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CV Jean-François Brière


Jean-François BRIERE (06/06/1971) – Directeur de recherche CNRS (DR2)

Laboratoire COBRA (Chimie Organique Bioorganique Réactivité et Analyse)

Université de Rouen Normandie, Bâtiment IRCOF (UMR CNRS 6014, INSA Rouen)

1, rue Tesnière - 76821 Mont Saint Aignan

- ReasearchID: Q-8910-2016; ORCID: 0000-0002-1381-4535

 

 

1998 Docteur en chimie organique à l’université de Rouen – Normandie - France (3 ans)

IRCOF, UMR CNRS 6014 à Mont Saint Aignan, Laboratoire du Prof. Guy Quéguiner

CHIMIE HETEROCYCLIQUE ET SUPRAMOLECULAIRE : « synthèse d’une enzyme artificielle afin d’activer la réaction entre un acide et une amine »

 

1999 Post-doctorant aux Pays-Bas (18 mois du 06/1999 au 09/2000)

Université d'Amsterdam, IMC, Laboratoire du Prof. Henk Hiemstra

SYNTHESE TOTALE: « total synthesis towards solanoeclepin A »

 

2001 Post-doctorant en Belgique (15 mois du 01/2001 au 04/2002)

Université catholique de Louvain, Laboratoire du Prof. Istvan E. Markó

Collaboration avec l’entreprise Rhodia Silicones à Lyon -CATALYSE:

"hydrosilylation catalysées par des complexes Platine/Carbène-N-hétérocyclique"

 

De la formation par la recherche au CNRS

HÉTÉROCYCLIQUES CHIRAUX BIOPERTINANT, SYNTHÈSE ASYMETRIQUE, ORGANOCATALYSE, NOUVELLES BRIQUES MOLÉCULAIRE ET RÉACTIVITÉ

 

2002 Cadre ingénieur de recherche à Lyon (69) (du 04/2002 au 11/2002)

Centre de recherche de l’entreprise Rhodia à Lyon avec encadrement de techniciens.

 

2002 CR2 CNRS au LCMT à Caen – UMR 6507 (12/2002 au 9/2007) - CR1-2006, HDR-2007

Directeur Dr. Patrick Metzner, groupe soufre et phosphore du Dr. Patrick Metzner

Elaboration de sulfures comme catalyseurs (ylures de sulfonium, réaction de MBH).

Sulfures aux propriétés olfactives.

 

2007 CR1 et 2017 DR2 CNRS au laboratoire COBRA à Rouen – UMR 6014 (> 10/2007)

Equipe Hétérocycles (Mutation géographique et thématique)

Animateur de l’axe organocatalyse de l’équipe Hétérocycles

Synthèse organocatalytiques d’hétérocycles chiraux d’intérêt pharmaceutique (Cible RCPG, ligands CB…).

Développement d’architectures à chiralité axiale contrôlée.


