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Keywords

Researcher identifiers

Number of documents

85

Guy Lippens


 

Curriculum Vitae

Guy Lippens, PhD

Research Director (DR1) at CNRS, Chemistry Department

TBI, UMR5504, INSA Toulouse, 31400 Toulouse

 

September 30th 1964                                                                          

Citizenship : Belgium

Gender : Male

 

Degrees

June 1987 : Engineering degree (maxima cum lauda), University of Ghent, Belgium.

January 1989 : Master’s degree in Applied and Engineering Physcis, Hydrogen diffusion in metal hydrides. Cornell University, Ithaca, NY (USA)

March 1992 : Ph.D., NMR structure of oxytocin bound to neurophysin, University of Ghent, Belgium.

April 1995 : HDR, University of Science and Technology Lille 1, Functional and structural study of phospho-binding proteins involved in cell cycle regulation , Lille, France

Training

July 1987 - Jan 1989: Graduate Student, Applied and Engineering Physics, Cornell University, Ithaca (USA)

February 1989 - April 1992: Graduate Student, University of Ghent/Free University of Brussels, Belgium.

May 1992 - September 1993: Post-doctoral research fellow, UMR8525, Pasteur Institute of Lille, France

 

Awards

June 1987 : Belgian American Educational Fellowship (BAEF)

June 1988 : IBM Graduate Fellowship

January 2012 : UK Alzheimer’s society Oral Communication Prize

 

Academic appointments

Oct. 1993 : Research Scientist CR1 UMR-CNRS 8525, Pasteur Institute of Lille, France

Oct. 1999 : Research Director DR2 UMR-CNRS 8525, Pasteur Institute of Lille, France

Oct. 2008 : Research Director DR1 UMR-CNRS 8576, University Lille 1, Lille, France

Sept. 2015: Research Director DR1 UMR-CNRS 5504, INSA Toulouse, France

 

