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47

Gwendal LAZENNEC


 

Research Director CNRS, PhD


Team Leader: Chemokines, inflammation and microenvironment

Member of the scientific committee of the GDR 3697 "Micronit" (Microenvironnment of tumor niches) and co-leader of the axis  "Biomarkers and therapeutic targeting of tumor niches".


Professional address.:    CNRS UMR 9005 Sys2Diag
                                    "Modélisation et Ingénierie des systèmes complexes biologiques pour le diagnostic"
                                     Cap delta, 1682 rue de la Valsière, 34184 Montpellier Cedex 4,  France

Web:        http://gwendal.lazennec.free.fr/


Journal articles47 documents

  • Colin Timaxian, Isabelle Raymond-Letron, Céline Bouclier, Linda Gulliver, Ludovic Le Corre, et al.. The health status alters the pituitary function and reproduction of mice in a Cxcr2 -dependent manner. Life Science Alliance, Life Science Alliance LLC, 2020, 3 (3), pp.e201900599. ⟨10.26508/lsa.201900599⟩. ⟨hal-02476814⟩
  • Florence Boissière-Michot, William Jacot, Julien Fraisse, Sophie Gourgou, Colin Timaxian, et al.. Prognostic Value of CXCR2 in Breast Cancer. Cancers, MDPI, 2020, 12 (8), pp.2076. ⟨10.3390/cancers12082076⟩. ⟨hal-02914978⟩
  • Gwendal Lazennec, Paula Lam. Recent discoveries concerning the tumor - mesenchymal stem cell interactions. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Elsevier, 2016, 1866 (2), pp.290-299. ⟨10.1016/j.bbcan.2016.10.004⟩. ⟨hal-02146513⟩
  • Coline Ple, Ying Fan, Saliha Ait Yahia, Han Vorng, Laetitia Everaere, et al.. Polycyclic Aromatic Hydrocarbons promote Th22 polarization by reciprocally regulating IL-22 and IL- 17. PLoS ONE, Public Library of Science, 2015, 10 (4), pp.e0122372. ⟨10.1371/journal.pone.0122372⟩. ⟨hal-03002029⟩
  • Pauline Escobar, Céline Bouclier, Julien Serret, Ivan Bièche, Madly Brigitte, et al.. IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production. Oncotarget, Impact journals, 2015, 6 (30), pp.29034-29047. ⟨10.18632/oncotarget.4732⟩. ⟨hal-02146528⟩
  • Coline Plé, Ying Fan, Saliha Ait Yahia, Han Vorng, Laetitia Everaere, et al.. Polycyclic Aromatic Hydrocarbons Reciprocally Regulate IL-22 and IL-17 Cytokines in Peripheral Blood Mononuclear Cells from Both Healthy and Asthmatic Subjects. PLoS ONE, Public Library of Science, 2015, 10 (4), pp.e0122372. ⟨10.1371/journal.pone.0122372⟩. ⟨hal-02146525⟩
  • Florence Boissière-Michot, Gwendal Lazennec, Hélène Frugier, Marta Jarlier, Lise Roca, et al.. Characterization of an adaptive immune response in microsatellite-instable colorectal cancer. OncoImmunology, Taylor & Francis, 2014, 3 (6), pp.e29256. ⟨10.4161/onci.29256⟩. ⟨hal-02146604⟩
  • Sunil Malonia, Bhawna Yadav, Surajit Sinha, Gwendal Lazennec, Samit Chattopadhyay. Chromatin remodeling protein SMAR1 regulates NF-κB dependent Interleukin-8 transcription in breast cancer. International Journal of Biochemistry and Cell Biology, Elsevier, 2014, 55, pp.220-226. ⟨10.1016/j.biocel.2014.09.008⟩. ⟨hal-02146532⟩
  • Jack-Michel Renoir, Véronique Marsaud, Gwendal Lazennec. Estrogen receptor signaling as a target for novel breast cancer therapeutics.: new targets in estradiol receptor-positive breast cancers. Biochemical Pharmacology, Elsevier, 2013, 85 (4), pp.449-65. ⟨10.1016/j.bcp.2012.10.018⟩. ⟨inserm-00758201⟩
