Recherche - Archive ouverte HAL Accéder directement au contenu

Filtrer vos résultats

58 résultats

Molecular basis of antigen recognition by T lymphocytes

Denis Gerlier , Jean-François Hernandez , Laurent Ettouati , Marie-Claude Biémont-Trescol , Nadia Walchshofer , et al.
31e Rencontres Internationales de Chimie Thérapeutique, Jul 1995, Lyon, France
Communication dans un congrès hal-01709175v1
Image document

Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates

Alice Legru , Federica Verdirosa , Yen Vo-Hoang , Giusy Tassone , Filippo Vascon , et al.
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16392-16419. ⟨10.1021/acs.jmedchem.2c01257⟩
Article dans une revue hal-03978634v1

Stratégies for the solid phase synthesis of arginine derivatives

Jean-François Hernandez
6th Hellenic Forum on Bioactive Peptide, May 2008, Patras, Greece
Communication dans un congrès hal-00347331v1

Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor

E. Ayral , P. Gloanec , Gilbert Berge , G. Nanteuil , P. Mennecier , et al.
Bioorganic and Medicinal Chemistry Letters, 2009, 19 (5), pp.1386-1391. ⟨10.1016/j.bmcl.2009.01.039⟩
Article dans une revue istex hal-00389293v1

Solid phase synthesis of mono- or disubstituted arginine containing peptides from an isothiocitrulline precursor

Abdallah Hamzé , Céline Gandreuil , Florence Andureu , Pierre Fulcrand , Jean-François Hernandez , et al.
Tetrahedon Letters, 2005, 46, pp.7349-7353
Article dans une revue hal-00125643v1
Image document

1,2,4‐Triazole‐3‐Thione Analogues with a 2‐Ethylbenzoic Acid at Position 4 as VIM‐type Metallo‐β‐Lactamase Inhibitors

Federica Verdirosa , Laurent Gavara , Laurent Sevaille , Giusy Tassone , Giuseppina Corsica , et al.
ChemMedChem, 2022, 17 (7), pp.e202100699. ⟨10.1002/cmdc.202100699⟩
Article dans une revue hal-03799357v1

Solid phase synthesis of dipeptidomimetic substrate-based NOS inhibitors through a side-chain anchoring approach

Youness Touati-Jallabe , Abdalah Hamze , Gilbert Bergé , Claudia Verna , Anne-Dominique Lajoix , et al.
20th American Peptide Symposium, Peptides for Youth, Jun 2007, Montreal, Canada. pp.1
Communication dans un congrès hal-00347379v1

Design and characterization of a new cell-permanent inhibitor of the ß-secretase BACE1

Frédéric Checler , Jean-François Hernandez , Solveig Lefranc-Julien , Jean Martinez , Vincent Lisowski
British Journal of Pharmacology, 2005, 2, pp.228-235
Article dans une revue hal-00125453v1
Image document

Taylor Dispersion Analysis and Atomic Force Microscopy Provide a Quantitative Insight into the Aggregation Kinetics of Aβ (1–40)/Aβ (1–42) Amyloid Peptide Mixtures

Mihai Deleanu , Olivier Deschaume , Luca Cipelletti , Jean-François Hernandez , Carmen Bartic , et al.
ACS Chemical Neuroscience, 2022, 13 (6), pp.786-795. ⟨10.1021/acschemneuro.1c00784⟩
Article dans une revue hal-03801189v1
Image document

The HslV Protease from Leishmania major and Its Activation by C-terminal HslU Peptides

Ndeye Kebe , Krishnananda Samanta , Priyanka Singh , Josephine Lai-Kee-Him , Viviana Apicella , et al.
International Journal of Molecular Sciences, 2019, 20 (5), pp.1021. ⟨10.3390/ijms20051021⟩
Article dans une revue hal-02339525v1

JLK Inhibitors : Isocoumarin Compounds as Putative Probes to Selectively Target the gama-Secretase Pathway

Frédéric Checler , Cristine Alves da Costa , Erwan Ayral , David Andrau , Cécile Dumanchin , et al.
Current Alzheimer Research, 2005, 2, pp.327-334
Article dans une revue hal-00125270v1

Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase

Moustapha Alfa Cissé , Céline Gandreuil , Frédéric Checler , Jean-François Hernandez , Jean Martinez , et al.
Biochemical and Biophysical Research Communications, 2006, 347, pp.254-260
Article dans une revue hal-00126118v1

P105 Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity

Olivier Burgy , Guillaume Wettstein , Pierre-Simon Bellaye Bellaye , Nathalie Decologne , Cindy Racoeur , et al.
QJM: An International Journal of Medicine, 2016, 109 (suppl_1), pp.S58. ⟨10.1093/qjmed/hcw120.006⟩
Article dans une revue hal-01512940v1

Structural insights into the design of inhbitors for the L1 metallo-ß-lactamase from Stenotrophomonas maltophilia

Lionel Nauton , Richard Kahn , G. Garau , Jean-François Hernandez , Otto Dideberg
Journal of Molecular Biology, 2008, 1, pp.257-269. ⟨10.1016/j.jmb.2007.10.036⟩
Article dans une revue istex hal-00341669v1

Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cells

G. Sarlak , H.H. Htoo , Jean-François Hernandez , H. Iizasa , F. Checler , et al.
Neuroscience, 2016, 312, pp.153-164. ⟨10.1016/j.neuroscience.2015.11.022⟩
Article dans une revue hal-03564404v1

Melatonin stimulates the nonamyloidogenic processing of β APP through the positive transcriptional regulation of ADAM10 and ADAM17

