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Regulation of T-type calcium channels: Signalling pathways and functional implications

Sylvaine Huc-Brandt , Arnaud Monteil , Isabelle Bidaud , Guillaume Barbara , Jean Chemin , et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1793 (6), pp.947-952. ⟨10.1016/j.bbamcr.2008.11.003⟩
Article dans une revue hal-02282056v1

Deciphering pathogenic mechanisms underlying human calcium channelopathies

Philippe Lory , Jean Chemin , Arnaud Monteil , Nathalie C. Guérineau , Sophie Nicole , et al.
Congrès de la Société Française de Physiologie, Jun 2019, Montpellier, France
Communication dans un congrès hal-03020963v1

Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties

Iulia Blesneac , Jean Chemin , Isabelle Bidaud , Sylvaine Huc-Brandt , Franck Vandermoere , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (44), pp.13705-10. ⟨10.1073/pnas.1511740112⟩
Article dans une revue hal-02064367v1
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The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β‐cell line

Leigh Anne Swayne , Alexandre Mezghrani , Annie Varrault , Jean Chemin , Gyslaine Bertrand , et al.
EMBO Reports, 2009, 10 (8), pp.873 - 880. ⟨10.1038/embor.2009.125⟩
Article dans une revue hal-03760963v1

A novel Nav1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity

Pascale Malapert , Guillaume Robert , Elena Brunet , Jean Chemin , Emmanuel Bourinet , et al.
iScience, 2024, 27 (4), pp.109396. ⟨10.1016/j.isci.2024.109396⟩
Article dans une revue hal-04525325v1
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Activity-dependent regulation of T-type calcium channels by submembrane calcium ions

Magali Cazade , Isabelle Bidaud , Philippe Lory , Jean Chemin
Article dans une revue hal-02440428v1
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The impact of C-tactile low-threshold mechanoreceptors on affective touch and social interactions in mice

Damien Huzard , Miquel Martin , François Maingret , Jean Chemin , Freddy Jeanneteau , et al.
Science Advances , 2022, 8 (26), pp.101-110. ⟨10.1126/sciadv.abo7566⟩
Article dans une revue hal-03714603v1
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Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate.

Véronique Juvin , Aubin Penna , Jean Chemin , Yea-Lih Lin , François-A Rassendren
Molecular Pharmacology, 2007, 72 (5), pp.1258-68. ⟨10.1124/mol.107.037044⟩
Article dans une revue inserm-00320694v1
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A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels

Jean Chemin , Tamara Timic Stamenic , Magali Cazade , Iulia Blesneac , Jodie Llinares , et al.
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-52194-6⟩
Article dans une revue hal-02348120v1
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T-Type Calcium Channel Inhibition Underlies the Analgesic Effects of the Endogenous Lipoamino Acids

Guillaume Barbara , Abdelkrim Alloui , J. Nargeot , Philippe Lory , Alain Eschalier , et al.
Journal of Neuroscience, 2009, 29 (42), pp.13106-13114. ⟨10.1523/JNEUROSCI.2919-09.2009⟩
Article dans une revue hal-03760947v1
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Modulation of T-type Ca2+ channels by Lavender and Rosemary extracts

Chaymae El Alaoui , Jean Chemin , Taoufiq Fechtali , Philippe Lory
PLoS ONE, 2017, 12 (10), pp.e0186864. ⟨10.1371/journal.pone.0186864⟩
Article dans une revue hal-02059065v1
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Peptidomimetic Targeting of Cavbeta2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function

Francesca Rusconi , Paola Ceriotti , Michele Miragoli , Pierluigi Carullo , Nicolò Salvarani , et al.
Circulation, 2016, 134 (7), pp.534--46. ⟨10.1161/CIRCULATIONAHA.116.021347⟩
Article dans une revue hal-01941170v1

Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine

Pietro Mesirca , Jean Chemin , Christian Barrère , Eleonora Torre , Laura Gallot , et al.
Nature Communications, 2024, 15 (1), pp.54. ⟨10.1038/s41467-023-43502-w⟩
Article dans une revue hal-04385916v1
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PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane.

