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Structural insights into substrate traffic and inhibition in acetylcholinesterase.

 Jacques-Philippe Colletier , Didier Fournier , Harry M Greenblatt , Jure Stojan , Joel L Sussman , et al.
EMBO Journal, 2006, 25 (12), pp.2746-56. ⟨10.1038/sj.emboj.7601175⟩
Article dans une revue hal-00120647v1
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Megahertz data collection from protein microcrystals at an X-ray free-electron laser

 Luis Grünbein , Johan Bielecki , Alexander Gorel , Miriam Stricker , Richard Bean , et al.
Nature Communications, 2018, 9 (1), pp.3487. ⟨10.1038/s41467-018-05953-4⟩
Article dans une revue hal-01912078v1

Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

 Urban Košak , Boris Brus , Damijan Knez , Roman Šink , Simon Žakelj , et al.
Scientific Reports, 2016, 6, pp.39495. ⟨10.1038/srep39495⟩
Article dans une revue hal-01465678v1

Multi Target directed ligands for the treatment of Alzheimer’s disease

 Sovy Chao , Killian Oukoloff , Monika Bouet , Diego Muñoz Torrero , Jacques-Philippe Colletier , et al.
Rencontres internationales de chimie thérapeutique (RICT, 52, 2016), Jul 2016, Caen, France
Poster de conférence hal-02544849v1

Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of α7 nicotinic acetylcholine receptor

 Rómulo Aráoz , Monika Bouet , Manuela Bartolini , Nicolas Coquelle , Jacques-Philippe Colletier , et al.
Biochemical Pharmacology, 2015, 97 (4), pp.621. ⟨10.1016/j.bcp.2015.08.006⟩
Article dans une revue hal-02329901v1

Serial femtosecond crystallography and ultrafast absorption spectroscopy of the photoswitchable fluorescent protein IrisFP

 Jacques-Philippe Colletier , M. Sliwa , François-Xavier Gallat , M. Sugahara , Virginia Guillon , et al.
Journal of Physical Chemistry Letters, 2016, 7 (5), pp.882 - 887. ⟨10.1021/acs.jpclett.5b02789⟩
Article dans une revue hal-01285611v1
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Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy.

 Joyce Woodhouse , Gabriela Nass Kovacs , Nicolas Coquelle , Lucas M. Uriarte , Virgile Adam , et al.
Nature Communications, 2020, 11 (1), pp.741. ⟨10.1038/s41467-020-14537-0⟩
Article dans une revue hal-02498645v1
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Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

 Stane Pajk , Damijan Knez , Urban Košak , Maja Zorović , Xavier Brazzolotto , et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.498-505. ⟨10.1080/14756366.2019.1710502⟩
Article dans une revue hal-03014299v1
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Rational control of off‐state heterogeneity in a photoswitchable fluorescent protein provides switching contrast enhancement

 Virgile Adam , Kyprianos Hadjidemetriou , Nickels Jensen , Robert L. Shoeman , Joyce Woodhouse , et al.
ChemPhysChem, 2022, 23 (19), pp.e202200192. ⟨10.1002/cphc.202200192⟩
Article dans une revue hal-03758975v1

Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.

 Boris Brus , Urban Košak , Samo Turk , Anja Pišlar , Nicolas Coquelle , et al.
Journal of Medicinal Chemistry, 2014, 57 (19), pp.8167-79
Article dans une revue hal-01131216v1

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

 Maria Kliachyna , Gianluca Santoni , Valentin Nussbaum , Julien Renou , Benoît Sanson , et al.
European Journal of Medicinal Chemistry, 2014, 78, pp.455-467. ⟨10.1016/j.ejmech.2014.03.044⟩
Article dans une revue hal-01131268v1
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Time-Resolved Serial Femtosecond Crystallography, Towards Molecular Movies of Biomolecules in Action

 Jacques-Philippe Colletier , Giorgio Schirò , Martin Weik
Petra Fromme; Sebastien Boutet; Mark Hunter. X-ray Free Electron Lasers, Springer International Publishing, pp.331-356, 2018, ⟨10.1007/978-3-030-00551-1_11⟩
Chapitre d'ouvrage hal-01993625v1

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

 Elisabet Viayna , Nicolas Coquelle , Monika Cieslikiewicz-Bouet , Pedro Cisternas , Carolina Oliva , et al.
Journal of Medicinal Chemistry, 2020, ⟨10.1021/acs.jmedchem.0c01775⟩
Article dans une revue hal-03094189v1

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.

 Damijan Knez , Boris Brus , Nicolas Coquelle , Izidor Sosič , Roman Šink , et al.
Bioorganic and Medicinal Chemistry, 2015, 23 (15), pp.4442-52
Article dans une revue hal-01199263v1
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Observing the overall rocking motion of a protein in a crystal

 Peixiang Ma , Yi Xue , Nicolas Coquelle , Jens D. Haller , Tairan Yuwen , et al.
Nature Communications, 2015, ⟨10.1038/ncomms9361⟩
Article dans une revue hal-01233308v1
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Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

 Diego Gauto , Leandro F Estrozi , Charles Schwieters , Grégory Effantin , Pavel Macek , et al.
Nature Communications, 2019, 10 (1), pp.2697. ⟨10.1038/s41467-019-10490-9⟩
Article dans une revue hal-02166767v1

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.

