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CV Jean-François Brière

Jean-François BRIERE (06/06/1971) – Directeur de recherche CNRS (DR2)

Laboratoire COBRA (Chimie Organique Bioorganique Réactivité et Analyse)

Université de Rouen Normandie, Bâtiment IRCOF (UMR CNRS 6014, INSA Rouen)

1, rue Tesnière - 76821 Mont Saint Aignan

- ReasearchID: Q-8910-2016; ORCID: 0000-0002-1381-4535

 

 

• 1998 Docteur en chimie organique à l’université de Rouen – Normandie - France (3 ans)

▪ IRCOF, UMR CNRS 6014 à Mont Saint Aignan, Laboratoire du Prof. Guy Quéguiner

▪ CHIMIE HETEROCYCLIQUE ET SUPRAMOLECULAIRE : « synthèse d’une enzyme artificielle afin d’activer la réaction entre un acide et une amine »

 

• 1999 Post-doctorant aux Pays-Bas (18 mois du 06/1999 au 09/2000)

▪ Université d'Amsterdam, IMC, Laboratoire du Prof. Henk Hiemstra

▪ SYNTHESE TOTALE: « total synthesis towards solanoeclepin A »

 

• 2001 Post-doctorant en Belgique (15 mois du 01/2001 au 04/2002)

▪ Université catholique de Louvain, Laboratoire du Prof. Istvan E. Markó

▪ Collaboration avec l’entreprise Rhodia Silicones à Lyon -CATALYSE:

"hydrosilylation catalysées par des complexes Platine/Carbène-N-hétérocyclique"

 

De la formation par la recherche au CNRS

HÉTÉROCYCLIQUES CHIRAUX BIOPERTINANT, SYNTHÈSE ASYMETRIQUE, ORGANOCATALYSE, NOUVELLES BRIQUES MOLÉCULAIRE ET RÉACTIVITÉ

 

• 2002 Cadre ingénieur de recherche à Lyon (69) (du 04/2002 au 11/2002)

▪ Centre de recherche de l’entreprise Rhodia à Lyon avec encadrement de techniciens.

 

• 2002 CR2 CNRS au LCMT à Caen – UMR 6507 (12/2002 au 9/2007) - CR1-2006, HDR-2007

▪ Directeur Dr. Patrick Metzner, groupe soufre et phosphore du Dr. Patrick Metzner

▪ Elaboration de sulfures comme catalyseurs (ylures de sulfonium, réaction de MBH).

▪ Sulfures aux propriétés olfactives.

 

• 2007 CR1 et 2017 DR2 CNRS au laboratoire COBRA à Rouen – UMR 6014 (> 10/2007)

▪ Equipe Hétérocycles (Mutation géographique et thématique)

▪Animateur de l’axe organocatalyse de l’équipe Hétérocycles

▪ Synthèse organocatalytiques d’hétérocycles chiraux d’intérêt pharmaceutique (Cible RCPG, ligands CB…).

▪ Développement d’architectures à chiralité axiale contrôlée.

