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Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti- Flaviviridae Activity

 Quentin Nevers , Isaac Ruiz , Nazim Ahnou , Flora Donati , Rozenn Brillet , et al.
Antimicrobial Agents and Chemotherapy, 2018, 62 (7), pp.e00126-18. ⟨10.1128/AAC.00126-18⟩
Article dans une revue hal-02327436v1
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A Phenyl-Pyrrolidine Derivative Reveals a Dual Inhibition Mechanism of Myocardial Mitochondrial Permeability Transition Pore, Which Is Limited by Its Myocardial Distribution

 Mathieu Panel , Abdelhakim Ahmed-Belkacem , Isaac Ruiz , Jean-François Guichou , Jean-Michel Pawlotsky , et al.
Journal of Pharmacology and Experimental Therapeutics, 2021, 376 (3), pp.348-357. ⟨10.1124/jpet.120.000359⟩
Article dans une revue hal-03155967v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

 Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin , et al.
XXVèmes Journées Francophones de Virologie, Société Française de Virologie, Apr 2023, Paris, France
Communication dans un congrès hal-04481153v1

Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

 Anne-Gaëlle Goubet , Agathe Dubuisson , Arthur Geraud , François-Xavier Danlos , Safae Terrisse , et al.
Cell Death and Differentiation, 2021, 28 (12), pp.3297-3315. ⟨10.1038/s41418-021-00817-9⟩
Article dans une revue hal-04438553v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

 Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin , et al.
36th International Conference on Antiviral Research, International Society for Antiviral Research (ISAR), Mar 2023, Lyon, France
Communication dans un congrès hal-04481101v1

Two- and three-dimensional in vitro models for investigating TBEV-induced neuropathogenesis and discovering therapeutic drugs

 Noémie Berry , Mazigh Fares , Gaëlle Gonzalez , Anne Huard de Verneuil , Noemie Aurine , et al.
Journées "Tiques et Maladies à Tiques", Groupe "Tiques et Maladies à Tiques" (TMT), Mar 2022, Nancy, France
Communication dans un congrès hal-04481097v1
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Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

 Abdelhakim Ahmed-Belkacem , Nazim Ahnou , Laetitia Barbotte , Czeslaw Wychowski , Coralie Pallier , et al.
Gastroenterology, 2010, 138 (3), pp.1112-22. ⟨10.1053/j.gastro.2009.11.053⟩
Article dans une revue inserm-00465965v1
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Discovery of Naturally Occurring Aurones That Are Potent Allosteric Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase.

 Romain Haudecoeur , Abdelhakim Ahmed-Belkacem , Wei Yi , Antoine Fortuné , Rozenn Brillet , et al.
Journal of Medicinal Chemistry, 2011, 54 (15), pp.5395-5402. ⟨10.1021/jm200242p⟩
Article dans une revue inserm-00618322v1
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Desloratadine, an FDA-approved Cationic Amphiphilic Drug, Inhibits SARS-CoV-2 Infection in Cell Culture and Primary Human Nasal Epithelial Cells by Blocking Viral Entry

 Margot Morin-Dewaele , Sophie Bartier , François Berry , Rozenn Brillet , Dennis Salomón López-Molina , et al.
Scientific Reports, 2022, 12 (1), pp.21053. ⟨10.1038/s41598-022-25399-5⟩
Article dans une revue hal-04420874v1
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Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

 Abdelhakim Ahmed-Belkacem , Lionel Colliandre , Nazim Ahnou , Quentin Nevers , Muriel Gelin , et al.
Nature Communications, 2016, 7, pp.Article Number: 12777. ⟨10.1038/ncomms12777⟩
Article dans une revue hal-01397719v1

Découverte d’une nouvelle famille de petites molécules non-peptidiques inhibitrices des Cyclophilines ayant une probable activité antivirale

 Olivier Cala , Abdelhakim Ahmed-Belkacem , Lionel Colliandre , Nazim Ahnou , Quentin Nevers , et al.
XXIXème congrès du GERM, Groupement d'études de résonance magnétique, May 2017, Aussois, France
Communication dans un congrès hal-01865380v1

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

 A. Ahmed-Belkacem , A. Pozza , F. Munoz-Martinez , Se Bates , S. Castanys , et al.
Cancer Research, 2005, 65, pp.4852-4860
Article dans une revue hal-00313594v1

Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors.

 A. Ahmed-Belkacem , S. Macalou , F. Borrelli , R. Capasso , E. Fattorusso , et al.
Journal of Medicinal Chemistry, 2007, 50, pp.1933-1938
Article dans une revue hal-00315101v1
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MK-571, a Cysteinyl Leukotriene Receptor 1 Antagonist, Inhibits Hepatitis C Virus Replication

 Isaac Ruiz , Quentin Nevers , Eva Hernández , Nazim Ahnou , Rozenn Brillet , et al.
Antimicrobial Agents and Chemotherapy, 2020, 64 (6), pp.697-706. ⟨10.1128/AAC.02078-19⟩
Article dans une revue pasteur-03139192v1

Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025)

 Laurent Softic , Rozenn Brillet , François Berry , Nazim Ahnou , Quentin Nevers , et al.
Antimicrobial Agents and Chemotherapy, 2020, 64 (7), pp.e00876-20. ⟨10.1128/AAC.00876-20⟩
Article dans une revue inserm-03258933v1

Inhibitors of cancer cell multidrug resistance mediated by breast cancer resistance protein (BCRP/ABCG2).

