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Illuminating the allosteric modulation of the calcium-sensing receptor
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Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4
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Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics
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Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice
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Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3
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Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand
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From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G-Protein-Coupled Receptors
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FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABA B Receptor
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation
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Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
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Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
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Class C G protein-coupled receptors: reviving old couples with new partners
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Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges
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RgIA4 potently blocks mouse $\alpha$9$\alpha$10 nAChRs and provides long lasting protection against oxaliplatin-induced cold allodynia
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Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation
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Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals
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OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity
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Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling
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Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective
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New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III
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Determination of the absolute configuration of phosphinic analogues of glutamate
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Editorial overview: Neurosciences: Targeting glutamatergic signaling in CNS diseases: new hopes?
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Allosteric modulation of metabotropic glutamate receptors by chloride ions
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Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer
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Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers
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Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats
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Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy
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Homogeneous time-resolved fluorescence-based assay to monitor extracellular signal-regulated kinase signaling in a high-throughput format
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The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and betaarrestin
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G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.
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An allosteric modulator to control endogenous G protein-coupled receptors with light
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Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor
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Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor
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Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations
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Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila.
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Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor
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Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease
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Interaction of Protease-Activated Receptor 2 with G Proteins and beta-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer
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A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.
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Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2
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Des dimères et des oligomères de récepteurs couplés aux protéines G, oui mais pourquoi ?
Julie Kniazeff
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hal-03363918v1
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Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors
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hal-02448364v1
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Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.
Gérald Lemonnier
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Stability of GABA B receptor oligomers revealed by dual TR‐FRET and drug‐induced cell surface targeting
Laëtitia Comps‐agrar
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G Protein Activation by Serotonin Type 4 Receptor Dimers: evidence that turning on two protomers is more efficient.
Lucie P. Pellissier
,
Gaël Barthet
,
Florence Gaven
,
Elisabeth Cassier
,
Eric Trinquet
Article dans une revue
hal-02482879v1
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A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects
Cyril Goudet
,
Bruno Vilar
,
Tiphanie Courtiol
,
Thierry Deltheil
,
Thomas Bessiron
Current Neuropharmacology, 2011, 9 (1), pp.26
Article dans une revue
hal-01384798v1
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IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
Anthony J. Harmar
,
Rebecca A. Hills
,
Edward M. Rosser
,
Martin Jones
,
O. Peter Buneman
Article dans une revue
hal-02667062v1
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Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment
D. Cuomo
,
G. Martella
,
E. Barabino
,
P. Platania
,
D. Vita
Journal of Neurochemistry, 2009, 109, pp.1096-1105
Article dans une revue
hal-00409236v1
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A novel series of group III metabotropic glutamate receptor (mGluR) agonists
Francine C. Acher
,
C. Selvam
,
N. Triballeau
,
N. Oueslati
,
I. Lemasson
Abstracts of Papers of the American Chemical Society, 2009, 237
Article dans une revue
hal-01384834v1
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Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson's disease symptoms? Design and evaluation of potent and selective agonists
Isabelle A. Lemasson
,
Chelliah Selvam
,
Nadia Oueslati
,
Isabelle Brabet
,
Tiphanie Courtiol
Abstracts of Papers of the American Chemical Society, 2009, 238
Article dans une revue
hal-01384832v1
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Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism
C. Beurrier
,
S. Lopez
,
D. Revy
,
C. Selvam
,
C. Goudet
FASEB Journal, 2009, 23, pp.3619-3628
Article dans une revue
hal-00582954v1
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Cell surface protein-protein interaction analysis with combined time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
Damien Maurel
,
Laetitia Comps-Agrar
,
Carsten Brock
,
Marie-Laure Rives
,
Emmanuel Bourrier
Article dans une revue
hal-00318856v1
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Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.
Philippe Rondard
,
Siluo Huang
,
Carine Monnier
,
Haijun Tu
,
Bertrand Blanchard
Article dans une revue
hal-00318880v1
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Modeling the binding and function of metabotropic glutamate receptors.