Journal articles48 documents

  • Ronan Le Goff, Olivier Mahé, Ronan Le Coz-Botrel, Sylvie Malo, Jean-Michel Goupil, et al.. Insight in chitosan aerogels derivatives - Application in catalysis. Reactive and Functional Polymers, Elsevier, 2020, 146, pp.104393. ⟨10.1016/j.reactfunctpolym.2019.104393⟩. ⟨hal-02376706⟩
  • Aurélien Jacquin-Labarre, Sébastien Coufourier, Rodolphe Tamion, Alexandra Le Foll, Vincent Levacher, et al.. Base-Assisted Intramolecular C–N Coupling Reaction from NH 2 -Bound Cyclopalladated L -Phenylalanine to Indoline-2-carboxylic Acid. Organometallics, American Chemical Society, 2020, 39 (5), pp.767-773. ⟨10.1021/acs.organomet.0c00030⟩. ⟨hal-02493098⟩
  • Andreas Eitzinger, Jean-François Brière, Dominique Cahard, Mario Waser. Enantioselective catalytic synthesis of α-aryl-α-SCF 3 -β 2,2 -amino acids. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18 (3), pp.405-408. ⟨10.1039/c9ob02666e⟩. ⟨hal-02442629⟩
  • Antonio Macchia, Andreas Eitzinger, Jean-François Brière, Mario Waser, Antonio Massa. Asymmetric Synthesis of Isoxazol-5-ones and Isoxazolidin-5-ones. SYNTHESIS, Georg Thieme Verlag, 2020, ⟨10.1055/s-0040-1706483⟩. ⟨hal-03037370⟩
  • Thomas Martzel, Julien Annibaletto, Pierre Millet, Etienne Pair, Morgane Sanselme, et al.. Organocatalytic Multicomponent Synthesis of α/β‐Dipeptide Derivatives. Chemistry - A European Journal, Wiley-VCH Verlag, 2020, 26, pp.8541. ⟨10.1002/chem.202001214⟩. ⟨hal-02523950⟩
  • Floris Buttard, Clément Berthonneau, Marie-Aude Hiebel, Jean-François Brière, Franck Suzenet. Organocatalytic aza-Michael Reaction to 3-Vinyl-1,2,4-triazines as a Valuable Bifunctional Platform. Journal of Organic Chemistry, American Chemical Society, 2019, 84 (6), pp.3702-3714. ⟨10.1021/acs.joc.9b00141⟩. ⟨hal-02197289⟩
  • Claire Segovia, Arthur Lebrêne, Vincent Levacher, Sylvain Oudeyer, Jean-François Brière. Enantioselective Catalytic Transformations of Barbituric Acid Derivatives. Catalysts, MDPI, 2019, 9 (2), pp.131. ⟨10.3390/catal9020131⟩. ⟨hal-02197279⟩
  • Philippe Champetter, Omar Castillo-Aguilera, Catherine Taillier, Jean-François Brière, Vincent Dalla, et al.. N-Alkoxyacrylamides in Domino Reactions: Catalytic and Stereoselective Access to δ-Lactams. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 47, pp.7703-7710. ⟨10.1002/ejoc.201901528⟩. ⟨hal-02376720⟩
  • Cécile Soulignac, Benedetta Cornelio, Frédérique Brégier, Franck Le Derf, Jean-François Brière, et al.. Heterogeneous-phase Sonogashira cross-coupling reaction on COC surface for the grafting of biomolecules – Application to isatin. Colloids and Surfaces B: Biointerfaces, Elsevier, 2019, 181, pp.639-647. ⟨10.1016/j.colsurfb.2019.06.001⟩. ⟨hal-02197292⟩
  • Thomas Martzel, Julien Annibaletto, Vincent Levacher, Jean-François Brière, Sylvain Oudeyer. C5‐Disubstituted Meldrum’s Acid Derivatives as Platform for the Organocatalytic Synthesis of C3‐Alkylated Dihydrocoumarins. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2019, 361 (5), pp.995-1000. ⟨10.1002/adsc.201801453⟩. ⟨hal-02197276⟩
  • Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière, Stéphane Perrio. Sulfinate-Organocatalyzed (3+2) Annulation Reaction of Propargyl or Allenyl Sulfones with Activated Imines. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2018, 2018 (36), pp.5069-5073. ⟨10.1002/ejoc.201800749⟩. ⟨hal-01846976⟩
