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Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

 Géraldine Lemaire , Cindy Benod , Virginie Nahoum , Arnaud Pillon , Anne-Marie Boussioux , et al.
Molecular Pharmacology, 2007, 72 (3), pp.572-81. ⟨10.1124/mol.106.033415⟩
Article dans une revue inserm-00157261v1

Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer

 Alexandre Prieur , Monica Cappellini , Guillaume Habif , Marie-Paule Lefranc , Thibault Mazard , et al.
Clinical Cancer Research, 2017, 23 (17), pp.5267--5280. ⟨10.1158/1078-0432.CCR-17-0533⟩
Article dans une revue hal-01760837v1

Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

 S. Paquet-Fifield , S. L. Koh , L. Cheng , L. M. Beyit , C. Shembrey , et al.
Cancer Research, 2018, 78 (11), pp.2925-2938. ⟨10.1158/0008-5472.CAN-17-1869⟩
Article dans une revue hal-02073196v1
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Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

 Caroline Raynal , Jean-Marc Pascussi , Géraldine Leguelinel , Cyril Breuker , Jovana Kantar , et al.
Molecular Cancer, 2010, 9 (1), pp.46. ⟨10.1186/1476-4598-9-46⟩
Article dans une revue inserm-00617237v1
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Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way

 Alice Marmugi , Céline Lukowicz , Frédéric Lasserre , Alexandra Montagner , Arnaud Polizzi , et al.
Toxicology and Applied Pharmacology, 2016, 303, pp.90 - 100. ⟨10.1016/j.taap.2016.05.006⟩
Article dans une revue hal-01837194v1

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

 M. Pelosi , V. Di Bartolo , V. Mounier , D. Mège , J. M. Pascussi , et al.
Journal of Biological Chemistry, 1999, 274 (20), pp.14229-37. ⟨10.1074/jbc.274.20.14229⟩
Article dans une revue hal-00138125v1
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Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.

 Jean Marc Pascussi , Agnes Robert , Minh Nguyen , Odile Walrant-Debray , Michèle Garabedian , et al.
Journal of Clinical Investigation, 2005, 115 (1), pp.177-86. ⟨10.1172/JCI200521867⟩
Article dans une revue inserm-00086875v1

Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system

 Géraldine Lemaire , Wissem Mnif , Jean-Marc Pascussi , Arnaud Pillon , Fanja Rabenoelina , et al.
Toxicological Sciences, 2006, 91 (2), pp.501-509. ⟨10.1093/toxsci/kfj173⟩
Article dans une revue hal-02879901v1

Different activation patterns of rat xenobiotic metabolism genes by two constituents of garlic

 Ping Zhang , Marie-Louise M.-L. Noordine , Claire C. Cherbuy , Pierre Vaugelade , Jean Marc Pascussi , et al.
Carcinogenesis, 2006, 27 (10), pp.2090-2095. ⟨10.1093/carcin/bgl064⟩
Article dans une revue istex hal-02668000v1
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Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

 Chris Planque , Fatemeh Rajabi , Fanny Grillet , Pascal Finetti , François Bertucci , et al.
Oncotarget, 2016, 7 (35), pp.56558-56573. ⟨10.18632/oncotarget.10646⟩
Article dans une revue hal-01431926v1

Bases fondamentales du processus métastatique

 Jean-Marc Pascussi , Julie Giraud , E. Samalin , Fanny Grillet , Julie Pannequin
Bulletin du Cancer, 2016, 103 (6 Suppl 1), pp.S39--47. ⟨10.1016/S0007-4551(16)30144-8⟩
Article dans une revue hal-01941169v1
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Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo

 Baddreddine Boussadia , Giuseppe Gangarossa , Laila Mselli-Lakhal , Marie-Claude Rousset , Frédéric de Bock , et al.
Experimental Neurology, 2016, 283, pp.39-48. ⟨10.1016/j.expneurol.2016.05.018⟩
Article dans une revue hal-02641172v1
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Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor

 Fabiana Oliviero , Céline Lukowicz , Badreddine Boussadia , Isabel Forner-Piquer , Jean-Marc Pascussi , et al.
Cells, 2020, 9 (11), pp.2426. ⟨10.3390/cells9112426⟩
Article dans une revue hal-03002015v1
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Di-(2-ethylhexyl)-phthalate (DEHP) activates the Constitutive Androstane Receptor (CAR): a novel signalling pathway sensitive to phthalates

 Alexandre Eveillard , Laila Mselli-Lakhal , Ariane Mogha , Frédéric Lasserre , Arnaud Polizzi , et al.
Biochemical Pharmacology, 2009, 77 (11), pp.1735. ⟨10.1016/j.bcp.2009.02.023⟩
Article dans une revue hal-00493499v1

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling

 Philippe Briolotti , Laurent Chaloin , Patrick Balaguer , Franck da Silva , Veronika Tománková , et al.
Toxicological Sciences, 2015, 148 (1), pp.261 - 275. ⟨10.1093/toxsci/kfv177⟩
Article dans une revue hal-01838127v1

Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells

 Julie Giraud , Laura Failla , Jean-Marc Pascussi , Ebba Louise Lagerqvist , Jérémy Ollier , et al.
Cancer Research, 2016, 76 (12), pp.3618 - 3628. ⟨10.1158/0008-5472.CAN-15-1497⟩
Article dans une revue hal-01905320v1

Mécanismes de résistance des cellules souches cancéreuses aux chimiothérapies

 Jean-Marc Pascussi
Bulletin du Cancer, 2017, 104 (12), pp.1080-1084. ⟨10.1016/j.bulcan.2017.10.013⟩
Article dans une revue hal-02078821v1
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The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences.

