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Dr Isabelle Fudal, INRAE Senior researcher, HDR

Unité Bioger (UMR 1290)
Team Effecteurs et pathogenèse chez Leptosphaeria maculans
Bâtiment 13, av. Lucien Brétignières, BP01
78850 Thiverval-Grignon

Contact :
Tél. : +33 (0)1 30 81 45 90
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I am a research scientist hired at INRA in the BIOGER unit in 2006, with a background in plant pathology, molecular biology and functional genomics. My main focus was, and still is, on deciphering fungal-plant interactions. Most of my research experience was devoted to understand fungal pathogenicity and signals produced by the fungus, which induce recognition of “non-self” and disease resistance (avirulence genes or effectors). Since I was hired as a permanent scientist at INRA, I am developing functional genomics approaches on plant-fungi interactions with a particular interest to fungal effectors on the model of interaction Leptosphaeria maculans / Brassica napus. The objective of my research project is to study the possible roles of effectors on pathogenicity towards B. napus (identification, expression, regulation, evolution and functional analysis). To achieve this goal, I develop a pluri-disciplinary project combining bioinformatics, transcriptomics, functional genomics, pathogenicity studies and evolutionary genomics. Recently, I focused part of my researches on the determinism of concerted regulation of effector genes during infection and pointed out on the importance of chromatin status in this regulation. I am co-leading the INRA SPE network REacTION (network on the epigenetic mechanisms that shape plant - Bioaggressors and Symbiotic Organisms interactions)

Curriculum vitae

Since 2020

INRAE Senior Researcher, UMR1290 BIOGER, Grignon


HDR, Université Paris-Sud, Orsay


INRA Researcher Scientist, UMR1290 Bioger, INRA, Grignon


Postdoc, Unité PMDV, INRA, Versailles


PhD, Université Paris-Sud, Orsay


Master Biologie, Diversité et Adaptation des Plantes Cultivées : option Phytopathologie (Paris)

1997- 2000

Engineer degree, Institut National Agronomique Paris-Grignon (INA P-G, Paris)

