NMR approaches in fragment-based drug design
Isabelle Krimm
ChemBioInteract "Conference on Drug Discovery & Drug Design: ChemBio Interactions" , Oct 2013, Lyon, France
Communication dans un congrès
hal-00955939v1
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BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR
Clémentine Aguirre
,
Tim Ten Brink
,
Olivier Walker
,
Florence Guillière
,
D. Davesne
,
et al.
Article dans une revue
in2p3-00839023v1
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The Dynamics of Copper Uptake in Human Cu,Zn-Superoxide Dismutase: a Solid-State NMR Study
Claire Raingeval
,
Olivier Cala
,
Béatrice Brion
,
Isabelle Krimm
XXIXème congrès du GERM , Groupement d'études de résonance magnétique, May 2017, Aussois, France
Communication dans un congrès
hal-01865374v1
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Letter to the Editor: 1H, 13C and 15N resonance assignments of poplar phloem glutaredoxin
Valérie Noguera
,
Nicolas Rouhier
,
Isabelle Krimm
,
Jean-Pierre Jacquot
,
Jean-Marc Lancelin
Article dans une revue
istex
hal-02681554v1
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NMR tool for the characterization of protein-fragment complexes
Olivier Cala
,
Clémentine Aguirre
,
Tim Ten Brink
,
Isabelle Krimm
GERM XXV - Conférence du Groupe Français d'Etude de Résonance Magnétique , Jun 2014, Biarritz, France
Communication dans un congrès
hal-01018840v1
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Performance of Protein–Ligand Docking with Simulated Chemical Shift Perturbations
Tim Ten Brink
,
Clémentine Aguirre
,
Thomas E. Exner
,
Isabelle Krimm
Article dans une revue
hal-01087991v1
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INPHARMA-based identification of ligand binding site in fragment-based drug design
Isabelle Krimm
Article dans une revue
hal-00819132v1
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Tackling the Interaction of the Multidomain Protein STAM2 with Ubiquitin and Diubiquitin Chains by NMR. Cooperativity or not, that is the Question !
Florence Guillière
,
Jean-Marc Lancelin
,
Isabelle Krimm
,
Olivier Walker
,
Anja Lange
XXVth International Conference on Magnetic Resonance in Biological Systems (ICMRBS) , Aug 2012, Lyon, France
Communication dans un congrès
hal-00958296v1
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NMR-Based Characterization of Protein-Fragment Complexes
Isabelle Krimm
Discovery Chemistry Congress , Mar 2013, Munich, Germany
Communication dans un congrès
hal-00819152v1
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Crystal Structure and Solution NMR Dynamics of a D (Type II) Peroxiredoxin Glutaredoxin and Thioredoxin Dependent: A New Insight into the Peroxiredoxin Oligomerism
Aude Echalier
,
Xavier Trivelli
,
Catherine Corbier
,
Nicolas Rouhier
,
Olivier Walker
,
et al.
Article dans une revue
istex
hal-02680941v1
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Binding evaluation of fragment-based scaffolds for probing allosteric enzymes
Isabelle Krimm
,
Jean-Marc Lancelin
,
Jean-Pierre Praly
Article dans une revue
hal-01087963v1
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NMR for Chemical Biology and Drug Discovery
Isabelle Krimm
52nd International Conference on Medicinal Chemistry , Jul 2016, Caen, France
Communication dans un congrès
hal-01397739v1
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2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site
Benoît Bestgen
,
Isabelle Krimm
,
Irina Kufareva
,
Ahmed Kamal
,
Wei Guang Seetoh
,
et al.
