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Isabelle Fournier

Professor Senior Member Institut Universitaire de France Vice President for Doctoral Research at University of Lille
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Présentation

Prof. Fournier is Distinguished Professor at University of Lille, and she holds a position as co-director of the PRISM Inserm U1192 Lab and as Vice President for Doctoral Research for the university. She is a bioanalytical chemist specialized in clinical mass spectrometry and proteomics. She started research working on fundamental of MALDI during her PhD at University Pierre & Marie Curie in Paris first and then, as a postdoctoral fellow within the group of Prof. Michael Karas in Frankfurt. In 2002, she established her own group at University of Lille where she started developing MALDI MS Imaging. She contributed to the field with several developments including strategies for imaging of FFPE tissues and proteins, and the development of tagged probes for specific imaging of mRNA and antigens. In 2009, she was hired as Full Professor and awarded a Junior position at Institut Universitaire de France. Since 2012, she got interested by the development of Spatially Resolved Proteomics in combination to MALDI MSI for applications in oncology. Over the past 5 years, she also worked on the development of in vivo MS for guided surgery and intraoperative analysis. She confounded the Imabiotech Company which provides services in MALDI MSI and recently CELEOS that will commercialize the SpiderMass technology. She was recently distinguished by the international distinguish award from MSACL and was awarded a senior position at Institut Universitaire de France in 2019.

Domaines de recherche

Chimie analytique Génomique, Transcriptomique et Protéomique [q-bio.GN] Imagerie

Compétences

mass spectrometry imaging proteomics spatial proteomics lipidomics health technology

Publications

Real-time glioblastoma tumor microenvironment assessment by SpiderMass for improved patient management.

Yanis Zirem , Léa Ledoux , Lucas Roussel , Claude Alain Maurage , Pierre Tirilly
Cell Reports Medicine, 2024, pp.101482. ⟨10.1016/j.xcrm.2024.101482⟩
Article dans une revue hal-04527077v1
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Employing non-targeted interactomics approach and subcellular fractionation to increase our understanding of the ghost proteome

Diego-Fernando Garcia del Rio , Tristan Cardon , S. Eyckerman , Isabelle Fournier , Amelie Bonnefond
iScience, 2023, Iscience, 26, pp.105943. ⟨10.1016/j.isci.2023.105943⟩
Article dans une revue hal-04401042v1

Development of a novel apigenin prodrug programmed for alkaline-phosphatase instructed self-inhibition to combat cancer.

D. Diamantis , A. D. Tsiailanis , C. Papaemmanouil , M. C. Nika , Z. Kanaki
Journal of Biomolecular Structure and Dynamics, 2023, Journal of Biomolecular Structure and Dynamics, pp.1-22. ⟨10.1080/07391102.2023.2247083⟩
Article dans une revue hal-04400762v1

Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome

Alice Capuz , Sylvain Osien , Tristan Cardon , Mélodie Anne Karnoub , Soulaimane Aboulouard
Cell Death and Disease, 2023, 14 (8), pp.526. ⟨10.1038/s41419-023-06037-y⟩
Article dans une revue hal-04476023v1

From precise surgery to precision surgery: The multiple dimensions of therapeutic precision for head and neck cancer

Antoine Galmiche , Zuzana Saidak , Emmanuel Babin , Esteban Brenet , Julien Davrou
Journal of Stomatology, Oral and Maxillofacial Surgery, 2023, ⟨10.1016/j.jormas.2022.11.018⟩
Article dans une revue hal-03881465v1

Correction: Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome

Alice Capuz , Sylvain Osien , Tristan Cardon , Mélodie Anne Karnoub , Soulaimane Aboulouard
Cell Death and Disease, 2023, 14 (10), pp.677. ⟨10.1038/s41419-023-06143-x⟩
Article dans une revue hal-04278155v1

Early Diagnosis: End-to-End CNN–LSTM Models for Mass Spectrometry Data Classification

Khawla Seddiki , Fŕed́eric Precioso , Melissa Sanabria , Michel Salzet , Isabelle Fournier
Analytical Chemistry, 2023, 95 (36), pp.13431-13437. ⟨10.1021/acs.analchem.3c00613⟩
Article dans une revue hal-04459618v1

Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome

Alice Capuz , Sylvain Osien , Tristan Cardon , Mélodie Anne Karnoub , Soulaimane Aboulouard
Cell Death and Disease, 2023, 14 (8), pp.526. ⟨10.1038/s41419-023-06037-y⟩
Article dans une revue hal-04528686v1
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Challenges in glioblastoma research: focus on the tumor microenvironment

Andreas Bikfalvi , Cristine Alves da Costa , Tony Avril , Jean-Vianney Barnier , Luc Bauchet
Trends in Cancer, 2023, 9 (1), pp.9-27. ⟨10.1016/j.trecan.2022.09.005⟩
Article dans une revue hal-03860005v1
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Establishment and characterization of canine mammary tumoroids for translational research.

Antonella Raffo Romero , Soulaimane Aboulouard , Emmanuel Bouchaert , Agata Rybicka , Dominique Tierny
BMC Biology, 2023, BMC Biology, 21, pp.23. ⟨10.1186/s12915-023-01516-2⟩
Article dans une revue hal-04401119v1
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Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome.

Alice Capuz , Sylvain Osien , Tristan Cardon , Melodie-Anne Karnoub , Soulaimane Aboulouard
Cell Death Dis, 2023, Cell Death Dis, 14, pp.526. ⟨10.1038/s41419-023-06037-y⟩
Article dans une revue hal-04400988v1
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Protocol to identify human subcellular alternative protein interactions using cross-linking mass spectrometry.

Diego-Fernando Garcia del Rio , Isabelle Fournier , Tristan Cardon , Michel Salzet
STAR Protocols, 2023, STAR Protocols, 4 (3), pp.102380. ⟨10.1016/j.xpro.2023.102380⟩
Article dans une revue hal-04400811v1
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Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion

Alice Capuz , Sylvain Osien , Melodie-Anne Karnoub , Soulaimane Aboulouard , Estelle Laurent
Cell Death and Disease, 2023, Cell Death and Disease, 14 (4), pp.237. ⟨10.1038/s41419-023-05737-9⟩
Article dans une revue hal-04278200v2
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Fallopian tube lesions as potential precursors of early ovarian cancer: a comprehensive proteomic analysis.

Maxence Wisztorski , Soulaimane Aboulouard , Lucas Roussel , Marie Duhamel , Philippe Saudemont
Cell Death and Disease, 2023, Cell Death and Disease, 14, pp.644. ⟨10.1038/s41419-023-06165-5⟩
Article dans une revue hal-04400929v1
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OpenProt 2.0 builds a path to the functional characterization of alternative proteins.

S. Leblanc , F. Yala , N. Provencher , J. F. Lucier , M. Levesque
Nucleic Acids Research, 2023, Nucleic Acids Research, ⟨10.1093/nar/gkad1050⟩
Article dans une revue hal-04423840v1
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Prophylactic Radical Fimbriectomy with Delayed Oophorectomy in Women with a High Risk of Developing an Ovarian Carcinoma: Results of a Prospective National Pilot Study

Éric Leblanc , Fabrice Narducci , Gwénaël Ferron , Audrey Mailliez , Jean Yves Charvolin
Cancers, 2023, 15 (4), ⟨10.3390/cancers15041141⟩
Article dans une revue hal-04068556v1
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Comparing MS imaging of lipids by WALDI and MALDI: two technologies for evaluating a common ground truth in MS imaging.

Lea Ledoux , Yanis Zirem , Florence Renaud , Ludovic Duponchel , Michel Salzet
Analyst, 2023, Analyst, 148, pp.4982-4986. ⟨10.1039/d3an01096a⟩
Article dans une revue hal-04401014v2
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Mass Spectrometry-Based Differentiation of Oral Tongue Squamous Cell Carcinoma and Nontumor Regions With the SpiderMass Technology

Nina Ogrinc , Christophe Attencourt , Emilien Colin , Ahmed Boudahi , Riad Tebbakha
Frontiers in Oral Health, 2022, 3, ⟨10.3389/froh.2022.827360⟩
Article dans une revue hal-03722795v1
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Spatial analysis of the glioblastoma proteome reveals specific molecular signatures and markers of survival.

