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Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
Géraldine Lemaire
,
Cindy Benod
,
Virginie Nahoum
,
Arnaud Pillon
,
Anne-Marie Boussioux
,
et al.
Article dans une revue
inserm-00157261v1
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Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer
Alexandre Prieur
,
Monica Cappellini
,
Guillaume Habif
,
Marie-Paule Lefranc
,
Thibault Mazard
,
et al.
Article dans une revue
hal-01760837v1
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Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells
S. Paquet-Fifield
,
S. L. Koh
,
L. Cheng
,
L. M. Beyit
,
C. Shembrey
,
et al.
Article dans une revue
hal-02073196v1
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Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells
Julie Giraud
,
Laura Failla
,
Jean-Marc Pascussi
,
Ebba Louise Lagerqvist
,
Jérémy Ollier
,
et al.
Article dans une revue
hal-01905320v1
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Mécanismes de résistance des cellules souches cancéreuses aux chimiothérapies
Jean-Marc Pascussi
Article dans une revue
hal-02078821v1
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The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences.
Jean-Marc Pascussi
,
Sabine Gerbal-Chaloin
,
Cédric Duret
,
Martine Daujat-Chavanieu
,
Marie-José Vilarem
,
et al.
Article dans une revue
inserm-00162144v1
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CYP1A1 Induction in the Colon by Serum: Involvement of the PPARα Pathway and Evidence for a New Specific Human PPREα Site
Pierre-Henri Villard
,
Fabrice Barlesi
,
Martine Armand
,
Thi-Mai-Anh Dao
,
Jean-Marc Pascussi
,
et al.
Article dans une revue
hal-01330877v1
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Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.
Jean Marc Pascussi
,
Agnes Robert
,
Minh Nguyen
,
Odile Walrant-Debray
,
Michèle Garabedian
,
et al.
Article dans une revue
inserm-00086875v1
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Pregnane X-receptor promotes stem cell-mediated colon cancer relapse
Chris Planque
,
Fatemeh Rajabi
,
Fanny Grillet
,
Pascal Finetti
,
François Bertucci
,
et al.
Article dans une revue
hal-01431926v1
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Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system
Géraldine Lemaire
,
Wissem Mnif
,
Jean-Marc Pascussi
,
Arnaud Pillon
,
Fanja Rabenoelina
,
et al.
Article dans une revue
hal-02879901v1
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Different activation patterns of rat xenobiotic metabolism genes by two constituents of garlic
Ping Zhang
,
Marie-Louise M.-L. Noordine
,
Claire C. Cherbuy
,
Pierre Vaugelade
,
Jean Marc Pascussi
,
et al.
Article dans une revue
istex
hal-02668000v1
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Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
M. Pelosi
,
V. Di Bartolo
,
V. Mounier
,
D. Mège
,
J. M. Pascussi
,
et al.
Article dans une revue
hal-00138125v1
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Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.
Caroline Raynal
,
Jean-Marc Pascussi
,
Géraldine Leguelinel
,
Cyril Breuker
,
Jovana Kantar
,
et al.
Article dans une revue
inserm-00617237v1
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Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way
Alice Marmugi
,
Céline Lukowicz
,
Frédéric Lasserre
,
Alexandra Montagner
,
Arnaud Polizzi
,
et al.
Article dans une revue
hal-01837194v1
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Bases fondamentales du processus métastatique
Jean-Marc Pascussi
,
Julie Giraud
,
E. Samalin
,
Fanny Grillet
,
Julie Pannequin
Article dans une revue
hal-01941169v1
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Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo
Baddreddine Boussadia
,
Giuseppe Gangarossa
,
Laila Mselli-Lakhal
,
Marie-Claude Rousset
,
Frédéric de Bock
,
et al.
Article dans une revue
hal-02641172v1
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Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor
Fabiana Oliviero
,
Céline Lukowicz
,
Badreddine Boussadia
,
Isabel Forner-Piquer
,
Jean-Marc Pascussi
,
et al.
Article dans une revue
hal-03002015v1
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Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling
Philippe Briolotti
,
Laurent Chaloin
,
Patrick Balaguer
,
Franck da Silva
,
Veronika Tománková
,
et al.
Article dans une revue
hal-01838127v1
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Di-(2-ethylhexyl)-phthalate (DEHP) activates the Constitutive Androstane Receptor (CAR): a novel signalling pathway sensitive to phthalates
Alexandre Eveillard
,
Laila Mselli-Lakhal
,
Ariane Mogha
,
Frédéric Lasserre
,
Arnaud Polizzi
,
et al.
Article dans une revue
hal-00493499v1
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Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.
Cedric Duret
,
Martine Daujat-Chavanieu
,
Jean-Marc Pascussi
,
Lydiane Pichard-Garcia
,
Patrick Balaguer
,
et al.
Article dans une revue
inserm-00086861v1
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Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture
Fanny Grillet
,
Elsa Bayet
,
Olivia Villeronce
,
Luke Zappia
,
Ebba Louise Lagerqvist
,
et al.
Article dans une revue
hal-01903677v1
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Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures
Léonie Runtz
,
Benoît Girard
,
Marion Toussenot
,
J. Espallergues
,
Alexis Fayd'Herbe de Maudave
,
et al.
Article dans une revue
hal-02073209v1
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Evidence for a new human CYP1A1 regulation pathway involving PPAR-α and 2 PPRE sites
E. Seree
,
Pierre-Henri Villard
,
M Pascussi
,
T Pineau
,
P. Maurel
,
et al.
Article dans une revue
hal-01773769v1
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Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds
Vanessa Delfosse
,
Beatrice Dendelé
,
Tiphaine Huet
,
Marina Grimaldi
,
Abdelhay Boulahtouf
,
et al.
Article dans une revue
hal-01838034v1
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GNS561, a New Autophagy Inhibitor Active against Cancer Stem Cells in Hepatocellular Carcinoma and Hepatic Metastasis from Colorectal Cancer
Sonia Brun
,
Jean-Marc Pascussi
,
Elena Patricia Gifu
,
Eloïne Bestion
,
Zuzana Macek-Jilkova
,
et al.
Article dans une revue
hal-03326462v1
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CD44v6 Defines a New Population of Circulating Tumor Cells Not Expressing EpCAM
Guillaume Belthier
,
Zeinab Homayed
,
Fanny Grillet
,
Christophe Duperray
,
Julie Vendrell
,
et al.
Article dans une revue
hal-03394453v1
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Novel aspects of PPARα-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study
Pascal G.P. Martin
,
Hervé Guillou
,
Frédéric Lasserre
,
Sébastien Dejean
,
Annaig Lan
,
et al.
Article dans une revue
hal-00661808v1
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Characterization of a novel PXR isoform with potential dominant-negative properties
Cyril Breuker
,
Chris Planque
,
Fatemeh Rajabi
,
Jean-Charles Nault
,
Gabrielle Couchy
,
et al.
Article dans une revue
hal-01942944v1
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Serum-derived hepatitis C virus infection of primary human hepatocytes is tetraspanin CD81 dependent.
Sonia Molina
,
Valerie Castet
,
Lydiane Pichard-Garcia
,
Czeslaw Wychowski
,
Eliane Meurs
,
et al.
Article dans une revue
inserm-00374410v1
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Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy
Lucile Bansard
,
Océane Bouvet
,
Elisa Moutin
,
Gaétan Le Gall
,
Alessandro Giammona
,
et al.
Article dans une revue
hal-03647464v1
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