  • Fabien Legros, Thomas Martzel, Jean-François Brière, Sylvain Oudeyer, Vincent Levacher. Organocatalytic Enantioselective Decarboxylative Protonation Reaction of Meldrum's Acid Derivatives under PTC Conditions. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2018, 2018 (17), pp.1975-1983. ⟨10.1002/ejoc.201800331⟩. ⟨hal-02024511⟩
  • N. Lespes, E. Pair, C. Maganga, M. Bretier, Vincent Tognetti, et al.. A Unique (3+2) Annulation Reaction between Meldrum's Acid and Nitrones: Mechanistic Insight by ESI-IMS-MS and DFT Studies. Chemistry - A European Journal, Wiley-VCH Verlag, 2018, 24 (16), pp.4086-4093. ⟨10.1002/chem.201705714⟩. ⟨hal-02024514⟩
  • Timothée Cadart, Vincent Levacher, Stéphane Perrio, Jean-François Brière. Construction of Isoxazolidin-5-ones with a Tetrasubstituted Carbon Center: Enantioselective Conjugate Addition Mediated by Phase-Transfer Catalysis. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2018, 360 (7), pp.1499-1509. ⟨10.1002/adsc.201800009⟩. ⟨hal-01830254⟩
  • Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière, Stéphane Perrio. Sulfinate-Organocatalyzed (3+2) Annulation of Allenyl Sulfones with 1,1-Dicyano Olefins in the Presence of a Quaternary Ammonium Phase Transfer Agent. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2018, 360 (14), pp.2696-2706. ⟨10.1002/adsc.201800466⟩. ⟨hal-01850385⟩
  • Jabrane Jouha, Floris Buttard, Magali Lorion, Clément Berthonneau, Mostafa Khouili, et al.. Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines. Organic Letters, American Chemical Society, 2017, 19 (18), pp.4770-4773. ⟨10.1021/acs.orglett.7b02132⟩. ⟨hal-02046286⟩
  • Alexandra Le Foll, Emmanuel Deau, Emilie Corrot, Laurent Bischoff, Vincent Levacher, et al.. A Meldrum's Acid Based Multicomponent Synthesis of N‐Fmoc‐isoxazolidin‐5‐ones: Entry to N‐Fmoc‐β‐amino Acids. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2017, 2017 (22), pp.3265-3273. ⟨10.1002/ejoc.201700472⟩. ⟨hal-02046289⟩
  • Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière, Stéphane Perrio. Unique Reactivity of α-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2017, 359 (1), pp.96-106. ⟨10.1002/adsc.201600929⟩. ⟨hal-01830252⟩
  • Clément Berthonneau, F. Buttard, M.-A. Hiebel, F. Suzenet, Jean-François Brière. Organocatalyzed Thia-Michael Addition and Sequential Inverse Electron Demanding Diels-Alder Reaction to 3-Vinyl-1,2,4- triazine Platforms. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2017, 359 (23), pp.4106-4110. ⟨10.1002/adsc.201700831⟩. ⟨hal-02046260⟩
  • J. Annibaletto, Sylvain Oudeyer, Vincent Levacher, Jean-François Brière. Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones. SYNTHESIS, Georg Thieme Verlag, 2017, 49 (10), pp.2117-2128. ⟨10.1055/s-0036-1588765⟩. ⟨hal-02046255⟩
  • Etienne Pair, Timothée Cadart, Vincent Levacher, Jean-François Brière. Meldrum's Acid: A Useful Platform in Asymmetric Organocatalysis. ChemCatChem, Wiley, 2016, 8 (11), pp.1882-1890. ⟨10.1002/cctc.201600247⟩. ⟨hal-02046231⟩
  • Timothée Cadart, Clément Berthonneau, Vincent Levacher, Stéphane Perrio, Jean-François Brière. Enantioselective Phase-Transfer Catalyzed α-Sulfanylation of Isoxazolidin-5-ones: An Entry to β 2,2 -Amino Acid Derivatives. Chemistry - A European Journal, Wiley-VCH Verlag, 2016, 22 (43), pp.15261-15264. ⟨10.1002/chem.201603910⟩. ⟨hal-01830257⟩
  • Christophe Berini, Muriel Sebban, Hassan Oulyadi, Morgane Sanselme, Vincent Levacher, et al.. Organocatalyzed Multicomponent Synthesis of Isoxazolidin-5-ones. Organic Letters, American Chemical Society, 2015, 17 (21), pp.5408-5411. ⟨10.1021/acs.orglett.5b02755⟩. ⟨hal-02046141⟩
