10.1016/j.expneurol.2006.09.006⟩. ⟨hal-00178296⟩
  • Valentine Bouet, Thomas Freret, J. Toutain, Didier Divoux, Michel Boulouard, et al.. Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Experimental Neurology, Elsevier, 2006, 203, pp.55-567. ⟨10.1016/j.expneurol.2006.09.006⟩. ⟨hal-00867774⟩
  • J. Althaus, M. Bernaudin, E. Petit, J. Toutain, O. Touzani, et al.. Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats. Neurochemistry International, Elsevier, 2006, 48, pp.687-695. ⟨hal-00022247⟩
  • Julien Chuquet, Karim Benchenane, Géraldine Liot, Mónica Fernández-Monreal, Jérôme Toutain, et al.. Matching Gene Expression with Hypometabolism after Cerebral Ischemia in the Nonhuman Primate. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2002, 22 (10), pp.1165-1169. ⟨10.1097/01.wcb.0000037987.07114.7c⟩. ⟨hal-02115394⟩

Conference papers33 documents

  • C. Anfray, S. Komaty, H. Ozcelik, C. Hélaine, J. Toutain, et al.. Assessment of nanosized zeolites to counteract hypoxia induced radio-resistance in glioblastoma. FEZA meeting virtual (Federation of European Zeolite Associations), Jul 2021, e-congrès, France. ⟨hal-03284468⟩
  • A Corroyer-Dulmont, S Valable, N Falzone, Am Frelin-Labalme, O Tietz, et al.. Early brain metastases treatment using VCAM-1 targeted alpha-particle therapy. 4th Nuclear Technologies for Health Symposium, NTHS2020, Feb 2020, Nantes, France. ⟨hal-02488870⟩
  • C. Maingueneau, A.-E. Lafargue, F. Fillesoye, J. Toutain, S. Valable, et al.. Development and in vivo preclinical validation of [18F]FLUSONIM, a highly hydrophilic 18F-labelled 2-nitroimidazole derivative for high performance hypoxia PET imaging. 4th Nuclear Technologies for Health Symposium, NTHS2020, Feb 2020, Nantes, France. ⟨hal-02489356⟩
  • K. Monthé-Sagan, O. Touzani, J. Toutain, J.L. Hanouz, Myriam Bernaudin, et al.. Evaluation préclinique de l’influence d'anesthésiques intraveineux sur les cellules de glioblastome et l’efficacité des traitements par chimio- et radiothérapie. Société Française d'Anesthésie-Réanimation (SFAR), Sep 2020, Paris, France. ⟨hal-02960958⟩
  • C. Brunaud, S. Valable, F.A. Dwiri, G. Ropars, J. Toutain, et al.. Relevance of multiparametric MRI to accurately detect radiation-induced brain injury in the rat. Journée de travail Cancéropôle Nord-Ouest, Axe 3 « Imagerie et adaptation thérapeutique » : Place de l'imagerie médicale dans la précision thérapeutique, Dec 2020, e-congrès, France. ⟨hal-03167478⟩
  • Clémence Maingueneau, Anne-Élodie Lafargue, Fabien Fillesoye, Jérôme Toutain, Samuel Valable, et al.. Développement et validation préclinique in vivo du [18F]FLUSONIM pour l’imagerie TEP de l’hypoxie de haute performance. Journées scientifiques du Cancéropôle Nord-Ouest, Dec 2019, Lille, France. ⟨hal-02414509⟩
  • Aurélien Corroyer-Dulmont, Samuel Valable, Jérôme Toutain, Didier Divoux, Méziane Ibazizene, et al.. Hypoxia image-Guided Radiotherapy for the treatment of brain metastases from primary lung cancer, a preclinical study.. 3ème Congrès National d'Imagerie du Vivant (CNIV), Feb 2019, Paris, France. ⟨hal-02200579⟩
  • A Corroyer-Dulmont, S Valable, N Falzone, A.M. Frelin-Labalme, O Tietz, et al.. VCAM-1 targeted alpha-particle therapy for early brain metastases. 4ème Journée Normande de Recherche Biomédicale, JNRB 2019, Nov 2019, Caen, France. ⟨hal-02402378⟩
  • Aurélien Corroyer-Dulmont, Samuel Valable, Nadia Falzone, Anne-Marie Frelin-Labalme, Ole Tietz, et al.. VCAM-1 targeted alpha-particle therapy for early brain metastases. ICRR 2019, Aug 2019, Manchester, United Kingdom. ⟨hal-02266822⟩