Journal articles30 documents

  • Méline Saubin, Clémentine Louet, Lydia Bousset, Frédéric Fabre, Pascal Frey, et al.. Improving sustainable crop protection using population genetics concepts. Molecular Ecology, Wiley, In press, ⟨10.1111/mec.16634⟩. ⟨hal-03746299⟩
  • Audren Jiquel, Julie Gervais, Aude Geistodt‐kiener, Régine Delourme, Elise Gay, et al.. A gene‐for‐gene interaction involving a ‘late’ effector contributes to quantitative resistance to the stem canker disease in Brassica napus. New Phytologist, Wiley, 2021, ⟨10.1111/nph.17292⟩. ⟨hal-03155959⟩
  • Elise J Gay, Jessica L Soyer, Nicolas Lapalu, Juliette Linglin, Isabelle Fudal, et al.. Large-scale transcriptomics to dissect 2 years of the life of a fungal phytopathogen interacting with its host plant. BMC Biology, BioMed Central, 2021, 19 (1), pp.e041118. ⟨10.1186/s12915-021-00989-3⟩. ⟨hal-03190704⟩
  • Mercedes Rocafort, Isabelle Fudal-Grolier Fudal, Carl Mesarich. Apoplastic effector proteins of plant-associated fungi and oomycetes. Current Opinion in Plant Biology, Elsevier, 2020, 56, pp.9-19. ⟨10.1016/j.pbi.2020.02.004⟩. ⟨hal-02894839⟩
  • Yohann Petit-Houdenot, Alexandre A. Degrave, Michel Meyer, Françoise Blaise, Bénédicte Ollivier, et al.. A two genes – for – one gene interaction between Leptosphaeria maculans and Brassica napus. New Phytologist, Wiley, 2019, 223 (1), pp.397-411. ⟨10.1111/nph.15762⟩. ⟨hal-02278749⟩
  • Isabelle Fudal, Marie-Helene Balesdent, Thierry Rouxel. Effector Biology in Fungal Pathogens of Nonmodel Crop Plants. Trends in Plant Science, Elsevier, 2018, 23 (9), pp.753 - +. ⟨10.1016/j.tplants.2018.07.002⟩. ⟨hal-02626782⟩
  • Andrea Sanchez-Vallet, Simone Fouche, Isabelle Fudal, Fanny E. Hartmann, Jessica L Soyer, et al.. The genome biology of effector gene evolution in filamentous plant pathogens. Annual Review of Phytopathology, Annual Reviews, 2018, 56, ⟨10.1146/annurev-phyto-080516-035303⟩. ⟨hal-02628719⟩
  • Yohann Petit, Isabelle Fudal. Complex Interactions between Fungal Avirulence Genes and Their Corresponding Plant Resistance Genes and Consequences for Disease Resistance Management. Frontiers in Plant Science, Frontiers, 2017, 8, ⟨10.3389/fpls.2017.01072⟩. ⟨hal-01602583⟩
  • Julie Gervais, Clémence Plissonneau, Juliette Linglin, Michel Meyer, Karine Labadie, et al.. Different waves of effector genes with contrasted genomic location are expressed by Leptosphaeria maculans during cotyledon and stem colonization of oilseed rape. Molecular Plant Pathology, Wiley, 2017, 18 (8), pp.1113 - 1126. ⟨10.1111/mpp.12464⟩. ⟨hal-01608614⟩
  • Clémence Plissonneau, Guillaume Daverdin, Bénédicte Ollivier, Françoise Blaise, Alexandre A. Degrave, et al.. A game of hide and seek between avirulence genes AvrLm4‐7 and AvrLm3 in Leptosphaeria maculans. New Phytologist, Wiley, 2016, 209 (4), pp.1613-1624. ⟨10.1111/nph.13736⟩. ⟨hal-02516669⟩
  • Rémi de Marchi, Maud Sorel, Brian Mooney, Isabelle Fudal-Grolier Fudal, Kevin Goslin, et al.. The N-end rule pathway regulates pathogen responses in plants. Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep26020⟩. ⟨hal-02104524⟩
  • Jessica Louise Soyer, Audrey Hamiot, Benedicte Ollivier, Marie-Helene Balesdent, Thierry Rouxel, et al.. The APSES transcription factor LmStuA is required for sporulation, pathogenic development and effector gene expression in Leptosphaeria maculans. Molecular Plant Pathology, Wiley, 2015, 16 (9), pp.1000-1005. ⟨10.1111/mpp.12249⟩. ⟨hal-01536499⟩