Publications: 190, h-Index 46


Journal articles83 documents

  • Neil Cox, Cyril Charlier, Ramadoss Vijayaraj, Marion de la Mare, Sophie Barbe, et al.. The covalent complex of Jo-In results from a long-lived, non-covalent intermediate state with near-native structure. Biochemical and Biophysical Research Communications, Elsevier, 2022, 589, pp.223-228. ⟨10.1016/j.bbrc.2021.12.028⟩. ⟨hal-03750388⟩
  • Cyril Charlier, Sabine Gavalda, Vinciane Borsenberger, Sophie Duquesne, Alain Marty, et al.. An NMR look at an engineered PET depolymerase. Biophysical Journal, Biophysical Society, In press, ⟨10.1016/j.bpj.2022.07.002⟩. ⟨hal-03739009⟩
  • Alexandra Tauzin, Zhi Wang, Gianluca Cioci, Xiaoqian Li, Aurore Labourel, et al.. Structural and Biochemical Characterization of a Nonbinding SusD-Like Protein Involved in Xylooligosaccharide Utilization by an Uncultured Human Gut Bacteroides Strain. MSphere, American Society for Microbiology., 2022, ⟨10.1128/msphere.00244-22⟩. ⟨hal-03796391⟩
  • Anastasiia Grigoreva, Julia Andreeva, Dmitry Bikmetov, Anastasiia Rusanova, Marina Serebryakova, et al.. Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensis. iScience, Elsevier, 2021, 24 (5), ⟨10.1016/j.isci.2021.102480⟩. ⟨hal-03270626⟩
  • Louise Badruna, Vincent Burlat, Pierre Roblin, Thomas Enjalbert, Guy Lippens, et al.. The Jo-In protein welding system is a relevant tool to create CBM-containing plant cell wall degrading enzymes. New Biotechnology, Elsevier, 2021, 65, pp.31-41. ⟨10.1016/j.nbt.2021.07.004⟩. ⟨hal-03340154⟩
  • Neil Cox, Cyril Charlier, Ramadoss Vijayaraj, Marion de La Mare, Sophie Barbe, et al.. The covalent complex of Jo-In results from a long-lived, non-covalent intermediate state with near-native structure. Biochemical and Biophysical Research Communications, Elsevier, 2021. ⟨hal-03554277⟩
  • Cyril Charlier, Neil Cox, Sophie Prud'Homme, Alain Geffard, Jean-Marc Nuzillard, et al.. Virtual decoupling to break the simplification versus resolution trade-off in nuclear magnetic resonance of complex metabolic mixtures. Magnetic Resonance, Groupement Ampere - Copernicus Publications, 2021, 2, pp.619-627. ⟨10.5194/mr-2-619-2021⟩. ⟨hal-03338624⟩
  • Pierre Millard, Serguei Sokol, Michael Kohlstedt, Christoph Wittmann, Fabien Létisse, et al.. IsoSolve: An Integrative Framework to Improve Isotopic Coverage and Consolidate Isotopic Measurements by Mass Spectrometry and/or Nuclear Magnetic Resonance. Analytical Chemistry, American Chemical Society, 2021, 93 (27), pp.9428-9436. ⟨10.1021/acs.analchem.1c01064⟩. ⟨hal-03307270⟩
  • Sophie Martine Prud’homme, Younes Mohamed Ismail Hani, Neil Cox, Guy Lippens, Jean-Marc Nuzillard, et al.. The Zebra Mussel (Dreissena polymorpha) as a Model Organism for Ecotoxicological Studies: A Prior 1H NMR Spectrum Interpretation of a Whole Body Extract for Metabolism Monitoring. Metabolites, MDPI, 2020, 10 (6), pp.256. ⟨10.3390/metabo10060256⟩. ⟨hal-02934872⟩
  • Alberto Palazzolo, Sophie Feuillastre, Viktor Pfeifer, Sébastien Garcia-Argote, Donia Bouzouita, et al.. Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2019, 58 (15), pp.4891-4895. ⟨10.1002/anie.201813946⟩. ⟨cea-02075752⟩
  • Marion Claverie, Gianluca Cioci, Matthieu Guionnet, Julia Schörghuber, Roman Lichtenecker, et al.. Futile Encounter Engineering of the DSR-M Dextransucrase Modifies the Resulting Polymer Length. Biochemistry, American Chemical Society, 2019, 58 (25), pp.2853-2859. ⟨10.1021/acs.biochem.9b00373⟩. ⟨hal-02176417⟩