Article dans une revue47 documents

  • Andreas Eitzinger, Jean-François Brière, Dominique Cahard, Mario Waser. Enantioselective catalytic synthesis of α-aryl-α-SCF 3 -β 2,2 -amino acids. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18 (3), pp.405-408. ⟨10.1039/c9ob02666e⟩. ⟨hal-02442629⟩
  • Thomas Martzel, Julien Annibaletto, Pierre Millet, Etienne Pair, Morgane Sanselme, et al.. Organocatalytic Multicomponent Synthesis of α/β‐Dipeptide Derivatives. Chemistry - A European Journal, Wiley-VCH Verlag, 2020, 26, pp.8541. ⟨10.1002/chem.202001214⟩. ⟨hal-02523950⟩
  • Ronan Le Goff, Olivier Mahé, Ronan Le Coz-Botrel, Sylvie Malo, Jean-Michel Goupil, et al.. Insight in chitosan aerogels derivatives - Application in catalysis. Reactive and Functional Polymers, Elsevier, 2020, 146, pp.104393. ⟨10.1016/j.reactfunctpolym.2019.104393⟩. ⟨hal-02376706⟩
  • Aurélien Jacquin-Labarre, Sébastien Coufourier, Rodolphe Tamion, Alexandra Le Foll, Vincent Levacher, et al.. Base-Assisted Intramolecular C–N Coupling Reaction from NH 2 -Bound Cyclopalladated L -Phenylalanine to Indoline-2-carboxylic Acid. Organometallics, American Chemical Society, 2020, 39 (5), pp.767-773. ⟨10.1021/acs.organomet.0c00030⟩. ⟨hal-02493098⟩
  • Claire Segovia, Arthur Lebrêne, Vincent Levacher, Sylvain Oudeyer, Jean-François Brière. Enantioselective Catalytic Transformations of Barbituric Acid Derivatives. Catalysts, MDPI, 2019, 9 (2), pp.131. ⟨10.3390/catal9020131⟩. ⟨hal-02197279⟩
  • Thomas Martzel, Julien Annibaletto, Vincent Levacher, Jean-François Brière, Sylvain Oudeyer. C5‐Disubstituted Meldrum’s Acid Derivatives as Platform for the Organocatalytic Synthesis of C3‐Alkylated Dihydrocoumarins. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2019, 361 (5), pp.995-1000. ⟨10.1002/adsc.201801453⟩. ⟨hal-02197276⟩
  • Cécile Soulignac, Benedetta Cornelio, Frédérique Brégier, Franck Le Derf, Jean-François Brière, et al.. Heterogeneous-phase Sonogashira cross-coupling reaction on COC surface for the grafting of biomolecules – Application to isatin. Colloids and Surfaces B: Biointerfaces, Elsevier, 2019, 181, pp.639-647. ⟨10.1016/j.colsurfb.2019.06.001⟩. ⟨hal-02197292⟩
  • Philippe Champetter, Omar Castillo-Aguilera, Catherine Taillier, Jean-François Brière, Vincent Dalla, et al.. N-Alkoxyacrylamides in Domino Reactions: Catalytic and Stereoselective Access to δ-Lactams. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 47, pp.7703-7710. ⟨10.1002/ejoc.201901528⟩. ⟨hal-02376720⟩
  • Floris Buttard, Clément Berthonneau, Marie-Aude Hiebel, Jean-François Brière, Franck Suzenet. Organocatalytic aza-Michael Reaction to 3-Vinyl-1,2,4-triazines as a Valuable Bifunctional Platform. Journal of Organic Chemistry, American Chemical Society, 2019, 84 (6), pp.3702-3714. ⟨10.1021/acs.joc.9b00141⟩. ⟨hal-02197289⟩
  • N. Lespes, E. Pair, C. Maganga, M. Bretier, Vincent Tognetti, et al.. A Unique (3+2) Annulation Reaction between Meldrum's Acid and Nitrones: Mechanistic Insight by ESI-IMS-MS and DFT Studies. Chemistry - A European Journal, Wiley-VCH Verlag, 2018, 24 (16), pp.4086-4093. ⟨10.1002/chem.201705714⟩. ⟨hal-02024514⟩
  • Timothée Cadart, Vincent Levacher, Stéphane Perrio, Jean-François Brière. Construction of Isoxazolidin-5-ones with a Tetrasubstituted Carbon Center: Enantioselective Conjugate Addition Mediated by Phase-Transfer Catalysis. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2018, 360 (7), pp.1499-1509. ⟨10.1002/adsc.201800009⟩. ⟨hal-01830254⟩
  • Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière, Stéphane Perrio. Sulfinate-Organocatalyzed (3+2) Annulation of Allenyl Sulfones with 1,1-Dicyano Olefins in the Presence of a Quaternary Ammonium Phase Transfer Agent. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2018, 360 (14), pp.2696-2706. ⟨10.1002/adsc.201800466⟩. ⟨hal-01850385⟩
  • Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière, Stéphane Perrio. Sulfinate-Organocatalyzed (3+2) Annulation Reaction of Propargyl or Allenyl Sulfones with Activated Imines. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2018, 2018 (36), pp.5069-5073. ⟨10.1002/ejoc.201800749⟩. ⟨hal-01846976⟩
  • Fabien Legros, Thomas Martzel, Jean-François Brière, Sylvain Oudeyer, Vincent Levacher. Organocatalytic Enantioselective Decarboxylative Protonation Reaction of Meldrum's Acid Derivatives under PTC Conditions. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2018, 2018 (17), pp.1975-1983. ⟨10.1002/ejoc.201800331⟩. ⟨hal-02024511⟩
  • Jabrane Jouha, Floris Buttard, Magali Lorion, Clément Berthonneau, Mostafa Khouili, et al.. Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines. Organic Letters, American Chemical Society, 2017, 19 (18), pp.4770-4773. ⟨10.1021/acs.orglett.7b02132⟩. ⟨hal-02046286⟩
  • J. Annibaletto, Sylvain Oudeyer, Vincent Levacher, Jean-François Brière. Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones. SYNTHESIS, Georg Thieme Verlag, 2017, 49 (10), pp.2117-2128. ⟨10.1055/s-0036-1588765⟩. ⟨hal-02046255⟩
  • Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière, Stéphane Perrio. Unique Reactivity of α-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2017, 359 (1), pp.96-106. ⟨10.1002/adsc.201600929⟩. ⟨hal-01830252⟩
  • Clément Berthonneau, F. Buttard, M.-A. Hiebel, F. Suzenet, Jean-François Brière. Organocatalyzed Thia-Michael Addition and Sequential Inverse Electron Demanding Diels-Alder Reaction to 3-Vinyl-1,2,4- triazine Platforms. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2017, 359 (23), pp.4106-4110. ⟨10.1002/adsc.201700831⟩. ⟨hal-02046260⟩
  • Alexandra Le Foll, Emmanuel Deau, Emilie Corrot, Laurent Bischoff, Vincent Levacher, et al.. A Meldrum's Acid Based Multicomponent Synthesis of N‐Fmoc‐isoxazolidin‐5‐ones: Entry to N‐Fmoc‐β‐amino Acids. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2017, 2017 (22), pp.3265-3273. ⟨10.1002/ejoc.201700472⟩. ⟨hal-02046289⟩
  • Timothée Cadart, Clément Berthonneau, Vincent Levacher, Stéphane Perrio, Jean-François Brière. Enantioselective Phase-Transfer Catalyzed α-Sulfanylation of Isoxazolidin-5-ones: An Entry to β 2,2 -Amino Acid Derivatives. Chemistry - A European Journal, Wiley-VCH Verlag, 2016, 22 (43), pp.15261-15264. ⟨10.1002/chem.201603910⟩. ⟨hal-01830257⟩
  • Etienne Pair, Timothée Cadart, Vincent Levacher, Jean-François Brière. Meldrum's Acid: A Useful Platform in Asymmetric Organocatalysis. ChemCatChem, Wiley, 2016, 8 (11), pp.1882-1890. ⟨10.1002/cctc.201600247⟩. ⟨hal-02046231⟩
  • Christophe Berini, Muriel Sebban, Hassan Oulyadi, Morgane Sanselme, Vincent Levacher, et al.. Organocatalyzed Multicomponent Synthesis of Isoxazolidin-5-ones. Organic Letters, American Chemical Society, 2015, 17 (21), pp.5408-5411. ⟨10.1021/acs.orglett.5b02755⟩. ⟨hal-02046141⟩