Xavier Rovira
,
David Roche
,
Juan Serra
,
Julie Kniazeff
,
Jean-Philippe Pin
Article dans une revue
hal-00319020v1
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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
Yelin Chen
,
Cyril Goudet
,
Jean-Philippe Pin
,
P Jeffrey Conn
Article dans une revue
inserm-00318958v1
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Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells.
Jiri Kumpost
,
Zdenka Syrova
,
Lenka Kulihova
,
Daniela Frankova
,
Jean-Charles Bologna
Article dans une revue
inserm-00319023v1
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Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism.
Mélanie Frauli
,
Nadia Hubert
,
Stephan Schann
,
Nicolas Triballeau
,
Hugues-Olivier Bertrand
Article dans une revue
inserm-00318866v1
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Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons.
Haijun Tu
,
Philippe Rondard
,
Chanjuan Xu
,
Federica Bertaso
,
Fangli Cao
Article dans une revue
hal-00319022v1
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Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.
Mohammed Akli Ayoub
,
Damien Maurel
,
Virginie Binet
,
Michel Fink
,
Laurent Prézeau
Article dans une revue
hal-00318930v1
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L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.
Chelliah Selvam
,
Cyril Goudet
,
Nadia Oueslati
,
Jean-Philippe Pin
,
Francine C. Acher
Article dans une revue
inserm-00318965v1
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Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain
Cyril Goudet
,
Eric Chapuy
,
Abdelkrim Alloui
,
Francine Acher
,
Jean-Philippe Pin
Article dans une revue
inserm-00318859v1
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Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors.
Virginie Binet
,
Béatrice Duthey
,
Jennifer Lecaillon
,
Claire Vol
,
Julie Quoyer
Article dans une revue
inserm-00318820v1
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Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
Pauline Sibille
,
Sébastien Lopez
,
Isabelle Brabet
,
Ornella Valenti
,
Nadia Oueslati
Article dans une revue
inserm-00318976v1
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Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Yelin Chen
,
Yi Nong
,
Cyril Goudet
,
Kamondanai Hemstapat
,
Tomas de Paulis
Article dans une revue
inserm-00319012v1
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Activation of a Dimeric Metabotropic Glutamate Receptor by Inter-Subunit Rearrangement
Carsten Brock
,
Nadia Oueslati
,
Stéphan Soler
,
Laure Boudier
,
Philippe Rondard
Article dans une revue
hal-00318871v1
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D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.
Eric Trinquet
,
Michel Fink
,
Hervé Bazin
,
Florence Grillet
,
Fabrice Maurin
Article dans une revue
inserm-00318996v1
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Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors.
Mélanie Frauli
,
Pascal Neuville
,
Claire Vol
,
Jean-Philippe Pin
,
Laurent Prézeau
Article dans une revue
inserm-00318879v1
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Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.
Christelle Masdeu
,
Hélène Faure
,
Josée Coulombe
,
Angèle Schoenfelder
,
André Mann
Article dans une revue
hal-00105551v1
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Asymmetry conformational changes in a GPCR dimer controlled by G-proteins
Marjorie Damian
,
Aimée Martin
,
Danielle Mesnier
,
Jean-Philippe Pin
,
Jean-Louis Banères
Article dans une revue
hal-00176784v1
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Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3.
Carsten Brock
,
Laure Boudier
,
Damien Maurel
,
Jaroslav Blahos
,
Jean-Philippe Pin
Article dans une revue
hal-00318967v2
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Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.
Cyril Goudet
,
Julie Kniazeff
,
Veronika Hlavackova
,
Fanny Malhaire
,
Damien Maurel
Article dans une revue
inserm-00318925v1
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Allosteric functioning of dimeric class C G-protein-coupled receptors.
Jean-Philippe Pin
,
Julie Kniazeff
,
Jianfeng Liu
,
Virginie Binet
,
Cyril Goudet
Article dans une revue
inserm-00094959v1
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Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR.
Veronika Hlavackova
,
Cyril Goudet
,
Julie Kniazeff
,
Alice Zikova
,
Damien Maurel
Article dans une revue
inserm-00318934v1
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Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.
Julie Kniazeff
,
Pierre-Philippe Saintot
,
Cyril Goudet
,
Jianfeng Liu
,
Annie Charnet
Article dans une revue
hal-00319013v1
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Cell surface detection of membrane protein interaction with homogeneous time-resolved fluorescence resonance energy transfer technology.