  • Tatyana Zyubko, Marina Serebryakova, Julia Andreeva, Mikhail Metelev, Guy Lippens, et al.. Efficient in vivo synthesis of lasso peptide pseudomycoidin proceeds in the absence of both the leader and the leader peptidase. Chemical Science , The Royal Society of Chemistry, 2019, 10 (42), pp.9699-9707. ⟨10.1039/C9SC02370D⟩. ⟨hal-02368109⟩
  • Guy Lippens, Benoît Gigant. Elucidating Tau function and dysfunction in the era of cryo-EM. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, In press, 294 (24), pp.9316-9325. ⟨10.1074/jbc.REV119.008031⟩. ⟨hal-02137974⟩
  • Neil Cox, Rainer Kuemmerle, Pierre Millard, Edern Cahoreau, Jean-Marie François, et al.. Integrated pH Measurement during Reaction Monitoring with Dual-Reception 1 H– 31 P NMR Spectroscopy. Analytical Chemistry, American Chemical Society, 2019, 91 (6), pp.3959-3963. ⟨10.1021/acs.analchem.8b05147⟩. ⟨hal-02131891⟩
  • Marie Dujardin, Vanesa Madan, Neha S Gandhi, François-Xavier Cantrelle, Hélène Launay, et al.. Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩. ⟨hal-02998113⟩
  • Juan M. Lopez, Ricardo Antiparra, Guy Lippens, Mirko Zimic, Patricia Sheen, et al.. Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi. Biomolecular NMR Assignments, 2019, 13 (1), pp.21-25. ⟨10.1007/s12104-018-9844-1⟩. ⟨hal-02170460⟩
  • Donia Bouzouita, Guy Lippens, Edwin A Baquero, Pier-Francesco Fazzini, Grégory Pieters, et al.. Tuning the catalytic activity and selectivity of water-soluble bimetallic RuPt nanoparticles by modifying their surface metal distribution. Nanoscale, Royal Society of Chemistry, 2019, 11 (35), pp.16544-16552. ⟨10.1039/C9NR04149D⟩. ⟨hal-02283913⟩
  • Clément Despres, Jing Di, François-Xavier Cantrelle, Zizheng Li, Isabelle Huvent, et al.. Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors. ACS Chemical Biology, American Chemical Society, 2019, 14 (6), pp.1363-1379. ⟨10.1021/acschembio.9b00325⟩. ⟨hal-02317189⟩
  • Davy Sinnaeve, Mickael Dinclaux, Edern Cahoreau, Pierre Millard, Jean-Charles Portais, et al.. Improved Isotopic Profiling by Pure Shift Heteronuclear 2D J -Resolved NMR Spectroscopy. Analytical Chemistry, American Chemical Society, 2018, 90 (6), pp.4025-4031. ⟨10.1021/acs.analchem.7b05206⟩. ⟨hal-02131883⟩
  • Marie Dujardin, François-Xavier Cantrelle, Guy Lippens, Xavier Hanoulle. Interaction study between HCV NS5A-D2 and NS5B using 19F NMR. Journal of Biomolecular NMR, Springer Verlag, 2018, 70 (1), pp.67-76. ⟨10.1007/s10858-017-0159-9⟩. ⟨hal-01886452⟩
  • Pierre Millard, Edern Cahoreau, Maud Heuillet, Jean-Charles Portais, Guy Lippens. (15)N-NMR-based approach for amino acids-based (13)C-metabolic flux analysis of metabolism. Analytical Chemistry, American Chemical Society, 2017, 89 (3), pp.2101-2106. ⟨10.1021/acs.analchem.6b04767⟩. ⟨hal-01602563⟩
  • Evelyne Louis, Francois-Xavier Cantrelle, Liesbet Mesotten, Gunter Reekmans, Liene Bervoets, et al.. Metabolic phenotyping of human plasma by H-1-NMR at high and medium magnetic field strengths: a case study for lung cancer. Magnetic Resonance in Chemistry, Wiley, 2017, 55 (8), pp.706-713. ⟨10.1002/mrc.4577⟩. ⟨hal-01886450⟩
  • Clement Despres, Cillian Byrne, Haoling Qi, François-Xavier Cantrelle, Isabelle Huvent, et al.. Identification of the Tau phosphorylation pattern that drives its aggregation. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (34), pp.9080 - 9085. ⟨10.1073/pnas.1708448114⟩. ⟨hal-01620128⟩
  • Luiza Bessa, Hélène Launay, Marie Dujardin, Xavier Cantrelle, Guy Lippens, et al.. NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, In press, 292 (44), pp.18024-18043. ⟨10.1074/jbc.M117.813766⟩. ⟨hal-01620117⟩
