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Researcher identifiers

Number of documents

43

Haoues Alout, PhD


 

Haoues ALOUT

Born on Nov. 6th 1980

French 

Tel: +33 4 67 61 49 99

Email: haoues.alout@inrae.fr ;  haoues.alout@cirad.fr

 

Professional status

May 2018 – present        Research Scientist at the Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), ASTRE lab (Animal-Santé-Territoires-Risques-Ecosystèmes) CIRAD/INRAE.

May 2017 – April 2018   Marie Skłodowska-Curie Postdoctoral Fellowship at the Institute of Evolutionary Sciences Montpellier (ISEM). IRWIC project, grant agreement number 74989.

Dec. 2013 – Feb. 2016    Research Scientist at the Arthropod-borne and Infectious Disease Laboratory, Colorado State University (AIDL).

Dec. 2012 – Nov. 2013   Postdoctoral position at the AIDL, Colorado State University

Oct. 2010 – Oct. 2012     Postdoctoral Fellow at the Institut de Recherche pour le Développement (IRD) and the Institut de Recherche en Science de la Santé (IRSS, Burkina Faso).

June /July 2009               Volunteer at the Tsaobis Baboon Project, Namibia. University of Montpellier, FR and Zoological Society of London, UK.

2005 - 2006                    Development engineer at the Genetic of Adaptation lab (ISEM) and the Center of Research on Macromolecular Biochemistry – Montpellier.

 

Diploma and awards

January 2009      Ph.D. in Evolutionary biology. Genetic of adaptation Laboratory. Institute of Evolutionary Sciences Montpellier (ISEM), University of Montpellier 2.

2007                   Prize for the best student poster in the IXth International Meeting on Cholinesterases, Suzhou, China.

2003 - 2004        Dîplome d’Etudes Supérieures Spécialisées (equivalent to master’s degree) in Biotechnology. University of Montpellier 1 and 2.

2002 - 2003        Postgraduate in Biochemistry at the University P. and M. Curie, Paris VI (France). Institute of Biomedical and Biomolecular Science. University of Portsmouth (UK).

 

teaching and mentoring

2019 – 2020      Teaching Master 2 (Gestion Intégrée des Maladies Animales Tropicales) at the National Veterinary School of Toulouse in Ecology and integrated vector control

2015 – 2019     Teaching Master 1 (Biodiversité Écologie Évolution) students in Vector biology, ecology and control. University of Montpellier.

2015                Training in Good clinical practices and Research ethics. RIMDAMAL project, Burkina Faso. (ClinicalTrial : NCT02509481).

2006 - 2014      Mentoring master students in biochemistry (France), parasitology (Burkina Faso) and vector biology (Benin, Madagascar)

2005                Training vector control operators in Detection and Analysis of Insecticide Resistance in mosquito. (Université de Monastir, Tunisia)

 

Funding

2021 – 2024     ANR - Genetic architectures of insecticide resistance: from genomics to vectorial capacity – ArchR (role: Co-Investigateur, ANR-20-CE34-0007)

2017 - 2019      Marie Skłodowska-Curie Fellowship. Influence of Insecticide Resistance, Wolbachia and their Interaction on Chikungunya transmission - IRWIC (agreement n°749897)

2015 - 2016      GCE round 14. Bill and Melinda Gates Foundation. Project: Dry-to-rainy season integrated control of NTDs and malaria (role: Co-Investigateur, BMGF:01818000168).

2010 – 2012     IRD Postdoctoral Fellowship (2010). Project: Impact of Insecticide Reistance on Malaria Transmission (Burkina Faso).

2006 – 2008     ANR (french national research agency) Evolution and managing insecticide resistance in mosquitoes – MOREVOL

 

Expertise

Reviewer for Insect Molecular Biology (1), Biologia (1), Journal of Economical Entomology (1), Journal of Medical Entomology (1), Pesticide Biochemistry and Physiology (2), Insect Biochemistry and Molecular Biology (7), Comparative Biochemistry and Molecular Biology (1), Pest Management Science (1), PLoS Neglected Tropical Diseases (2), PLoS One (1), BMC Infectious Diseases (1), EcoHealth (1), Journal of Medicinal Chemistry (1), Evolutionary Applications (3) et Lancet Infectious Diseases (1)

Referee for funding agencies: ANR (Agence Nationale de la Recherche), ANSES, MRC (Medical Research Council), Crick African Network and Marie Skłodowska-Curie Fellowship.

