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CV-Jamel EL BENNA

 

 

 
   

Name :   Jamel EL BENNA.

 

 

 

Title and position:PhD, Research Director at CNRS.

 

 

 

Laboratory: INSERM-U1149, CNRS-ERL8252,Center of Research on Inflammation (CRI),

 

Team « Phagocytes, NADPH Oxidases and Immunogenetics in Systemic Inflammation » 

 

Faculté de Médecine Xavier Bichat, 16 rue Henri Huchard 75018 Paris, France,

 

Tél: 01 57 27 77 23, Email : jamel.elbenna@inserm.fr

 

 

 

Education/Training:

 

University Paris 11 Orsay - Master’s degree - (1988) - Biochemistry and Immunology

 

University Paris 11 Orsay – PhD - (1992) - Biochemistry and Immunology

 

Scripps Research Institute, La Jolla, CA, USA - Postdoctoral - (1992-1995) - Biochemistry

 

University Paris 7 - HDR - (2003) - Biochemistry and Immunology

 

 

 

Personal Statement:

 

Reactive oxygen species (ROS) play a critical role both in host defense and in induction of pathological inflammatory processes. So far only limited information is available as to how ROS production becomes out of control in inflammatory diseases. A better knowledge of the different steps that participate in the initiation and termination of the production of ROS is required to further understand the mechanisms that lead to deregulation of their production in inflammatory diseases. For years, I have been interested in the pathways involved in the activation and regulation of the phagocyte NADPH oxidase/NOX2. P47phox is a critical cytosolic component in the organization of the active NOX2. My work has identified the p47phox phosphorylated sites and demonstrated their functional importance. We have also showed that the proinflammatory cytokines TNFalpha and GM-CSF which induce NOX2 hyperactivation or priming, are able to induce the phosphorylation of p47phox on a specific site. We produced an antibody against phospho-p47phox, interestingly, the antibody we developed allowed us to detect hyper-phosphorylation of p47phox in neutrophils from synovial fluids obtained from patients with rheumatoid arthritis (RA). We also developed a peptide composed of a peptide vector and a p47phox amino acid sequence. This peptide inhibits the hyperactivation of neutrophils induced in vitro by TNF and GM-CSF and the hyperactivation of neutrophil from synovial fluids of RA patients. We have also shown that the proline isomerase Pin1 is involved in TNF-induced NOX2 hyperactivation by binding to phospho-p47phox.

 

 

 

Position and Employment: 

 

1995-2006: Research  Scientist (CR1) at CNRS.

 

2006-present : Research  Director (DR2 and DR1) at CNRS.

 

 

 

Scientific functions:

 

Supervisor of a research group in INSERM U479 unit (1998-2004)

 

Supervisor of a research group in INSERM U683/U773 unit (2005-2008)

 

Supervision of 8 thesis ; examiner of 10 thesis

 

Scientific Expertise for : ANR, INSERM, CNRS, Swiss Science Fondation.

 

Organisation of 3 meetings.

 

Member of the editorial Board: Biochem. Pharmacol, Open J.Inflammation,Am.J.Blood Research.

 

Referee for scientific reviews (JBC,Blood,J.Immunol,J.Leuk.Biol,EMBOJ, Biochem.Pharmacol)

 

Member of the scientific committee of “bio-therapy.net“ site

 

Member of the faculté X.Bichat executive board (2000-2004).

 

 

 

Teaching : 3 Masters (University Paris 7-Saint Louis, University Paris 7-Bichat, University Paris 11-Orsay).

 

 

 

Grants and patents : grant from ANR (2008-2010), ARC (2 contrats), ARP (4 contrats), American Arthritis Foundation Award (USA), patent (US60/774,653 ; 60/774,653).

 

 

 

Membership : American Society for Biochemistry and Molecular Biology (ASBMB), American Association for the Advancement of Science (AAAS), The Society for Free Radical Research International (SFRRI).

 

 

 

Publications and communications: (For PubMed search please use “Benna J”): 166 publications, 14 book chapters, 150 abstracts, 44 invited speaker.