  • Jack-Michel Renoir, Véronique Marsaud, Gwendal Lazennec. Estrogen receptor signaling as a target for novel breast cancer therapeutics. Biochemical Pharmacology, Elsevier, 2013, 85 (4), pp.449-465. ⟨10.1016/j.bcp.2012.10.018⟩. ⟨hal-03002141⟩
  • Isabelle Ray-Coquard, Franck Chauvin, Eric Leblanc, Christophe Caux, Hélène Hoarau, et al.. [PAIR-gynaecology: multi/interdisciplinary for gynecologic cancer research. Problems needed to be resolved].. Bulletin du Cancer, John Libbey Eurotext, 2012, 99 (4), pp.479-98. ⟨10.1684/bdc.2012.1558⟩. ⟨hal-00723410⟩
  • Isabelle Ray-Coquard, Franck Chauvin, Éric Leblanc, Christophe Caux, Hélène Hoarau, et al.. Le PAIR-gynécologie: Recherche multi/interdisciplinaire en cancérologie gynécologique. Les problèmes à résoudre en 2012. Bulletin du Cancer, John Libbey Eurotext, 2012, 99 (4), pp.479-498. ⟨10.1684/bdc.2012.1558⟩. ⟨halshs-00785750⟩
  • Carine Bossard, Muriel Busson, David Vindrieux, Françoise Gaudin, Véronique Machelon, et al.. Potential Role of Estrogen Receptor Beta as a Tumor Suppressor of Epithelial Ovarian Cancer. PLoS ONE, Public Library of Science, 2012, 7 (9), pp.e44787. ⟨10.1371/journal.pone.0044787⟩. ⟨hal-03002049⟩
  • David Vindrieux, Ludovic Le Corre, Jer-Tsong Hsieh, Raphaël Métivier, Pauline Escobar, et al.. Coxsackie and adenovirus receptor is a target and a mediator of estrogen action in breast cancer. Endocrine-Related Cancer, BioScientifica, 2011, 18 (3), pp.311-321. ⟨10.1530/ERC-10-0230⟩. ⟨hal-03002183⟩
  • Christoph Franz Adam Vogel, Wen Li, Dalei Wu, Jamie K. Miller, Colleen Sweeney, et al.. Functional integration of the Ah receptor with RelB and IL-8 confers the pro-survival advantage to mammary epithelial cells of inflammatory breast tumors. Archives of Biochemistry and Biophysics, Elsevier, 2011, 512 (1), pp.78-86. ⟨10.1016/j.abb.2011.05.011⟩. ⟨hal-03002041⟩
  • Christoph Franz Adam Vogel, Wen Li, Dalei Wu, Jamie Miller, Colleen Sweeney, et al.. Functional integration of the Ah receptor with RelB and IL-8 confers the pro-survival advantage to mammary epithelial cells of inflammatory breast tumors. Archives of Biochemistry and Biophysics, Elsevier, 2011, 512 (1), pp.78-86. ⟨10.1016/j.abb.2011.05.011⟩. ⟨hal-03002191⟩
  • David Vindrieux, Ludovic Le Corre, Jer-Tsong Hsieh, Raphaël Métivier, Pauline Escobar, et al.. Coxsackie and adenovirus receptor is a target and a mediator of estrogen action in breast cancer.. Endocrine-Related Cancer, BioScientifica, 2011, 18 (3), pp.311-21. ⟨10.1530/ERC-10-0230⟩. ⟨hal-01117400⟩
  • Gwendal Lazennec, Ann Richmond. Chemokines and their receptors: new insights in cancer inflammation. Trends in Molecular Medicine, Elsevier, 2010, 16 (3), pp.133-144. ⟨10.1016/j.molmed.2010.01.003⟩. ⟨hal-03002095⟩
  • Carine Chavey, Gwendal Lazennec, Sylviane Lagarrigue, Cyrielle Clapé, Irena Iankova, et al.. CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance. Cell Metabolism, Elsevier, 2009, 9 (4), pp.339-349. ⟨10.1016/j.cmet.2009.03.002⟩. ⟨hal-03002081⟩
  • Carine Chavey, Gwendal Lazennec, Sylviane Lagarrigue, Cyrielle Clapé, Irena Iankova, et al.. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.. Cell Metabolism, Elsevier, 2009, 9 (4), pp.339-49. ⟨10.1016/j.cmet.2009.03.002⟩. ⟨inserm-00375507⟩
  • C. Chavey, Gwendal Lazennec, S. Lagarrigue, C. Clape, I. Iankova, et al.. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metabolism, Elsevier, 2009, 9 (4), pp.339--49. ⟨10.1016/j.cmet.2009.03.002⟩. ⟨hal-02194094⟩