  • Elodie Pérès, Jérôme Toutain, Carole Brunaud, Omar Touzani, Edwige Petit, et al.. Evaluation par IRM des dommages cérébraux induits par la radiothérapie dans un modèle de rat. 3ème Congrès National d'Imagerie du Vivant (CNIV), Feb 2019, Paris, France. ⟨hal-02266830⟩
  • Y Khelif, R Le Gal, C Renoult, J Toutain, Ms Quittet, et al.. A combination of stem cells and an extracellular matrix agent as a new therapeutic strategy for ischemic stroke. 7th Mediterranean Neuroscience Conference MNS2019, Jun 2019, Marrakech, Morocco. ⟨hal-02406380⟩
  • Gwenn Ropars, Rozenn Le Gal, Fatima-Azzahra Dwiri, Jérôme Toutain, Carole Brunaud, et al.. Etude multiparamétrique des effets de l'irradiation cérébrale chez le rat : des altérations tissulaires jusqu'aux déficits cognitifs. 12èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France. ⟨hal-02266824⟩
  • Elodie Pérès, Jérôme Toutain, Carole Brunaud, François Kauffmann, Mikaël Naveau, et al.. Evaluation des dommages cérébraux radio-induits par l’exposition à de faibles et fortes doses de rayonnements ionisants sur un modèle de rat adulte. 12èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France. ⟨hal-02266823⟩
  • Y Khelif, J Toutain, Ms Quittet, S Chantepie, X Laffray, et al.. Heparan sulfate mimetics are neuroprotective and neuroregenerative agents for ischemic stroke.. Bioregate Forum - European Regenrative Medicine, Dec 2018, Nantes, France. ⟨hal-02267171⟩
  • A Corroyer-Dulmont, S Valable, J Toutain, D Divoux, M Ibazizène, et al.. Hypoxia imaging: interest of Image-Guided Radiotherapy for the treatment of brain metastases from lung cancer, a preclinical study. 3ème Journée Normande de Recherche Biomédicale, JNRB 2018, Sep 2018, Rouen, France. ⟨hal-02267175⟩
  • A Corroyer-Dulmont, S Valable, J Toutain, D Divoux, M Ibazizène, et al.. Hypoxia imaging: interest of Image-Guided Radiotherapy for the treatment of brain metastases from lung cancer, a preclinical study. Workshop “Imaging and therapeutic targeting in cancerology: New advances and trends in preclinical and clinical studies”., Sep 2018, Le Bono, France. ⟨hal-02267161⟩
  • Yacine Khelif, Ms Quittet, Jérôme Toutain, Didier Divoux, F Sineriz, et al.. RGTA is a novel matrix therapy for ischemic stroke. 21st Annual Meeting of the LARC-Neuroscience network, Oct 2017, Lille, France. ⟨hal-02304978⟩
  • Y Khelif, Ms Quittet, J Toutain, D Divoux, F Sineriz, et al.. A novel ischemic stroke matrix therapy based on the RGTA. 2ème Journée Normande de Recherche Biomédicale, JNRB 2017, Nov 2017, Caen, France. ⟨hal-02269621⟩
  • A Corroyer-Dulmont, S Valable, J Toutain, D Divoux, M Ibazizène, et al.. Caractérisation par imagerie multimodale IRM et TEP des métastases cérébrales pour l’adaptation des traitements de radiothérapie. Journée du Cancéropôle Nord-Ouest Axe 3 : "Imagerie Fonctionnelle et Radiothérapie”, Dec 2017, Caen, France. ⟨hal-02268079⟩
  • Y Khelif, Ms Quittet, J Toutain, D Divoux, F Sineriz, et al.. An analogue of heparan sulfate as a novel neuroprotective and neuroregenerative agent for ischemic stroke. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function & 13th International Conference on Quantification of Brain Function with PET, Apr 2017, Berlin, Germany. pp.106-107. ⟨hal-02265376⟩