  • Aurélie Badillo, Véronique Receveur-Brechot, Stéphane Sarrazin, François-Xavier Cantrelle, Frédéric Delolme, et al.. Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A. Biochemistry, American Chemical Society, 2017, 56 (24), pp.3029 - 3048. ⟨10.1021/acs.biochem.7b00212⟩. ⟨hal-01785410⟩
  • Luis Miguel Martinez-Pietro, Edwin A Baquero, Grégory Pieters, Juan Flores, Ernesto de Jesus, et al.. Monitoring of nanoparticle reactivity in solution: interaction of l -lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange. Chemical Communications, Royal Society of Chemistry, 2017, 53 (43), pp.5850-5853. ⟨10.1039/c7cc02445b⟩. ⟨hal-02004103⟩
  • Haoling Qi, Sudhakaran Prabakaran, François-Xavier Cantrelle, Béatrice Chambraud, Jeremy Gunawardena, et al.. Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (14), pp.7742 - 7753. ⟨10.1074/jbc.M115.700914⟩. ⟨hal-01389831⟩
  • Juan Lopez, Robert Schneider, Francois-Xavier Cantrelle, Isabelle Huvent, Guy Lippens. Studying Intrinsically disordered proteins under true in vivo conditions by combined cross-polarization and carbonyl-detection NMR spectroscopy. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2016, 55 (26), pp.7418-7422. ⟨10.1002/anie.201601850⟩. ⟨hal-01886415⟩
  • Guy Lippens, Isabelle Landrieu, Caroline Smet, Isabelle Huvent, Neha Gandhi, et al.. NMR Meets Tau: Insights into Its Function and Pathology. Ancient biomolecules, Informa UK (Taylor & Francis), 2016, 6 (2), ⟨10.3390/biom6020028⟩. ⟨hal-01389829⟩
  • Cillian Byrne, Morkos A. Henen, Mathilde Belnou, François-Xavier Cantrelle, Amina Kamah, et al.. A β-Turn Motif in the Steroid Hormone Receptor’s Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52. Biochemistry, American Chemical Society, 2016, 55 (38), pp.5366 - 5376. ⟨10.1021/acs.biochem.6b00506⟩. ⟨hal-01389826⟩
  • Neha S Gandhi, Isabelle Landrieu, Cillian Byrne, Predrag Kukic, Laziza Amniai, et al.. A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2015, 127 (23), pp.6923-6927 ⟨10.1002/ange.201501898⟩. ⟨hal-01145963⟩
  • Yoann Sottejeau, Alexis Bretteville, François-Xavier Cantrelle, Nicolas Malmanche, Florie Demiaute, et al.. Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain. Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2015, 3 (1), ⟨10.1186/s40478-015-0237-8⟩. ⟨hal-01221659⟩
  • Julien Giustiniani, Kevin Guillemeau, Omar Dounane, Elodie Sardin, Isabelle Huvent, et al.. The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior.. FASEB Journal, Federation of American Society of Experimental Biology, 2015, Epub ahead of print. ⟨hal-01145979⟩
  • Juan Lopez, Puneet Ahuja, Isabelle Landrieu, Francois-Xavier Cantrelle, Isabelle Huvent, et al.. H/D exchange of a 15 N labelled Tau fragment as measured by a simple Relax-EXSY experiment. Journal of Magnetic Resonance, Elsevier, 2014, Journal of Magnetic Resonance, 249, pp.32-37. ⟨10.1016/j.jmr.2014.10.008⟩. ⟨hal-03235804⟩
  • Julien Giustiniani, Béatrice Chambraud, Elodie Sardin, Omar Dounane, Kevin Guillemeau, et al.. Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, pp.4584-9. ⟨hal-01077897⟩
  • Amina Kamah, Isabelle Huvent, François-Xavier Cantrelle, Haoling Qi, Guy Lippens, et al.. Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein.. Biochemistry, American Chemical Society, 2014, 53 (18), pp.3020-32. ⟨10.1021/bi500006v⟩. ⟨hal-01077868⟩