Marie Duhamel , L. Drelich , Maxence Wisztorski , Soulaimane Aboulouard , Jean-Pascal Gimeno
Nature Communications, 2022, Nature Communications, 13, pp.6665. ⟨10.1038/s41467-022-34208-6⟩
Article dans une revue hal-04212126v1
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Path to clonal theranostics in luminal breast cancers

Nawale Hajjaji , Soulaimane Aboulouard , Tristan Cardon , Delphine Bertin , Yves-Marie Robin
Frontiers in Oncology, 2022, Frontiers in Oncology, 11, pp.802177. ⟨10.3389/fonc.2021.802177⟩
Article dans une revue hal-04022193v1

On-tissue spatially resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape

Stacy Alyse Malaker , Jusal Quanico , Antonella Raffo-Romero , Firas Kobeissy , Soulaimane Aboulouard
Cell Chemical Biology, 2022, 29 (1), pp.30-42.e4. ⟨10.1016/j.chembiol.2021.05.007⟩
Article dans une revue hal-04460596v1
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Direct In Vivo Analysis of CBD- and THC-Acid Cannabinoids and Classification of Cannabis Cultivars Using SpiderMass.

Nina Ogrinc , S. Schneider , A. Bourmaud , N. Gengler , Michel Salzet
Metabolites, 2022, Metabolites, 12, ⟨10.3390/metabo12060480⟩
Article dans une revue hal-04412905v1

Trop-2, Na+/K+ ATPase, CD9, PKCα, cofilin assemble a membrane signaling super-complex that drives colorectal cancer growth and invasion

Emanuela Guerra , Valeria Relli , Martina Ceci , Romina Tripaldi , Pasquale Simeone
Oncogene, 2022, 41 (12), pp.1795-1808. ⟨10.1038/s41388-022-02220-1⟩
Article dans une revue hal-04460581v1

The Antibody Dependant Neurite Outgrowth Modulation Response Involvement in Spinal Cord Injury

Alice Capuz , Mélodie-Anne Karnoub , Sylvain Osien , Mélanie Rose , Céline Mériaux
Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.882830⟩
Article dans une revue hal-04278167v1

Shedding Light on the Ghost Proteome

Tristan Cardon , Isabelle Fournier , Michel Salzet
Trends in Biochemical Sciences, 2021, 46 (3), pp.239-250. ⟨10.1016/j.tibs.2020.10.003⟩
Article dans une revue hal-04446903v1
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Robot-assisted spidermass for in vivo real-time topography mass spectrometry imaging

Nina Ogrinc , Alexandre Kruszewski , Paul Chaillou , Philippe Saudemont , Chann Lagadec
Analytical Chemistry, 2021, Analytical Chemistry, ⟨10.1021/acs.analchem.1c01692⟩
Article dans une revue hal-03990566v1
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Unveiling a ghost proteome in the glioblastoma non-coding rnas

Tristan Cardon , Isabelle Fournier , Michel Salzet
Frontiers in Cell and Developmental Biology, 2021, Frontiers in Cell and Developmental Biology, 9, pp.703583. ⟨10.3389/fcell.2021.703583⟩
Article dans une revue hal-04011459v1
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Apport des outils de chemobiologie à l’imagerie par spectrométrie de masse

David Touboul , Isabelle Fournier
L'Actualité Chimique, 2021
Article dans une revue hal-03840976v1
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In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer

Soulaimane Aboulouard , Maxence Wisztorski , Marie Duhamel , Philippe Saudemont , Tristan Cardon
Cell Reports Medicine, 2021, Cell Reports Medicine, 2 (6), pp.100318. ⟨10.1016/j.xcrm.2021.100318⟩
Article dans une revue hal-04009565v1
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Toward high spatially resolved proteomics using expansion microscopy

Lauranne Drelich , Soulaimane Aboulouard , Julien Franck , Michel Salzet , Isabelle Fournier
Analytical Chemistry, 2021, Analytical Chemistry, 93 (36), pp.12195-12203. ⟨10.1021/acs.analchem.0c05372⟩
Article dans une revue hal-04011475v1
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In utero exposure to metformin reduces the fertility of male offspring in adulthood

Mélanie C. Faure , Rita Khoueiry , Jusal Quanico , Hervé Acloque , Marie-Justine Guerquin
Frontiers in Endocrinology, 2021, 12, pp.1-18. ⟨10.3389/fendo.2021.750145⟩
Article dans une revue hal-03462578v1
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Direct water-assisted laser desorption/ionization mass spectrometry lipidomic analysis and classification of formalin-fixed paraffin-embedded sarcoma tissues without dewaxing

Nina Ogrinc , Pierre-Damien Caux , Yves-Marie Robin , Emmanuel Bouchaert , Benoit Fatou
Clinical chemistry, 2021, 67 (11), pp.1513-1523. ⟨10.1093/clinchem/hvab160⟩
Article dans une revue hal-04019390v1
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The NANOTUMOR consortium - Towards the Tumor Cell Atlas

Florent Colin , Kristine Schauer , Ali Hamiche , Pierre Martineau , Jean-Paul Borg
Biology of the Cell, 2021, 113 (6), pp.272-280. ⟨10.1111/boc.202000135⟩
Article dans une revue hal-03169719v1
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Protein kinase c activation drives a differentiation program in an oligodendroglial precursor model through the modulation of specific biological networks

Marina Damato , Tristan Cardon , Maxence Wisztorski , Isabelle Fournier , Damiana Pieragostino
International Journal of Molecular Sciences, 2021, International Journal of Molecular Sciences, 22 (10), pp.5245. ⟨10.3390/ijms22105245⟩
Article dans une revue hal-03967287v1

Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications

Khalil Mallah , Kazem Zibara , Coline Kerbaj , Ali Eid , Nour Khoshman
Mass Spectrometry Reviews, 2021, 42 (1), pp.189-205. ⟨10.1002/mas.21719⟩
Article dans une revue hal-04443805v1
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Therapeutic anti-glioma effect of the combined action of pcsk inhibitor with the anti-tumoral factors secreted by poly (i:c)-stimulated macrophages

Melanie Rose , Marie Duhamel , Soulaimane Aboulouard , Firas Kobeissy , Dominique Tierny
Cancer Gene Therapy, 2021, Cancer Gene Therapy, 29, pp.22-36. ⟨10.1038/s41417-020-00286-1⟩
Article dans une revue hal-04009706v1
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Surfaceome proteomic of glioblastoma revealed potential targets for immunotherapy

Melanie Rose , Tristan Cardon , Soulaimane Aboulouard , Nawale Hajjaji , Firas Kobeissy
Frontiers in Immunology, 2021, Frontiers in Immunology, 12, pp.746168. ⟨10.3389/fimmu.2021.746168⟩
Article dans une revue hal-04009596v1

Persistence of Coxsackievirus B4 in Pancreatic β Cells Disturbs Insulin Maturation, Pattern of Cellular Proteins, and DNA Methylation

Magloire Pandoua Nekoua , Antoine Bertin , Famara Sane , Jean-Pascal Gimeno , Isabelle Fournier
Microorganisms, 2021, 9 (6), pp.1125. ⟨10.3390/microorganisms9061125⟩
Article dans une revue inserm-04456755v1
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Persistence of coxsackievirus b4 in pancreatic ? cells disturbs insulin maturation, pattern of cellular proteins, and dna methylation

Magloire Pandoua Nekoua , Antoine Bertin , Famara Sane , Jean-Pascal Gimeno , Isabelle Fournier
Microorganisms, 2021, Microorganisms, 9 (6), pp.1125. ⟨10.3390/microorganisms9061125⟩
Article dans une revue hal-03955619v1

Spinal Cord Injury: Animal Models, Imaging Tools and the Treatment Strategies

Dasa Cizkova , Adriana-Natalia Murgoci , Veronika Cubinkova , Filip Humenik , Zuzana Mojzisova
Neurochemical Research, 2020, 45 (1), pp.134-143. ⟨10.1007/s11064-019-02800-w⟩
Article dans une revue inserm-02941635v1
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Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling

Daniele Vergara , Sara Ravaioli , Eugenio Fonzi , Loredaria Adamo , Marina Damato
International Journal of Molecular Sciences, 2020, 21 (3), pp.715. ⟨10.3390/ijms21030715⟩
Article dans une revue inserm-02941786v1
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Reference and Ghost Proteins Identification in Rat C6 Glioma Extracellular Vesicles

Adriana-Natalia Murgoci , Tristan Cardon , Soulaimane Aboulouard , Marie Duhamel , Isabelle Fournier
iScience, 2020, 23 (5), pp.101045. ⟨10.1016/j.isci.2020.101045⟩
Article dans une revue inserm-02941792v1
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Cumulative learning enables convolutional neural network representations for small mass spectrometry data classification

Khawla Seddiki , Philippe Saudemont , Frédéric Precioso , Nina Ogrinc , Maxence Wisztorski
Nature Communications, 2020, 11 (1), pp.5595. ⟨10.1038/s41467-020-19354-z⟩
Article dans une revue hal-03132326v1
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Sars-cov-2 interactome with human ghost proteome: a neglected world encompassing a wealth of biological data

Tristan Cardon , Isabelle Fournier , Michel Salzet
Microorganisms, 2020, Microorganisms, 8 (12), pp.2036. ⟨10.3390/microorganisms8122036⟩
Article dans une revue hal-03966962v1

A Hidden Human Proteome Signature Characterizes the Epithelial Mesenchymal Transition Program

Daniele Vergara , Tiziano Verri , Marina Damato , Marco Trerotola , Pasquale Simeone
Current Pharmaceutical Design, 2020, 26 (3), pp.372-375. ⟨10.2174/1381612826666200129091610⟩
Article dans une revue inserm-02941785v1
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The Role of a Proprotein Convertase Inhibitor in Reactivation of Tumor-Associated Macrophages and Inhibition of Glioma Growth

Mélanie Rose , Marie Duhamel , Soulaimane Aboulouard , Firas Kobeissy , Emilie Le Rhun
Molecular Therapy - Oncolytics, 2020, 17, pp.31-46. ⟨10.1016/j.omto.2020.03.005⟩
Article dans une revue inserm-02940430v1
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Alternative proteins are functional regulators in cell reprogramming by PKA activation

Tristan Cardon , Julien Franck , Etienne Coyaud , Estelle Laurent , Marina Damato
Nucleic Acids Research, 2020, 48 (14), pp.7864-7882. ⟨10.1093/nar/gkaa277⟩
Article dans une revue inserm-02941812v1
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Openprot 2021: deeper functional annotation of the coding potential of eukaryotic genomes

Marie A. Brunet , Jean-Francois Lucier , Maxime Levesque , Sebastien Leblanc , Jean-Francois Jacques
Nucleic Acids Research, 2020, Nucleic Acids Research, 49 (D1), pp.D380-D388. ⟨10.1093/nar/gkaa1036⟩
Article dans une revue hal-04028636v1
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Location of neonatal microglia drives small extracellular vesicles content and biological functions in vitro

Adriana-Natalia Murgoci , Marie Duhamel , Antonella Raffo-Romero , Khalil Mallah , Soulaimane Aboulouard
Journal of Extracellular Vesicles, 2020, 9 (1), pp.1727637. ⟨10.1080/20013078.2020.1727637⟩
Article dans une revue inserm-02941810v1
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Mechanisms of innate events during skin reaction following intradermal injection of seasonal influenza vaccine

Jessica Gonnet , Lauranne Poncelet , Celine Meriaux , Elena Gonçalves , Lina Weiss
Journal of Proteomics, 2020, 216, pp.103670. ⟨10.1016/j.jprot.2020.103670⟩
Article dans une revue hal-03984601v2

Epigenetic Studies Revealed a Ghost Proteome in PC1/3 KD Macrophages under Antitumoral Resistance Induced by IL-10

Tristan Cardon , Bilgehan Ozcan , Soulaimane Aboulouard , Firas Kobeissy , Marie Duhamel
Article dans une revue hal-04445712v1
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Nuclei of HeLa cells interactomes unravel a network of ghost proteins involved in proteins translation

Tristan Cardon , Michel Salzet , Julien Franck , Isabelle Fournier
Biochimica et Biophysica Acta (BBA) - General Subjects, 2019, 1863 (10), pp.1458-1470. ⟨10.1016/j.bbagen.2019.05.009⟩
Article dans une revue inserm-02941645v1
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The multiverse nature of epithelial to mesenchymal transition

Pasquale Simeone , Marco Trerotola , Julien Franck , Tristan Cardon , Marco Marchisio
Seminars in Cancer Biology, 2019, 58, pp.1-10. ⟨10.1016/j.semcancer.2018.11.004⟩
Article dans une revue inserm-02940760v1

Proteomic profile of high-risk luminal A early breast cancers.

Nawale Hajjaji , Soulaimane Aboulouard , Yves-Marie Robin , Delphine Bertin , Isabelle Fournier
Journal of Clinical Oncology, 2019, 37 (15_suppl), pp.3077-3077. ⟨10.1200/JCO.2019.37.15_suppl.3077⟩
Article dans une revue inserm-02941546v1

Canine Bone Marrow-derived Mesenchymal Stem Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors

Filip Humenik , Dasa Cizkova , Stefan Cikos , Lenka Luptakova , Aladar Madari
Molecular and Cellular Proteomics, 2019, 18 (9), pp.1824-1835. ⟨10.1074/mcp.RA119.001507⟩
Article dans une revue inserm-02941608v1

Optimizing the substrate-mediated laser ablation of biological tissues: Quest for the best substrate material

T. Maulouet , B. Fatou , C. Focsa , M. Salzet , I. Fournier
Applied Surface Science, 2019, 473, pp.486-492. ⟨10.1016/j.apsusc.2018.12.173⟩
Article dans une revue hal-02406750v1

Mapping Spatiotemporal Microproteomics Landscape in Experimental Model of Traumatic Brain Injury Unveils a link to Parkinson's Disease

Khalil Mallah , Jusal Quanico , Antonella Raffo-Romero , Tristan Cardon , Soulaimane Aboulouard
Molecular and Cellular Proteomics, 2019, 18 (8), pp.1669-1682. ⟨10.1074/mcp.RA119.001604⟩
Article dans une revue inserm-02941592v1

Utilisation of Ambient Laser Desorption Ionisation Mass Spectrometry (ALDI-MS) Improves Lipid-Based Microbial Species Level Identification

Simon Cameron , Zsolt Bodai , Burak Temelkuran , Alvaro Perdones-Montero , Frances Bolt
Scientific Reports, 2019, 9 (1), pp.3006. ⟨10.1038/s41598-019-39815-w⟩
Article dans une revue hal-04462355v1
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Mass spectrometry-based intraoperative tumor diagnostics: a letter in reply

Isabelle Fournier , Michel Salzet
Future Science OA, 2019, 5 (7), pp.FSO403. ⟨10.2144/fsoa-2019-0037⟩
Article dans une revue inserm-02941629v1

Water-assisted laser desorption/ionization mass spectrometry for minimally invasive in vivo and real-time surface analysis using SpiderMass

Nina Ogrinc , Philippe Saudemont , Julia Balog , Yves-Marie Robin , Jean-Pascal Gimeno
Nature Protocols, 2019, 14 (11), pp.3162-3182. ⟨10.1038/s41596-019-0217-8⟩
Article dans une revue inserm-02941578v1

Optimized Sample Preparation Workflow for Improved Identification of Ghost Proteins

Tristan Cardon , Flore Hervé , Vivian Delcourt , Xavier Roucou , Michel Salzet
Analytical Chemistry, 2019, 92 (1), pp.1122-1129. ⟨10.1021/acs.analchem.9b04188⟩
Article dans une revue inserm-02941813v1
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Proteomic characterisation of leech microglia extracellular vesicles (EVs): comparison between differential ultracentrifugation and Optiprep™ density gradient isolation

T Arab , A Raffo-Romero , C van Camp , Q Lemaire , F Le Marrec-Croq
Journal of Extracellular Vesicles, 2019, 8 (1), pp.1603048. ⟨10.1080/20013078.2019.1603048⟩
Article dans une revue inserm-02941660v1