 

 

 

 

 

 

 

 

 

 

Journal articles51 documents

  • Fatma Tannich, Asma Tlili, Coralie Pintard, Amina Chniguir, Bruno Eto, et al.. Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine. Inflammopharmacology, Springer Verlag, 2020, 28 (2), pp.487-497. ⟨10.1007/s10787-019-00655-9⟩. ⟨hal-03026124⟩
  • Zhimin Song, Elodie Hudik, Romain Le Bars, Blandine Roux, Pham My-Chan Dang, et al.. Class I phosphoinositide 3-kinases control sustained NADPH oxidase activation in adherent neutrophils. Biochemical Pharmacology, Elsevier, 2020, 178, pp.114088. ⟨10.1016/j.bcp.2020.114088⟩. ⟨hal-03013159⟩
  • Jamel El Benna, Cyril Renassia, Sabine Louis, Sylvain Cuvellier, Nadia Boussetta, et al.. Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed. Blood Advances, The American Society of Hematology, 2020, 4 (16), pp.3853-3863. ⟨10.1182/bloodadvances.2020002198⟩. ⟨hal-03013143⟩
  • Jamel El Benna, Cyril Renassia, Sabine Louis, Sylvain Cuvellier, Nadia Boussetta, et al.. Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed. Blood Advances, The American Society of Hematology, 2020, 4 (16), pp.3853-3863. ⟨10.1182/bloodadvances.2020002198⟩. ⟨hal-03015834⟩
  • Jamel El Benna, Pham My-Chan Dang, Loïc Rolas, Jamel El-Benna. The Dual Role of Reactive Oxygen Species-Generating Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Gastrointestinal Inflammation and Therapeutic Perspectives. Antioxidants and Redox Signaling, Mary Ann Liebert, 2020, 33 (5), pp.354-373. ⟨10.1089/ars.2020.8018⟩. ⟨hal-03013163⟩
  • Jamel El Benna, Houssam Raad, Hussein Mouawia, Hamad Hassan, Mohamed El-Seblani, et al.. The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils. Free Radical Biology and Medicine, Elsevier, 2020, 160, pp.19-27. ⟨10.1016/j.freeradbiomed.2020.07.021⟩. ⟨hal-03013150⟩
  • Jamel El Benna, Coralie Pintard, Marwa Ben Khemis, Dan Liu, Pham My-Chan Dang, et al.. Apocynin prevents GM-CSF-induced-ERK1/2 activation and -neutrophil survival independently of its inhibitory effect on the phagocyte NADPH oxidase NOX2. Biochemical Pharmacology, Elsevier, 2020, 177, pp.113950. ⟨10.1016/j.bcp.2020.113950⟩. ⟨hal-03013161⟩
  • Zhimin Song, Elodie Hudik, Romain Le Bars, Blandine Roux, Pham My-Chan Dang, et al.. Class I phosphoinositide 3-kinases control sustained NADPH oxidase activation in adherent neutrophils. Biochemical Pharmacology, 2020, 178, pp.114088. ⟨10.1016/j.bcp.2020.114088⟩. ⟨hal-02928180⟩
  • Pham My-Chan Dang, Loïc Rolas, Jamel El Benna. The dual role of ROS-generating NADPH oxidases in gastrointestinal inflammation and therapeutic perspectives. Antioxidants and Redox Signaling, Mary Ann Liebert, 2020, 33 (5), pp.354-373. ⟨10.1089/ars.2020.8018⟩. ⟨hal-03014284⟩
  • Cyril Renassia, Sabine Louis, Sylvain Cuvellier, Nadia Boussetta, Jean-Christophe Deschemin, et al.. Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed. Blood Advances, The American Society of Hematology, 2020, 4 (16), pp.3853-3863. ⟨10.1182/bloodadvances.2020002198⟩. ⟨hal-03013177⟩
  • Coralie Pintard, Marwa Ben Khemis, Dan Liu, Pham My-Chan Dang, Margarita Hurtado-Nedelec, et al.. Apocynin prevents GM-CSF-induced-ERK1/2 activation and -neutrophil survival independently of its inhibitory effect on the phagocyte NADPH oxidase NOX2. Biochemical Pharmacology, Elsevier, 2020, 177, pp.113950. ⟨10.1016/j.bcp.2020.113950⟩. ⟨hal-03014681⟩
  • Houssam Raad, Hussein Mouawia, Hamad Hassan, Mohamed El-Seblani, Riad Arabi-Derkawi, et al.. The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils. Free Radical Biology and Medicine, Elsevier, 2020, 160, pp.19-27. ⟨10.1016/j.freeradbiomed.2020.07.021⟩. ⟨hal-03014609⟩