  • Isabelle Huvent, Amina Kamah, François-Xavier Cantrelle, Nicolas Barois, Christian Slomianny, et al.. A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge.. Biochemical and Biophysical Research Communications, Elsevier, 2014, 445 (2), pp.299-303. ⟨10.1016/j.bbrc.2014.01.161⟩. ⟨hal-01077911⟩
  • Benoît Gigant, Isabelle Landrieu, Caroline Fauquant, Pascale Barbier, Isabelle Huvent, et al.. Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy.. Journal of the American Chemical Society, American Chemical Society, 2014, pp.12615-23. ⟨hal-01077829⟩
  • Gary S Mcdowell, Christopher J Hindley, Guy Lippens, Isabelle Landrieu, Anna Philpott. Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2.. BMC Biochemistry, BioMed Central, 2014, pp.24. ⟨hal-01081937⟩
  • Juan Lopez, Puneet Ahuja, Melanie Gerard, Jean-Michel Wieruszeski, Guy Lippens. A new strategy for sequential assignment of intrinsically unstructured proteins based on (15)N single isotope labelling.. Journal of Magnetic Resonance, Elsevier, 2013, 236, pp.1-6. ⟨10.1016/j.jmr.2013.07.007⟩. ⟨hal-00903369⟩
  • Caroline Smet-Nocca, Hélène Launay, Jean-Michel Wieruszeski, Guy Lippens, Isabelle Landrieu. Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA.. Journal of Biomolecular NMR, Springer Verlag, 2013, 55 (4), pp.323-37. ⟨10.1007/s10858-013-9716-z⟩. ⟨hal-00903359⟩
  • Kunie Ando, Pierre Dourlen, Anne-Véronique Sambo, Alexis Bretteville, Karim Bélarbi, et al.. Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.. Neurobiol Aging, 2013, 34 (3), pp.757-69. ⟨10.1016/j.neurobiolaging.2012.08.004⟩. ⟨hal-00765859⟩
  • Francois-Xavier Theillet, Caroline Smet-Nocca, Stamatios Liokatis, Rossukon Thongwichian, Jonas Kosten, et al.. Cell signaling, post-translational protein modifications and NMR spectroscopy.. Journal of Biomolecular NMR, Springer Verlag, 2012, 54 (3), pp.217-36. ⟨10.1007/s10858-012-9674-x⟩. ⟨hal-00765863⟩
  • Sudhakaran Prabakaran, Guy Lippens, Hanno Steen, Jeremy Gunawardena. Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding.. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Wiley, 2012, 4 (6), pp.565-83. ⟨10.1002/wsbm.1185⟩. ⟨hal-00765876⟩
  • Peter Borghgraef, Clément Menuet, Clara Theunis, Justin V Louis, Herman Devijver, et al.. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.. PLoS ONE, Public Library of Science, 2012, pp.e84442. ⟨hal-01077942⟩
  • Claire Rosnoblet, Bernd Fritzinger, Dominique Legrand, Hélène Launay, Jean-Michel Wieruszeski, et al.. Hepatitis C Virus NS5B and Host Cyclophilin A share a common binding site on NS5A.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, epub ahead of print. ⟨10.1074/jbc.M112.392209⟩. ⟨hal-00765873⟩
  • Pierre Lebrun, Dominique Raze, Bernd Fritzinger, Jean-Michel Wieruszeski, Franck Biet, et al.. Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis.. PLoS ONE, Public Library of Science, 2012, 7 (3), pp.e32421. ⟨10.1371/journal.pone.0032421⟩. ⟨hal-00713026⟩
  • Guy Lippens, Laziza Amniai, Jean-Michel Wieruszeski, Alain Sillen, Arnaud Leroy, et al.. Towards understanding the phosphorylation code of tau.. Biochemical Society Transactions, Portland Press, 2012, 40 (4), pp.698-703. ⟨10.1042/BST20120050⟩. ⟨hal-00765867⟩
  • Justin V Louis, Ellen Martens, Peter Borghgraef, Caroline Lambrecht, Ward Sents, et al.. Mice lacking phosphatase PP2A subunit PR61/B'{delta} (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3{beta}. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, epub ahead of print. ⟨10.1073/pnas.1018777108⟩. ⟨hal-00586855⟩