  • Carine Chavey, Marcus Muhlbauer, Carine Bossard, Ariane Freund, Sebastien Durand, et al.. Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer.. Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2008, 74 (5), pp.1359-66. ⟨10.1124/mol.108.047332⟩. ⟨inserm-00308891⟩
  • Gwendal Lazennec, Christian Jorgensen. Concise review: adult multipotent stromal cells and cancer: risk or benefit?: Adult stromal cells and cancer. Stem Cells / Stem Cells (Miamisburg), Alphamed Press, 2008, 26 (6), pp.1387-94. ⟨10.1634/stemcells.2007-1006⟩. ⟨inserm-00271551⟩
  • Nathalie Picard, Catherine Charbonneau, Mélanie Sanchez, Anne Licznar, Muriel Busson, et al.. Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta.. Molecular Endocrinology -Baltimore-, Endocrine Society, 2008, 22 (2), pp.317-30. ⟨10.1210/me.2007-0281⟩. ⟨inserm-00268259⟩
  • Claudia Amura, Kelley Brodsky, Berenice Gitomer, Kim Mcfann, Gwendal Lazennec, et al.. CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation.. American Journal of Physiology - Cell Physiology, American Physiological Society, 2008, 294 (3), pp.C786-96. ⟨10.1152/ajpcell.00457.2007⟩. ⟨inserm-00268266⟩
  • Ivan Bièche, Carine Chavey, Catherine Andrieu, Muriel Busson, Sophie Vacher, et al.. CXC chemokines located in the 4q21 region are up-regulated in breast cancer.. Endocrine-Related Cancer, BioScientifica, 2007, 14 (4), pp.1039-1052. ⟨10.1677/erc.1.01301⟩. ⟨inserm-00153602⟩
  • Carine Chavey, Frédéric Bibeau, Sophie Gourgou-Bourgade, Sandrine Burlinchon, Florence Boissière, et al.. Oestrogen receptor negative breast cancers exhibit high cytokine content.. Breast Cancer Research, BioMed Central, 2007, 9 (1), pp.R15. ⟨10.1186/bcr1648⟩. ⟨inserm-00143810⟩
  • Christoph Vogel, Eric Sciullo, Wen Li, Pat Wong, Gwendal Lazennec, et al.. RelB, a new partner of aryl hydrocarbon receptor-mediated transcription.. Molecular Endocrinology -Baltimore-, Endocrine Society, 2007, 21 (12), pp.2941-55. ⟨10.1210/me.2007-0211⟩. ⟨inserm-00268250⟩
  • Corinne Henriquet, Claire Gougat, Audrey Combes, Gwendal Lazennec, Marc Mathieu. Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells.. Lung Cancer, Elsevier, 2007, 56 (2), pp.167-74. ⟨10.1016/j.lungcan.2006.12.003⟩. ⟨inserm-00143972⟩
  • Simi Ali, Gwendal Lazennec. Chemokines: novel targets for breast cancer metastasis.. CANCER AND METASTASIS REVIEW, 2007, 26 (3-4), pp.401-420. ⟨10.1007/s10555-007-9073-z⟩. ⟨inserm-00168311⟩
  • D. Marot, I. Bieche, C. Aumas, S. Esselin, C. Bouquet, et al.. High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors.. Endocrine-Related Cancer, BioScientifica, 2007, 14 (3), pp.691-702. ⟨hal-00177513⟩
  • D. Marot, I. Bieche, C. Aumas, S. Esselin, C. Bouquet, et al.. High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors.. Endocrine-Related Cancer, BioScientifica, 2007, 14 (3), pp.691-702. ⟨10.1677/ERC-07-0012⟩. ⟨hal-00171094⟩
  • Vanessa Duong, Anne Licznar, Raphaël Margueron, Nathalie Boulle, Muriel Busson, et al.. ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors.. Oncogene, Nature Publishing Group, 2006, 25 (12), pp.1799-806. ⟨10.1038/sj.onc.1209102⟩. ⟨inserm-00143967⟩
  • Gwendal Lazennec. Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis.. Cancer Letters, Elsevier, 2006, 231 (2), pp.151-7. ⟨10.1016/j.canlet.2005.01.021⟩. ⟨inserm-00143901⟩
