Skip to Main content

Researcher identifiers

Number of documents


curriculum vitae

Civil Status

Pidoux Guillaume


17th July 1978



Senior Researcher (CRCN) INSERM with permanent position 


French Public Organization:

INSERM UMR-S1180 - Signalling & Cardiovascular Pathophysiology - Faculty of Pharmacy - University Paris Saclay


Other activities:

Executive board

2010-2015        Team leader of the Cell Fusion group Inserm UMR-S767

2013-2015        Supervision of postdoctoral fellow (S. Degrelle granted by ANR Grant 11-BSV1-03501)

2010-2015        Supervision of permanent Inserm technician (F. Ferreira) and engineer (P. Gerbaud)

2021-2024        Supervision of postdoctoral fellow (to be recruited granted by ANR Grant CardioTarget)


Supervision of students

2004-2018      Supervision and trainings of 10 master students (7 x M2, 3 x M1)

2013-2016      Co-supervision of a PhD fellow with Pr. K. Tasken (A. Dukic, PhD defended 12th December 2016)

2017-2021      Co-supervision of a PhD fellow with Dr. R. Fischmeister (C. Deflers; CIFRE fellowship & FRM)

2018-2022      Supervision of a PhD fellow (AS. Colombe; LabEx fellowship)


Memberships in panel university committee

2014                 PhD committee, France, University Descartes (Bandje K.)  

2015                 PhD committee, France, University Paris-Sud (Bobin P.) 

2019                 Mid-PhD committee, Swiss, Lausanne University (Osman H.) (defense expected in 2022)

2019                 PhD committee, France, University Paris-Saclay (Gallego C.)

2020                 HDR committee, France, University Versailles-Saint-Quentin (Tarrade-Couturier A.)


Memberships in individual scientific reviewing activities

2018-2018       LabEx Lermit Emergence grant review committee 

2019-2019       H2020: ERC Starting grant LS9 reviewer

2020-2020       Ligue Suisse contre le Cancer reviewer   

2020-2020       GAČR: Czech Science Foundation reviewer


Animation & Network

Since 2011     Co-director of the French cAMP Network

2011-2016      Elected member of the EPG Planning committee by EPG (European Placenta Group)

2018               Member of CoLab LabEx Lermit


2020               Member of joined CoPil & CoLab LabEx Lermit


Teaching activities (≈ 10h / year)

Since 2019      Master biology, physiopathology, pharmacology of the heart and circulation (University Paris-Saclay)

2020                International Master Development of Drugs and Health Products (in English, University Paris-Saclay)


Reviewing manuscript

Reviewing on a regular basis (≈ 20 / year): Endocrinology, J Cell Sci, Mol Cell Biol, MBoC, J Cell Physiol, Sci. Reports, PloS One, Cell Signaling, BBA, Cells, Biomolecules, iScience ...


Metrics (September 2020)

44 publications (Web of Knowledge), h-index 15 (Web of Knowledge)

ORCID ID: 0000-0002-5074-429X 


Previous Positions

01/01/2007-31/12/2009 - OSLO - EMBL Nordic - NCMM - Postdoc

01/01/2010-31/08/2012 - PARIS - INSERM UMR-S767 - Postdoc

01/09/2012-31/07/2015 - PARIS - INSERM UMR-S767 - Inserm Junior Researcher (CR2)

01/08/2015-                   - Chatenay-Malabry - INSERM UMR-S1180 - Inserm Researcher (CRCN)



2000     University Paris-Sud, Orsay, France              B.Sc.                             Cell biology, physiology

2002     University Paris-Sud, Orsay, France              Master                           Cell biology, physiology

2006     University Paris-Diderot, Paris, France          Ph.D.                            Cell biology, physiology

2013     University Paris-Descartes, Paris, France      Habilitation (HDR)       Cell signaling



Scientific production


2011                Grant Yggdrasil (collaborative France – Norway) (18 k€)

2012-2015        Co-partner of ANR (French National Agency) Grant 11-BSV1-03501-PlacentA5 (340 k€) 