Damien Maurel
,
Julie Kniazeff
,
Gérard Mathis
,
Eric Trinquet
,
Jean-Philippe Pin
Article dans une revue
hal-00318979v1
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Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.
Jianfeng Liu
,
Damien Maurel
,
Sébastien Etzol
,
Isabelle Brabet
,
Hervé Ansanay
Article dans une revue
hal-00319008v1
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The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor.
Virginie Binet
,
Carole Brajon
,
Laurent Le Corre
,
Francine Acher
,
Jean-Philippe Pin
Article dans une revue
inserm-00318926v1
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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
Cyril Goudet
,
Florence Gaven
,
Julie Kniazeff
,
Claire Vol
,
Jianfeng Liu
Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (1), pp.378-83. ⟨10.1073/pnas.0304699101⟩
Article dans une revue
inserm-00319003v1
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Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.
Julie Kniazeff
,
Anne-Sophie Bessis
,
Damien Maurel
,
Hervé Ansanay
,
Laurent Prézeau
Article dans une revue
hal-00318999v1
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Divergent Evolution in Metabotropic Glutamate Receptors
Christian Mitri
,
Marie-Laure Parmentier
,
Jean-Philippe Pin
,
Joël Bockaert
,
Yves Grau
Article dans une revue
hal-02506712v1
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Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons
Fabrice Ango
,
David Robbe
,
J.C. Tu
,
B. Xiao
,
P.F. Worley
Article dans une revue
hal-00016884v1
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A single olfactory receptor specifically binds a set of odorant molecules
Isabelle Gaillard
,
Sylvie Rouquier
,
Jean-Philippe Pin
,
Patrice Mollard
,
Sylvain Richard
Article dans une revue
hal-02948481v1
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A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.
Béatrice Duthey
,
Sara Caudron
,
Julie Perroy
,
Bernhard Bettler
,
Laurent Fagni
Article dans une revue
inserm-00318936v1
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Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.
Fabrice Ango
,
Laurent Prézeau
,
Thomas Muller
,
Jian C. Tu
,
Bo Xiao
Article dans une revue
inserm-00318959v1
|
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The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways
Julie Perroy
,
G. J. Gutierrez
,
V. Coulon
,
Joël Bockaert
,
Jean-Philippe Pin
Article dans une revue
hal-02197463v1
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BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
Fiona Y. Carroll
,
Andreas Stolle
,
Philip M. Beart
,
Arnd Voerste
,
Isabelle Brabet
Article dans une revue
inserm-00319007v1
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Aminobicyclo (2.2.1.)heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2
Frederique Tellier
,
Francine Acher
,
I. Brabet
,
J.-P. Pin
Bioorganic and Medicinal Chemistry, 1998, 6, pp.195-208
Article dans une revue
hal-02691001v1
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Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists
Nathalie Todeschi
,
Josyane Gharbi-Benarous
,
Francine Acher
,
Valery Laure
,
Jean-Philippe Pin
Article dans une revue
hal-02356241v1
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Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids : new tools to discriminate between metabotropic glutamate receptor subtypes
Francine C. Acher
,
Frédérique Tellier
,
Robert Azerad
,
Isabelle N. Brabet
,
Laurent Fagni
Journal of Medicinal Chemistry, 1997, 40, pp.3119-3129
Article dans une revue
hal-02694452v1
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Synthesis of conformationally-constrained analogs of glutamic acid as structural probes of glutamatergic receptors
Frederique Tellier
,
Francine Acher
,
I. Brabet
,
J.-P. Pin
,
J. Bockaert
Comptes rendus de l’Académie des sciences. Série 2, 1995, 321, pp.385-392
Article dans une revue
hal-02705357v1
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Synthesis of conformationally-constrained stereospecific analogs of glutamic acid as antagonists of metabotropic receptors
Frederique Tellier
,
Francine Acher
,
I. Brabet
,
J.-P. Pin
,
J. Bockaert
Bioorganic and Medicinal Chemistry Letters, 1995, 5 (22), pp.2627-2632
Article dans une revue
hal-02705336v1
|