  • Delphine Ohayon, Alessia de Chiara, Pham My-Chan Dang, Nathalie Thieblemont, Simon Chatfield, et al.. Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. Journal of Experimental Medicine, Rockefeller University Press, 2019, 216 (11), pp.2669-2687. ⟨10.1084/jem.20180371⟩. ⟨hal-03014849⟩
  • Eugénie Koumakis, Joëlle Millet-Botti, Jamel El-Benna, Christine Leroy, Valérie Boitez, et al.. Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-018-37551-1⟩. ⟨hal-03025280⟩
  • Amina Chniguir, Jamel El Benna, Coralie Pintard, Dan Liu, Pham My-Chan Dang, et al.. Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-55043-8⟩. ⟨hal-02400955⟩
  • Amina Chniguir, Fatma Zioud, Viviana Marzaioli, Jamel El-Benna, Rafik Bachoual. Syzygium aromaticum aqueous extract inhibits human neutrophils myeloperoxidase and protects mice from LPS-induced lung inflammation. Pharmaceutical Biology, Taylor & Francis, 2019, 57 (1), pp.56-64. ⟨10.1080/13880209.2018.1557697⟩. ⟨hal-02392058⟩
  • Nesrine Makhezer, Marwa Ben Khemis, Dan Liu, Yamina Khichane, Viviana Marzaioli, et al.. NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions. Mucosal Immunology, Nature Pub. Group, 2019, 12 (1), pp.117-131. ⟨10.1038/s41385-018-0086-4⟩. ⟨hal-02386462⟩
  • Riad Arabi-Derkawi, Yvonne O’dowd, Ni Cheng, Loïc Rolas, Tarek Boussetta, et al.. The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2019, 202 (5), pp.1549-1558. ⟨10.4049/jimmunol.1800610⟩. ⟨hal-02386501⟩
  • Jamel El Benna, Fatma Zioud, Viviana Marzaioli, Jamel El-Benna, Rafik Bachoual. Punica granatum and Citrillus colocynthis Aqueous Extracts Protect Mice from LPS-Induced Lung Inflammation and Inhibit Metalloproteinases-2 and -9. Indian Journal of Pharmaceutical Education and Research, 2019, 53 (3), pp.503-510. ⟨10.5530/ijper.53.3.82⟩. ⟨hal-02400949⟩
  • Fatma Tannich, Asma Tlili, Coralie Pintard, Amina Chniguir, Bruno Eto, et al.. Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine. Inflammopharmacology, Springer Verlag, In press, ⟨10.1007/s10787-019-00655-9⟩. ⟨hal-02387505⟩
  • Min Liu, Samia Bedouhene, Margarita Hurtado-Nedelec, Coralie Pintard, Pham My-Chan Dang, et al.. The Prolyl Isomerase Pin1 Controls Lipopolysaccharide-Induced Priming of NADPH Oxidase in Human Neutrophils. Frontiers in Immunology, Frontiers, 2019, 10, ⟨10.3389/fimmu.2019.02567⟩. ⟨hal-02387513⟩
  • Amina Chniguir, Fatma Zioud, Viviana Marzaioli, Jamel El-Benna, Rafik Bachoual. Syzygium aromaticum aqueous extract inhibits human neutrophils myeloperoxidase and protects mice from LPS-induced lung inflammation. Pharmaceutical Biology, Taylor & Francis, 2019, 57 (1), pp.55-63. ⟨10.1080/13880209.2018.1557697⟩. ⟨hal-03025271⟩
  • Sarah Rio, Marc Gastou, Narjesse Karboul, Raphaёl Derman, Thunwarat Suriyun, et al.. Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1. Blood, American Society of Hematology, 2019, 133 (12), pp.1358-1370. ⟨10.1182/blood-2018-09-875674⟩. ⟨hal-02339695⟩
  • Delphine Ohayon, Alessia de Chiara, Pham My-Chan Dang, Nathalie Thieblemont, Simon Chatfield, et al.. Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. Journal of Experimental Medicine, Rockefeller University Press, 2019, 216 (11), pp.2669-2687. ⟨10.1084/jem.20180371⟩. ⟨hal-02355202⟩
  • Riad Arabi-Derkawi, Yvonne O’dowd, Ni Cheng, Loïc Rolas, Tarek Boussetta, et al.. The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2019, 202 (5), pp.1549-1558. ⟨10.4049/jimmunol.1800610⟩. ⟨hal-03014701⟩
  • Amina Chniguir, Coralie Pintard, Dan Liu, Pham My-Chan Dang, Jamel El-Benna, et al.. Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-55043-8⟩. ⟨hal-03014330⟩