  • Karine Blondeau, Françoise Blaise, Marc Graille, Shiv D Kale, Juliette Linglin, et al.. Crystal structure of the effector AvrLm4-7 of Leptosphaeria maculans reveals insights into its translocation into plant cells and recognition by resistance proteins.. Plant Journal, Wiley, 2015, 83 (4), pp.610-24. ⟨10.1111/tpj.12913⟩. ⟨hal-01446655⟩
  • Kaveh Ghanbarnia, Isabelle Fudal, Nicholas J. Larkan, Matthew G. Links, Marie-Helene Balesdent, et al.. Rapid identification of the Leptosphaeria maculans avirulence gene AvrLm2 using an intraspecific comparative genomics approach. Molecular Plant Pathology, Wiley, 2015, 16 (7), pp.699 - 709. ⟨10.1111/mpp.12228⟩. ⟨hal-01536462⟩
  • Jessica L. Soyer, Thierry T. Rouxel, Isabelle Fudal-Grolier Fudal. Chromatin-based control of effector gene expression in plant-associated fungi. Current Opinion in Plant Biology, Elsevier, 2015, 26, pp.51-56. ⟨10.1016/j.pbi.2015.05.025⟩. ⟨hal-02638628⟩
  • Jonathan J. Grandaubert, Rohan G.T. Lowe, Jessica L. Soyer, C.L. Schoch, Angela P van de Wouw, et al.. Transposable element-assisted evolution and adaptation to host plant within the Leptosphaeria maculans-Leptosphaeria biglobosa species complex of fungal pathogens. BMC Genomics, BioMed Central, 2014, 15 (891), pp.OA. ⟨10.1186/1471-2164-15-891⟩. ⟨hal-02631920⟩
  • Jessica Soyer, Mennat El Ghalid, Nicolas Glaser, Bénédicte Ollivier, Juliette Linglin, et al.. Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus [i]Leptosphaeria maculans[/i]. PLoS Genetics, Public Library of Science, 2014, 10 (3), 19 p. ⟨10.1371/journal.pgen.1004227⟩. ⟨hal-01019254⟩
  • Régine Delourme, Lydia Bousset-Vaslin, Magali Ermel, Philippe Duffe, Anne-Laure Besnard, et al.. Quantitative resistance affects the speed of frequency increase but not the diversity of the virulence alleles overcoming a major resistance gene to [i]Leptosphaeria maculans[/i] in oilseed rape. Infection, Genetics and Evolution, Elsevier, 2014, 27, pp.490-499. ⟨10.1016/j.meegid.2013.12.019⟩. ⟨hal-01208690⟩
  • Brett M. B. M. Tyler, Shiv D. S. D. Kale, Qunqing Q. Wang, Kai K. Tao, Helen R. H. R. Clark, et al.. Microbe-Independent Entry of Oomycete RxLR Effectors and Fungal RxLR-Like Effectors Into Plant and Animal Cells Is Specific and Reproducible. Molecular Plant-Microbe Interactions, American Phytopathological Society, 2013, 26 (6), pp.611 - 616. ⟨10.1094/mpmi-02-13-0051-ia⟩. ⟨hal-01001070⟩
  • Marie-Helene Balesdent, Isabelle Fudal-Grolier Fudal, Bénédicte B. Ollivier, Pascal P. Bally, Jonathan J. Grandaubert, et al.. The dispensable chromosome of Leptosphaeria maculans shelters an effector gene conferring avirulence towards Brassica rapa.. New Phytologist, Wiley, 2013, 198 (3), pp.887-898. ⟨10.1111/nph.12178⟩. ⟨hal-01004245⟩
  • Guillaume Daverdin, Thierry Rouxel, Lilian Gout, Jean-Noel Aubertot, Isabelle Fudal, et al.. Genome Structure and Reproductive Behaviour Influence the Evolutionary Potential of a Fungal Phytopathogen. PLoS Pathogens, Public Library of Science, 2012, 8 (11), 15 p. ⟨10.1371/journal.ppat.1003020⟩. ⟨hal-01019027⟩
  • Ahmed Salim A. S. Bourras, Michel M. Meyer, Jonathan J. Grandaubert, Nicolas N. Lapalu, Isabelle Fudal-Grolier Fudal, et al.. Incidence of Genome Structure, DNA Asymmetry, and Cell Physiology on T-DNA Integration in Chromosomes of the Phytopathogenic Fungus Leptosphaeria maculans. G3, Genetics Society of America, 2012, 2 (8), pp.891-904. ⟨10.1534/g3.112.002048⟩. ⟨hal-01000638⟩
  • Shiv D. Kale, Biao Gu, Daniel G.S. Capelluto, Daolong Dou, Emily Feldman, et al.. External lipid P13P mediates entry of eukaryotic pathogen effectors into plant and animal host cells. Cell, Elsevier, 2010, 142 (2), pp.284-295. ⟨10.1016/j.cell.2010.06.008⟩. ⟨hal-02667928⟩
