Jean-Jacques LAREYRE
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Documents
Identifiants chercheurs
jean-jacques-lareyre-
0000-0003-0747-0024
- IdRef : 094355177
Présentation
My research aim to better understand molecular mechanisms underlying the sexual maturation (puberty) in fish, particularly in male. The initiation of the male gametogenesis (spermatogenesis) is an important biological process that impacts puberty onset and ultimately fish fertility. Puberty onset depends on the activation of the gonadotrope axis (GnRHs) that ultimately control the release from the pituitary of two gonadotropins named FSH and LH. Both hormones control the two main testicular functions (spermatogeneis and steroidogenesis). Spermatogeneis relies on the balance between renewal and proliferation/differentiation of germ stem cells. The role of the sexual hormones (gonadotropins and gonadotropin induced sexual steroids) in the regulation of this balance remains poorly understood.
My basic research aims to :
- characterize the molecular profile of adult germ stem cells in teleost fish species
- characterize gonadal factors that may be involved in the regulation of germ stem cell fate (germ stem cell renewal or germline differentiation)
- understanding the molecular mechanisms underlying the distinct effects of the sexual hormones (steroids and gonadotropins)
My applied research aims to :
- improve the practicability of germ stem cell grafting
- develop early markers of precocious puberty
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