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Antibiotic adjuvants to rescue Pseudomonas aeruginosa from tetracycline antibiotics resistance

 Azza Troudi , Hana Douafer , Jean-Michel Michel Bolla , Naouel Klibi , Jean Michel Brunel
Anti-Infective Agents, In press, ⟨10.2174/2211352518999200629164624⟩
Article dans une revue hal-03085025v1
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Three-Component Synthesis of Chromeno β-Lactam Hybrids for Inflammation and Cancer Screening

 Nassim Borazjani , Saghi Sepehri , Maryam Behzadi , Aliasghar Jarrahpour , Javad Ameri Rad , et al.
European Journal of Medicinal Chemistry, 2019, 179, pp.389-403. ⟨10.1016/j.ejmech.2019.06.036⟩
Article dans une revue hal-02392426v1
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Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives

 Aurore Tourville , Sarah Viguier , Florencia González-Lizárraga , Rodrigo Hernán Tomas-Grau , Paola Ramirez , et al.
Antioxidants , 2023, 12 (3), pp.575. ⟨10.3390/antiox12030575⟩
Article dans une revue hal-04014845v1
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Characterization of a new aerosol antibiotic/adjuvant combination for the treatment of P. aeruginosa lung infections

 Hana Douafer , Véronique Andrieu , Emmanuel Wafo , Jean Michel Brunel
International Journal of Pharmaceutics, 2020, 586, pp.119548. ⟨10.1016/j.ijpharm.2020.119548⟩
Article dans une revue hal-03085007v1
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Multiparametric Profiling for Identification of Chemosensitizers against Gram-Negative Bacteria

 Vincent Lôme , Jean-Michel Brunel , Jean-Marie Pagès , Jean-Michel Michel Bolla
Frontiers in Microbiology, 2018, 9, ⟨10.3389/fmicb.2018.00204⟩
Article dans une revue hal-01824504v1
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Diversity, metabolome profiling and bioactivities of benthic filamentous cyanobacteria isolated from coastal mangroves of Mayotte

 Huibin Wang , Sébastien Halary , Charlotte Duval , Cécile Bernard , Marc Troussellier , et al.
Frontiers in Marine Science, 2023, 10, ⟨10.3389/fmars.2023.1201594⟩
Article dans une revue mnhn-04174558v1
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Artificial intelligence: The future for organic chemistry?

 Jean Michel Brunel , Franck Peiretti
ACS Omega, 2018, 3 (10), pp.13263-13266. ⟨10.1021/acsomega.8b01773⟩
Article dans une revue hal-01980645v2
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A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth

 Sylvie Carmona , Jean-Michel Brunel , Renaté Bonier , Véronique Sbarra , Stéphane Robert , et al.
Oncotarget, 2019, 10, pp.6651 - 6667
Article dans une revue hal-02447470v1
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In-Vitro Archaeacidal Activity of Biocides against Human-Associated Archaea

 Saber Khelaifia , Jean Michel Brunel , Michel Drancourt
PLoS ONE, 2013, 8 (5), pp.e62738. ⟨10.1371/journal.pone.0062738⟩
Article dans une revue hal-01772477v1
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Rapid Detection of Carbapenem Resistance in Acinetobacter baumannii Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

 Marie Kempf , Sofiane Bakour , Christophe Flaudrops , Meryem Berrazeg , Jean-Michel Brunel , et al.
PLoS ONE, 2012, 7 (2), pp.e31676. ⟨10.1371/journal.pone.0031676⟩
Article dans une revue hal-01772590v1
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Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?

 Chanaz Salmi , Celine Loncle , Nicolas Nvidal@mnhn.Fr Vidal , Yves Letourneux , Jacques Fantini , et al.
PLoS ONE, 2008, 3 (7), pp.e2765. ⟨10.1371/journal.pone.0002765⟩
Article dans une revue hal-00400776v1
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Claramines: A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity

 Marine Blanchet , Diane Borselli , Anne Rodallec , Franck Peiretti , Nicolas Vidal , et al.
ChemMedChem, 2018, 13 (10), pp.1018-1027. ⟨10.1002/cmdc.201800073⟩
Article dans une revue hal-02110834v1
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α,ω-Diacyl-Substituted Analogues of Natural and Unnatural Polyamines: Identification of Potent Bactericides That Selectively Target Bacterial Membranes

 Dan Chen , Melissa M Cadelis , Florent Rouvier , Thomas Troia , Liam R Edmeades , et al.
International Journal of Molecular Sciences, 2023, 24 (6), pp.5882. ⟨10.3390/ijms24065882⟩
Article dans une revue hal-04244633v1
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Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b

 Adrien Boes , Jean-Michel Brunel , Adeline Derouaux , Frederic Kerff , Ahmed Bouhss , et al.
Antibiotics, 2020, 9 (7), pp.373. ⟨10.3390/antibiotics9070373⟩
Article dans une revue hal-03085034v1
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RTA1 Is Involved in Resistance to 7-Aminocholesterol and Secretion of Fungal Proteins in Cryptococcus neoformans

 Emily S Smith-Peavler , Ronakkumar Patel , Adejumoke Mary Onumajuru , Bethany G Bowring , Joyce L Miller , et al.
Pathogens, 2022, 11 (11), pp.1239. ⟨10.3390/pathogens11111239⟩
Article dans une revue hal-03833117v1
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Comparison of Proteomic Responses (CoPR) -a global approach to antibiotic mechanism of action elucidation

 R.C.H. Senges , J.J. Stepanek , M. Wenzel , N. Raatschen , U. Ay, , et al.
Antimicrobial Agents and Chemotherapy, 2020, 65 (1), pp.e01373-20. ⟨10.1128/AAC.01373-20⟩
Article dans une revue hal-03085016v1
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New Polyaminoisoprenyl Antibiotics Enhancers against Two Multidrug-Resistant Gram-Negative Bacteria from Enterobacter and Salmonella Species