  • Francis Parlange, Guillaume G. Daverdin, Marie-Line Kuhn, Isabelle Fudal-Grolier Fudal, Marie-Helene Balesdent, et al.. Leptosphaeria maculans avirulence gene AvrLm4-7 confers a dual recognition specificity by the Rlm4 and Rlm7 resistance genes of oilseed rape and circumvents Rlm4-mediated recognition through a single amino acid change. Molecular Microbiology, Wiley, 2009, 71 (4), pp.851-863. ⟨10.1111/j.1365-2958.2008.06547.x⟩. ⟨hal-02663864⟩
  • Isabelle Fudal-Grolier Fudal, Simon Ross, Hortense H. Brun, Anne-Laure A.-L. Besnard, Magali M. Ermel, et al.. Repeat-induced point mutation (RIP) as an alternative mechanism of evolution toward virulence in Leptosphaeria maculans. Molecular Plant-Microbe Interactions, American Phytopathological Society, 2009, 22 (8), pp.932-941. ⟨10.1094/MPMI-22-8-0932⟩. ⟨hal-02667764⟩
  • Jérôme Collemare, M. Pianfetti, M. Houllé, A.E. Morin, Laurent Camborde, et al.. Magnaporhe grisea avirulence gene ACE1 belons to an infection-specific gene cluster involved in secondary metabolism. New Phytologist, Wiley, 2008, 179 (1), pp.196-208. ⟨10.1111/j.1469-8137.2008.02459.x⟩. ⟨hal-02669102⟩
  • Isabelle Fudal, Jérôme Collemare, Heidi U. Böhnert, Delphine Melayah, Marc-Henri Lebrun. Expression of Magnaporthe grisea Avirulence Gene ACE1 Is Connected to the Initiation of Appressorium-Mediated Penetration. Eukaryotic Cell, American Society for Microbiology, 2007, 6 (3), pp.546-554. ⟨10.1128/EC.00330-05⟩. ⟨halsde-00180977⟩
  • Isabelle Fudal-Grolier Fudal, S Ross, Lilian L. Gout, Francoise F. Blaise, Marie-Line Kuhn, et al.. Heterochromatin-like regions as ecological niches for avirulence genes in the Leptosphaeria maculans genome : map-based cloning of AvrLm6. Molecular Plant-Microbe Interactions, American Phytopathological Society, 2007, 20 (4), pp.459-470. ⟨10.1094/MPMI-20-4-0459⟩. ⟨hal-02656853⟩
  • Lilian L. Gout, Isabelle Fudal-Grolier Fudal, Marie-Line Kuhn, Francoise F. Blaise, Maria Eckert, et al.. Lost in the middle of nowhere: the AvrLm1 avirulence gene of the dothideomycete Leptosphaeria maculans. Molecular Microbiology, Wiley, 2006, 60 (1), pp.67-80. ⟨10.1111/j.1365-2958.2006.05076.x⟩. ⟨hal-02662679⟩
  • Brett C Couch, Isabelle Fudal, Marc-Henri M.-H. Lebrun, Didier Tharreau, Barbara Valent, et al.. Origins of host-specific populations of the blast pathogen Magnaporthe oryzae in crop domestication with subsequent expansion of pandemic clones on rice and weeds of rice. Genetics, Genetics Society of America, 2005, 170 (2), pp.613-630. ⟨10.1534/genetics.105.041780⟩. ⟨hal-02681928⟩

Preprints, Working Papers, ...3 documents

  • Méline Saubin, Clémentine Louet, Lydia Bousset, Frédéric Fabre, Isabelle Fudal, et al.. Improving the design of sustainable crop protection strategies thanks to population genetics concepts. 2021. ⟨hal-03394837⟩
  • Colin Clairet, Nicolas Lapalu, Adeline Simon, Jessica Soyer, Muriel Viaud, et al.. Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures. 2021. ⟨hal-03324321⟩
  • Noureddine Lazar, Carl Mesarich, Yohann Petit-Houdenot, Nacera Talbi, Ines Li de La Sierra-Gallay, et al.. A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins. 2021. ⟨hal-03324327⟩

Habilitation à diriger des recherches1 document

  • Isabelle Fudal-Grolier Fudal. Génomique fonctionnelle des interactions plantes / champignons. Sciences du Vivant [q-bio]. Université Paris Sud - Paris 11, 2014. ⟨tel-02801567⟩