Expert for the French Agency for Food, Environmental and Occupational Health & Safety (ANSES): member of the “Insecticide resistance in mosquito vectors” working group (2020-2022)

 

 

PoPULAR PRESS

Midi Libre. Les Poux font de la résistance (sept 25th 2016). http://www.midilibre.fr/2016/09/24/les-poux-font-de-la-resistance,1398418.php

Forbes. Nobel Prize-Winning Drug Ivermectin May Fight Malaria (oct 27th 2015). https://www.forbes.com/sites/judystone/2015/10/27/nobel-prize-winning-drug-ivermectin-may-fight-malaria/#2c321e8a6026

Science Magazine. Drug could kill mosquitoes when they feast on human blood (oct 27th 2015). http://www.sciencemag.org/news/2015/10/drug-could-kill-mosquitoes-when-they-feast-human-blood

Collegian Central. Colorado State researchers study malaria prevention (nov. 11th 2014). http://collegian.com/2014/11/colorado-state-researchers-study-malaria-prevention/101215/

Source. Researcher: Fight malaria with deadly mosquito meals (nov. 5th 2014). http://source.colostate.edu/researcher-fight-malaria-deadly-mosquito-meals/


Journal articles37 documents

  • Hannah C. Slater, Brian D. Foy, Kevin Kobylinski, Carlos Chaccour, Oliver J. Watson, et al.. Ivermectin as a novel complementary malaria control tool to reduce incidence and prevalence: a modelling study. The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2020, 20 (4), pp.498-508. ⟨10.1016/S1473-3099(19)30633-4⟩. ⟨hal-02450316⟩
  • Fode Diop, Haoues Alout, Cheikh Diagne, Michèle Bengue, Cecile Baronti, et al.. Differential Susceptibility and Innate Immune Response of Aedes aegypti and Aedes albopictus to the Haitian Strain of the Mayaro Virus. Viruses, MDPI, 2019, 11 (10), pp.924. ⟨10.3390/v11100924⟩. ⟨hal-02396716⟩
  • Brian Foy, Haoues Alout, Jonathan Seaman, Sangeeta Rao, Tereza Magalhaes, et al.. Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial. The Lancet, Elsevier, 2019, 393 (10180), pp.1517-1526. ⟨10.1016/S0140-6736(18)32321-3⟩. ⟨hal-02434760⟩
  • Chilinh Nguyen, Meg Gray, Timothy A. Burton, Soleil L. Foy, John R. Foster, et al.. Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals. PLoS Neglected Tropical Diseases, Public Library of Science, 2019, 13 (3), pp.e0007210. ⟨10.1371/journal.pntd.0007210⟩. ⟨hal-02626865⟩
  • Célestine Atyame Nten, Haoues Alout, Laurence Mousson, Marie Vazeille, Mawlouth Diallo, et al.. Insecticide resistance genes affect Culex quinquefasciatus vector competence for West Nile virus. Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2019, 286 (1894), pp.20182273. ⟨10.1098/rspb.2018.2273⟩. ⟨pasteur-02098394⟩
  • Léa Lugassy, Ludivine Amdouni-Boursier, Haoues Alout, Romuald Berrebi, Christophe Boëte, et al.. What is the evidence that ecosystem components or functions have an impact on infectious diseases? A systematic review protocol. Environmental Evidence, BioMed Central, 2019, 8 (4), 11 p. ⟨10.1186/s13750-019-0147-5⟩. ⟨hal-02617792⟩
  • Benoît Assogba, Haoues Alout, Alphonsine Koffi, Cédric Penetier, Luc Djogbénou, et al.. Adaptive deletion in resistance gene duplications in the malaria vector Anopheles gambiae. Evolutionary Applications, Blackwell, 2018, 11 (8), pp.1245-1256. ⟨10.1111/eva.12619⟩. ⟨hal-01914795⟩
  • Magali Garcia, Haoues Alout, Fode Diop, Alexia Damour, Michèle Bengue, et al.. Innate immune response of primary human keratinocytes to West Nile virus infection and its modulation by mosquito maliva. Frontiers in Cellular and Infection Microbiology, Frontiers, 2018, 8, pp.387. ⟨10.3389/fcimb.2018.00387⟩. ⟨hal-01921855⟩
  • Benjamin J. Krajacich, Jacob I. Meyers, Haoues Alout, Roch K. Dabiré, Floyd E. Dowell, et al.. Analysis of near infrared spectra for age-grading of wild populations of Anopheles gambiae. Parasites and Vectors, BioMed Central, 2017, 10 (1), ⟨10.1186/s13071-017-2501-1⟩. ⟨hal-02619983⟩
  • Haoues Alout, Brian D. Foy. Ivermectin: a complimentary weapon against the spread of malaria?. Expert Review of Anti-infective Therapy, Expert Reviews, 2017, 15 (3), pp.231-240. ⟨10.1080/14787210.2017.1271713⟩. ⟨hal-02625607⟩