2012-2014        Grant INSERM (40 k€)

2013                Funding CAMPLP for equipment (30 k€)

2021-2024        Coordinator of ANR (French National Agency) Grant ANR-20-CE18-0017 (401 k€)



2012                  Gordon Research Conference best short communication, Cyclic Nucleotide Phosphodiesterases (Italy)

2012                  Nominated for Gábor Than Award


2012                  SFBBM award for the best scientific paper of the month (March 2012, EMBO J)



2002-2006        PhD Fellowship “Avenir-Inserm”, INSERM

2007-2010        Laureate of the European fellowship EMBiO “metabolic disorders”, UiO, Norway

2010                 FEBS fellowship to attend to the workshop “spatiotemporal dynamics of cell signalling” (Norway)

2010                 SFBBM fellowship to attend to the 35th FEBS congress (Sweden)

2010-2012        Postdoc Fellowship from Fondation PremUP, Univ. Paris Descartes, France



·       Management

2013                Scientific team management - session for facility directors, team leaders and researchers (Inserm)

2013                Recruitment of scientific team

2013                Supervise and support your PhD fellow


·       Research support

2005                Animal experiment diploma (French Level-1) 

2012                Adobe Illustrator

2014                GraphPad Prism

2014                Biological statistics

2014                Image processing and analysis


2015                Programing and macro-control under ImageJ




2012    Pidoux G. & Tasken K. DOFI no. 12043: Method to regulate the opening of connexin-43 junctions

Journal articles24 documents

  • Pascale Gerbaud, Padma Murthi, Jean Guibourdenche, Fabien Guimiot, Benoît Sarazin, et al.. Study of Human T21 Placenta Suggests a Potential Role of Mesenchymal Spondin-2 in Placental Vascular Development. Endocrinology, Endocrine Society, 2019, 160 (3), pp.684-698. ⟨10.1210/en.2018-00826⟩. ⟨inserm-02472525⟩
  • Aleksandra Dukic, Pascale Gerbaud, Jean Guibourdenche, Bernd Thiede, Kjetil Taskén, et al.. Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion. Biochemical Journal, Portland Press, 2018, 475 (2), pp.455-476. ⟨10.1042/BCJ20170529⟩. ⟨inserm-02472530⟩
  • Severine S. Degrelle, Pascale Gerbaud, Ludovic Leconte, Fátima Ferreira, Guillaume Pidoux. Annexin-A5 organized in 2D-network at the plasmalemma eases human trophoblast fusion OPEN. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.42173. ⟨10.1038/srep42173⟩. ⟨inserm-02440462⟩
  • Aleksandra Dukic, Linda Hofstad Haugen, Guillaume Pidoux, Edward Leithe, Oddmund Bakke, et al.. A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells. Cellular Signalling, Elsevier, 2017, 32, pp.1-11. ⟨10.1016/j.cellsig.2017.01.008⟩. ⟨inserm-02472534⟩
  • Pascale Gerbaud, Fatima Ferreira, Guillaume Pidoux. [Role and regulation of cAMP signaling in human trophoblast fusion].. Biologie Aujourd'hui, EDP sciences, 2016, 210 (3), pp.139-151. ⟨10.1051/jbio/2016017⟩. ⟨inserm-02472540⟩