A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program

Anna Maria Giudetti , Stefania de Domenico , Andrea Ragusa , Paola Lunetti , Antonio Gaballo
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864 (3), pp.344-357. ⟨10.1016/j.bbalip.2018.12.011⟩
Article dans une revue inserm-02941613v1
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Distinct Protein Expression Networks are Activated in Microglia Cells after Stimulation with IFN-γ and IL-4

Daniele Vergara , Annamaria Nigro , Alessandro Romano , Stefania de Domenico , Marina Damato
Cells, 2019, 8 (6), pp.580. ⟨10.3390/cells8060580⟩
Article dans une revue inserm-02941561v1

Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Lipids in Experimental Model of Traumatic Brain Injury Detecting Acylcarnitines as Injury Related Markers

Khalil Mallah , Jusal Quanico , Antonella Raffo-Romero , Tristan Cardon , Soulaimane Aboulouard
Analytical Chemistry, 2019, 91 (18), pp.11879-11887. ⟨10.1021/acs.analchem.9b02633⟩
Article dans une revue inserm-02941587v1
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OpenProt: a more comprehensive guide to explore eukaryotic coding potential and proteomes

Marie A Brunet , Mylène Brunelle , Jean-François Lucier , Vivian Delcourt , Maxime Levesque
Nucleic Acids Research, 2019, 8 (47(D1)), pp.D403-D410. ⟨10.1093/nar/gky936⟩
Article dans une revue inserm-02941503v1

Deciphering molecular consequences of the proprotein convertase 1/3 inhibition in macrophages for application in anti-tumour immunotherapy

Franck Rodet , Alice Capuz , Tsukasa Hara , Rinaldo van Meel , Marie Duhamel
Journal of Biotechnology, 2018, 282, pp.80-85. ⟨10.1016/j.jbiotec.2018.07.002⟩
Article dans une revue hal-04445717v1
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The Protein Coded by a Short Open Reading Frame, Not by the Annotated Coding Sequence, Is the Main Gene Product of the Dual-Coding Gene MIEF1

Vivian Delcourt , Mylène Brunelle , Annie Roy , Jean-François Jacques , Michel Salzet
Molecular and Cellular Proteomics, 2018, 17 (12), pp.2402-2411. ⟨10.1074/mcp.RA118.000593⟩
Article dans une revue inserm-02940894v1
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Small Proteins Encoded by Unannotated ORFs are Rising Stars of the Proteome, Confirming Shortcomings in Genome Annotations and Current Vision of an mRNA

Vivian Delcourt , Antanas Staskevicius , Michel Salzet , Isabelle Fournier , Xavier Roucou
Proteomics, 2018, 18 (10), pp.1700058. ⟨10.1002/pmic.201700058⟩
Article dans une revue inserm-02940662v1

Temporally and spatially-resolved microproteomics and MALDI MSI lipidomic analysis for traumatic brain injury biomarker identification

Khalil Mallah , Jusal Quanico , Firas Kobeissy , Kazem Zibara , Michel Salzet
African Journal of Biotechnology, 2018, 280S, pp.S8. ⟨10.1016/j.jbiotec.2018.06.327⟩
Article dans une revue inserm-02940837v1
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Proteomic expression profile of injured rat peripheral nerves revealed biological networks and processes associated with nerve regeneration

Daniele Vergara , Alessandro Romano , Eleonora Stanca , Velia La Pesa , Laura Aloisi
Journal of Cellular Physiology, 2018, 233 (8), pp.6207-6223. ⟨10.1002/jcp.26478⟩
Article dans une revue inserm-02940755v1
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β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

Concetta Saponaro , Sara Sergio , Antonio Coluccia , Maria de Luca , Giuseppe La Regina
Oncogene, 2018, 37 (24), pp.3301-3316. ⟨10.1038/s41388-018-0170-y⟩
Article dans une revue inserm-02940774v1

Real time and in vivo pharmaceutical and environmental studies with SpiderMass instrument

B. Fatou , P. Saudemont , M. Duhamel , Michael Ziskind , C. Focsa
Journal of Biotechnology, 2018, 281, pp.61-66. ⟨10.1016/j.jbiotec.2018.06.339⟩
Article dans une revue inserm-02940936v1
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Real-Time Molecular Diagnosis of Tumors Using Water-Assisted Laser Desorption/Ionization Mass Spectrometry Technology

Philippe Saudemont , Jusal Quanico , Yves-Marie Robin , Anna Baud , Julia Balog
Cancer Cell, 2018, 34 (5), pp.840-851.e4. ⟨10.1016/j.ccell.2018.09.009⟩
Article dans une revue inserm-02940768v1
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Spatially-Resolved Top-down Proteomics Bridged to MALDI MS Imaging Reveals the Molecular Physiome of Brain Regions

Vivian Delcourt , Julien Franck , Jusal Quanico , Jean-Pascal Gimeno , Maxence Wisztorski
Molecular and Cellular Proteomics, 2018, 17 (2), pp.357-372. ⟨10.1074/mcp.M116.065755⟩
Article dans une revue inserm-02941492v1

Can real time molecular analyses change the paradigm of dog sarcoma diagnosis and classification?

Isabelle Fournier , Philippe Saudemont , Jusal Quanico , Benoit Fatou , Kevin Minier
Journal of Biotechnology, 2018, 280, pp.S4. ⟨10.1016/j.jbiotec.2018.06.315⟩
Article dans une revue inserm-02940781v1

Shedding new light on spinal cord injury

Michel Salzet , Jusal Quanico , Dasa Cizkova , Melodie Anne Karnoub , Zarha Laouby
Journal of Biotechnology, 2018, 280, pp.S4. ⟨10.1016/j.jbiotec.2018.06.314⟩
Article dans une revue inserm-02940788v1

Paclitaxel Treatment and Proprotein Convertase 1/3 (PC1/3) Knockdown in Macrophages is a Promising Antiglioma Strategy as Revealed by Proteomics and Cytotoxicity Studies

Marie Duhamel , Mélanie Rose , Franck Rodet , Adriana Natalia Murgoci , Lea Zografidou
Molecular and Cellular Proteomics, 2018, 17 (6), pp.1126-1143. ⟨10.1074/mcp.RA117.000443⟩
Article dans une revue hal-01847515v1
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3D MALDI mass spectrometry imaging reveals specific localization of long-chain acylcarnitines within a 10-day time window of spinal cord injury

Jusal Quanico , Lena Hauberg-Lotte , Stephanie Devaux , Zahra Laouby , Celine Meriaux
Scientific Reports, 2018, 8 (1), pp.16083. ⟨10.1038/s41598-018-34518-0⟩
Article dans une revue inserm-02940797v1

Remote Atmospheric Pressure Infrared Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry (Remote IR-MALDI MS) of Proteins

Benoit Fatou , Michael Ziskind , Philippe Saudemont , Jusal Quanico , Cristian Focsa
Molecular and Cellular Proteomics, 2018, 17 (8), pp.1637-1649. ⟨10.1074/mcp.TIR117.000582⟩
Article dans une revue inserm-02940859v1
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Lipid Changes Associated with Traumatic Brain Injury Revealed by 3D MALDI-MSI

Khalil Mallah , Jusal Quanico , Dennis Trede , Firas Kobeissy , Kazem Zibara
Analytical Chemistry, 2018, 90 (17), pp.10568-10576. ⟨10.1021/acs.analchem.8b02682⟩
Article dans une revue inserm-02940820v1
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Brain-Cortex Microglia-Derived Exosomes: Nanoparticles for Glioma Therapy

Adriana-Natalia Murgoci , Dasa Cizkova , Petra Majerova , Eva Petrovova , Lubomir Medvecky
ChemPhysChem, 2018, 19 (10), pp.1205-1214. ⟨10.1002/cphc.201701198⟩
Article dans une revue inserm-02940806v1
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Localized Intrathecal Delivery of Mesenchymal Stromal Cells Conditioned Medium Improves Functional Recovery in a Rat Model of Spinal Cord Injury