  • Magali Lorion, Gerald Guillaumet, Jean-François Brière, Franck Suzenet. Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels–Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms. Organic Letters, American Chemical Society, 2015, 17 (12), pp.3154-3157. ⟨10.1021/acs.orglett.5b01487⟩. ⟨hal-01167194⟩
  • Etienne Pair, Vincent Levacher, Jean-François Brière. Modified multicomponent Biginelli–Atwal reaction towards a straightforward construction of 5,6-dihydropyrimidin-4-ones. RSC Advances, Royal Society of Chemistry, 2015, 5 (57), pp.46267-46271. ⟨10.1039/c5ra08792a⟩. ⟨hal-01158390⟩
  • Olivier Mahé, Jean-François Brière, Isabelle Dez. Chitosan: an Upgraded Polysaccharide Waste for Organocatalysis. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, 2015 (12), pp.2559-2578. ⟨10.1002/ejoc.201403396⟩. ⟨hal-01148499⟩
  • Rosmara Mansueto, Leonardo Degennaro, Jean-François Brière, Karen Griffin, Michael Shipman, et al.. Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: investigation into the role of the aziridine nitrogen stereodynamics. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (42), pp.8505-8511. ⟨10.1039/c4ob01457j⟩. ⟨hal-01141457⟩
  • Etienne Pair, Christophe Berini, Romain Noël, Morgane Sanselme, Vincent Levacher, et al.. Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach. Chemical Communications, Royal Society of Chemistry, 2014, 50 (71), pp.10218-10221. ⟨10.1039/c4cc04852k⟩. ⟨hal-01141340⟩
  • Sylvain Laclef, Catherine Taillier, Christine Penloup, Aurélie Viger, Jean-François Brière, et al.. Scalable asymmetric synthesis of a key fragment of Bcl-2/Bcl-xL inhibitors †. RSC Advances, Royal Society of Chemistry, 2014, 4 (75), pp.39817-39821. ⟨10.1039/c4ra07821g⟩. ⟨hal-01141445⟩
  • Romain Noël, Vincent Gembus, Vincent Levacher, Jean-François Brière. Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (8), pp.1245-1249. ⟨10.1039/C3OB42406E⟩. ⟨hal-01141350⟩
  • Sylvain Oudeyer, Jean-François Brière, Vincent Levacher. Progress in Catalytic Asymmetric Protonation. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2014, 2014 (28), pp.6103-6119. ⟨10.1002/ejoc.201402213⟩. ⟨hal-01141335⟩
  • Svetlana Postikova, Mohamad Sabbah, Daniel Wightman, Ich Tuan Nguyen, Morgane Sanselme, et al.. Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.. Journal of Organic Chemistry, American Chemical Society, 2013, 78 (16), pp.8191-8197. ⟨10.1021/jo401259w⟩. ⟨hal-00997427⟩
  • Tony Tite, Mohamad Sabbah, Vincent Levacher, Jean-François Brière. Organocatalysed decarboxylative protonation process from Meldrum's acid: enantioselective synthesis of isoxazolidinones.. Chemical Communications, Royal Society of Chemistry, 2013, 49 (98), pp.11569-11571. ⟨10.1039/c3cc47695b⟩. ⟨hal-00997428⟩
  • Svetlana Postikova, Tony Tite, Vincent Levacher, Jean-François Brière. Organocatalyzed Synthesis of Isoxazolidin-5-ones: The Meldrum's Acid Approach. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2013, 355 (13), pp.2513-2517. ⟨10.1002/adsc.201300465⟩. ⟨hal-01015420⟩
  • Vincent Gembus, Solenn Janvier, Jean-Pierre Lecouvé, Lucile Vaysse-Ludot, Jean-François Brière, et al.. Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (10), pp.2003-2007. ⟨10.1039/c2ob06762e⟩. ⟨hal-00997078⟩
  • Jean-François Brière, Sylvain Oudeyer, Vincent Dalla, Vincent Levacher. Recent advances in cooperative ion pairing in asymmetric organocatalysis. Chemical Society Reviews, Royal Society of Chemistry, 2012, 41 (5), pp.1696-1707. ⟨10.1039/c1cs15200a⟩. ⟨hal-00997086⟩