Aubin Penna , Véronique Juvin , Jean Chemin , Vincent Compan , Michael Monet , et al.
Cell Calcium, 2006, 39 (6), pp.495-507. ⟨10.1016/j.ceca.2006.01.009⟩
Article dans une revue inserm-00320745v1
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Cav3.2 calcium channels: the key protagonist of the supraspinal effect of paracetamol

Nicolas Kerckhove , Christophe Mallet , Amaury François , Mathieu Boudes , Jean Chemin , et al.
Pain, 2014, 155 (4), pp.764-772. ⟨10.1016/j.pain.2014.01.015⟩
Article dans une revue hal-02356344v1

Modulation of T-type calcium channels by bioactive lipids

Jean Chemin , Magali Cazade , Philippe Lory
Pflügers Archiv European Journal of Physiology, 2014, 466 (4), pp.689--700. ⟨10.1007/s00424-014-1467-5⟩
Article dans une revue hal-01943333v1
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Cross-modulation and molecular interaction at the Cav3.3 protein between the endogenous lipids and the T-type calcium channel antagonist TTA-A2

Magali Cazade , Cindy E. Nuss , Isabelle Bidaud , J. J. Renger , V. N. Uebele , et al.
Molecular Pharmacology, 2014, 85 (2), pp.218--225. ⟨10.1124/mol.113.089581⟩
Article dans une revue hal-01942947v1
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P2X2 and P2X5 Subunits Define a New Heteromeric Receptor with P2X7-Like Properties

Vincent Compan , Lauriane Ulmann , Olga Stelmashenko , Jean Chemin , Séverine Chaumont , et al.
Journal of Neuroscience, 2012, 32 (12), pp.4284-4296. ⟨10.1523/JNEUROSCI.6332-11.2012⟩
Article dans une revue hal-03760928v1
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Gd3+ and calcium sensitive, sodium leak currents are features of weak membrane-glass seals in patch clamp recordings

Adrienne N. Boone , Adriano Senatore , Jean Chemin , Arnaud Monteil , J. David Spafford
PLoS ONE, 2014, 9 (6), pp.e98808. ⟨10.1371/journal.pone.0098808⟩
Article dans une revue hal-01943334v1

Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model

Sophie Sakkaki , Giuseppe Gangarossa , Benoit Lerat , D. Francon , Luc Forichon , et al.
Neuropharmacology, 2016, 101, pp.320--9. ⟨10.1016/j.neuropharm.2015.09.032⟩
Article dans une revue hal-01936765v1

5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone

Magali Cazade , Isabelle Bidaud , P. B. Hansen , Philippe Lory , Jean Chemin
Pflügers Archiv European Journal of Physiology, 2014, 466 (9), pp.1759--68. ⟨10.1007/s00424-013-1411-0⟩
Article dans une revue hal-01942946v1
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CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism

Georgios Daniil , Fabio L. Fernandes-Rosa , Jean Chemin , Iulia Blesneac , Jacques Beltrand , et al.
EBioMedicine, 2016, 13, pp.225 - 236. ⟨10.1016/j.ebiom.2016.10.002⟩
Article dans une revue hal-01936768v1

De novo mutation screening in childhood-onset cerebellar atrophy identifies gain-of-function mutations in the CACNA1G calcium channel gene

Jean Chemin , Karine Siquier-Pernet , Michael Nicouleau , Giulia Barcia , Ali Ahmad , et al.
Brain - A Journal of Neurology , 2018, 141 (7), pp.1998-2013. ⟨10.1093/brain/awy145⟩
Article dans une revue hal-02017665v1
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Calmodulin regulates Ca v 3 T-type channels at their gating brake

Jean Chemin , Valentina Taiakina , Arnaud Monteil , Michael Piazza , Wendy Guan , et al.
Journal of Biological Chemistry, 2017, 292 (49), pp.20010-20031. ⟨10.1074/jbc.M117.807925⟩
Article dans une revue hal-02328290v1

Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids.

Jean Chemin , Amanda Patel , Fabrice Duprat , Frederick Sachs , Michel Lazdunski , et al.
Pflügers Archiv European Journal of Physiology, 2007, epub ahead of print. ⟨10.1007/s00424-007-0250-2⟩
Article dans une revue istex hal-00171100v1
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Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNa V 1 .7 and hCa V 3 voltage‐gated channels

Julien Giribaldi , Jean Chemin , Marie Tuifua , Jennifer Deuis , Rosanna Mary , et al.
FEBS Journal, In press, ⟨10.1111/febs.16773⟩
Article dans une revue hal-04031653v1