 Jean-Marc Pascussi , Sabine Gerbal-Chaloin , Cédric Duret , Martine Daujat-Chavanieu , Marie-José Vilarem , et al.
Annual Review of Pharmacology, 2008, 48, pp.1-32. ⟨10.1146/annurev.pharmtox.47.120505.105349⟩
Article dans une revue inserm-00162144v1
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CYP1A1 Induction in the Colon by Serum: Involvement of the PPARα Pathway and Evidence for a New Specific Human PPREα Site

 Pierre-Henri Villard , Fabrice Barlesi , Martine Armand , Thi-Mai-Anh Dao , Jean-Marc Pascussi , et al.
PLoS ONE, 2011, 6 (1), pp.e14629. ⟨10.1371/journal.pone.0014629⟩
Article dans une revue hal-01330877v1
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Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

 Cedric Duret , Martine Daujat-Chavanieu , Jean-Marc Pascussi , Lydiane Pichard-Garcia , Patrick Balaguer , et al.
Molecular Pharmacology, 2006, 70, pp.329-39. ⟨10.1124/mol.105.022046⟩
Article dans une revue inserm-00086861v1
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Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture

 Fanny Grillet , Elsa Bayet , Olivia Villeronce , Luke Zappia , Ebba Louise Lagerqvist , et al.
Gut, 2017, 66 (10), pp.1802 - 1810. ⟨10.1136/gutjnl-2016-311447⟩
Article dans une revue hal-01903677v1

Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures

 Léonie Runtz , Benoît Girard , Marion Toussenot , J. Espallergues , Alexis Fayd'Herbe de Maudave , et al.
Epilepsia, 2018, 59 (1), pp.123-134. ⟨10.1111/epi.13942⟩
Article dans une revue hal-02073209v1
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Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

 Vanessa Delfosse , Beatrice Dendelé , Tiphaine Huet , Marina Grimaldi , Abdelhay Boulahtouf , et al.
Nature Communications, 2015, 6 (1), ⟨10.1038/ncomms9089⟩
Article dans une revue hal-01838034v1
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Evidence for a new human CYP1A1 regulation pathway involving PPAR-α and 2 PPRE sites

 E. Seree , Pierre-Henri Villard , M Pascussi , T Pineau , P. Maurel , et al.
Gastroenterology, 2004, 127 (5), pp.1436 - 1445. ⟨10.1053/j.gastro.2004.08.023⟩
Article dans une revue hal-01773769v1
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CD44v6 Defines a New Population of Circulating Tumor Cells Not Expressing EpCAM

 Guillaume Belthier , Zeinab Homayed , Fanny Grillet , Christophe Duperray , Julie Vendrell , et al.
Cancers, 2021, 13 (19), pp.4966. ⟨10.3390/cancers13194966⟩
Article dans une revue hal-03394453v1

Novel aspects of PPARα-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study

 Pascal G.P. Martin , Hervé Guillou , Frédéric Lasserre , Sébastien Dejean , Annaig Lan , et al.
Hepatology, 2007, 45 (3), pp.767-777. ⟨10.1002/hep.21510⟩
Article dans une revue hal-00661808v1

Characterization of a novel PXR isoform with potential dominant-negative properties

 Cyril Breuker , Chris Planque , Fatemeh Rajabi , Jean-Charles Nault , Gabrielle Couchy , et al.
Journal of Hepatology, 2014, 61 (3), pp.609--16. ⟨10.1016/j.jhep.2014.04.030⟩
Article dans une revue hal-01942944v1
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Serum-derived hepatitis C virus infection of primary human hepatocytes is tetraspanin CD81 dependent.

 Sonia Molina , Valerie Castet , Lydiane Pichard-Garcia , Czeslaw Wychowski , Eliane Meurs , et al.
Journal of Virology, 2008, 82 (1), pp.569-74. ⟨10.1128/JVI.01443-07⟩
Article dans une revue inserm-00374410v1
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Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy

 Lucile Bansard , Océane Bouvet , Elisa Moutin , Gaétan Le Gall , Alessandro Giammona , et al.
Stem Cell Reports, 2022, 17 (4), pp.835-848. ⟨10.1016/j.stemcr.2022.02.005⟩
Article dans une revue hal-03647464v1
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GNS561, a New Autophagy Inhibitor Active against Cancer Stem Cells in Hepatocellular Carcinoma and Hepatic Metastasis from Colorectal Cancer

 Sonia Brun , Jean-Marc Pascussi , Elena Patricia Gifu , Eloïne Bestion , Zuzana Macek-Jilkova , et al.
American Journal of Cancer, 2021, 12 (18), pp.5432-5438. ⟨10.7150/jca.58533⟩
Article dans une revue hal-03326462v1
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