GDM

Cécile Gateau, Guilherme Dias de Melo, Philippe Uriac, Olivier Tasseau, Jacques Renault, et al.. Irreversible inhibitors of the proline racemase (PRAC) unveil innovative mechanism of action as antibacterial against Clostridioides difficile. Chemical Biology and Drug Design, Wiley, In press, ⟨10.1111/cbdd.14005⟩. ⟨hal-03504249⟩

Guilherme Dias de Melo, Nicolas Coatnoan, Nicolas Gouault, Jean-François Cupif, Jacques Renault, et al.. Prodrugs as new therapies against Chagas disease: In vivo synergy between Trypanosoma cruzi proline racemase inhibitors and benznidazole. Journal of Global Antimicrobial Resistance, Elsevier, In press, ⟨10.1016/j.jgar.2021.10.030⟩. ⟨hal-03504248⟩

Guilherme Dias de Melo, Françoise Lazarini, Florence Larrous, Lena Feige, Etienne Kornobis, et al.. Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin. EMBO Molecular Medicine, Wiley Open Access, 2021, pp.e14122. ⟨10.15252/emmm.202114122⟩. ⟨pasteur-03279176⟩

Felipe Pérez Benavides, Giovana Boff Araujo Pinto, Marta Cristina Thomas Heckler, Diana Milena Rodríguez Hurtado, Livia Ramos Teixeira, et al.. Intrathecal Transplantation of Autologous and Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Dogs. Cell Transplantation, Cognizant Communication Corporation, 2021, 30, pp.096368972110344. ⟨10.1177/09636897211034464⟩. ⟨hal-03504205⟩

Phanramphoei Frantz, Aleksandr Barinov, Claude Ruffié, Chantal Combredet, Valérie Najburg, et al.. A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.6277. ⟨10.1038/s41467-021-26506-2⟩. ⟨pasteur-03416317⟩

Frédéric Rivière, François Lefèvre, Julien Burger, Guilherme Dias de Melo, Jean Nicolas Tournier, et al.. Two-photon microscopy analysis reveals different pulmonary damage after infection by influenza or SARS-CoV-2. Respiratory Medicine and Research, Elsevier, 2021, 80, pp.100862. ⟨10.1016/j.resmer.2021.100862⟩. ⟨hal-03504202⟩

Guilherme Dias de Melo, Françoise Lazarini, Sylvain Levallois, Charlotte Hautefort, Vincent Michel, et al.. COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters. Science Translational Medicine, American Association for the Advancement of Science (AAAS), 2021, pp.eabf8396. ⟨10.1126/scitranslmed.abf8396⟩. ⟨pasteur-03242618⟩

Rémy Robinot, Mathieu Hubert, Guilherme Dias de Melo, Françoise Lazarini, Timothée Bruel, et al.. SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4354. ⟨10.1038/s41467-021-24521-x⟩. ⟨pasteur-03319522⟩

Jan Hellert, Julian Buchrieser, Florence Larrous, Andrea Minola, Guilherme Dias de Melo, et al.. Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.596. ⟨10.1038/s41467-020-14398-7⟩. ⟨pasteur-02868882⟩

Hervé Bourhy, Guilherme Dias de Melo, Arnaud Tarantola. Nouveaux aspects de la lutte contre la rage. Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2020, ⟨10.1016/j.banm.2020.09.036⟩. ⟨pasteur-02983037⟩

Guilherme Dias de Melo, Florian Sonthonnax, Gabriel Lepousez, Grégory Jouvion, Andrea Minola, et al.. A combination of two human monoclonal antibodies cures symptomatic rabies. EMBO Molecular Medicine, Wiley Open Access, 2020, pp.e12628. ⟨10.15252/emmm.202012628⟩. ⟨pasteur-02983042⟩

Fernanda Grecco Grano, José Eduardo dos Santos Silva, Guilherme Dias De Melo, Gisele Fabrino Machado. Leishmania hide-and-seek: Parasite amastigotes in the choroid plexus of a dog with neurological signs in an endemic municipality in Brazil. Veterinary Parasitology : Regional Studies and Reports, Elsevier, 2019, 17, pp.100291. ⟨10.1016/j.vprsr.2019.100291⟩. ⟨hal-03504206⟩

V.A. Canello, K. Gravena, M.C.H. Tovar, D.P.M. Dias, L.M.W. Gomide, et al.. Metaloproteinases no tecido laminar do casco de equinos submetidos à obstrução intraluminal do cólon menor. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Universidade Federal de Minas Gerais, 2018, 70 (1), pp.45-52. ⟨10.1590/1678-4162-9378⟩. ⟨hal-03504211⟩