 A. Ahmed-Belkacem , A. Pozza , S. Macalou , Jm Perez-Victoria , A. Boumendjel , et al.
Anti-Cancer Drugs, 2006, 17, pp.239-243
Article dans une revue hal-00313593v1

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

 Xavier Lahaye , Takeshi Satoh , Matteo Gentili , Silvia Cerboni , Aymeric Silvin , et al.
Cell Reports, 2016, 15 (4), pp.879-892. ⟨10.1016/j.celrep.2016.03.074⟩
Article dans une revue hal-02988517v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

 Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin , et al.
36th International Conference on Antiviral Research, Mar 2023, Lyon, France
Poster de conférence hal-04480802v1

Modeling SARS-COV2-infected central nervous system using human neuronal/glial cells to identify antiviral drugs

 Noémie Berry , Nazim Ahnou , Rozenn Brillet , François Piumi , Dennis Salomón López-Molina , et al.
Nouvelles stratégies antivirales : de la recherche à clinique - New antiviral strategies: form bench to bedside., Apr 2023, Paris, France
Poster de conférence hal-04481120v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

 Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin , et al.
Journées d’Animation Scientifiques du Département de Santé Animale, INRAE (Département de Santé Animale), Oct 2022, Aglet, France
Communication dans un congrès hal-04481147v1
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B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

 Amel Meguellati , Abdelhakim Ahmed-Belkacem , Wei Yi , Romain Haudecoeur , Marie Crouillère , et al.
European Journal of Medicinal Chemistry, 2014, 80, pp.579-592. ⟨10.1016/j.ejmech.2014.04.005⟩
Article dans une revue hal-04015683v1
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Real-world efficacy and safety of direct-acting antiviral drugs in patients with chronic hepatitis C and inherited blood disorders

 Isaac Ruiz , Slim Fourati , Abdelhakim Ahmed-Belkacem , Christophe Rodriguez , Giovanna Scoazec , et al.
European Journal of Gastroenterology & Hepatology, In press, ⟨10.1097/MEG.0000000000002003⟩
Article dans une revue hal-03139178v1

Modeling SARS-COV2-infected central nervous system using human neuronal-glial cells to identify antirviral drugs

 Noémie Berry , Nazim Ahnou , Rozenn Brillet , François Piumi , Dennis Salomón López-Molina , et al.
XXVèmes Journées Francophones de Virologie, Apr 2023, Paris, France
Poster de conférence hal-04481111v1

Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.

 A. Boumendjel , S. Macalou , H. Ahmed-Belkacem , M. Blanc , A. Di Pietro
Bioorganic and Medicinal Chemistry, 2007, 15, pp.2892-2897
Article dans une revue hal-00387355v1
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Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury

 Mathieu Panel , Isaac Ruiz , Rozenn Brillet , Fouad Lafdil , Fatima Teixeira-Clerc , et al.
Gastroenterology, 2019, 157 (5), pp.1368-1382. ⟨10.1053/j.gastro.2019.07.026⟩
Article dans une revue hal-02391962v1
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New Pseudodimeric Aurones as Palm Pocket Inhibitors of Hepatitis C Virus RNA-dependent RNA Polymerase

 Amel Meguellati , Abdelhakim Ahmed-Belkacem , Alessandra Nurisso , Wei Yi , Rozenn Brillet , et al.
European Journal of Medicinal Chemistry, 2016, ⟨10.1016/j.ejmech.2016.03.005⟩
Article dans une revue hal-04015727v1

Purification of breast cancer resistance protein ABCG2 and role of arginine-482

 A. Pozza , Jm Perez-Victoria , A. Sardo , A. Ahmed-Belkacem , Xxxx Dipietroa
Cellular and Molecular Life Sciences, 2006, 63, pp.1912-1922
Article dans une revue hal-00314875v1

Fitness-associated substitutions following failure of direct-acting antivirals assessed by deep sequencing of full-length hepatitis C virus genomes

 Slim Fourati , Christophe Rodriguez , Alexandre Soulier , Flora Donati , Sabah Hamadat , et al.
Alimentary Pharmacology and Therapeuthics, 2020, 52 (10), pp.1583-1591. ⟨10.1111/apt.16054⟩
Article dans une revue hal-03207989v1

Role des cyclophilines dans le cycle des Coronavirus

 Manon Delaplace , Hélène Huet , Gambino Adèle , Chantal Allee , Paul Brown , et al.
Journées Scientifiques et Doctorales de l'ANSES (JSDA) 2022, Oct 2022, Maisons-Alfort, France
Poster de conférence anses-03856075v1

TBEV-infected human neuronal/glial cells identify antiviral drugs

 Noémie Berry , Valentine Chaillot , Marielle Cochet-Bernoin , François Piumi , Kamila Gorna , et al.
28th international symposium on hepatitis C virus, flaviviruses and related viruses., Jul 2022, Ghent, Belgium
Poster de conférence hal-04480746v1
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