  • Haoues Alout, Brian Foy. Ivermectin: a complimentary weapon against the spread of malaria?. Expert Review of Anti-infective Therapy, Expert Reviews, 2017, 15 (3), pp.231-240. ⟨hal-01944453⟩
  • Benjamin Krajacich, Jacob Meyers, Haoues Alout, Roch Dabiré, Floyd Dowell, et al.. Analysis of near infrared spectra for age-grading of wild populations of Anopheles gambiae. Parasites and Vectors, BioMed Central, 2017, 10 (1), ⟨10.1186/s13071-017-2501-1⟩. ⟨hal-01944438⟩
  • Haoues Alout, Benjamin Roche, Roch Kounbobr Dabiré, Anna Cohuet. Consequences of insecticide resistance on malaria transmission. PLoS Pathogens, Public Library of Science, 2017, 13 (9), pp.e1006499. ⟨10.1371/journal.ppat.1006499⟩. ⟨hal-01942723⟩
  • Haoues Alout, Pierrick Labbe, Fabrice Chandre, Anna Cohuet. Malaria Vector Control Still Matters despite Insecticide Resistance. Trends in Parasitology, Elsevier, 2017, 33 (8), pp.610 - 618. ⟨10.1016/j.pt.2017.04.006⟩. ⟨hal-01938020⟩
  • Haoues Alout, Roch Dabiré, Luc Djogbénou, Luc Abate, Vincent Corbel, et al.. Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae. Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep29755⟩. ⟨hal-01944457⟩
  • Haoues Alout, Pierrick Labbé, A Berthomieu, Patrick Makoundou, Philippe Fort, et al.. High chlorpyrifos resistance in Culex pipiens mosquitoes: strong synergy between resistance genes. Heredity, Nature Publishing Group, 2016, 116 (2), pp.224-231. ⟨10.1038/hdy.2015.92⟩. ⟨hal-01944470⟩
  • Benjamin J. Krajacich, Brendan Labrecque, Lawrence S. Fakoli, Joseph W. Diclaro, Brian D. Foy, et al.. Sampling host-seeking anthropophilic mosquito vectors in West Africa: Comparisons of an active human-baited tent-trap against gold standard methods. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2015, 92 (2), pp.415-421. ⟨10.4269/ajtmh.14-0303⟩. ⟨hal-02630660⟩
  • Jonathan A. Seaman, Haoues Alout, Jacob I. Meyers, Mark D. Stenglein, Roch K. Dabiré, et al.. Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals. BMC Genomics, BioMed Central, 2015, 16, ⟨10.1186/s12864-015-2029-8⟩. ⟨hal-02632006⟩
  • Haoues Alout, Benjamin J. Krajacich, Jacob I. Meyers, Nathan D. Grubaugh, Doug E. Brackney, et al.. Evaluation of ivermectin mass drug administration for malaria transmission control across different West African environments. Malaria Journal, BioMed Central, 2014, 13 (1), 10 p. ⟨10.1186/1475-2875-13-417⟩. ⟨hal-02631695⟩
  • Kevin C. Kobylinski, Haoues Alout, Brian D. Foy, Archie Clements, Poom Adisakwattana, et al.. Rationale for the coadministration of albendazole and ivermectin to humans for malaria parasite transmission control. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2014, 91 (4), pp.655-662. ⟨10.4269/ajtmh.14-0187⟩. ⟨hal-02631850⟩
  • Haoues Alout, Bienvenue Yameogo, Luc Salako Djogbenou, Fabrice Chandre, Roch Kounbobr Dabiré, et al.. Interplay between Plasmodium infection and resistance to insecticides in vector mosquitoes. Journal of Infectious Diseases, Oxford University Press (OUP), 2014, 210 (9), pp.1464-1470. ⟨10.1093/infdis/jiu276⟩. ⟨hal-02641602⟩
  • Haoues Alout, Innocent Djègbé, Fabrice Chandre, Luc Salako Djogbenou, Roch Kounbobr Dabiré, et al.. Insecticide exposure impacts vector-parasite interactions in insecticide-resistant malaria vectors. Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2014, 281 (1786), ⟨10.1098/rspb.2014.0389⟩. ⟨hal-02641601⟩
  • Haoues Alout, Nicaise Tuikue Ndam, Marcel Maurice Sandeu, Innocent Djègbé, Fabrice Chandre, et al.. Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates. PLoS ONE, Public Library of Science, 2013, 8 (5), pp.e63849. ⟨10.1371/journal.pone.0063849⟩. ⟨hal-02653010⟩
  • Haoues Alout, Pierrick Labbe, Arnaud Berthomieu, Luc Djogbénou, Jean-Paul Leonetti, et al.. Novel AChE Inhibitors for Sustainable Insecticide Resistance Management. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47125. ⟨10.1371/journal.pone.0047125⟩. ⟨hal-01938151⟩