Sheila S.S. Nogueira, Marlos Sousa, Fabio Gava, Fernando Rosa, Guilherme Melo, et al.. Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy. Pesquisa Veterinária Brasileira, Colégio Brasileiro de Patologia Animal - CBPA, 2018, 38 (2), pp.320-327. ⟨10.1590/1678-5150-PVB-4990⟩. ⟨hal-03504209⟩

Ana Paula Prudente Jacintho, Guilherme Melo, Gisele Machado, Paulo Henrique Leal Bertolo, Pamela Rodrigues Reina Moreira, et al.. Expression of matrix metalloproteinase-2 and metalloproteinase-9 in the skin of dogs with visceral leishmaniasis. Parasitology Research, Springer Verlag (Germany), 2018, 117 (6), pp.1819-1827. ⟨10.1007/s00436-018-5868-9⟩. ⟨hal-03504208⟩

Fernanda Grano, José Eduardo dos S. Silva, Guilherme Melo, Milena de Souza, Valéria M.F. Lima, et al.. Toll-like receptors and cytokines in the brain and in spleen of dogs with visceral leishmaniosis. Veterinary Parasitology, 2018, 253, pp.30-38. ⟨10.1016/j.vetpar.2018.02.030⟩. ⟨hal-03504207⟩

Patricia de Aguiar Amaral, Delphine Autheman, Guilherme Dias de Melo, Nicolas Gouault, Jean-François Cupif, et al.. Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography. PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (10), ⟨10.1371/journal.pntd.0006853⟩. ⟨hal-01935360⟩

Roberta Duarte, Paulo Ricardo D.A. Rocha, Alex Nakamura, Rafael Cipriano, Milena Viol, et al.. Detection of natural occurrence of Tritrichomonas foetus in cats in Araçatuba, São Paulo, Brazil. Pesquisa Veterinária Brasileira, Colégio Brasileiro de Patologia Animal - CBPA, 2018, 38 (2), pp.309-314. ⟨10.1590/1678-5150-PVB-5115⟩. ⟨hal-03504210⟩

Gisele Machado, Guilherme Dias de Melo, Silvia Perri, Fernando Fernandes, Olívia Moraes, et al.. Perceptions of animal experimentation: a longitudinal survey with veterinary students in Araçatuba, São Paulo, Brazil. Journal of Biological Education, Taylor & Francis (Routledge), 2017, 51 (4), pp.391-398. ⟨10.1080/00219266.2016.1257501⟩. ⟨hal-03504213⟩

Guilherme Dias de Melo, Sophie Goyard, Hervé Lecoeur, Eline Rouault, Pascale Pescher, et al.. New insights into experimental visceral leishmaniasis: Real-time in vivo imaging of Leishmania donovani virulence. PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (9), pp.e0005924. ⟨10.1371/journal.pntd.0005924⟩. ⟨hal-03504212⟩

Guilherme D. Melo, Sophie Goyard, Laurence Fiette, Alexandre Boissonnas, Christophe Combadiere, et al.. Unveiling Cerebral Leishmaniasis: parasites and brain inflammation in Leishmania donovani infected mice. Scientific Reports, Nature Publishing Group, 2017, 7, pp.8454. ⟨10.1038/s41598-017-09085-5⟩. ⟨hal-01581802⟩

Marlos Sousa, Amanda B.G. Lima, Cristiane R.A. Araújo, Vinícius B.C. Silva, Adriano Ramos, et al.. Blood pressure and renal injury in dogs with visceral leishmaniasis. Pesquisa Veterinária Brasileira, Colégio Brasileiro de Patologia Animal - CBPA, 2016, 36 (9), pp.857-863. ⟨10.1590/S0100-736X2016000900011⟩. ⟨hal-03504216⟩

Milena Araúz Viol, Felix Guerrero, Bruno César Miranda de Oliveira, Monally Conceição Costa de Aquino, Saulo Hudson Loiola, et al.. Identification of Leishmania spp. promastigotes in the intestines, ovaries, and salivary glands of Rhipicephalus sanguineus actively infesting dogs. Parasitology Research, Springer Verlag (Germany), 2016, 115 (9), pp.3479-3484. ⟨10.1007/s00436-016-5111-5⟩. ⟨hal-03504214⟩