 Jean Michel Brunel
Journal of Medicinal Chemistry, 2020, 63 (18), pp.10496-10508. ⟨10.1021/acs.jmedchem.0c01335⟩
Article dans une revue hal-03085044v1
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Scope and limitations on aerosol drug delivery for the treatment of infectious respiratory diseases

 Hana Douafer , Véronique Andrieu , Jean Michel Brunel
Journal of Controlled Release, 2020, 325, pp.276-292. ⟨10.1016/j.jconrel.2020.07.002⟩
Article dans une revue hal-03081317v1
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6-Polyaminosteroid Squalamine Analogues Display Antibacterial Activity against Resistant Pathogens

 Delphine Vergoz , Flore Nilly , Florie Desriac , Magalie Barreau , Antoine Géry , et al.
International Journal of Molecular Sciences, 2023, 24 (10), pp.8568. ⟨10.3390/ijms24108568⟩
Article dans une revue hal-04161494v1
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Spermine Derivatives of Indole‐3‐carboxylic Acid, Indole‐3‐acetic Acid and Indole‐3‐acrylic Acid as Gram‐Negative Antibiotic Adjuvants

 Melissa Cadelis , Steven Li , Marie‐Lise Bourguet‐Kondracki , Marine Blanchet , Hana Douafer , et al.
ChemMedChem, 2020, ⟨10.1002/cmdc.202000359⟩
Article dans une revue hal-03084985v1
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Alaninyl variants of the marine natural product halocyamine A and their antibacterial properties

 Hugo K.H. Fong , Melissa Cadelis , Jean Michel Brunel , Marie-Lise Bourguet-Kondracki , David Barker , et al.
Tetrahedron, 2018, 74 (48), pp.6929-6938. ⟨10.1016/jet.2018.10.021⟩
Article dans une revue hal-02056446v1
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Investigation of α,ω-Disubstituted Polyamine-Cholic Acid Conjugates Identifies Hyodeoxycholic and Chenodeoxycholic Scaffolds as Non-Toxic, Potent Antimicrobials

 Kenneth Sue , Melissa M Cadelis , Thomas Troia , Florent Rouvier , Marie-Lise Bourguet-Kondracki , et al.
Antibiotics, 2023, 12 (2), pp.404. ⟨10.3390/antibiotics12020404⟩
Article dans une revue hal-04244618v1
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Indole-3-Acetamido-Polyamines as Antimicrobial Agents and Antibiotic Adjuvants

 Kenneth Sue , Melissa M Cadelis , Evangelene S Gill , Florent Rouvier , Marie-Lise Bourguet-Kondracki , et al.
Biomolecules, 2023, 13 (8), pp.1226. ⟨10.3390/biom13081226⟩
Article dans une revue hal-04244766v1
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The beta secretase BACE1 regulates the expression of insulin receptor in the liver

 Paul Meakin , Anna Mezzapesa , Eva Benabou , Mary Haas , Bernadette Bonardo , et al.
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-03755-2⟩
Article dans une revue inserm-01762378v1

Synthesis and biological evaluation of some novel diastereoselective benzothiazole beta-lactam conjugates

 Maryam Alborz , Aliasghar Jarrahpour , Roya Pournejati , Hamid Reza Karbalaei-Heidari , Veronique Sinou , et al.
European Journal of Medicinal Chemistry, 2018, 143, pp.283-291. ⟨10.1016/j.ejmech.2017.11.053⟩
Article dans une revue hal-02143539v1

Synthesis of New 3,20-Bispolyaminosteroid Squalamine Analogues and Evaluation of Their Antimicrobial Activities

 Lamia Djouhri-Bouktab , Nicolas Nvidal@mnhn.Fr Vidal , Jean-Marc Rolain , Jean Michel Brunel
Journal of Medicinal Chemistry, 2011, 54 (20), pp.7417--7421. ⟨10.1021/jm200506x⟩
Article dans une revue hal-01460294v1
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Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction

 Pierre-Alain Thiébaut , Eugénie Delile , David Coquerel , Jean-Michel Brunel , Sylvanie Renet , et al.
Vascular Pharmacology, 2018, 109, pp.36-44. ⟨10.1016/j.vph.2018.05.011⟩
Article dans une revue inserm-02296610v1

In vitro activity of aminosterols against yeasts involved in blood stream infections

 Kamel Alhanout , Lamia Djouhri , Nicolas Nvidal@mnhn.Fr Vidal , Jean Michel Brunel , Renaud Piarroux , et al.
Medical Mycology, 2011, 49 (2), pp.121--125. ⟨10.3109/13693786.2010.502189⟩
Article dans une revue hal-01460280v1
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Synthesis, docking and evaluation of in vitro anti-inflammatory activity of novel morpholine capped β-lactam derivatives

 Roghayeh Heiran , Saghi Sepehri , Aliasghar Jarrahpour , Carole Digiorgio , Hana Douafer , et al.
Bioorganic Chemistry, 2020, 102, pp.104091. ⟨10.1016/j.bioorg.2020.104091⟩
Article dans une revue hal-03085012v1
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Scope and Limitations of Exploiting the Ability of the Chemosensitizer NV716 to Enhance the Activity of Tetracycline Derivatives against Pseudomonas aeruginosa

 Margot Draveny , Clémence Rose , Alexis Pinet , Laurent Ferrié , Bruno Figadère , et al.
Molecules, 2023, 28 (11), pp.4262. ⟨10.3390/molecules28114262⟩
Article dans une revue hal-04244665v1
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