Dasa Cizkova , Veronika Cubinkova , Tomas Smolek , Adriana-Natalia Murgoci , Jan Danko
International Journal of Molecular Sciences, 2018, 19 (3), pp.870. ⟨10.3390/ijms19030870⟩
Article dans une revue inserm-02941495v1

ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

Francesco Drago , Marta Lombardi , Ilaria Prada , Martina Gabrielli , Pooja Joshi
Frontiers in Pharmacology, 2017, 8, ⟨10.3389/fphar.2017.00910⟩
Article dans une revue hal-04449135v1

RhoA Inhibitor Treatment At Acute Phase of Spinal Cord Injury May Induce Neurite Outgrowth and Synaptogenesis

Stephanie Devaux , Dasa Cizkova , Khalil Mallah , Melodie Anne Karnoub , Zahra Laouby
Molecular and Cellular Proteomics, 2017, 16 (8), pp.1394 - 1415. ⟨10.1074/mcp.M116.064881⟩
Article dans une revue hal-01827747v1
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β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells

Daniele Vergara , Eleonora Stanca , Flora Guerra , Paola Priore , Antonio Gaballo
Frontiers in Physiology, 2017, 8, pp.544. ⟨10.3389/fphys.2017.00544⟩
Article dans une revue inserm-02940615v1
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Proteomic and transcriptomic investigation of acne vulgaris microcystic and papular lesions: Insights in the understanding of its pathophysiology

Jusal Quanico , Jean-Pascal Gimeno , Florence Nadal-Wollbold , Christiane Casas , Sandrine Alvarez-Georges
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017, 1861 (3), pp.652-663. ⟨10.1016/j.bbagen.2016.10.021⟩
Article dans une revue inserm-02940626v1

Evaluation of non-supervised MALDI mass spectrometry imaging combined with microproteomics for glioma grade III classification

Emilie Le Rhun , Marie Duhamel , Maxence Wisztorski , Jean-Pascal Gimeno , Fahed Zairi
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017, 1865 (7), pp.875-890. ⟨10.1016/j.bbapap.2016.11.012⟩
Article dans une revue inserm-02940640v1
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NanoLC-MS coupling of liquid microjunction microextraction for on-tissue proteomic analysis

Jusal Quanico , Julien Franck , Tristan Cardon , Eric Leblanc , Maxence Wisztorski
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017, 1865 (7), pp.891-900. ⟨10.1016/j.bbapap.2016.11.002⟩
Article dans une revue inserm-02940625v1

Combined Mass Spectrometry Imaging and Top-down Microproteomics Reveals Evidence of a Hidden Proteome in Ovarian Cancer

Vivian Delcourt , Julien Franck , Eric Leblanc , Fabrice Narducci , Yves-Marie Robin
EBioMedicine, 2017, 21, pp.55-64. ⟨10.1016/j.ebiom.2017.06.001⟩
Article dans une revue inserm-02940659v1
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ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

Francesco Drago , Marta Lombardi , Ilaria Prada , Martina Gabrielli , Pooja Joshi
Frontiers in Pharmacology, 2017, 8, pp.910. ⟨10.3389/fphar.2017.00910⟩
Article dans une revue inserm-02940650v1

β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells

Daniele Vergara , Eleonora Stanca , Flora Guerra , Paola Priore , Antonio Gaballo
Frontiers in Physiology, 2017, 8, ⟨10.3389/fphys.2017.00544⟩
Article dans une revue hal-04449125v1

Integrated mass spectrometry imaging and omics workflows on the same tissue section using grid-aided, parafilm-assisted microdissection

Jusal Quanico , Julien Franck , Maxence Wisztorski , Michel Salzet , Isabelle Fournier
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017, 1861 (7), pp.1702-1714. ⟨10.1016/j.bbagen.2017.03.006⟩
Article dans une revue inserm-02940635v1

On-tissue Direct Monitoring of Global Hydrogen/Deuterium Exchange by MALDI Mass Spectrometry: Tissue Deuterium Exchange Mass Spectrometry (TDXMS)

Jusal Quanico , Julien Franck , Michel Salzet , Isabelle Fournier
Molecular and Cellular Proteomics, 2016, 15 (10), pp.3321-3330. ⟨10.1074/mcp.O116.059832⟩
Article dans une revue hal-04449154v1
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Spatially-resolved protein surface microsampling from tissue sections using liquid extraction surface analysis

Maxence Wisztorski , Annie Desmons , Jusal Quanico , Benoit Fatou , Jean-Pascal Gimeno
Proteomics, 2016, 16 (11-12), pp.1622-1632. ⟨10.1002/pmic.201500508⟩
Article dans une revue inserm-02940393v1

A Proteomic Analysis of Human Uterine Myoma

Antonio Rizzello , Julien Franck , Marcello Pellegrino , Francesco Nuccio , Pasquale Simeone
Current Protein and Peptide Science, 2016, 18 (2), pp.167-174. ⟨10.2174/1389203717666160322150603⟩
Article dans une revue hal-04447450v1

The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways

M. Duhamel , F. Rodet , A. Murgoci , R. Desjardins , H. Gagnon
Scientific Reports, 2016, 6 (1), pp.19360. ⟨10.1038/srep19360⟩
Article dans une revue hal-04445727v1
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The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways

M. Duhamel , F. Rodet , A. Murgoci , R. Desjardins , H. Gagnon
Scientific Reports, 2016, 6, pp.19360. ⟨10.1038/srep19360⟩
Article dans une revue inserm-02940434v1
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Laser induced post-desolvation of MALDI clusters

Laurent Diologent , Gérard Bolbach , Cristian Focsa , Michael Ziskind , Isabelle Fournier
International Journal of Mass Spectrometry, 2016, 416, pp.29-36. ⟨10.1016/j.ijms.2016.12.005⟩
Article dans une revue hal-01420190v1

Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages

Marie Duhamel , Franck Rodet , Adriana Murgoci , Maxence Wisztorski , Robert Day
EuPA Open Proteomics, 2016, 11, pp.20-22. ⟨10.1016/j.euprot.2016.03.003⟩
Article dans une revue hal-04447345v1
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Translating epithelial mesenchymal transition markers into the clinic: Novel insights from proteomics

Daniele Vergara , Pasquale Simeone , Julien Franck , Marco Trerotola , Anna Giudetti
EuPA Open Proteomics, 2016, 10, pp.31-41. ⟨10.1016/j.euprot.2016.01.003⟩
Article dans une revue inserm-02940397v1

Proteomic Analysis of the Spatio-temporal Based Molecular Kinetics of Acute Spinal Cord Injury Identifies a Time- and Segment-specific Window for Effective Tissue Repair

Stephanie Devaux , Dasa Cizkova , Jusal Quanico , Julien Franck , Serge Nataf
Molecular and Cellular Proteomics, 2016, 15 (8), pp.2641-2670. ⟨10.1074/mcp.M115.057794⟩
Article dans une revue hal-01850361v1
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In vivo Real-Time Mass Spectrometry for Guided Surgery Application

Benoit Fatou , Philippe Saudemont , Eric Leblanc , Denis Vinatier , Violette Mesdag
Scientific Reports, 2016, 6, pp.25919. ⟨10.1038/srep25919⟩
Article dans une revue inserm-02940425v1
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Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease

Jae Ho Kim , Julien Franck , Taewook Kang , Helmut Heinsen , Rivka Ravid
Scientific Reports, 2015, 5, pp.11138. ⟨10.1038/srep11138⟩
Article dans une revue inserm-02940247v1

MALDI-MS and NanoSIMS imaging techniques to study cnidarian?dinoflagellate symbioses

C. Kopp , M. Wisztorski , J. Revel , M. Mehiri , V. Dani
Zoology, 2015, 118 (2), pp.125 - 131. ⟨10.1016/j.zool.2014.06.006⟩
Article dans une revue hal-01546914v1
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Delivery of Alginate Scaffold Releasing Two Trophic Factors for Spinal Cord Injury Repair

I. Grulova , L. Slovinska , J. Blaško , S. Devaux , M. Wisztorski
Scientific Reports, 2015, 5, pp.13702. ⟨10.1038/srep13702⟩
Article dans une revue inserm-02940249v1