  • Magali Lorion, Gerald Guillaumet, Jean-François Brière, Franck Suzenet. Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels–Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms. Organic Letters, American Chemical Society, 2015, 17 (12), pp.3154-3157. ⟨10.1021/acs.orglett.5b01487⟩. ⟨hal-01167194⟩
  • Olivier Mahé, Jean-François Brière, Isabelle Dez. Chitosan: an Upgraded Polysaccharide Waste for Organocatalysis. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, 2015 (12), pp.2559-2578. ⟨10.1002/ejoc.201403396⟩. ⟨hal-01148499⟩
  • Etienne Pair, Vincent Levacher, Jean-François Brière. Modified multicomponent Biginelli–Atwal reaction towards a straightforward construction of 5,6-dihydropyrimidin-4-ones. RSC Advances, Royal Society of Chemistry, 2015, 5 (57), pp.46267-46271. ⟨10.1039/c5ra08792a⟩. ⟨hal-01158390⟩
  • Rosmara Mansueto, Leonardo Degennaro, Jean-François Brière, Karen Griffin, Michael Shipman, et al.. Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: investigation into the role of the aziridine nitrogen stereodynamics. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (42), pp.8505-8511. ⟨10.1039/c4ob01457j⟩. ⟨hal-01141457⟩
  • Sylvain Oudeyer, Jean-François Brière, Vincent Levacher. Progress in Catalytic Asymmetric Protonation. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2014, 2014 (28), pp.6103-6119. ⟨10.1002/ejoc.201402213⟩. ⟨hal-01141335⟩
  • Etienne Pair, Christophe Berini, Romain Noël, Morgane Sanselme, Vincent Levacher, et al.. Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach. Chemical Communications, Royal Society of Chemistry, 2014, 50 (71), pp.10218-10221. ⟨10.1039/c4cc04852k⟩. ⟨hal-01141340⟩
  • Sylvain Laclef, Catherine Taillier, Christine Penloup, Aurélie Viger, Jean-François Brière, et al.. Scalable asymmetric synthesis of a key fragment of Bcl-2/Bcl-xL inhibitors †. RSC Advances, Royal Society of Chemistry, 2014, 4 (75), pp.39817-39821. ⟨10.1039/c4ra07821g⟩. ⟨hal-01141445⟩
  • Romain Noël, Vincent Gembus, Vincent Levacher, Jean-François Brière. Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (8), pp.1245-1249. ⟨10.1039/C3OB42406E⟩. ⟨hal-01141350⟩
  • Svetlana Postikova, Mohamad Sabbah, Daniel Wightman, Ich Tuan Nguyen, Morgane Sanselme, et al.. Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.. Journal of Organic Chemistry, American Chemical Society, 2013, 78 (16), pp.8191-8197. ⟨10.1021/jo401259w⟩. ⟨hal-00997427⟩
  • Tony Tite, Mohamad Sabbah, Vincent Levacher, Jean-François Brière. Organocatalysed decarboxylative protonation process from Meldrum's acid: enantioselective synthesis of isoxazolidinones.. Chemical Communications, Royal Society of Chemistry, 2013, 49 (98), pp.11569-11571. ⟨10.1039/c3cc47695b⟩. ⟨hal-00997428⟩
  • Svetlana Postikova, Tony Tite, Vincent Levacher, Jean-François Brière. Organocatalyzed Synthesis of Isoxazolidin-5-ones: The Meldrum's Acid Approach. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2013, 355 (13), pp.2513-2517. ⟨10.1002/adsc.201300465⟩. ⟨hal-01015420⟩
  • Vincent Gembus, Solenn Janvier, Jean-Pierre Lecouvé, Lucile Vaysse-Ludot, Jean-François Brière, et al.. Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (10), pp.2003-2007. ⟨10.1039/c2ob06762e⟩. ⟨hal-00997078⟩
  • Jean-François Brière, Sylvain Oudeyer, Vincent Dalla, Vincent Levacher. Recent advances in cooperative ion pairing in asymmetric organocatalysis. Chemical Society Reviews, Royal Society of Chemistry, 2012, 41 (5), pp.1696-1707. ⟨10.1039/c1cs15200a⟩. ⟨hal-00997086⟩