Mayuri Shukla , Htut Htut Htoo , Phitchayapak Wintachai , Jean-François Hernandez , Claire Dubois , et al.
Journal of Pineal Research, 2015, 58 (2), pp.151-165. ⟨10.1111/jpi.12200⟩
Article dans une revue istex hal-03564177v1

The bacterial-like HslVU protease complex subunits are involved in the control of different cell cycle events in trypanosomatids

Diane-Ethna Mbang-Benet , Yvon Sterkers , Christelle Morelle , Ndeye-Mathy Kebe , Lucien Crobu , et al.
Acta Tropica, 2014, 131, pp.22-31. ⟨10.1016/j.actatropica.2013.11.017⟩
Article dans une revue hal-02518501v1

Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity

O. Burgy , G. Wettstein , P. Bellaye , N. Decologne , C. Racoeur , et al.
Science Translational Medicine, 2016, 8 (326), pp.326ra20 - 326ra20. ⟨10.1126/scitranslmed.aad7785⟩
Article dans une revue hal-01435309v1

Solid phase synthesis of arginine derivatives : cyclic peptides with a guaninidine bridge and NOS inhibitors using a side-chai anchoring approach

Jean-François Hernandez , Youness Touati-Jallabe , Vincent Lisowski , Abdallah Hamze , Gilbert Bergé , et al.
Modern solid phase peptide synthesis & its applicationns, Oct 2007, Port-Douglas, Australia
Communication dans un congrès hal-00347702v1

Les récepteurs muscariniques M1 et M3 induisent le métabolisme physiologique de la PrPc et de la ßAPP en modulant la phosphorylation et l'activité d'ADAM 17

Frédéric Checlerc , Moustapha Alfa Cissé , Claire Sunyach , Babara E Slack , Céline Gandreuil , et al.
9ème Réunion francophone sur la maladie d'Alzheimer et les syndromes apparentés, Nov 2007, Nice, France
Communication dans un congrès hal-00347725v1

Multiscale Surface Self-Assembly of an Amyloid-like Peptide

Mathilde Lepère , Corinne Chevallard , Jean-François Hernandez , Anna Mitraki , Patrick Guenoun
Langmuir, 2007, 23, pp.8150-8155. ⟨10.1021/la701042t⟩
Article dans une revue istex hal-00258831v1
Image document

1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-b-lactamase inhibitors with re-sensitization activity

Alice Legru , Federica Verdirosa , Jean-François Hernandez , Giusi Tassone , Filomena Sannio , et al.
European Journal of Medicinal Chemistry, 2021, 226, pp.113873. ⟨10.1016/j.ejmech.2021.113873⟩
Article dans une revue hal-03719307v1

Structure-Activity Relationships of JMV4463, a Vectorized Cathepsin D Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA-Based Vector

Lubomir Vezenkov , Clément Sanchez , Virginie Bellet , Vincent Martin , Marie Maynadier , et al.
ChemMedChem, 2016, 11 (3), pp.302-308. ⟨10.1002/cmdc.201500457⟩
Article dans une revue istex hal-02388735v1
Image document

Knottin cyclization : impact on structure and dynamics

Annie Heitz , Olga Avrutina , Dung Le-Nguyen , Ulf Diederichsen , Jean-François Hernandez , et al.
BMC Structural Biology, 2008, pp.1-19. ⟨10.1186/1472-6807-8-54⟩
Article dans une revue hal-00389417v1
Image document

Taylor dispersion analysis discloses the impairment of Aβ peptide aggregation by the presence of a fluorescent tag

Mihai Deleanu , Jean-François Hernandez , Hervé Cottet , Joseph Chamieh
Electrophoresis, 2023, 44 (7-8), pp.701-710. ⟨10.1002/elps.202200192⟩
Article dans une revue hal-04243854v1
Image document

N -Acyl Benzotriazole Derivatives for the Synthesis of Dipeptides and Tripeptides and Peptide Biotinylation by Mechanochemistry

Lori Gonnet , Thibault Tintillier , Natacha Venturini , Laure Konnert , Jean-François Hernandez , et al.
ACS Sustainable Chemistry & Engineering, 2017, 5 (4), pp.2936-2941. ⟨10.1021/acssuschemeng.6b02439⟩
Article dans une revue hal-03095301v1

Solid phase synthesis of arginine derivatives

Jean-François Hernandez
Conférence de l'Ecole Doctorale "Sciences chimiques" de l'Université de Florence. Pôle Scientifique, Dpt de Chimie Organique "Ugo Schiff", Apr 2008, Sesto-Florentino, Italy
Communication dans un congrès hal-00347324v1
Image document

4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition

Laurent Gavara , Federica Verdirosa , Alice Legru , Paola Sandra Mercuri , Lionel Nauton , et al.
Biomolecules, 2020, 10 (8), pp.1094. ⟨10.3390/biom10081094⟩
Article dans une revue hal-02997710v1

Solid phase synthesis of cyclic peptides with a guanidine bridge

Jean-François Hernandez , Vincent Lisowski , Youness Touati-Jallabe , Abdallah Hamze , Annie Heitz , et al.
4th International Peptide Symposium in conjunction with 7th Australian Peptide Symposium and 2nd Asia Pacific International Peptide Symposium, 2007, Cairns, Australia. pp.1
Communication dans un congrès hal-00347387v1

Kinetics, inhibition and oligomerization of Epstein-Barr virus protease

Maryse Buisson , Lucie Rivail , Marc Jamin , Rob W.H Ruigrock , Wim P. Burmeister , et al.
FEBS Letters, 2006, 580, pp.6570-6578
Article dans une revue hal-00126209v1