Parafilm-assisted microdissection: a sampling method for mass spectrometry-based identification of differentially expressed prostate cancer protein biomarkers

J. Quanico , J. Franck , J. Gimeno , R. Sabbagh , M. Salzet
Chemical Communications, 2015, 51 (22), pp.4564-4567. ⟨10.1039/c4cc08331h⟩
Article dans une revue hal-04456902v1

Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study

M. Duhamel , F. Rodet , N. Delhem , F. Vanden Abeele , F. Kobeissy
Molecular and Cellular Proteomics, 2015, 14 (11), pp.2857-77. ⟨10.1074/mcp.M115.052480⟩
Article dans une revue hal-01850616v1

Parafilm-assisted microdissection: a sampling method for mass spectrometry-based identification of differentially expressed prostate cancer protein biomarkers

J. Quanico , J. Franck , J. Gimeno , R. Sabbagh , M. Salzet
Chemical Communications, 2015, 51 (22), pp.4564-4567. ⟨10.1039/C4CC08331H⟩
Article dans une revue hal-04449501v1
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Substrate-Mediated Laser Ablation under Ambient Conditions for Spatially-Resolved Tissue Proteomics

Benoit Fatou , Maxence Wisztorski , Cristian Focsa , Michel Salzet , Michael Ziskind
Scientific Reports, 2015, 5, pp.18135. ⟨10.1038/srep18135⟩
Article dans une revue inserm-02940254v1

Inter- and intra-organ spatial distributions of sea star saponins by MALDI imaging

Marie Demeyer , Maxence Wisztorski , Corentin Decroo , Julien de Winter , Guillaume Caulier
Analytical and Bioanalytical Chemistry, 2015, 407 (29), pp.8813-8824. ⟨10.1007/s00216-015-9044-0⟩
Article dans une revue hal-02939600v1

Parafilm-assisted microdissection: a sampling method for mass spectrometry-based identification of differentially expressed prostate cancer protein biomarkers

J. Quanico , J. Franck , J. Gimeno , R. Sabbagh , M. Salzet
Chemical Communications, 2015, 51 (22), pp.4564-4567. ⟨10.1039/C4CC08331H⟩
Article dans une revue hal-04449202v1

Parafilm-assisted microdissection: a sampling method for mass spectrometry-based identification of differentially expressed prostate cancer protein biomarkers

J. Quanico , J. Franck , J. Gimeno , R. Sabbagh , Michel Salzet
Chemical Communications, 2015, 51 (22), pp.4564-4567. ⟨10.1039/c4cc08331h⟩
Article dans une revue inserm-02940232v1
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Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verbana and its gut symbiont Aeromonas veronii

Aurélie Tasiemski , François Massol , Virginie Cuvillier-Hot , Céline Boidin-Wichlacz , Emmanuel Roger
Scientific Reports, 2015, 5, pp.17498. ⟨10.1038/srep17498⟩
Article dans une revue hal-01239548v1

Alterations of protein composition along the rostro-caudal axis after spinal cord injury: proteomic, in vitro and in vivo analyses

Dasa Cizkova , Julien Franck , Lucia Slovinska , Ivana Grulova , Christophe Lefebvre
Frontiers in Cellular Neuroscience, 2014, 8, ⟨10.3389/fncel.2014.00105⟩
Article dans une revue hal-04455729v1

Human temporal lobe epilepsy analyses by tissue proteomics

Céline Mériaux , Julien Franck , Dan Bi Park , Jusal Quanico , Young Hye Kim
Hippocampus, 2014, 24 (6), pp.628-642. ⟨10.1002/hipo.22246⟩
Article dans une revue hal-04455749v1

Modulation properties of factors released by bone marrow stromal cells on activated microglia: an in vitro study

Dasa Cizkova , Stéphanie Devaux , Françoise Le Marrec-Croq , Julien Franck , Lucia Slovinska
Scientific Reports, 2014, 4 (1), pp.7514. ⟨10.1038/srep07514⟩
Article dans une revue hal-04449213v1

On the origin of increased sensitivity and mass resolution using silicon masks in MALDI

Laurent Diologent , Julien Franck , Maxence Wisztorski , A. Treizebre , Cristian Focsa
Analytical Chemistry, 2014, 86, pp.1404-1413. ⟨10.1021/ac401329r⟩
Article dans une revue hal-00946711v1

Quantification-Based Mass Spectrometry Imaging of Proteins by Parafilm Assisted Microdissection

Julien Franck , Jusal Quanico , Maxence Wisztorski , Robert Day , Michel Salzet
Analytical Chemistry, 2013, 85 (17), pp.8127-8134. ⟨10.1021/ac4009397⟩
Article dans une revue hal-04455753v1

Ionic matrices pre-spotted matrix-assisted laser desorption/ionization plates for patient maker following in course of treatment, drug titration, and MALDI mass spectrometry imaging

David Bonnel , Julien Franck , Céline Mériaux , Michel Salzet , Isabelle Fournier
Analytical Biochemistry, 2013, 434 (1), pp.187-198. ⟨10.1016/j.ab.2012.10.035⟩
Article dans une revue hal-04455799v1

Development of liquid microjunction extraction strategy for improving protein identification from tissue sections

Jusal Quanico , Julien Franck , Claire Dauly , Kerstin Strupat , Jocelyn Dupuy
Journal of Proteomics, 2013, 79, pp.200-218. ⟨10.1016/j.jprot.2012.11.025⟩
Article dans une revue hal-04455771v1

Microproteomics by liquid extraction surface analysis: Application to FFPE tissue to study the fimbria region of tubo‐ovarian cancer

Maxence Wisztorski , Benoit Fatou , Julien Franck , Annie Desmons , Isabelle Farré
PROTEOMICS - Clinical Applications, 2013, 7 (3-4), pp.234-240. ⟨10.1002/prca.201200070⟩
Article dans une revue hal-04455765v1

TARGETED MASS spectrometry Imaging: Specific Targeting Mass Spectrometry imaging technologies from history to perspective

Hugo Gagnon , Julien Franck , Maxence Wisztorski , Robert Day , Isabelle Fournier
Progress in Histochemistry and Cytochemistry, 2012, 47 (3), pp.133-174. ⟨10.1016/j.proghi.2012.08.002⟩
Article dans une revue hal-04455827v1

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits

F. Brignole-Baudouin , N. Desbenoit , G. Hamm , H. Liang , J. P. Both
PLoS ONE, 2012, 7 (11), pp.e50180. ⟨10.1371/journal.pone.0050180⟩
Article dans une revue hal-00764054v1

Multivariate analyses for biomarkers hunting and validation through on-tissue bottom-up or in-source decay in MALDI-MSI: application to prostate cancer

David Bonnel , Rémi Longuespee , Julien Franck , Morad Roudbaraki , Pierre Gosset
Analytical and Bioanalytical Chemistry, 2011, 401 (1), pp.149-165. ⟨10.1007/s00216-011-5020-5⟩
Article dans une revue hal-04455842v1

Multiple Changes in Peptide and Lipid Expression Associated with Regeneration in the Nervous System of the Medicinal Leech

C. Meriaux , K. Arafah , A. Tasiemski , M. Wisztorski , J. Bruand
PLoS ONE, 2011, 6 (4), pp.1-20. ⟨10.1371/journal.pone.0018359⟩
Article dans une revue hal-00589141v1

On-tissue protein identification and imaging by MALDI-Ion mobility mass spectrometry

Jonathan Stauber , Luke Macaleese , Julien Franck , Emmanuelle Claude , Marten Snel
Journal of The American Society for Mass Spectrometry, 2010, 21 (3), pp.338-347. ⟨10.1016/j.jasms.2009.09.016⟩
Article dans une revue hal-04456026v1

MALDI imaging and profiling MS of higher mass proteins from tissue

Alexandra Van Remoortere , René van Zeijl , Nico van den Oever , Julien Franck , Rémi Longuespée
Journal of The American Society for Mass Spectrometry, 2010, 21 (11), pp.1922-1929. ⟨10.1016/j.jasms.2010.07.011⟩
Article dans une revue hal-04456009v1

MALDI imaging mass spectrometry in ovarian cancer for tracking, identifying, and validating biomarkers.

