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Jean-Marc Brondello

Tissue accumulation of p16INK4A-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). Indeed, these cell-cycle arrested cells affect tissue function and homestasis through cell-to-cell juxtacrine and paracrine specific mechanisms. Using in vivo transgenic murine models for senescence detection and depletion altogether with in vitro 2D and 3D culture conditions for osteoarticular cells, our group aims at:

  • identifying senescent articular joint cells that drive tissue degeneration
  • developing strategies to eliminate such cells in vitro and in vivo
  • restoring joint functions in elderly to delay prosthetic surgery

Article dans une revue17 documents

  • Damien Veret, Christian Jorgensen, Jean-Marc Brondello. Osteoarthritis in time for senotherapeutics. Joint Bone Spine, Elsevier Masson, 2021, 88 (2), pp.105084. ⟨10.1016/j.jbspin.2020.105084⟩. ⟨hal-03163864⟩
  • Damien Veret, Jean-Marc Brondello. Sénothérapies : Avancées et nouvelles perspectives cliniques. médecine/sciences, EDP Sciences, 2020, 36 (12), pp.1135-1142. ⟨10.1051/medsci/2020220⟩. ⟨hal-03049534⟩
  • Jean-Marc Brondello, Farida Djouad, Christian Jorgensen. Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritis?. Cells, MDPI, 2019, 8 (10), pp.1257. ⟨10.3390/cells8101257⟩. ⟨hal-02555388⟩
  • Olivier Malaise, Yassin Tachikart, Michael Constantinides, Marcus Mumme, Rosanna Ferreira-Lopez, et al.. Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development. Aging, Impact Journals, 2019, 11 (20), pp.9128-9146. ⟨10.18632/aging.102379⟩. ⟨hal-02551968⟩
  • Patricia Luz-Crawford, Javier Hernandez, Farida Djouad, Noymar Luque-Campos, Andrès Caicedo, et al.. Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer. Current Stem Cell Research & Therapy, Bentham Science Publishers Ltd, 2019, 10 (1), pp.232. ⟨10.1186/s13287-019-1307-9⟩. ⟨inserm-02376241⟩
  • Yassin Tachikart, Olivier Malaise, Marcus Mumme, Christian Jorgensen, Jean-Marc Brondello. Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases. Biochemical Pharmacology, Elsevier, 2019, 165, pp.126-133. ⟨10.1016/j.bcp.2019.03.017⟩. ⟨hal-02877478⟩
  • Paul Chuchana, Anne-Laure Mausset-Bonnefont, Marc Mathieu, Francisco Espinoza, Marisa Teigell, et al.. Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis.. Aging, Impact Journals, 2018, 10 (6), pp.1442-1453. ⟨10.18632/aging.101481⟩. ⟨hal-01834060⟩
  • Yassin Tachikart, Olivier Malaise, Michael Constantinides, Christian Jorgensen, Jean-Marc Brondello. Cibler les cellules sénescentes : Une révolution dans le traitement des pathologies ostéo-articulaires. médecine/sciences, EDP Sciences, 2018, Les Cahiers de Myologie, 34 (6-7), pp.547 - 553. ⟨10.1051/medsci/20183406014⟩. ⟨hal-03179760⟩
  • Marie-Luce Vignais, Andrès Caicedo, Jean-Marc Brondello, Christian Jorgensen. Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy. Stem Cells International, Hindawi Publishing Corporation, 2017, 2017, pp.6917941. ⟨10.1155/2017/6917941⟩. ⟨hal-01759757⟩
  • Olivier Malaise, Yassin Tachikart, Jean-Marc Brondello. Senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery?. AME Medical Journal, 2017, 2, pp.161 - 161. ⟨10.21037/amj.2017.10.01⟩. ⟨hal-01838428⟩
  • Rita Vicente, Anne-Laure Mausset-Bonnefont, Christian Jorgensen, Pascale Louis-Plence, Jean-Marc Brondello. Cellular senescence impact on immune cell fate and function. Aging Cell, Wiley Open Access, 2016, 15 (3), pp.400 - 406. ⟨10.1111/acel.12455⟩. ⟨hal-01834241⟩
  • Andrès Caicedo, Vanessa Fritz, Jean-Marc Brondello, Mickaël Ayala, Indira Dennemont, et al.. MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function. Scientific Reports, Nature Publishing Group, 2015, 5 (1), ⟨10.1038/srep09073⟩. ⟨hal-01834600⟩
  • David Guérit, Jean-Marc Brondello, Paul Chuchana, Didier Philipot, Karine Toupet, et al.. FOXO3A Regulation by miRNA-29a Controls Chondrogenic Differentiation of Mesenchymal Stem Cells and Cartilage Formation. Stem Cells and Development, Mary Ann Liebert, 2014, 23 (11), pp.1195 - 1205. ⟨10.1089/scd.2013.0463⟩. ⟨hal-01836483⟩
  • Didier Philipot, David Guérit, Daniela Platano, Paul Chuchana, Eleonora Olivotto, et al.. p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodelling in osteoarthritis.. Arthritis Research and Therapy, BioMed Central, 2014, 16 (1), pp.R58. ⟨10.1186/ar4494⟩. ⟨inserm-00983071⟩
  • J. Basbous, Dora Knani, Nathalie Bonneaud, Dominique Giorgi, Jean-Marc Brondello, et al.. Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage. Cell Cycle, Taylor & Francis, 2012, 11 (12), pp.2380-9012. ⟨10.4161/cc.20858⟩. ⟨hal-00705749⟩
  • Claire Vinatier, Carine Bouffi, Christophe Merceron, Jan Gordeladze, Jean-Marc Brondello, et al.. Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy.. Current Stem Cell Research & Therapy, Bentham Science Publishers Ltd, 2009, 4 (4), pp.318-29. ⟨inserm-00423696⟩
  • Jean-Marc Brondello, Bernard Ducommun, Anne Fernandez, Ned Lamb. Linking PCNA-dependent replication and ATR by human Claspin.. Biochemical and Biophysical Research Communications, Elsevier, 2007, 354 (4), pp.1028-33. ⟨10.1016/j.bbrc.2007.01.091⟩. ⟨inserm-00147047⟩