  • Haoues Alout, Pierrick Labbé, Nicole Pasteur, Mylène Weill. High incidence of ace-1 duplicated haplotypes in resistant Culex pipiens mosquitoes from Algeria. Insect Biochemistry and Molecular Biology, Elsevier, 2011, 41 (1), pp.29-35. ⟨10.1016/j.ibmb.2010.09.009⟩. ⟨halsde-00633660⟩
  • Michaël Luciano Tantely, Pablo Tortosa, Haoues Alout, Claire Berticat, Arnaud Berthomieu, et al.. Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réunion Island. Insect Biochemistry and Molecular Biology, Elsevier, 2010, 40 (4), pp.317--324. ⟨10.1016/j.ibmb.2010.02.005⟩. ⟨hal-01274621⟩
  • Haoues Alout, Pierrick Labbe, Arnaud Berthomieu, Nicole Pasteur, Mylène Weill. Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populations. Insect Biochemistry and Molecular Biology, Elsevier, 2009, 39 (12), pp.884 - 891. ⟨10.1016/j.ibmb.2009.10.005⟩. ⟨hal-01938164⟩
  • Jahangir Khajehali, Thomas van Leeuwen, Maria Grispou, Evangelia Morou, Haoues Alout, et al.. Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychidae) resistant to organophosphates. Pest Management Science, Wiley, 2009, 66 (2), pp.n/a-n/a. ⟨10.1002/ps.1884⟩. ⟨hal-01944635⟩
  • Haoues Alout, Mylène Weill. Amino-acid substitutions in acetylcholinesterase 1 involved in insecticide resistance in mosquitoes. Chemico-Biological Interactions, Elsevier, 2008, 175 (1-3, sp. Issue), pp.138-141. ⟨10.1016/j.cbi.2008.03.018⟩. ⟨halsde-00454646⟩
  • Haoues Alout, Luc Djogbénou, Claire Berticat, Fabrice Chandre, Mylène Weill. Comparison of Anopheles gambiae and Culex pipiens acetycholinesterase 1 biochemical properties. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, Elsevier, 2008, 150 (3), pp.271-277. ⟨10.1016/j.cbpb.2008.03.008⟩. ⟨halsde-00454638⟩
  • Luc Djogbénou, Fabrice Chandre, Arnaud Berthomieu, Roch Dabiré, Alphonsine Koffi, et al.. Evidence of Introgression of the ace-1R Mutation and of the ace-1 Duplication in West African Anopheles gambiae s. s.. PLoS ONE, Public Library of Science, 2008, 3 (5), pp.e2172. ⟨10.1371/journal.pone.0002172⟩. ⟨halsde-00527414⟩
  • Haoues Alout, Arnaud Berthomieu, Feng Cui, Yi Tan, Claire Berticat, et al.. Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 insensitivity in Culex vishnui and Culex tritaeniorhynchus (Diptera: Culicidae) from China.. Journal of Medical Entomology, Entomological Society of America, 2007, 44 (3), pp.463-9. ⟨10.1093/jmedent/44.3.463⟩. ⟨hal-01945512⟩
  • Haoues Alout, Arnaud Berthomieu, Andreas Andreas Hadjivassilis, Mylène Weill. A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipiens mosquitoes from Cyprus. Insect Biochemistry and Molecular Biology, Elsevier, 2007, 37 (1), pp.41-47. ⟨10.1016/j.ibmb.2006.10.001⟩. ⟨halsde-00367134⟩
  • Pierrick Labbé, Arnaud Berthomieu, Claire Berticat, Haoues Alout, Michel Raymond, et al.. Independent duplications of the acetylcholinesterase gene conferring insecticide resistance in the mosquito Culex pipiens. Molecular Biology and Evolution, Oxford University Press (OUP), 2007, 24 (4), pp.1056-1067. ⟨10.1093/molbev/msm025⟩. ⟨halsde-00186494⟩
  • Elise Huchard, Michel Martinez, Haoues Alout, Emmanuel Douzery, Georges Lutfalla, et al.. Acetylcholinesterase genes within the Diptera: takeover and loss in true flies. Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2006, 273 (1601), pp.2595-2604. ⟨10.1098/rspb.2006.3621⟩. ⟨hal-01945529⟩
  • Feng Cui, Michel Raymond, Arnaud Berthomieu, Haoues Alout, Mylene Weill, et al.. Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens (Diptera: Culicidae).. Journal of Medical Entomology, Entomological Society of America, 2006, 43 (5), pp.878-83. ⟨hal-01945532⟩
  • F. Cui, Michel Raymond, Arnaud Berthomieu, Haoues Alout, Mylène Weill, et al.. Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens. Journal of Medical Entomology, Entomological Society of America, 2006, 43, pp.878-883. ⟨halsde-00184864⟩

