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NRF2 signaling cascade in amyotrophic lateral sclerosis: bridging the gap between promise and reality

Pauline Tarot , Christelle Lasbleiz , Jean-Charles Liévens
Neural Regeneration Research, 2024, 19 (5), pp.1006-1012. ⟨10.4103/1673-5374.385283⟩
Article dans une revue hal-04436982v1
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Sigma-1 receptor: culprit and rescuer in motor neuron diseases

Jean-Charles Liévens , Tangui Maurice
Neural Regeneration Research, 2021, 16 (1), pp.106. ⟨10.4103/1673-5374.286961⟩
Article dans une revue hal-02996077v1

Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's disease.

Marie-Thérèse Besson , Pascale Dupont , Yih-Woei C Fridell , Jean-Charles Liévens
Human Molecular Genetics, 2010, 19 (17), pp.3372-82. ⟨10.1093/hmg/ddq249⟩
Article dans une revue hal-00625236v1

Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila

J. C. Lievens , T. Rival , M. Iche , H. Chneiweiss , S. Birman
Human Molecular Genetics, 2005, 14, pp.713-724
Article dans une revue hal-00118469v1
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Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

Ernesto Manzo , Ileana Lorenzini , Dianne Barrameda , Abigail O'Conner , Jordan Barrows , et al.
Article dans une revue hal-03005486v1
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Sigma-1 receptor chaperones rescue nucleocytoplasmic transport deficit seen in cellular and Drosophila ALS/FTD models

Pin-Tse Lee , Jean-Charles Liévens , Shao-Ming Wang , Jian-Ying Chuang , Bilal Khalil , et al.
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-19396-3⟩
Article dans une revue hal-02990866v1
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Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines

Lucie Crouzier , Elodie Richard , Camille Diez , Hala Alzaeem , Morgane Denus , et al.
Human Molecular Genetics, 2022, 31 (16), pp.2711-2727. ⟨10.1093/hmg/ddac065⟩
Article dans une revue hal-03757700v1
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PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease

Bilal Khalil , Najla El Fissi , Aicha Aouane , Marie-Jeanne Cabirol-Pol , Thomas Rival , et al.
Cell Death and Disease, 2015, 6 (1), pp.e1617 - e1617. ⟨10.1038/cddis.2014.581⟩
Article dans une revue hal-01787280v1

Huntington chorea in Drosophila and mice: toward new therapeutic steps.

J.C. Lievens , S. Birman
Médecine/Sciences, 2003, 19, pp.593-599
Article dans une revue hal-00310975v1
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Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?

Bilal Khalil , Jean-Charles Liévens
Neural Regeneration Research, 2017, 12 (7), pp.1052-1061. ⟨10.4103/1673-5374.211179⟩
Article dans une revue hal-01998697v1
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Enhanced Neuronal Glucose Transporter Expression Reveals Metabolic Choice in a HD Drosophila Model

Marie Thérèse Besson , Karin Alegría , Pamela Garrido-Gerter , Luis Felipe Barros , Jean-Charles Liévens
PLoS ONE, 2015, 10 (e0118765), ⟨10.1371/journal.pone.0118765⟩
Article dans une revue hal-01218042v1

The Drosophila inner-membrane protein PMI controls crista biogenesis and mitochondrial diameter.

Marc Macchi , Najla El Fissi , Roberta Tufi , Mélanie Bentobji , Jean-Charles Liévens , et al.
Journal of Cell Science, 2013, 126 (Pt 3), pp.814-24. ⟨10.1242/jcs.115675⟩
Article dans une revue hal-00843395v1

Astrocytes in Huntington's chorea: accomplice or guilty of the neuronal death?

S. Birman , J.C. Lievens
Médecine/Sciences, 2007, 23, pp.845-849
Article dans une revue hal-00310867v1

Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila.

Pascale Dupont , Marie-Thérèse Besson , Jérôme Devaux , Jean-Charles Liévens
Neurobiology of Disease, 2012, epub ahead of print. ⟨10.1016/j.nbd.2012.04.007⟩
Article dans une revue istex hal-00701180v1
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Sigma-1 receptor is a key genetic modulator in amyotrophic lateral sclerosis

Simon Couly , Bilal Khalil , Véronique Viguier , Julien Roussel , Tangui Tm Maurice , et al.
Human Molecular Genetics, 2020, 29 (4), pp.529-540. ⟨10.1093/hmg/ddz267⟩
Article dans une revue hal-02360092v1

AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease

M. Iche , S. Birman , J.C. Lievens , M. Laval , C. Faivre-Sarrailh
Human Molecular Genetics, 2008, 17, pp.882-894
Article dans une revue hal-00310865v1

Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models

Lucie Crouzier , Alberto Danese , Yuko Yasui , Elodie Richard , Jean-Charles Liévens , et al.
Science Translational Medicine, 2022, 14 (631), pp.eabh3763. ⟨10.1126/scitranslmed.abh3763⟩
Article dans une revue hal-03757649v1

Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies

Bilal Khalil , Marie-Jeanne Cabirol-Pol , Laetitia Miguel , Alexander J. Whitworth , Magalie Lecourtois , et al.
Neurobiology of Aging, 2017, 54, pp.71--83. ⟨10.1016/j.neurobiolaging.2017.02.016⟩
Article dans une revue hal-01994093v1
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Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling

Christelle Lasbleiz , Amandine Peyrel , Pauline Tarot , Jérôme Sarniguet , Lucie Crouzier , et al.
Redox Biology, 2022, 58, pp.102542. ⟨10.1016/j.redox.2022.102542⟩
Article dans une revue hal-04210325v1