  • S Valable, J Toutain, A Corroyer-Dulmont, A Chakhoyan, D Divoux, et al.. StO2-MRI sensitively images hypoxia in the brain: validation in both ischemic and tumoral situations. 2ème Congrès National d'Imagerie du Vivant CNIV 2017, Nov 2017, Paris, France. ⟨hal-02268068⟩
  • Anfray C., Goldyn K., Komaty S., Allioux C., Zaarour M., et al.. Biomedical use of nanosized zeolites for aggressive brain tumors. 7th FEZA Conference “The ZEOLITES: Materials with Engineered Properties”, Jul 2017, Sofia, Bulgaria. ⟨hal-02268071⟩
  • G Lambert, E.A. Pérès, K Bordji, D Divoux, J Toutain, et al.. Implication de HAF dans la croissance des glioblastomes : caractérisation in vitro et in vivo. 10èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2017, Deauville, France. ⟨hal-02268085⟩
  • Yacine Khelif, Ms Quittet, Toutain Jérôme, Divoux Didier, F Sineriz, et al.. An analogue of heparan sulfate as a novel neuroprotective and neuroregenerative agent for ischemic stroke. Brain & Brain PET 2017, Apr 2017, Berlin, Germany. ⟨hal-02269032⟩
  • Y Khelif, Ms Quittet, J Toutain, D Divoux, F Sineriz, et al.. RGTA-4131®, an analogue of heparan sulfate, is a potential novel protective and regenerative therapy for ischemic stroke. Congrès de la section 28 du CNRS « Pharmacologie, Bio-ingenierie, imagerie, biotechnologie », Jun 2016, Bordeaux, France. ⟨hal-02269678⟩
  • Y Khelif, Ms Quittet, J Toutain, D Divoux, F Sineriz, et al.. A novel ischemic stroke matrix therapy based on the RGTA. 1ère Journée Normande de Recherche Biomédicale, JNRB 2016, Sep 2016, Rouen, France. ⟨hal-02270571⟩
  • A Chakhoyan, A Corroyer-Dulmont, An Gérault, J Toutain, L Chazaviel, et al.. Etude par IRM multiparamétrique des effets du Carbogène sur la vascularisation et l’oxygénation dans deux modèles de glioblastomes. Workshop du Cancéropôle Nord-Ouest axe 3 - Imagerie fonctionnelle et radiothérapie, Jan 2016, Lille, France. ⟨hal-02270581⟩
  • C. Anfray, S. Komaty, C. Allioux, J. Toutain, O. Touzani, et al.. Zeolites: a new theranostic tool for glioblastoma. New chemical and biological tools for targeting in cancer imaging and therapy. Cancéropôle Grand-Ouest international workshop, Sep 2016, Le Bono, France. ⟨hal-02269683⟩
  • O Touzani, J Toutain. Encadrement des "Apprentis Chercheurs". Association "L'Arbre des connaissances", 2015, Caen, France. ⟨hal-02332144⟩
  • A Corroyer-Dulmont, E.A. Pérès, An Gerault, A Savina, J Toutain, et al.. Multimodal imaging reveals [18F]-FLT-PET as a specific and early readout of temozolomide combined with Bevacizumab response in a recurrent glioblastoma model.. 3rd Nuclear Technologies for Health Symposium, Mar 2015, Nantes, France. ⟨hal-02271935⟩
  • A Corroyer-Dulmont, A Gerault, E.A. Pérès, A Savina, J Toutain, et al.. Apport de l’imagerie multimodale IRM et TEP dans la caractérisation précoce de l’efficacité du Bevacizumab combiné ou non au témozolomide dans un modèle de GBM humain de récidive tumorale. 2ème Congrès de la Société Française de Résonance Magnétique en Biologie et Médecine, SFRMBM, Mar 2015, Grenoble, France. ⟨hal-02270627⟩
  • A Chakhoyan, A Corroyer-Dulmont, E Petit, L Chazalviel, J Toutain, et al.. Hyperoxic gas-induced changes in two models of glioma: an MRI study to assess blood volume and oxygen saturation in rats.. “New Advances in animal Models and preclinical Imaging for translational Research in Cancerology” Workshop, Sep 2015, La Pointe de Pen Bron, France. ⟨hal-02270583⟩
  • Clément Anfray, L Belkacem, K Bordji, L Chazalviel, A Chakhoyan, et al.. Atelier XPlore ton cerveau. Semaine du cerveau, Mar 2015, Caen, France. ⟨hal-02331578⟩