Mohamed El Ayed , David Bonnel , Remi Longuespée , Céline Castelier , Julien Franck
Medical Science Monitor, 2010, 16 (8), pp.BR233-45
Article dans une revue hal-04456012v1

Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids

Céline Meriaux , Julien Franck , Maxence Wisztorski , Michel Salzet , Isabelle Fournier
Journal of Proteomics, 2010, 73 (6), pp.1204-1218. ⟨10.1016/j.jprot.2010.02.010⟩
Article dans une revue hal-04456017v1

MALDI mass spectrometry imaging of proteins exceeding 30,000 daltons.

Julien Franck , Rémi Longuespée , Maxence Wisztorski , Alexandra van Remoortere , René van Zeijl
Medical Science Monitor, 2010, 16 (9), pp.BR293-9
Article dans une revue hal-04456014v1

MALDI imaging mass spectrometry: state of the art technology in clinical proteomics

Julien Franck , Karim Arafah , Mohamed Elayed , David Bonnel , Daniele Vergara
Molecular and Cellular Proteomics, 2009, 8 (9), pp.2023-2033. ⟨10.1074/mcp.R800016-MCP200⟩
Article dans une revue hal-04456037v1

On-Tissue N-Terminal Peptide Derivatizations for Enhancing Protein Identification in MALDI Mass Spectrometric Imaging Strategies

J. Franck , M. El Ayed , M. Wisztorski , M. Salzet , I. Fournier
Analytical Chemistry, 2009, 81 (20), pp.8305-8317. ⟨10.1021/ac901043n⟩
Article dans une revue hal-04456028v1

Improving Tissue Preparation for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging. Part 1: Using Microspotting

Julien Franck , Karim Arafah , Alan Barnes , Maxence Wisztorski , Michel Salzet
Analytical Chemistry, 2009, 81 (19), pp.8193-8202. ⟨10.1021/ac901328p⟩
Article dans une revue hal-04456031v1

Molecular MALDI imaging: an emerging technology for neuroscience studies.

Maxence Wisztorski , Dominique Croix , Eduardo Macagno , Isabelle Fournier , Michel Salzet
Developmental Neurobiology, 2008, 68 (6), pp.845-58. ⟨10.1002/dneu.20623⟩
Article dans une revue hal-00350103v1

Tissue imaging using MALDI-MS: a new frontier of histopathology proteomics.

Isabelle Fournier , Maxence Wisztorski , Michel Salzet
Expert Review of Proteomics, 2008, 5 (3), pp.413-24. ⟨10.1586/14789450.5.3.413⟩
Article dans une revue hal-00350102v1

MALDI imaging of formalin-fixed paraffin-embedded tissues: application to model animals of Parkinson disease for biomarker hunting.

J. Stauber , R. Lemaire , J. Franck , D. Bonnel , D. Croix
Journal of Proteome Research, 2008, 7 (3), pp.969-78. ⟨10.1021/pr070464x⟩
Article dans une revue hal-00350106v1
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MALDI Imaging of Formalin-Fixed Paraffin-Embedded Tissues: Application to Model Animals of Parkinson Disease for Biomarker Hunting.

J. Stauber , R. Lemaire , M. Wisztorski , Julien Franck , Bonnel David
Journal of Proteome Research, 2008, 7 (7), pp.969-978
Article dans une revue hal-00268379v1

MITICS (MALDI Imaging Team Imaging Computing System): a new open source mass spectrometry imaging software.

Olivia Jardin-Mathé , David Bonnel , Julien Franck , Maxence Wisztorski , Eduardo Macagno
Journal of Proteomics, 2008, 71 (3), pp.332-45. ⟨10.1016/j.jprot.2008.07.004⟩
Article dans une revue hal-00350101v1
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Molecular profiling of matrix coated and native tissue sections by UV and IR MALDI-O-TOF-MS.

Klaus Dreisewerd , R. Lemaire , G. Pohlentz , M. Salzet , M. Wisztorski
Analytical Chemistry, 2007, 79 (6), pp.2463 -2471. ⟨10.1021/ac061768q⟩
Article dans une revue hal-00086947v1
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Direct Analysis and MALDI Imaging of Formalin-Fixed, Paraffin-Embedded Tissue Sections

R. Lemaire , A. Desmons , J. C. Tabet , R. Day , M. Salzet
J. Proteome Res., 2007, 6 (4), pp.1295 -1305. ⟨10.1021/pr060549i⟩
Article dans une revue hal-00167250v1
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MALDI imaging: a new technology to discover and validate new biomarkers

M. Wisztorski , R. Lemaire , J. Stauber , S. Ait-Menguellet , O. Jardin-Mathé
Médecine/Sciences, 2007, 23 (1), pp.31-36
Article dans une revue hal-00086943v1
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Tag-mass: Specific molecular imaging of transcriptome and proteome by mass spectrometry based on photocleavable tag

R. Lemaire , J. Stauber , M. Wisztorski , C. van Camp , A. Desmons
Journal of Proteome Research, 2007, 6 (6), pp.2057-2067. ⟨10.1021/pr0700044⟩
Article dans une revue hal-00167235v1
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Solid ionic matrices for direct tissue analysis and MALDI imaging.

R. Lemaire , J. C. Tabet , P. Ducoroy , J. B. Hendra , M. Salzet
Analytical Chemistry, 2006, 78 (3), pp.809 -819. ⟨10.1021/ac0514669⟩
Article dans une revue hal-00086905v1
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Lipopolysaccharide mediated regulation of neuroendocrine associated proprotein convertases and neuropeptide precursor processing in the rat spleen.

G. Lansac , W. Dong , Cm Dubois , N. Benlarbi , C. Afonso
Journal of Neuroimmunology, 2006, 171 (2), pp.57-71. ⟨10.1016/jneuroim.2005.09.019⟩
Article dans une revue hal-00086906v1

Direct profiling and MALDI Imaging in clinical proteomic

J. Stauber , R. Lemaire , M. Wisztorski , S. Ait-Menguellet , J. P. Lucot
Molecular and Cellular Proteomics, 2006, 5 (10), pp.S247-S247
Article dans une revue hal-00086942v1

Solid ionic matrixes for direct tissue analysis & MALDI imaging.

R. Lemaire , J.-C. Tabet , P. Ducoroy , J. Hendra , M. Salzet
Analytical Chemistry, 2006, 78, pp.809-819
Article dans une revue hal-00120848v1
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MALDI-MS Direct Tissue Analysis of Proteins: Improving Signal Sensitivity Using Organic Treatments

R. Lemaire , M. Wisztorski , A. Desmons , J. C. Tabet , R. Day
Analytical Chemistry, 2006, 78 (20), pp.7145 -7153. ⟨10.1021/ac060565z⟩
Article dans une revue hal-00086901v1
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Direct Analyses of neuropeptides by in situ MALDI-TOF mass spectrometry in the rat brain

I. Fournier , R. Day , M. Salzet
Neuroendocrinology Letters, 2003, 1 (24), pp.9-14
Article dans une revue hal-00167329v1

The Colibactin-Producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance.

Nilmara de Oliveira Alves , Guillaume Dalmasso , Darja Nikitina , Amaury Vaysse , Richard Ruez
41 ème CECED, Mar 2024, Monptellier, France
Communication dans un congrès hal-04543437v1
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Reduced finite element modelling and closed-loop control of pneumatic-driven soft continuum robots

Paul Chaillou , Jialei Shi , Alexandre Kruszewski , Isabelle Fournier , Helge Wurdemann
2023 IEEE International Conference on Soft Robotics (RoboSoft), Apr 2023, Singapore, France. pp.1-8, ⟨10.1109/RoboSoft55895.2023.10122081⟩
Communication dans un congrès hal-04101252v1

Real-Time Molecular Diagnosis of Tumors Using Atmospheric Pressure Infrared Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry

P Saudemont , J Quanico , A. Baud , B Fatou , D Tierny
15th International Conference on Laser Ablation, Sep 2019, Maui, United States
Communication dans un congrès hal-02407005v1

Abstract 367: Trop-2 activates a dormant Na + /K + -ATPase/PKCα/CD9/ezrin signaling axis to override the basal growth program of cancer cells

Marco Trerotola , Valeria Relli , Romina Tripaldi , Andrea Sacchetti , Kristina Havas
Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC, Jul 2017, Paris, France. pp.367-367, ⟨10.1158/1538-7445.AM2017-367⟩
Communication dans un congrès inserm-02940617v1

MALDI DIRECT ANALYSIS AND IMAGING OF FROZEN VERSUS FFPE TISSUES: WHAT STRATEGY FOR WHICH SAMPLE?