Article dans une revue
hal-02004986v1
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Etude de complexes protéine-ligand par RMN quantitative dans le contexte du Drug Design
Clémentine Aguirre
,
Florence Guillière
,
Dany Davesne
,
Isabelle Krimm
XIIIème Journée Rhône-Alpes de RMN , Jun 2012, Grenoble, France
Communication dans un congrès
hal-00819233v1
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Conception de molécules bioactives par la méthode des fragments
Isabelle Krimm
Ecole thématique de criblage , Sep 2012, Sorrèze, France
Communication dans un congrès
hal-00819206v1
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NMR investigation of protein–ligand interactions for G-protein coupled receptors
Claire Raingeval
,
Isabelle Krimm
Article dans une revue
hal-02188261v1
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Glutathionylation induces the dissociation of 1-Cys D-peroxiredoxin non-covalent homodimer
Valérie Noguera-Mazon
,
Jérôme Lemoine
,
Olivier Walker
,
Nicolas Rouhier
,
Arnaud Salvador
,
et al.
Article dans une revue
hal-02661917v1
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Changements conformationnels de la protéine Bcl-xL lors de son interaction avec une molécule fragment révélés par RMN
Clémentine Aguirre
,
Tim Ten Brink
,
Isabelle Krimm
Journée RMN Grand Sud-Est (XIVe JRA) , May 2013, Lyon, France
Communication dans un congrès
hal-00873772v1
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The Journey Towards Solubility Assessment of Small Molecules Using HPLC-DAD
Nada Hemmani
,
Anaïs Cacilie Martin
,
Andy Larivière
,
Mathis Tresallet
,
Kensa Tchang
,
et al.
8th International Electronic Conference on Medicinal Chemistry , Nov 2022, Basel (on line), Switzerland.
⟨10.3390/ECMC2022-13143⟩
Communication dans un congrès
hal-03840347v1
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NMR for fragment-based drug design
Isabelle Krimm
1st European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015) , Aug 2015, Münster, Germany
Communication dans un congrès
hal-01234684v1
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Overview of liquid-NMR approaches for fragment-based lead discovery
Isabelle Krimm
NMR-day on Drug Discovery & Delivery: New Approaches , Marina Veronesi, Stefania Girotto and Luca Mollica - Istituto Italiano di Tecnologia, Oct 2015, Gênes, Italy
Communication dans un congrès
hal-01234692v1
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Rôle de la RMN pour la conception de médicaments à partir de fragments
Isabelle Krimm
Conférence invitée au CERMN , Oct 2013, Caen, France
Communication dans un congrès
hal-00955944v1
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NMR methods for fragment selection
Isabelle Krimm
Drug Discovery Chemistry 2014 , Apr 2014, San Diego, United States
Communication dans un congrès
hal-00955933v1
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Ligand specificity in fragment-based drug design
Isabelle Krimm
Drug Discovery Chemistry 2011 , Apr 2011, San Diego, United States
Communication dans un congrès
hal-00819236v1
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Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors
Irina Kufareva
,
Benoît Bestgen
,
Paul Brear
,
Renaud Prudent
,
Béatrice Laudet
,
et al.
Article dans une revue
hal-02348673v1
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A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors
Jérémy Caburet
,
Benjamin Boucherle
,
Sofiane Bourdillon
,
Giorgia Simoncelli
,
Federica Verdirosa
,
et al.
Article dans une revue
hal-03861812v1
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Characterization of the yeast peroxiredoxin Ahp1 in its reduced active and overoxidized inactive forms using NMR.
Xavier Trivelli
,
Isabelle Krimm
,
Christine Ebel
,
Lionel Verdoucq
,
Valérie Prouzet-Mauléon
,
et al.
Article dans une revue
istex
hal-00169108v1
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Fragment-based screening: a promising avenue for drug design
Isabelle Krimm
Article dans une revue
hal-01187367v1
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NMR for Fragment-Based Drug Design
Olivier Cala
,
Isabelle Krimm
27th International Conference on Magnetic Resonance in Biological Systems - ICMRBS2016 , Aug 2016, Kyoto, Japan
Poster de conférence
hal-01397732v1
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Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors
Lucile Lecas
,
Lucie Hartmann
,
Lydia Caro
,
Sarah Mohamed-Bouteben
,
Claire Raingeval
,
et al.
Article dans une revue
hal-03045118v1
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