Fernanda Grano, José Eduardo dos S. Silva, Guilherme Dias de Melo, Juliana Perosso, Valéria M.F. Lima, et al.. T lymphocyte immunophenotypes in the cerebrospinal fluid of dogs with visceral leishmaniasis. Veterinary Parasitology, 2016, 232, pp.12-20. ⟨10.1016/j.vetpar.2016.11.006⟩. ⟨hal-03504215⟩

Leandro Maia, Fernanda da Cruz Landim- Alvarenga, Marilda Onghero Taffarel, Carolina Nogueira de Moraes, Gisele Fabrino Machado, et al.. Feasibility and safety of intrathecal transplantation of autologous bone marrow mesenchymal stem cells in horses. BMC Veterinary Research, BioMed Central, 2015, 11 (1), ⟨10.1186/s12917-015-0361-5⟩. ⟨hal-03504220⟩

Guilherme Dias de Melo, José Eduardo S. Silva, Fernanda Grano, Milena Souza, Gisele Machado. Leishmania infection and neuroinflammation: Specific chemokine profile and absence of parasites in the brain of naturally-infected dogs. Journal of Neuroimmunology, 2015, 289, pp.21-29. ⟨10.1016/j.jneuroim.2015.10.004⟩. ⟨hal-03504218⟩

Cáris Maroni Nunes, Valéria Marçal Félix De Lima, Guilherme Dias De Melo, Henrique Borges De Paula, Maria Esther Gonçalves Pereira, et al.. Serological, parasitological and molecular tests for canine visceral leishmaniosis diagnosis in a longitudinal study. Revista Brasileira de Parasitologia Veterinária, 2015, 24 (4), pp.402-409. ⟨10.1590/S1984-29612015073⟩. ⟨hal-03504221⟩

G.D. de Melo, F. Grano, J. Silva, B. Kremer, V. Lima, et al.. Blood-brain barrier disruption during spontaneous canine visceral leishmaniasis. Parasite Immunology, Wiley, 2015, 37 (12), pp.635-645. ⟨10.1111/pim.12285⟩. ⟨hal-03504217⟩

Fernanda Grano, Guilherme Melo, Silvia Belinchón-Lorenzo, Luis Gómez-Nieto, Gisele Machado. First detection of Leishmania infantum DNA within the brain of naturally infected dogs. Veterinary Parasitology, 2014, 204 (3-4), pp.376-380. ⟨10.1016/j.vetpar.2014.05.015⟩. ⟨hal-03504223⟩

Guilherme Dias de Melo, J. Silva, F. Grano, C. Homem, G. Machado. Compartmentalized gene expression of toll-like receptors 2, 4 and 9 in the brain and peripheral lymphoid organs during canine visceral leishmaniasis. Parasite Immunology, Wiley, 2014, 36 (12), pp.726-731. ⟨10.1111/pim.12148⟩. ⟨hal-03504224⟩

Rodrigo Storti Pereira, Augusto Schweigert, Guilherme Dias De Melo, Fernando Vissani Fernandes, Felipe Augusto Ruiz Sueiro, et al.. Ki-67 labeling in canine perianal glands neoplasms: a novel approach for immunohistological diagnostic and prognostic. BMC Veterinary Research, BioMed Central, 2013, 9 (1), ⟨10.1186/1746-6148-9-83⟩. ⟨hal-03504230⟩

Gisele Machado, Fernanda Bernardi, Fernando Y.M. Hosomi, Juliana Peiró, Rudi Weiblen, et al.. Bovine herpesvirus-5 infection in a rabbit experimental model: Immunohistochemical study of the cellular response in the CNS. Microbial Pathogenesis, Elsevier, 2013, 57, pp.10-16. ⟨10.1016/j.micpath.2013.01.003⟩. ⟨hal-03504227⟩

Gisele Machado, Guilherme Dias de Melo, Milena Souza, Andressa Machado, Daniela Migliolo, et al.. Zymographic patterns of MMP-2 and MMP-9 in the CSF and cerebellum of dogs with subacute distemper leukoencephalitis. Veterinary Immunology and Immunopathology, 2013, 154 (1-2), pp.68-74. ⟨10.1016/j.vetimm.2013.04.006⟩. ⟨hal-03504228⟩

Guilherme Melo, Túlio Seraguci, Augusto Schweigert, José Eduardo S. Silva, Fernanda Grano, et al.. Pro-inflammatory cytokines predominate in the brains of dogs with visceral leishmaniasis: A natural model of neuroinflammation during systemic parasitic infection. Veterinary Parasitology, 2013, 192 (1-3), pp.57-66. ⟨10.1016/j.vetpar.2012.11.002⟩. ⟨hal-03504229⟩