 Cyril Ronco , Eugénie Carletti , Jacques-Philippe Colletier , Martin Weik , Florian Nachon , et al.
ChemMedChem, 2012, 7 (3), pp.400-405. ⟨10.1002/cmdc.201100438⟩
Article dans une revue istex hal-00996475v1
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Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams

 Nicolas Coquelle , Aaron S. Brewster , Ulrike Kapp , Anastasya Shilova , Britta Weinhausen , et al.
Acta crystallographica Section D : Structural biology [1993-..], 2015, 71, pp.1184-1196. ⟨10.1107/S1399004715004514⟩
Article dans une revue hal-01572740v1

Toward an innovative treatment of Alzheimer's disease: Synthesis and evaluation of multi-target directed ligands (MTDLs) targeting acetylcholinesterase (AChE) and alpha7 nicotinic acetylchloline receptors (alpha7 nAChRs)

 Monika Cieslikiewicz-Bouet , Sovy Chao , Ludovic Jean , R. Araoz , D. Servent , et al.
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.209-210
Communication dans un congrès hal-02024978v1

Novel uncharged reactivators against OP-inhibition of human acetylcholinesterase

 Rachid Baati , Maria Klyachina , Valentin Nussbaum , Pierre-Yves Renard , Ludovic Jean , et al.
France, Patent n° : EP13306584.7. 2013
Brevet hal-01150304v1

Inhibition Pathways of the Potent Organophosphate CBDP with Cholinesterases Revealed by X-ray Crystallographic Snapshots and Mass Spectrometry

 Eugénie Carletti , Jacques-Philippe Colletier , Lawrence M Schopfer , Gianluca Santoni , Patrick Masson , et al.
Chemical Research in Toxicology, 2013, 26 (2), pp.280 - 289. ⟨10.1021/tx3004505⟩
Article dans une revue hal-01662503v1
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Les porines : un rôle vital et un lien social au sein du biofilm de Providencia stuartii

 Mariam El-Khatib , Guillaume Tetreau , Jacques-Philippe Colletier
Médecine/Sciences, 2019, 35 (4), pp.291-295. ⟨10.1051/medsci/2019059⟩
Article dans une revue hal-02984720v1

Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1.

 Om P Choudhary , Aviv Paz , Joshua L Adelman , Jacques-Philippe Colletier , Jeff Abramson , et al.
Nature Structural and Molecular Biology, 2014, 21 (7), pp.626-32
Article dans une revue hal-01131228v1

Varied Probability of Staying Collapsed/Extended at the Conformational Equilibrium of Monomeric Aβ40 and Aβ42.

 Wanling Song , Yuanyuan Wang , Jacques-Philippe Colletier , Huaiyu Yang , Yechun Xu
Scientific Reports, 2015, 5, pp.11024
Article dans une revue hal-01199233v1

Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMα peptides

 Nir Salinas , Jacques-Philippe Colletier , Asher Moshe , Meytal Landau
Nature Communications, 2018, 9 (1), pp.3512. ⟨10.1038/s41467-018-05490-0⟩
Article dans une revue hal-01924638v1
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Virus particle assembly into crystalline domains enabled by the coffee ring effect

 Ronald Gebhardt , Jean-Marie Teulon , Jean-Luc Pellequer , Manfred Burghammer , Jacques-Philippe Colletier , et al.
Soft Matter, 2014, 10 (30), pp.5458-5462. ⟨10.1039/c4sm00414k⟩
Article dans une revue hal-01572715v1

Sampling the conformational energy landscape of a hyperthermophilic protein by engineering key substitutions.

 Jacques-Philippe Colletier , Alexey Aleksandrov , Nicolas Coquelle , S. Mraihi , E. Mendoza-Barber , et al.
Molecular Biology and Evolution, 2012, 29 (6), pp.1683-94. ⟨10.1093/molbev/mss015⟩
Article dans une revue hal-00764440v1

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.

 Alice Soragni , Shida Yousefi , Christina Stoeckle , Angela B Soriaga , Michael R Sawaya , et al.
Molecular Cell, 2015, 57 (6), pp.1011-21
Article dans une revue hal-01162651v1
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

 Killian Oukoloff , Nicolas Coquelle , Manuela Bartolini , Marina Naldi , Rémy Le Guével , et al.
European Journal of Medicinal Chemistry, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩
Article dans une revue hal-02055769v1
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Socialization of Providencia stuartii Enables Resistance to Environmental Insults

 Julie Lopes , Guillaume Tetreau , Kevin Pounot , Mariam El Khatib , Jacques-Philippe Colletier
Microorganisms, 2022, 10 (5), pp.901. ⟨10.3390/microorganisms10050901⟩
Article dans une revue hal-03847651v1
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