  • M a J Hervé, G Meduri, F G Petit, T S Domet, Gwendal Lazennec, et al.. Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus. Journal of Endocrinology, BioScientifica, 2006, 188 (1), pp.91-99. ⟨10.1677/joe.1.06184⟩. ⟨hal-02441847⟩
  • Jean-Sébastien Annicotte, Carine Chavey, Nadège Servant, Jacques Teyssier, Aurélie Bardin, et al.. The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.. Oncogene, Nature Publishing Group, 2005, 24 (55), pp.8167-75. ⟨10.1038/sj.onc.1208950⟩. ⟨inserm-00144663⟩
  • Ariane Freund, Valérie Jolivel, Sébastien Durand, Nathalie Kersual, Dany Chalbos, et al.. Mechanisms underlying differential expression of interleukin-8 in breast cancer cells.. Oncogene, Nature Publishing Group, 2004, 23 (36), pp.6105-14. ⟨10.1038/sj.onc.1207815⟩. ⟨inserm-00143639⟩
  • Jennifer Cheng, Eun Jig Lee, Laird Madison, Gwendal Lazennec. Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis.. FEBS Letters, Wiley, 2004, 566 (1-3), pp.169-72. ⟨10.1016/j.febslet.2004.04.025⟩. ⟨inserm-00143968⟩
  • Allison Bardin, Nathalie Boulle, Gwendal Lazennec, Françoise Vignon, Pascal Pujol. Loss of ERbeta expression as a common step in estrogen-dependent tumor progression.. Endocrine-Related Cancer, BioScientifica, 2004, 11 (3), pp.537-51. ⟨inserm-00153815⟩
  • Anne Licznar, Simona Caporali, Annick Lucas, Alessandro Weisz, Françoise Vignon, et al.. Identification of genes involved in growth inhibition of breast cancer cells transduced with estrogen receptor.. FEBS Letters, Wiley, 2003, 553 (3), pp.445-50. ⟨inserm-00143969⟩
  • Annick Lucas, Eric Kremer, Silvio Hemmi, José Luis, Françoise Vignon, et al.. Comparative transductions of breast cancer cells by three DNA viruses.. Biochemical and Biophysical Research Communications, Elsevier, 2003, 309 (4), pp.1011-6. ⟨10.1016/j.bbrc.2003.08.101⟩. ⟨inserm-00143970⟩
  • Ariane Freund, Corine Chauveau, Jean-Paul Brouillet, Annick Lucas, Matthieu Lacroix, et al.. IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells.. Oncogene, Nature Publishing Group, 2003, 22 (2), pp.256-65. ⟨10.1038/sj.onc.1206113⟩. ⟨inserm-00143840⟩
  • Gwendal Lazennec, James Thomas, Benita Katzenellenbogen. Involvement of cyclic AMP response element binding protein (CREB) and estrogen receptor phosphorylation in the synergistic activation of the estrogen receptor by estradiol and protein kinase activators.. Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2001, 77 (4-5), pp.193-203. ⟨inserm-00143971⟩
  • Gwendal Lazennec, Damien Bresson, Annick Lucas, Corine Chauveau, Françoise Vignon. ER beta inhibits proliferation and invasion of breast cancer cells.. Endocrinology, Endocrine Society, 2001, 142 (9), pp.4120-30. ⟨inserm-00153812⟩
  • Gwendal Lazennec, Laurence Canaple, Damien Saugy, Walter Wahli. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.. Molecular Endocrinology -Baltimore-, Endocrine Society, 2000, 14 (12), pp.1962-75. ⟨inserm-00153813⟩
  • F. Pakdel, F. Delaunay, B. Ducouret, G. Flouriot, L. Kern, et al.. Regulation of gene expression and biological activity of rainbow trout estrogen receptor. Fish Physiology and Biochemistry, Springer Verlag, 1997, 17 (1/6), pp.123-133. ⟨10.1023/A:1007706207857⟩. ⟨hal-02442869⟩
  • T. Madigou, C. Tiffoche, Gwendal Lazennec, Julien Pelletier, M.L. Thieulant. The sheep estrogen receptor : cloning and regulation of expression in the hypothalamo-pituitary axis. Molecular and Cellular Endocrinology, Elsevier, 1996, 121, pp.153-163. ⟨hal-02690364⟩