  • Sudhakaran Prabakaran, Robert A Everley, Isabelle Landrieu, Jean-Michel Wieruszeski, Guy Lippens, et al.. Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions.. Molecular Systems Biology, EMBO Press, 2011, 7, pp.482. ⟨10.1038/msb.2011.15⟩. ⟨hal-00586931⟩
  • Isabelle Landrieu, Xavier Hanoulle, Bernd Fritzinger, Dragos Horvath, Jean-Michel Wieruszeski, et al.. Ranking High Affinity Ligands of Low Solubility by NMR Spectroscopy. ACS Medicinal Chemistry Letters, American Chemical Society, 2011, 2 (6), pp.485-487. ⟨10.1021/ml200039u⟩. ⟨hal-00618277⟩
  • Isabelle Landrieu, Caroline Smet-Nocca, Laziza Amniai, Justin Vijay Louis, Jean-Michel Wieruszeski, et al.. Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.. PLoS ONE, Public Library of Science, 2011, 6 (6), pp.e21521. ⟨10.1371/journal.pone.0021521⟩. ⟨hal-00618270⟩
  • Laziza Amniai, Guy Lippens, Isabelle Landrieu. Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach.. Biochemical and Biophysical Research Communications, Elsevier, 2011, epub ahead of print. ⟨10.1016/j.bbrc.2011.08.046⟩. ⟨hal-00618266⟩
  • Furqan Sami, Caroline Smet-Nocca, Meera Khan, Isabelle Landrieu, Guy Lippens, et al.. Molecular Basis for an Ancient Partnership between Prolyl Isomerase Pin1 and Phosphatase Inhibitor-2.. Biochemistry, American Chemical Society, 2011, 50 (30), pp.6567-78. ⟨10.1021/bi200553e⟩. ⟨hal-00618273⟩
  • Caroline Smet-Nocca, Malgorzata Broncel, Jean-Michel Wieruszeski, Caroline Tokarski, Xavier Hanoulle, et al.. Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.. Molecular BioSystems, Royal Society of Chemistry, 2011, 7 (5), pp.1420-9. ⟨10.1039/c0mb00337a⟩. ⟨hal-00586849⟩
  • Caroline Fauquant, Virginie Redeker, Isabelle Landrieu, Jean-Michel Wieruzseski, Dries Verdegem, et al.. Systematic identification of tubulin interacting fragments of the microtubule-associated protein TAU leads to a highly efficient promoter of microtubule assembly.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, epub ahead of print. ⟨10.1074/jbc.M111.223545⟩. ⟨hal-00618268⟩
  • David Bourry, Davy Sinnaeve, Katelijne Gheysen, Bernd Fritzinger, Gianni Vandenborre, et al.. Intermolecular interaction studies using small volumes.. Magnetic Resonance in Chemistry, Wiley, 2011, 49 (1), pp.9-15. ⟨10.1002/mrc.2699⟩. ⟨hal-00586937⟩
  • Dries Verdegem, Aurelie Badillo, Jean-Michel Wieruszeski, Isabelle Landrieu, Arnaud Leroy, et al.. Domain 3 of NS5A protein from the hepatitis C virus has intrinsic {alpha}-helical propensity and is a substrate of Cyclophilin A.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, epub ahead of print. ⟨10.1074/jbc.M110.182436⟩. ⟨hal-00586923⟩
  • Pedro Lameiras, Leslie Boudesocque, Zéphirin Mouloungui, Jean-Hugues Renault, Jean-Michel Wieruszeski, et al.. Glycerol and glycerol carbonate as ultraviscous solvents for mixture analysis by NMR.. Journal of Magnetic Resonance, Elsevier, 2011, 212 (1), pp.161-8. ⟨10.1016/j.jmr.2011.06.021⟩. ⟨hal-00618281⟩
  • Xavier Carette, Nicolas Blondiaux, Eve Willery, Sylviane Hoos, Nathalie Lecat-Guillet, et al.. Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands. Nucleic Acids Research, Oxford University Press, 2011, 40 (7), pp.3018 - 3030. ⟨10.1093/nar/gkr1113⟩. ⟨pasteur-03525621⟩
  • Lotte Coelmont, Xavier Hanoulle, Udayan Chatterji, Carola Berger, Joke Snoeck, et al.. DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.. PLoS ONE, Public Library of Science, 2010, 5 (10), pp.e13687. ⟨10.1371/journal.pone.0013687⟩. ⟨hal-00586948⟩