  • Edouard Lecarpentier, Anthony Atallah, Jean Guibourdenche, Marylise Hebert-Schuster, Sarah Vieillefosse, et al.. Fluid Shear Stress Promotes Placental Growth Factor Upregulation in Human Syncytiotrophoblast Through the cAMP–PKA Signaling Pathway. Hypertension, American Heart Association, 2016, 68 (6), pp.1438-1446. ⟨10.1161/HYPERTENSIONAHA.116.07890⟩. ⟨inserm-02472544⟩
  • Guillaume Pidoux, Kjetil Taskén. Anchored PKA as a gatekeeper for gap junctions. Communicative and Integrative Biology, Taylor & Francis Open, 2015, 8 (4), pp.e1057361. ⟨10.1080/19420889.2015.1057361⟩. ⟨inserm-02472545⟩
  • Pascale Gerbaud, Kjetil Taskén, Guillaume Pidoux. Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion. Frontiers in Pharmacology, Frontiers, 2015, 6, pp.202. ⟨10.3389/fphar.2015.00202⟩. ⟨inserm-02472551⟩
  • Guillaume Pidoux, Pascale Gerbaud, Jean Guibourdenche, Patrice Therond, Fatima Ferreira, et al.. Formaldehyde Crosses the Human Placenta and Affects Human Trophoblast Differentiation and Hormonal Functions. PLoS ONE, Public Library of Science, 2015, 10 (7), pp.e0133506. ⟨10.1371/journal.pone.0133506⟩. ⟨inserm-02472555⟩
  • Pascale Gerbaud, Guillaume Pidoux. An overview of molecular events occurring in human trophoblast fusion. Placenta, Elsevier, 2015, 36 (Suppl1), pp.S35-42. ⟨10.1016/j.placenta.2014.12.015⟩. ⟨inserm-02556112v2⟩
  • Marie Clémence Leguy, Stéphanie Brun, Guillaume Pidoux, Houria Salhi, Agnès Choiset, et al.. Pattern of secretion of pregnancy-associated plasma protein-A (PAPP-A) during pregnancies complicated by fetal aneuploidy, in vivo and in vitro. Reproductive Biology and Endocrinology, BioMed Central, 2014, ⟨10.1186/1477-7827-12-129⟩. ⟨inserm-02556117⟩
  • Guillaume Pidoux, Pascale Gerbaud, Jim Dompierre, Birgitte Lygren, Therese Solstad, et al.. A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion. Journal of Cell Science, Company of Biologists, 2014, 129 (Pt19), pp.4172-4185. ⟨10.1242/jcs.149609⟩. ⟨inserm-02556121⟩
  • Guillaume Pidoux, Pascale Gerbaud, Mélanie Cocquebert, Nadine Segond, Josette Badet, et al.. Review: Human trophoblast fusion and differentiation: Lessons from trisomy 21 placenta. Placenta, Elsevier, 2012, 33, Suppl:S81-86. ⟨10.1016/j.placenta.2011.11.007⟩. ⟨inserm-02556136⟩
  • W E Ackerman Iv, J N Bulmer, A M Carter, J R Chaillet, L Chamley, et al.. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta, Elsevier, 2012, 33 (Suppl(0)), pp.S15-22. ⟨10.1016/j.placenta.2011.11.022⟩. ⟨inserm-02556127⟩
  • Pascale Gerbaud, Guillaume Pidoux, Jean Guibourdenche, Niroshani Pathirage, Jean Marc Costa, et al.. Mesenchymal Activin-A Overcomes Defective Human Trisomy 21 Trophoblast Fusion. Endocrinology, Endocrine Society, 2011, 152 (12), pp.5017-5028. ⟨10.1210/en.2011-1193⟩. ⟨inserm-02556144⟩
  • Guillaume Pidoux, Oliwia Witczak, Elisabeth Jarnaess, Linda Myrvold, Henning Urlaub, et al.. Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. EMBO Journal, EMBO Press, 2011, 30 (21), pp.4371-4386. ⟨10.1038/emboj.2011.365⟩. ⟨inserm-02556141⟩
  • Guillaume Pidoux, Kjetil Taské. REVIEW Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins. Journal of Molecular Endocrinology, BioScientifica, 2010, 44 (5), pp.271-284. ⟨10.1677/JME-10-0010⟩. ⟨inserm-02556153⟩
