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jean-marc Brondello

20
Documents
Identifiants chercheurs

Présentation

https://orcid.org/0000-0001-5991-3945
Tissue accumulation of p16INK4A-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). Indeed, these cell-cycle arrested cells affect tissue function and homestasis through cell-to-cell juxtacrine and paracrine specific mechanisms. Using in vivo transgenic murine models for senescence detection and depletion altogether with in vitro 2D and 3D culture conditions for osteoarticular cells, our group aims at: - identifying senescent articular joint cells that drive tissue degeneration - developing strategies to eliminate such cells in vitro and in vivo - restoring joint functions in elderly to delay prosthetic surgery

Publications

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Establishment of a collection of human pluripotent stem cell lines (iPSC) from mesenchymal stem cells (MSC) from three healthy elderly donors

Lydiane Pichard , Jean-Marc Brondello , Fabienne Becker , Romain Desprat , Frédéric de Ceuninck
Stem Cell Research, 2021, 53, pp.102297. ⟨10.1016/j.scr.2021.102297⟩
Article dans une revue hal-03664523v1

Osteoarthritis in time for senotherapeutics

Damien Veret , Christian Jorgensen , Jean-Marc Brondello
Joint Bone Spine, 2021, 88 (2), pp.105084. ⟨10.1016/j.jbspin.2020.105084⟩
Article dans une revue hal-03163864v1
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Sénothérapies

Damien Veret , Jean-Marc Brondello
Médecine/Sciences, 2020, 36 (12), pp.1135-1142. ⟨10.1051/medsci/2020220⟩
Article dans une revue hal-03049534v1
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Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis

Lydiane Pichard , Jean-Marc Brondello , Fabienne Becker , Romain Desprat , Frédéric de Ceuninck
Stem Cell Research, 2020, 44, pp.101721. ⟨10.1016/j.scr.2020.101721⟩
Article dans une revue hal-02961555v1
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Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer

Patricia Luz-Crawford , Javier Hernandez , Farida Djouad , Noymar Luque-Campos , Andrès Caicedo
Current Stem Cell Research & Therapy, 2019, 10 (1), pp.232. ⟨10.1186/s13287-019-1307-9⟩
Article dans une revue inserm-02376241v1
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Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritis?

Jean-Marc Brondello , Farida Djouad , Christian Jorgensen
Cells, 2019, 8 (10), pp.1257. ⟨10.3390/cells8101257⟩
Article dans une revue hal-02555388v1

Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development

Olivier Malaise , Yassin Tachikart , Michael Constantinides , Marcus Mumme , Rosanna Ferreira-Lopez
Aging, 2019, 11 (20), pp.9128-9146. ⟨10.18632/aging.102379⟩
Article dans une revue hal-02551968v1
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Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases

Yassin Tachikart , Olivier Malaise , Marcus Mumme , Christian Jorgensen , Jean-Marc Brondello
Biochemical Pharmacology, 2019, 165, pp.126-133. ⟨10.1016/j.bcp.2019.03.017⟩
Article dans une revue hal-02877478v1
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Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis.

Paul Chuchana , Anne-Laure Mausset-Bonnefont , Marc Mathieu , Francisco Espinoza , Marisa Teigell
Aging, 2018, 10 (6), pp.1442-1453. ⟨10.18632/aging.101481⟩
Article dans une revue hal-01834060v1
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Cibler les cellules sénescentes : Une révolution dans le traitement des pathologies ostéo-articulaires

Yassin Tachikart , Olivier Malaise , Michael Constantinides , Christian Jorgensen , Jean-Marc Brondello
Médecine/Sciences, 2018, Les Cahiers de Myologie, 34 (6-7), pp.547 - 553. ⟨10.1051/medsci/20183406014⟩
Article dans une revue hal-03179760v1

Senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery?

Olivier Malaise , Yassin Tachikart , Jean-Marc Brondello
AME Medical Journal, 2017, 2, pp.161 - 161. ⟨10.21037/amj.2017.10.01⟩
Article dans une revue hal-01838428v1
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Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

Marie-Luce Vignais , Andrès Caicedo , Jean-Marc Brondello , Christian Jorgensen
Stem Cells International, 2017, 2017, pp.6917941. ⟨10.1155/2017/6917941⟩
Article dans une revue hal-01759757v1
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Cellular senescence impact on immune cell fate and function

Rita Vicente , Anne-Laure Mausset-Bonnefont , Christian Jorgensen , Pascale Louis-Plence , Jean-Marc Brondello
Aging Cell, 2016, 15 (3), pp.400 - 406. ⟨10.1111/acel.12455⟩
Article dans une revue hal-01834241v1
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MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

Andrès Caicedo , Vanessa Fritz , Jean-Marc Brondello , Mickaël Ayala , Indira Dennemont
Scientific Reports, 2015, 5 (1), ⟨10.1038/srep09073⟩
Article dans une revue hal-01834600v1

FOXO3A Regulation by miRNA-29a Controls Chondrogenic Differentiation of Mesenchymal Stem Cells and Cartilage Formation

David Guérit , Jean-Marc Brondello , Paul Chuchana , Didier Philipot , Karine Toupet
Stem Cells and Development, 2014, 23 (11), pp.1195 - 1205. ⟨10.1089/scd.2013.0463⟩
Article dans une revue hal-01836483v1
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p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodelling in osteoarthritis.

Didier Philipot , David Guérit , Daniela Platano , Paul Chuchana , Eleonora Olivotto
Arthritis Research and Therapy, 2014, 16 (1), pp.R58. ⟨10.1186/ar4494⟩
Article dans une revue inserm-00983071v1

Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage

J. Basbous , Dora Knani , Nathalie Bonneaud , Dominique Giorgi , Jean-Marc Brondello
Cell Cycle, 2012, 11 (12), pp.2380-9012. ⟨10.4161/cc.20858⟩
Article dans une revue hal-00705749v1
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Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy.

Claire Vinatier , Carine Bouffi , Christophe Merceron , Jan Gordeladze , Jean-Marc Brondello
Current Stem Cell Research & Therapy, 2009, 4 (4), pp.318-29
Article dans une revue inserm-00423696v1
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Linking PCNA-dependent replication and ATR by human Claspin.

Jean-Marc Brondello , Bernard Ducommun , Anne Fernandez , Ned J. Lamb
Biochemical and Biophysical Research Communications, 2007, 354 (4), pp.1028-33. ⟨10.1016/j.bbrc.2007.01.091⟩
Article dans une revue inserm-00147047v1

DNA damage checkpoint kinase Chk2 triggers replicative senescence

Véronique Gire , Pierre Roux , David Wynford-Thomas , Jean-Marc Brondello , Vjekoslav Dulic
EMBO Journal, 2004, 23 (13), pp.2554-2563. ⟨10.1038/sj.emboj.7600259⟩
Article dans une revue hal-03763012v1