  • Arnaud Leroy, Isabelle Landrieu, Isabelle Huvent, Dominique Legrand, Bernadette Coddeville, et al.. Spectroscopic studies of GSK3β phosphorylation of the neuronal Tau protein and its interaction with the N-terminal domain of apolipoprotein E. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (43), pp.33435-33444. ⟨10.1074/jbc.M110.149419⟩. ⟨hal-00641629⟩
  • François Devred, Pascale Barbier, Daniel Lafitte, Isabelle Landrieu, Guy Lippens, et al.. Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR.. Methods in Cell Biology, Elsevier, 2010, 95, pp.449-480. ⟨10.1016/S0091-679X(10)95023-1⟩. ⟨hal-00508818⟩
  • Isabelle Landrieu, Xavier Hanoulle, Fanny Bonachera, Arnaud Hamel, Nathalie Sibille, et al.. Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.. Biochemistry, American Chemical Society, 2010, 49 (22), pp.4679-86. ⟨10.1021/bi1003266⟩. ⟨hal-00508817⟩
  • Nathalie Sibille, Xavier Hanoulle, Fanny Bonachera, Dries Verdegem, Isabelle Landrieu, et al.. Selective backbone labelling of ILV methyl labelled proteins.. Journal of Biomolecular NMR, Springer Verlag, 2009, 43 (4), pp.219-27. ⟨10.1007/s10858-009-9307-1⟩. ⟨hal-00373458⟩
  • Xavier Hanoulle, Aurélie Badillo, Jean-Michel Wieruszeski, Dries Verdegem, Isabelle Landrieu, et al.. Hepatitis C virus NS5A protein is a substrate for the Peptidyl-Prolyl cis/trans isomerase activity of Cyclophilins A and B.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, epub ahead of print. ⟨10.1074/jbc.M809244200⟩. ⟨hal-00373457⟩
  • Laziza Amniai, Pascale Barbier, Alain Sillen, Jean-Michel Wieruszeski, Vincent Peyrot, et al.. Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.. FASEB Journal, Federation of American Society of Experimental Biology, 2009, 23 (4), pp.1146-52. ⟨10.1096/fj.08-121590⟩. ⟨hal-00348164⟩
  • Jean-Michel Wieruszeski, Bernd Fritzinger, Xavier Hanoulle, José C Martins, Guy Lippens. Sandwich-ELISE NMR: reducing the sample volume of NMR samples.. Journal of Magnetic Resonance, Elsevier, 2008, 193 (1), pp.37-40. ⟨10.1016/j.jmr.2008.04.006⟩. ⟨hal-00293593⟩
  • Sophie Rodius, Olivier Chaloin, Michèle Moes, Elisabeth Schaffner-Reckinger, Isabelle Landrieu, et al.. The talin rod IBS2 alpha helix interacts with the beta 3 integrin cytoplasmic tail membrane proximal helix by establishing charge complementary salt bridges.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, epub ahead of print. ⟨10.1074/jbc.M709704200⟩. ⟨hal-00293590⟩
  • Vanessa Dehennaut, Xavier Hanoulle, Jean-François Bodart, Jean-Pierre Vilain, Jean-Claude Michalski, et al.. Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry.. Biochemical and Biophysical Research Communications, Elsevier, 2008, 369 (2), pp.539-46. ⟨10.1016/j.bbrc.2008.02.063⟩. ⟨hal-00315662⟩
  • Andrew J Baldwin, John Christodoulou, Paul D Barker, Christopher M Dobson, Guy Lippens. Contribution of rotational diffusion to pulsed field gradient diffusion measurements.. Journal of Chemical Physics, American Institute of Physics, 2007, 127 (11), pp.114505. ⟨10.1063/1.2759211⟩. ⟨hal-00273334⟩
  • Alain Sillen, Pascale Barbier, Isabelle Landrieu, Sylvie Lefebvre, Jean-Michel Wieruszeski, et al.. NMR Investigation of the Interaction between the Neuronal Protein Tau and the Microtubules.. Biochemistry, American Chemical Society, 2007, 46 (11), pp.3055-3064. ⟨10.1021/bi061920i⟩. ⟨hal-00139673⟩
  • Xavier Hanoulle, Aurélie Melchior, Nathalie Sibille, Benjamin Parent, Agnès Denys, et al.. Structural and functional characterisation of the interaction between cyclophilin B and A heparin derived oligosaccharide.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, epub ahead of print. ⟨10.1074/jbc.M706353200⟩. ⟨hal-00175485⟩