  • Guillaume Pidoux, Pascale Gerbaud, Sédami Gnidehou, Michael Grynberg, Graziello Geneau, et al.. ZO-1 is involved in trophoblastic cell differentiation in human placenta.. American Journal of Physiology - Cell Physiology, American Physiological Society, 2010, 298 (6), pp.C1517-26. ⟨10.1152/ajpcell.00484.2008⟩. ⟨hal-00498310⟩
  • Guillaume Pidoux, Pascale Gerbaud, Vassilis Tsatsaris, Olivier Marpeau, Fatima Ferreira, et al.. Biochemical characterization and modulation of LH/CG-receptor during human trophoblast differentiation.: LH/CG-R in human trophoblast differentiation.. Journal of Cellular Physiology, Wiley, 2007, 212 (1), pp.26-35. ⟨10.1002/jcp.20995⟩. ⟨inserm-00116966⟩
  • Guillaume Pidoux, Pascale Gerbaud, Olivier Marpeau, Jean Guibourdenche, Fatima Ferreira, et al.. Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies.: hCG signaling is impaired in trisomy 21 pregnancy. Endocrinology, Endocrine Society, 2007, 148 (11), pp.5403-13. ⟨10.1210/en.2007-0589⟩. ⟨inserm-00168635⟩
  • Jean-Louis Frendo, Jean Guibourdenche, Guillaume Pidoux, Michel Vidaud, Dominique Luton, et al.. Trophoblast production of a weakly bioactive human chorionic gonadotropin in trisomy 21-affected pregnancy.: hCG and Down Syndrome. Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2004, 89 (2), pp.727-32. ⟨10.1210/jc.2003-030668⟩. ⟨inserm-00128419⟩
  • Guillaume Pidoux, Pascale Gerbaud, Ingrid Laurendeau, Jean Guibourdenche, G Bertin, et al.. Large Variability of Trophoblast Gene Expression Within and Between Human Normal Term Placentae. Placenta, Elsevier, 2004, 25 (5), pp.469-473. ⟨10.1016/j.placenta.2003.10.016⟩. ⟨inserm-02556159⟩
  • Guillaume Pidoux, Jean Guibourdenche, Jean-Louis Frendo, Pascale Gerbaud, M Conti, et al.. Impact of Trisomy 21 on Human Trophoblast Behaviour and Hormonal Function. Placenta, Elsevier, 2004, 25 (SupplA), pp.S79-84. ⟨10.1016/j.placenta.2004.01.007⟩. ⟨inserm-02556164⟩
  • Laurent Cronier, Jean-Louis Frendo, Norah Defamie, Guillaume Pidoux, Gladys Bertin, et al.. Requirement of Gap Junctional Intercellular Communication for Human Villous Trophoblast Differentiation 1. Biology of Reproduction, Society for the Study of Reproduction, 2003, 69 (5), pp.1472-1480. ⟨10.1095/biolreprod.103.016360⟩. ⟨inserm-02556169⟩

Book sections1 document

  • André Malassiné, Guillaume Pidoux, Pascale Gerbaud, Jean Louis Frendo, Danièle Evain-Brion. Human Trophoblast in Trisomy 21: A Model for Cell–Cell Fusion Dynamic Investigation. Advances in Experimental Medicine and Biology book series, pp.103-112, 2011, ⟨10.1007/978-94-007-0782-5_4⟩. ⟨inserm-02556149⟩

Preprints, Working Papers, ...1 document

  • Anne-Sophie Colombe, Guillaume Pidoux. Cardiac cAMP-PKA signaling compartmentalization in myocardial infarction. 2021. ⟨inserm-03175997⟩

Theses1 document


Habilitation à diriger des recherches1 document

  • Guillaume Pidoux. Différenciation du trophoblaste humain - Implication des macrocomplexes PKA/AKAP lors de la fusion cellule-cellule. Sciences du Vivant [q-bio]. Paris Descartes, 2013. ⟨tel-02556193⟩