  • Min Liu, Samia Bedouhene, Margarita Hurtado-Nedelec, Coralie Pintard, Pham My-Chan Dang, et al.. The Prolyl Isomerase Pin1 Controls Lipopolysaccharide-Induced Priming of NADPH Oxidase in Human Neutrophils. Frontiers in Immunology, Frontiers, 2019, 10, ⟨10.3389/fimmu.2019.02567⟩. ⟨hal-03014335⟩
  • Nesrine Makhezer, Marwa Khemis, Dan Liu, Yamina Khichane, Viviana Marzaioli, et al.. NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions. Mucosal Immunology, Nature Pub. Group, 2019, 12 (1), pp.117-131. ⟨10.1038/s41385-018-0086-4⟩. ⟨hal-03014379⟩
  • Héloïse Flament, Vanessa Granger, Corinne Vezinet, Viviana Marzaioli, Caroline Kannengiesser, et al.. Aspergillus -induced pneumonia in adult without obvious immunodeficiency: test the burst!. European Respiratory Journal, European Respiratory Society, 2018, 51 (4), pp.1702711. ⟨10.1183/13993003.02711-2017⟩. ⟨hal-02381391⟩
  • Jamel El Benna, Angela Minnella, Jerry Zhao, Xiangning Jiang, Emil Jakobsen, et al.. Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling. Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-35725-5⟩. ⟨hal-02392066⟩
  • Jamel El Benna, Loïc Rolas, Abdelali Boussif, Emmanuel Weiss, Philippe Lettéron, et al.. NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation. Gut, BMJ Publishing Group, 2018, 67 (8), pp.1505-1516. ⟨10.1136/gutjnl-2016-313443⟩. ⟨hal-02392080⟩
  • Sahra Belambri, Loïc Rolas, Houssam Raad, Margarita Hurtado-Nedelec, Pham My-Chan Dang, et al.. NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits. European Journal of Clinical Investigation, Wiley, 2018, 48, pp.e12951. ⟨10.1111/eci.12951⟩. ⟨hal-02387491⟩
  • Fabien Bastaert, Saadé Kheir, Vinciane Saint-Criq, Bérengère Villeret, Pham My-Chan Dang, et al.. Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation. Frontiers in Immunology, Frontiers, 2018, 9, ⟨10.3389/fimmu.2018.01675⟩. ⟨hal-02977363⟩
  • Vivien Beziat, Juan Li, Jian-Xin Lin, Cindy Ma, Peng Li, et al.. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩. ⟨hal-02392068⟩
  • Irene Kyrmizi, Helena Ferreira, Agostinho Carvalho, Julio Alberto Landero Figueroa, Pavlos Zarmpas, et al.. Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis. Nature Microbiology, Nature Publishing Group, 2018, 3 (7), pp.791-803. ⟨10.1038/s41564-018-0167-x⟩. ⟨hal-02392085⟩
  • Fabien Bastaert, Saadé Kheir, Vinciane Saint-Criq, Bérengère Villeret, Pham My-Chan Dang, et al.. Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation. Frontiers in Immunology, Frontiers, 2018, 9, pp.1675. ⟨10.3389/fimmu.2018.01675⟩. ⟨inserm-02078851⟩
  • Viviana Marzaioli, Margarita Hurtado-Nedelec, Coralie Pintard, Asma Tlili, Jean-Claude Marie, et al.. NOX5 and p22phox are 2 novel regulators of human monocytic differentiation into dendritic cells. Blood, American Society of Hematology, 2017, 130 (15), pp.1734-1745. ⟨10.1182/blood-2016-10-746347⟩. ⟨hal-02387489⟩
  • Samia Bedouhene, Farida Moulti-Mati, Pham My-Chan Dang, Jamel El-Benna. Oleuropein and hydroxytyrosol inhibit the N-formyl-methionyl-leucyl-phenylalanine-induced neutrophil degranulation and chemotaxis via AKT, p38, and ERK1/2 MAP-Kinase inhibition. Inflammopharmacology, Springer Verlag, 2017, 25 (6), pp.673-680. ⟨10.1007/s10787-017-0367-7⟩. ⟨hal-02387479⟩
  • Esther Bertran, Guia Carrara, Pham My-Chan Dang, Bilge Debelec–butuner, Irundika H.K. Dias, et al.. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology, Elsevier, 2017, 13, pp.94-162. ⟨10.1016/j.redox.2017.05.007⟩. ⟨hal-02491048⟩