R. Lemaire , J. Stauber , M. Wisztorski , O. Jardin-Mathé , M. Salzet
55th ASMS, Jun 2007, Indianapolis, United States. pp.0
Communication dans un congrès hal-00167284v1
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Enhanced spatial resolution of MALDI images using silicon masks

Nicolas Verplanck , Maxence Wisztorski , Jonathan Stauber , J.C. Camart , Michel Salzet
11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2007, 2007, Paris, France. pp.41-43
Communication dans un congrès hal-00284454v1

DIRECT PROFILING AND MALDI IMAGING OF TISSUES: NEW DEVELOPMENTS AND CLINICAL APPLICATIONS FOR OVARIAN CANCER

S. Ait-Menguellet , I. Fournier , R. Lemaire , J. P. Lucot , D. Vinatier
Clinical Proteomics in Oncology, 2006, Dijon, France. pp.10
Communication dans un congrès hal-00167326v1

Nanostructured surface as EWOOD counter electrode for matrix-free mass spectrometry analysis

B. Salhi , Yannick Coffinier , N. Verplanck , M. Wisztorski , G. Piret
Trends in Nanotechnology, 2006, Grenoble, France
Communication dans un congrès hal-00127824v1

MALDI imaging by using solid ionic matrixes for direct analysis of tissues.

Jean-Claude Tabet , Rémy Lemaire , P. Ducoroy , J.B Hendra , A. Desmons
3rd International Conference “Genomics, Proteomics, Bioinformatics, and Nanotechnologies for Medicine”, Jul 2006, NOVOSIBIRSK, Russia
Communication dans un congrès hal-00104882v1

L'imagerie par spectrométrie de masse MALDITOF

M. Wisztorski , O. Jardin-Mathe , V. Thomy , R. Lemaire , P. Ducoroy
Journée André Verbert, 2005, Lille, France
Communication dans un congrès hal-00126224v1

Vers une imagerie par spectrométrie de masse clinique à haut débit

M. Wisztorski , R. Lemaire , O. Jardin-Mathe , C. Courcelle , V. Thomy
Journée Innovations en Protéomique, 1ères rencontres du MASTER Protéomique de Lille, 2005, Villeneuve d Ascq, France
Communication dans un congrès hal-00126223v1

L'imagerie par spectrométrie de masse MALDITOF : innovations et perspectives

M. Wisztorski , O. Jardin-Mathe , V. Thomy , R. Lemaire , P. Ducoroy
Proceedings of the 1st Symposium of Analytical Chemistry and Biology : from molecule to proteome, 2005, Montpellier, France
Communication dans un congrès hal-00131330v1

NOUVEAUX DEVELOPPEMENTS POUR L'IMAGERIE MALDI :VERS L'IMAGERIE CLINIQUE A HAUT DEBIT

P. Ducoroy , I. Fournier , R. Lemaire , M. Salzet , Jc. Tabet
1er SCBA - 22èmes Journées Françaises de Spectrométrie de Masse, Sep 2005, France. pp.0
Communication dans un congrès hal-00167327v1

Analyse directe de neuropeptides dans le cerveau de rat par spectrométrie de masse MALDI-TOF In Situ

R. Day , I. Fournier , M. Salzet
Societé Française de Spectrométrie de masse, club jeune, 2002, Chaville, France. pp.0
Communication dans un congrès hal-00167328v1

Spatial metabolomics reveals a reprogramming of lipid metabolism by bacterial colibactin supporting immunosuppressive microenvironment in right-sided colon cancer

Nilmara de Oliveira Alves , Olivier Boulard , Amaury Vaysse , Guillaume Dalmasso , Darja Nikitina
5 Metabolism & Cancer, Nov 2023, Nice, France
Poster de conférence hal-04543485v1

Neuronal adenosine A2A receptor overexpression exacerbates memory deficits and synaptic loss in an amyloidogenic mouse model of Alzheimer’s disease

D. Blum , V. Gomez-Murcia , V. K. Carvalho , C. Montmasson , Ac. Meriaux
FENS, Jul 2022, PARIS, France
Poster de conférence hal-03974166v1

Résolution structural 3D et ciblage thérapeutique du complexe oncogénique MUC4-ErbB2 dans le cancer du pancréas.

Nicolas Stoup , Maxime Liberelle , Julien Franck , Nicolas Renault , Patricia Melnyk
14èmes Journées Scientifiques Annuelles du Cancéropole Nord-Ouest (CNO), May 2022, Deauville, France
Poster de conférence hal-04547404v1

Neuronal upregulation of adenosine a2a receptors exacerbates memory deficits in mouse models of alzheimer's disease

David Blum , K. Gomez-Murcia , Carvalho K. , M. Dumoulin , Faivre E.
AD/PD virtual meeting, Sep 2021, virtual meeting, France
Poster de conférence hal-03974273v1

Micro-Sampling of Biological Tissue by Substrate-Mediated Laser Ablation: Toward Spatially-Resolved Proteomics at µm Scale

T Maulouet , B Fatou , M. Salzet , I. Fournier , C. Focsa
15th International Conference on Laser Ablation, Sep 2019, Maui, United States
Poster de conférence hal-02406998v1

Ambient Mass Spectrometry Imaging by Water-Assisted Laser Desorption/Ionization for Ex Vivo and in Vivo Applications.

Nina Ogrinc , Paul Chaillou , Alexandre Kruszewski , Christian Duriez , Michel Salzet
Methods in Molecular Biology, 2688, Springer, pp.83-94, 2023, ⟨10.1007/978-1-0716-3319-9_8⟩
Chapitre d'ouvrage hal-04400799v1

MALDI Mass Spectrometry Imaging and Spatially-resolved Proteomics

E. Chicano-Galvez , Michel Salzet , Isabelle Fournier , E Chicano-Galvez
MALDI Mass Spectrometry Imaging: From Fundamentals to Spatial Omics, Royal Society of Chemistry, 2021, 978-1-83916-241-1. ⟨10.1039/9781839165191⟩
Chapitre d'ouvrage hal-04552159v1

Combined MALDI Mass Spectrometry Imaging and Parafilm-Assisted Microdissection-Based LC-MS/MS Workflows in the Study of the Brain

Jusal Quanico , Julien Franck , Maxence Wisztorski , Michel Salzet , Isabelle Fournier
Combined MALDI Mass Spectrometry Imaging and Parafilm-Assisted Microdissection-Based LC-MS/MS Workflows in the Study of the Brain, 1598, pp.269-283, 2017, ⟨10.1007/978-1-4939-6952-4_13⟩
Chapitre d'ouvrage inserm-02940633v1

Progress and Potential of Imaging Mass Spectrometry Applied to Biomarker Discovery

Jusal Quanico , Julien Franck , Maxence Wisztorski , Michel Salzet , Isabelle Fournier
Progress and potential of imaging mass spectrometry applied to biomarker discovery, pp.21-43, 2017, ⟨10.1007/978-1-4939-6952-4_2⟩
Chapitre d'ouvrage inserm-02940629v1

Droplet-Based Liquid Extraction for Spatially-Resolved Microproteomics Analysis of Tissue Sections

Maxence Wisztorski , Jusal Quanico , Julien Franck , Benoit Fatou , Michel Salzet
Droplet-Based Liquid Extraction for Spatially-Resolved Microproteomics Analysis of Tissue Sections, pp.49-63, 2017, ⟨10.1007/978-1-4939-7051-3_6⟩
Chapitre d'ouvrage inserm-02940613v1
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Développements en Imagerie par Spectrométrie de Masse MALDI et Applications aux Problématiques Biologiques

I. Fournier
Sciences pharmaceutiques. Université des Sciences et Technologie de Lille - Lille I, 2005
HDR tel-00167305v1