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Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 '- and 3 '-modified thymidine analogues

Philippe van Rompaey , Koen Nauwelaerts , Veerle Vanheusden , Jef Rozenski , Hélène Munier-Lehmann , et al.
European Journal of Organic Chemistry, 2003, 15, pp.2911-2918. ⟨10.1002/ejoc.200300177⟩
Article dans une revue pasteur-00167037v1

Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts.

Thomas Ludwig , Hélène Munier-Lehmann , Ulrike Bauer , Michael Hollinshead , Catherine Ovitt , et al.
EMBO Journal, 1994, 13 (15), pp.3430-7
Article dans une revue pasteur-00167086v1

Function of the two mannose 6-phosphate receptors in lysosomal enzyme transport.

Hélène Munier-Lehmann , Fabienne Mauxion , Bernard Hoflack
Biochemical Society Transactions, 1996, 24 (1), pp.133-6
Article dans une revue pasteur-00167081v1

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Marianne Lucas-Hourani , Hélène Munier-Lehmann , Olivier Helynck , Anastassia Komarova , Philippe Desprès , et al.
Journal of visualized experiments : JoVE, 2014, 87, pp.e51222. ⟨10.3791/51222⟩
Article dans une revue pasteur-01113538v1
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Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

Gilles Labesse , Thomas Alexandre , Muriel Gelin , Ahmed Haouz , Hélène Munier-Lehmann
Acta crystallographica Section D : Structural biology [1993-..], 2015, 71, pp.1890-1899. ⟨10.1107/S1399004715013115⟩
Article dans une revue istex pasteur-01197071v1

Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.

Paris Laskaris , Ahmad Atrouni , José Antonio Calera , Christophe d'Enfert , Hélène Munier-Lehmann , et al.
Antimicrobial Agents and Chemotherapy, 2016, 60 (10), pp.5631-9. ⟨10.1128/AAC.00324-16⟩
Article dans une revue pasteur-01515325v1

Structural basis for the allosteric inhibition of UMP kinase from Gram‐positive bacteria, a promising antibacterial target

Patrick Walter , Ariel E Mechaly , Julien Bous , Ahmed Haouz , Patrick England , et al.
FEBS Journal, 2022, 289 (16), pp.4869-4887. ⟨10.1111/febs.16393⟩
Article dans une revue pasteur-04096367v1

On dihydroorotate dehydrogenases and their inhibitors and uses.

Hélène Munier-Lehmann , Pierre-Olivier Vidalain , Frédéric Tangy , Yves Louis Janin
Journal of Medicinal Chemistry, 2013, 56 (8), pp.3148-67. ⟨10.1021/jm301848w⟩
Article dans une revue pasteur-00819070v1
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A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism

Paris Laskaris , Rocío Vicentefranqueira , Olivier Helynck , Grégory Jouvion , José Antonio Calera , et al.
Antimicrobial Agents and Chemotherapy, 2018, 62 (6), pp.e02510-17. ⟨10.1128/AAC.02510-17⟩
Article dans une revue pasteur-01968421v1
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs

Antoine Gedeon , Nour Ayoub , Sébastien Brûlé , Bertrand Raynal , Gouzel Karimova , et al.
Protein Science, In press, pp.e4703. ⟨10.1002/pro.4703⟩
Article dans une revue pasteur-04164361v1

Binding of 3'-anthraniloyl-2'-deoxy-ATP to calmodulin-activated adenylate cyclase from Bordetella pertussis and Bacillus anthracis.

Robert S. Sarfati , Vinod K. Kansal , Hélène Munier , Philippe Glaser , Anne-Marie Gilles , et al.
Journal of Biological Chemistry, 1990, 265 (31), pp.18902-6
Article dans une revue pasteur-00167102v1

Re-expression of the Mannose 6-Phosphate Receptors in Receptor-deficient Fibroblasts. COMPLEMENTARY FUNCTION OF THE TWO MANNOSE 6-PHOSPHATE RECEPTORS IN LYSOSOMAL ENZYME TARGETING

Hélène Munier-Lehmann , F Mauxion , U Bauer , P Lobel , B Hoflack
Journal of Biological Physics and Chemistry, 1996, 271 (25), pp.15166-74. ⟨10.1074/jbc.271.25.15166⟩
Article dans une revue hal-01197122v1

Drug design and identification of potent leads against Mycobacterium tuberculosis thymidine monophosphate kinase.

S. van Calenbergh , Sylvie Pochet , Hélène Munier-Lehmann
Current Topics in Medicinal Chemistry, 2012, 12 (7), pp.694-705. ⟨10.2174/156802612799984580⟩
Article dans une revue pasteur-00705879v1

A phenotypic assay to identify chikungunya virus inhibitors targeting the nonstructural protein nsP2.

Marianne Lucas-Hourani , Alexandru Lupan , Philippe Desprès , Sylviane Thoret , Olivier Pamlard , et al.
Journal of Biomolecular Screening, 2013, 18 (2), pp.172-9. ⟨10.1177/1087057112460091⟩
Article dans une revue hal-00798263v1

Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Olga Familiar , Hélène Munier-Lehmann , Ana Negri , Federico Gago , Dominique Douguet , et al.
ChemMedChem, 2008, 3 (7), pp.1083-93. ⟨10.1002/cmdc.200800060⟩
Article dans une revue istex pasteur-00316018v1

A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes.