  • Olivier Mahé, Isabelle Dez, Vincent Levacher, Jean-François Brière. Enantioselective synthesis of bio-relevant 3,5-diaryl pyrazolines. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (19), pp.3946-3954. ⟨10.1039/c2ob25227a⟩. ⟨hal-00997072⟩
  • Vincent Gembus, Christophe Furman, Régis Millet, Roxane Mansouri, Philippe Chavatte, et al.. Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.. European Journal of Medicinal Chemistry, Elsevier, 2012, 58, pp.396-404. ⟨10.1016/j.ejmech.2012.10.031⟩. ⟨hal-00997079⟩
  • Vincent Gembus, Svetlana Postikova, Vincent Levacher, Jean-François Brière. Highly regio- and diastereoselective anionic [3 + 2] cycloaddition under phase transfer catalytic conditions.. Journal of Organic Chemistry, American Chemical Society, 2011, 76 (10), pp.4194-4199. ⟨10.1021/jo2005268⟩. ⟨hal-00992154⟩
  • Olivier Mahé, Isabelle Dez, Vincent Levacher, Jean-François Brière. Enantioselective phase-transfer catalysis: synthesis of pyrazolines.. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2010, 49 (39), pp.7072-7075. ⟨10.1002/anie.201002485⟩. ⟨hal-00992138⟩
  • Vincent Gembus, Jean-Jacques Bonnet, François Janin, Pierre Bohn, Vincent Levacher, et al.. Synthesis of pyrazolines by a site isolated resin-bound reagents methodology. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, 8 (14), pp.3287-3293. ⟨10.1039/c004704j⟩. ⟨hal-00992140⟩
  • Olivier Mahé, Denis Frath, Isabelle Dez, Francis Marsais, Vincent Levacher, et al.. TBD-organocatalysed synthesis of pyrazolines. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2009, 7 (18), pp.3648-3651. ⟨10.1039/b911577c⟩. ⟨hal-01915860⟩
  • Benjamin Lefranc, Alain Valla, Krishna Ethiraj, Jean-Noel Jaubert, Patrick Metzner, et al.. Synthesis and Evaluation of Enantiopure 6-Thiabicyclo[3.2.1]octanes for Asymmetric Epoxidation of Benzaldehyde. SYNLETT, Georg Thieme Verlag, 2008, 2008 (11), pp.1679-1683. ⟨10.1055/s-2008-1077878⟩. ⟨hal-01939333⟩
  • J.F. Brière, Pascale Pracros, A.Y. Le Roux, J.S. Pierre. A novel rate model of temperature-dependent development for arthropods. Environmental Entomology, Entomological Society of America, 1999, 28 (1), pp.22-29. ⟨hal-02693593⟩
  • J.F. Brière, Pascale Pracros. Comparison of temperature-dependent growth models with the development of Lobesia botrana (Lepidoptera : Tortricidae). Environmental Entomology, Entomological Society of America, 1998, 27 (1), pp.94-101. ⟨hal-02698672⟩
  • J.F. Brière, Pascale Pracros. Risques d'Eudémis. Une avancée dans la modélisation quantitative. Viti, 1998, 227 (2), pp.18-20. ⟨hal-02692465⟩
  • J.F. Brière, Pascale Pracros. Un nouveau modèle pour lutter contre l'Eudémis : prévoir pour mieux maîtriser. Union Girondine des Vins de Bordeaux, 1998, pp.24-25. ⟨hal-02690610⟩
  • J.F. Brière, Pascale Pracros, J. Stöckel. Nouvelle conception de la modélisation de l'Eudémis : une prévision des niveaux et des périodes de risques. ADALIA Bulletin d'information technique Club Protection Raisonnée, 1995, pp.16-18. ⟨hal-02705738⟩

Book sections1 document

  • Sylvain Oudeyer, Vincent Levacher, Jean-François Brière. Chiral Quaternary Ammonium Salts in Organocatalysis. Maxime R. Vitale; Sylvain Oudeyer; Vincent Levacher; Jean-Francois Briere. Radical and ion-pairing strategies in asymmetric organocatalysis, ISTE Press; Elsevier, pp.87-173, 2017, 978-1-78548-127-7. ⟨10.1016/B978-1-78548-127-7.50002-2⟩. ⟨hal-02024983⟩