  • Guy Lippens, Alain Sillen, Isabelle Landrieu, Laziza Amniai, Nathalie Sibille, et al.. Tau aggregation in Alzheimer's disease : what role for phosphorylation ?. Prion, Taylor & Francis, 2007, 1 (1), pp.21-25. ⟨hal-00161158⟩
  • Guy Lippens, Jean-Michel Wieruszeski, Marcel Piotto, Karim Elbayed, Marise Bourdonneau. New DEFT sequences for the acquisition of one-dimensional carbon NMR spectra of small unlabelled molecules.. Magnetic Resonance in Chemistry, Wiley, 2006, 44, pp.943-947. ⟨hal-00103769⟩
  • Isabelle Landrieu, Caroline Smet, Jean-Michel Wieruszeski, Anne-Véronique Sambo, René Wintjens, et al.. Exploring the Molecular Function of PIN1 by Nuclear Magnetic Resonance.. Current Protein and Peptide Science, Bentham Science Publishers, 2006, 7, pp.179-194. ⟨hal-00085621⟩
  • Xavier Hanoulle, Jean-Michel Wieruszeski, Pierre Rousselot-Pailley, Isabelle Landrieu, Camille Locht, et al.. Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria.. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2006, 58 (4), pp.768. ⟨10.1093/jac/dkl332⟩. ⟨hal-00103724⟩
  • Guy Lippens, Alain Sillen, Caroline Smet, Jean-Michel Wieruszeski, Arnaud Leroy, et al.. Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy.. Protein and Peptide Letters, Bentham Science Publishers, 2006, 13, pp.235-246. ⟨hal-00085628⟩
  • Marco da Costa, Liên Bach, Isabelle Landrieu, Yannick Bellec, Olivier Catrice, et al.. Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A.. The Plant cell, American Society of Plant Biologists (ASPB), 2006, 18, pp.1426-1437. ⟨hal-00085654⟩
  • Malika Hamdane, Pierre Dourlen, Alexis Bretteville, Anne-Véronique Sambo, Stéphanie Ferreira, et al.. Pin1 allows for differential Tau dephosphorylation in neuronal cells.. Molecular and Cellular Neuroscience, Elsevier, 2006, 32, pp.155-160. ⟨hal-00085645⟩
  • Philippe Talaga, Virginie Cogez, Jean-Michel Wieruszeski, Bernd Stahl, Jérôme Lemoine, et al.. Osmoregulated periplasmic glucans of the free-living photosynthetic bacterium Rhodobacter sphaeroides. European Journal of Biochemistry, Wiley, 2002, 269, pp.2464-2472. ⟨hal-00021144⟩
  • Jean-Michel Wieruszeski, Anne Bohin, Jean-Pierre Bohin, Guy Lippens. In vivo detection of the cyclic osmoregulated periplasmic glucan of Ralstonia solanacearum by high-resolution magic angle spinning NMR.. Journal of Magnetic Resonance, Elsevier, 2001, 151, pp.1-6. ⟨hal-00021378⟩
  • I. Landrieu, P. Casteels, B. Odaert, Lieven de Veylder, D. Portetelle, et al.. Recombinant production of the p10CKS1At protein from Arabidopsis thaliana and 13C and 15N double-isotopic enrichment for NMR studies. Protein Expression and Purification, Elsevier, 1999, 16, pp.144-151. ⟨hal-02686867⟩

Conference papers1 document

  • Donia Bouzouita, Simon Tricard, Luis Miguel Martinez-Pietro, Guy Lippens, Bruno Chaudret. Tuning the catalytic activity/selectivity of water-soluble bimetallic RuPt nanoparticles by modifying their surface metal distribution. 257. National Meeting of the American-Chemical-Society (ACS), Mar 2019, Orlando, United States. ⟨hal-02274479⟩

Book sections1 document

  • Haoling Qi, Clément Despres, Sudhakaran Prabakaran, Francois-Xavier Cantrelle, Béatrice Chambraud, et al.. The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein. Nocca Smet, Caroline. Tau protein : methods and protocols, 1523, Springer New York, pp.179-213, 2017, 978-1-4939-6596-0. ⟨10.1007/978-1-4939-6598-4_11⟩. ⟨hal-03235823⟩