  • Olivier Mahé, Isabelle Dez, Vincent Levacher, Jean-François Brière. Enantioselective synthesis of bio-relevant 3,5-diaryl pyrazolines. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (19), pp.3946-3954. ⟨10.1039/c2ob25227a⟩. ⟨hal-00997072⟩
  • Vincent Gembus, Christophe Furman, Régis Millet, Roxane Mansouri, Philippe Chavatte, et al.. Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.. European Journal of Medicinal Chemistry, Elsevier, 2012, 58, pp.396-404. ⟨10.1016/j.ejmech.2012.10.031⟩. ⟨hal-00997079⟩
  • Vincent Gembus, Svetlana Postikova, Vincent Levacher, Jean-François Brière. Highly regio- and diastereoselective anionic [3 + 2] cycloaddition under phase transfer catalytic conditions.. Journal of Organic Chemistry, American Chemical Society, 2011, 76 (10), pp.4194-4199. ⟨10.1021/jo2005268⟩. ⟨hal-00992154⟩
  • Vincent Gembus, Jean-Jacques Bonnet, François Janin, Pierre Bohn, Vincent Levacher, et al.. Synthesis of pyrazolines by a site isolated resin-bound reagents methodology. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, 8 (14), pp.3287-3293. ⟨10.1039/c004704j⟩. ⟨hal-00992140⟩
  • Olivier Mahé, Isabelle Dez, Vincent Levacher, Jean-François Brière. Enantioselective phase-transfer catalysis: synthesis of pyrazolines.. Angewandte Chemie (English Edition), John Wiley & Sons, 2010, 49 (39), pp.7072-7075. ⟨10.1002/anie.201002485⟩. ⟨hal-00992138⟩
  • Olivier Mahé, Denis Frath, Isabelle Dez, Francis Marsais, Vincent Levacher, et al.. TBD-organocatalysed synthesis of pyrazolines. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2009, 7 (18), pp.3648-3651. ⟨10.1039/b911577c⟩. ⟨hal-01915860⟩
  • Benjamin Lefranc, Alain Valla, Krishna Ethiraj, Jean-Noel Jaubert, Patrick Metzner, et al.. Synthesis and Evaluation of Enantiopure 6-Thiabicyclo[3.2.1]octanes for Asymmetric Epoxidation of Benzaldehyde. SYNLETT, Georg Thieme Verlag, 2008, 2008 (11), pp.1679-1683. ⟨10.1055/s-2008-1077878⟩. ⟨hal-01939333⟩
  • J.F. Brière, Pascale Pracros, A.Y. Le Roux, J.S. Pierre. A novel rate model of temperature-dependent development for arthropods. Environmental Entomology, Entomological Society of America, 1999, 28 (1), pp.22-29. ⟨hal-02693593⟩
  • J.F. Brière, Pascale Pracros. Un nouveau modèle pour lutter contre l'Eudémis : prévoir pour mieux maîtriser. Union Girondine des Vins de Bordeaux, 1998, pp.24-25. ⟨hal-02690610⟩
  • J.F. Brière, Pascale Pracros. Comparison of temperature-dependent growth models with the development of Lobesia botrana (Lepidoptera : Tortricidae). Environmental Entomology, Entomological Society of America, 1998, 27 (1), pp.94-101. ⟨hal-02698672⟩
  • J.F. Brière, Pascale Pracros. Risques d'Eudémis. Une avancée dans la modélisation quantitative. Viti, 1998, 227 (2), pp.18-20. ⟨hal-02692465⟩
  • J.F. Brière, Pascale Pracros, J. Stöckel. Nouvelle conception de la modélisation de l'Eudémis : une prévision des niveaux et des périodes de risques. ADALIA Bulletin d'information technique Club Protection Raisonnée, 1995, pp.16-18. ⟨hal-02705738⟩

Chapitre d'ouvrage1 document

  • Sylvain Oudeyer, Vincent Levacher, Jean-François Brière. Chiral Quaternary Ammonium Salts in Organocatalysis. Maxime R. Vitale; Sylvain Oudeyer; Vincent Levacher; Jean-Francois Briere. Radical and ion-pairing strategies in asymmetric organocatalysis, ISTE Press; Elsevier, pp.87-173, 2017, 978-1-78548-127-7. ⟨10.1016/B978-1-78548-127-7.50002-2⟩. ⟨hal-02024983⟩