Fabienne Mauxion , Roland Le Borgne , Hélène Munier-Lehmann , Bernard Hoflack
Journal of Biological Chemistry, 1996, 271 (4), pp.2171-8
Article dans une revue pasteur-00167083v1

A new family of inhibitors of mycobacterium tuberculosis thymidine monophosphate kinase.

Cécile Gasse , Valérie Huteau , Dominique Douguet , Hélène Munier-Lehmann , Sylvie Pochet
Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (8-9), pp.1057-61. ⟨10.1080/15257770701513349⟩
Article dans une revue pasteur-00202300v1

Real-Time monitoring of Equid alphaherpesviruses infectivity in equine dermal cell based on impedance measurements: effects of aciclovir and ganciclovir treatments

Côme Thieulent , Erika Hue , Christine Fortier , Peggy Suzanne , Stéphan Zientara , et al.
Fourth Havemeyer Equine Herpesvirus Workshop, Oct 2018, Beaufort, United States
Communication dans un congrès hal-02294033v1
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Le ganciclovir, pour traiter la rhinopneumonie demain ?

Côme Thieulent , Erika Hue , Christine Fortier , Peggy Suzanne , Stéphan Zientara , et al.
Journées sciences et innovations équines, May 2019, Saumur, France
Communication dans un congrès hal-02286181v1

A Casein Kinase II Phosphorylation Site in the Cytoplasmic Domain of the Cation-dependent Mannose 6-Phosphate Receptor Determines the High Affinity Interaction of the AP-1 Golgi Assembly Proteins with Membranes

Fabienne Mauxion , Roland Le Borgne , Hélène Munier-Lehmann , Bernard Hoflack
Journal of Biological Physics and Chemistry, 1996, 271 (4), pp.2171-2178. ⟨10.1074/jbc.271.4.2171⟩
Article dans une revue hal-01197131v1

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.

Ahmed Haouz , Veerle Vanheusden , Hélène Munier-Lehmann , Mattheus Froeyen , Piet Herdewijn , et al.
Journal of Biological Chemistry, 2003, 278 (7), pp.4963-71. ⟨10.1074/jbc.M209630200⟩
Article dans une revue pasteur-00167043v1
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Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

Marianne Lucas-Hourani , Daniel Dauzonne , Pierre Jorda , Gaëlle Cousin , Alexandru Lupan , et al.
PLoS Pathogens, 2013, 9 (10), pp.e1003678. ⟨10.1371/journal.ppat.1003678⟩
Article dans une revue pasteur-01113535v1

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

Maria Buchieri , Mena Cimino , Sonia Rebollo-Ramirez , Claire Beauvineau , Alessandro Cascioferro , et al.
Journal of Medicinal Chemistry, 2017, 60 (17), pp.7425 - 7433. ⟨10.1021/acs.jmedchem.7b00726⟩
Article dans une revue pasteur-01693404v1

Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis

Kajitha Suthagar , Wanting Jiao , Hélène Munier-Lehmann , Antony Fairbanks
Carbohydrate Research, 2018, 457, pp.32-40. ⟨10.1016/j.carres.2018.01.001⟩
Article dans une revue pasteur-01968406v1
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A real‐time cell‐binding assay reveals dynamic features of STxB–Gb3 cointernalization and STxB‐mediated cargo delivery into cancer cells

João Crispim Encarnação , Valeria Napolitano , Giulia Opassi , U. Helena Danielson , Grzegorz Dubin , et al.
FEBS Letters, 2020, 594 (15), pp.2406-2420. ⟨10.1002/1873-3468.13847⟩
Article dans une revue pasteur-02892876v1

Real-time monitoring of Equid herpesviruses infectivity in equine dermal cell based on impedance measurements

Erika Hue , Christine Fortier , Peggy Suzanne , Aymeric Hans , Stéphan Zientara , et al.
10th International Equine Infectious Diseases Conference, Apr 2016, Buenos Aires, Argentina. pp.S69-S70, ⟨10.1016/j.jevs.2016.02.150⟩
Communication dans un congrès hal-02273332v1
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AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity.

Clément Carré , Caroline Jacquier , Anne-Laure Bougé , Fabrice de Chaumont , Corinne Besnard-Guerin , et al.
PLoS ONE, 2013, 8 (9), pp.e74296. ⟨10.1371/journal.pone.0074296⟩
Article dans une revue pasteur-00877254v1

Identification of antiviral molecules against West-Nile virus by an approach combining cell imaging and equine neural cells derived from induced-pluripotent stem cells.

Marielle Cochet-Bernoin , François Piumi , Kamila Gorna , Gaelle Gonzalez , Anne Danckaert , et al.
International Equine Infectious Diseases Conference 2021 - IEIDC XI, Sep 2021, DEAUVILLE, France
Communication dans un congrès hal-03355807v1
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Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.

Constance Auvynet , Dimitri Topalis , Christophe Caillat , Hélène Munier-Lehmann , Edward Seclaman , et al.
Biochemical and Biophysical Research Communications, 2009, 388 (1), pp.6-11. ⟨10.1016/j.bbrc.2009.07.089⟩
Article dans une revue pasteur-00417244v1

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

Yanlin Jian , Fabian Hulpia , Martijn D.P. Risseeuw , He Eun Forbes , Hélène Munier-Lehmann , et al.
European Journal of Medicinal Chemistry, 2020, 201, pp.112450. ⟨10.1016/j.ejmech.2020.112450⟩
Article dans une revue pasteur-02892861v1