  • Jamel El-Benna, Margarita Hurtado-Nedelec, Viviana  Marzaioli, Jean-Claude Marie, Marie-Anne Gougerot-Pocidalo, et al.. Priming of the neutrophil respiratory burst: role in host defense and inflammation. Immunological Reviews, Wiley, 2016, 273 (1), pp.180-193. ⟨10.1111/imr.12447⟩. ⟨hal-02387472⟩
  • Hanane Boukemara, Margarita Hurtado-Nedelec, Viviana Marzaioli, Dalila Bendjeddou, Jamel El Benna, et al.. Anvillea garcinii extract inhibits the oxidative burst of primary human neutrophils. BMC Complementary and Alternative Medicine, BioMed Central, 2015, 16 (1), pp.433. ⟨10.1186/s12906-016-1411-7⟩. ⟨inserm-01391783⟩
  • Mohamed-Amine Jabri, Kais Rtibi, Haifa Tounsi, Karim Hosni, Abdelaziz Souli, et al.. Myrtle berry seed aqueous extract inhibits human neutrophil myeloperoxidase in vitro and attenuates acetic acid-induced ulcerative colitis in rats. RSC Advances, Royal Society of Chemistry, 2015, 5 (80), pp.64865-64877. ⟨10.1039/c5ra07172k⟩. ⟨pasteur-01375016⟩
  • Kais Rtibi, Mohamed Jabri, Slimen Selmi, Abdelaziz Souli, Hichem Sebai, et al.. Gastroprotective effect of carob (Ceratonia siliqua L.) against ethanol-induced oxidative stress in rat. BMC Complementary and Alternative Medicine, BioMed Central, 2015, 15, pp.292. ⟨10.1186/s12906-015-0819-9⟩. ⟨inserm-02066456⟩
  • Abdelaziz Souli, Hichem Sebai, Latifa Chehimi, Kais Rtibi, Haifa Tounsi, et al.. Hepatoprotective effect of carob against acute ethanol-induced oxidative stress in rat. Toxicology and Industrial Health, SAGE Publications, 2015, 31 (9), pp.802-810. ⟨10.1177/0748233713475506⟩. ⟨pasteur-01375042⟩
  • Imen Elatrech, Viviana Marzaioli, Hanane Boukemara, Odile Bournier, Christel Neut, et al.. Escherichia coli LF82 Differentially Regulates ROS Production and Mucin Expression in Intestinal Epithelial T84 Cells. Inflammatory Bowel Diseases, Lippincott, Williams & Wilkins, 2015, 21, pp.1018 - 1026. ⟨10.1097/MIB.0000000000000365⟩. ⟨hal-01481550⟩
  • Hichem Sebai, Mohamed-Amine Jabri, Abdelaziz Souli, Karim Hosni, Slimen Selmi, et al.. Protective effect of Artemisia campestris extract against aspirin-induced gastric lesions and oxidative stress in rat. RSC Advances, Royal Society of Chemistry, 2014, 4 (91), pp.49831 - 49841. ⟨10.1039/c4ra08564g⟩. ⟨pasteur-01375101⟩
  • Sanae Ben Mkaddem, Gilles Hayem, Friederike Jönsson, Elisabetta Rossato, Erwan Boedec, et al.. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.. Journal of Clinical Investigation, American Society for Clinical Investigation, 2014, 124 (9), pp.3945-3959. ⟨10.1172/JCI74572⟩. ⟨pasteur-02512366⟩
  • Miao Liu, Tarek Boussetta, Karama Makni-Maalej, Michèle Fay, Fathi Driss, et al.. Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities.. Lipids, Springer Verlag, 2014, 49 (1), pp.49-57. ⟨10.1007/s11745-013-3863-6⟩. ⟨inserm-00909219⟩
  • Jamel El-Benna, Pham My-Chan Dang, Axel Périanin. Peptide-Based Inhibitors Of The Phagocyte Nadph Oxidase. Biochemical Pharmacology, Elsevier, 2010, 80 (6), pp.778. ⟨10.1016/j.bcp.2010.05.020⟩. ⟨hal-00608935⟩
  • Houssam Raad, Marie-Hélène Paclet, Tarek Boussetta, Yolande Kroviarski, Françoise Morel, et al.. Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox.. FASEB Journal, Federation of American Society of Experimental Biology, 2009, 23 (4), pp.1011-22. ⟨10.1096/fj.08-114553⟩. ⟨hal-00400692⟩
  • Cyrille Hoarau, Bénédicte Gérard, Emmanuel Lescanne, Dominique Henry, Stéphanie François, et al.. TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 179 (7), pp.4754-65. ⟨inserm-00179394⟩

Conference papers1 document

  • Ph Detilleux, L Vallier, C Legallais, E Leclerc, M Prot J, et al.. Toxicologie predictive: les voies du futur. Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France. ⟨hal-01122677⟩

Book sections2 documents