Conference papers2 documents

  • Haoues Alout. Is malaria vector control still useful despite insecticide resistance?. 2018 Institut Pasteur International Network Symposium, Nov 2018, Paris, France. ⟨hal-02788777⟩
  • Haoues Alout. Is vector control still useful despite insecticide resistance?. Journées d'Animation Scientifique du Département Santé Animale, Oct 2018, Nantes, France. ⟨hal-02788925⟩

Poster communications2 documents

  • Haoues Alout, Alice Namias, Pierrick Labbé, Célestine Atyame Nten, Pablo Tortosa, et al.. Insecticide resistance modulates densovirus effect in Aedes albopictus. EMBO conference on Molecular and Population Biology of Mosquitoes and Other Disease Vectors: Current, Resurgent and Emerging Diseases, Jul 2019, Kolymbari, Greece. 2019. ⟨hal-02790906⟩
  • Haoues Alout. Age-dependent susceptiblility to ivermectin and gene expression following an ivermectin blood meal in the malaria vector Anopheles gambiae. EMBO conference on Molecular and Population Biology of Mosquitoes and Other Disease Vectors: Current, Resurgent and Emerging Diseases, Jul 2015, Kolymbari, Greece. 2017. ⟨hal-02785632⟩

Book sections2 documents

  • Pierrick Labbé, Jean-Philippe David, Haoues Alout, Pascal Milesi, Nicole Pasteur, et al.. Evolution of resistance to insecticide in disease vectors. Genetics and evolution of infectious diseases, Academic press, Elsevier, 2017, 9780127999425. ⟨10.1016/B978-0-12-799942-5.00014-7⟩. ⟨hal-02786153⟩
  • Pierrick Labbe, Haoues Alout, Luc Djogbénou, Nicole Pasteur, Mylène Weill. Evolution of resistance to insecticide in disease vectors. Genetics and Evolution of Infectious Disease, Elsevier, Academic Press, 2011, 9780123848901. ⟨10.1016/B978-0-12-384890-1.00014-5⟩. ⟨hal-02805959⟩