Keila Priscilla Sakamoto, Guilherme Dias de Melo, Gisele Fabrino Machado. T and B lymphocytes in the brains of dogs with concomitant seropositivity to three pathogenic protozoans: Leishmania chagasi, Toxoplasma gondii and Neospora caninum. BMC Research Notes, BioMed Central, 2013, 6 (1), ⟨10.1186/1756-0500-6-226⟩. ⟨hal-03504233⟩

Fernanda Grecco Grano, José Eduardo dos Santos Silva, G.D. Melo, Augusto Schweigert, P.C. Ciarlini, et al.. Visceral mast cell tumor and mastocythemia in a dog. Brazilian Journal of Veterinary Pathology, Brazilian Association of Veterinary Pathology, 2012, 5 (3), pp.142-145. ⟨hal-03504245⟩

José Eduardo dos Santos Silva, Fernanda Grecco Grano, G.D. Melo, Augusto Schweigert, L.D.R.P. Ciarlini, et al.. Squamous Cell Lung Carcinoma in a Cat. Brazilian Journal of Veterinary Pathology, Brazilian Association of Veterinary Pathology, 2012, 5 (3), pp.133-136. ⟨hal-03504246⟩

Guilherme Dias de Melo, Mary Marcondes, Gisele Machado. Canine cerebral leishmaniasis: Potential role of matrix metalloproteinase-2 in the development of neurological disease. Veterinary Immunology and Immunopathology, 2012, 148 (3-4), pp.260-266. ⟨10.1016/j.vetimm.2012.05.007⟩. ⟨hal-03504235⟩

Gisele Fabrino Machado, Maria-Gisela Laranjeira, Augusto Schweigert, Guilherme Dias de Melo. Porencephaly and cortical dysplasia as cause of seizures in a dog. BMC Veterinary Research, BioMed Central, 2012, 8 (1), pp.246. ⟨10.1186/1746-6148-8-246⟩. ⟨hal-03504236⟩

Guilherme Dias de Melo, Gisele Machado. Glial reactivity in dogs with visceral leishmaniasis: correlation with T lymphocyte infiltration and with cerebrospinal fluid anti-Leishmania antibody titres. Cell and Tissue Research, Springer Verlag, 2011, 346 (3), pp.293-304. ⟨10.1007/s00441-011-1290-7⟩. ⟨hal-03504239⟩

Guilherme Melo, Natalia Marangoni, Mary Marcondes, Valéria M.F. Lima, Gisele Machado. High levels of serum matrix metalloproteinases in dogs with natural visceral leishmaniosis: A preliminary report. Veterinary Journal, Elsevier, 2011, 188 (2), pp.243-245. ⟨10.1016/j.tvjl.2010.03.017⟩. ⟨hal-03504240⟩

N. Marangoni, G.D. Melo, O. Moraes, M. Souza, S. Perri, et al.. Levels of matrix metalloproteinase-2 and metalloproteinase-9 in the cerebrospinal fluid of dogs with visceral leishmaniasis. Parasite Immunology, Wiley, 2011, 33 (6), pp.330-334. ⟨10.1111/j.1365-3024.2011.01285.x⟩. ⟨hal-03504238⟩

G.F. Machado, M.B. Castro, G.D. Melo, W.L. Ferreira, E.G. Aylon, et al.. Intravascular lymphomatosis in the central nervous system of dogs: immunohistochemical investigation in two cases. Brazilian Journal of Veterinary Pathology, Brazilian Association of Veterinary Pathology, 2011, 4 (1), pp.47-51. ⟨hal-03504243⟩

Gisele Machado, Guilherme Melo, Olívia Moraes, Milena Souza, Mary Marcondes, et al.. Differential alterations in the activity of matrix metalloproteinases within the nervous tissue of dogs in distinct manifestations of visceral leishmaniasis. Veterinary Immunology and Immunopathology, 2010, 136 (3-4), pp.340-345. ⟨10.1016/j.vetimm.2010.03.024⟩. ⟨hal-03504198⟩

G.D. Melo, G.F. Machado. Choroid plexus involvement in dogs with spontaneous visceral leishmaniasis: a histopathological investigation. Brazilian Journal of Veterinary Pathology, Brazilian Association of Veterinary Pathology, 2009, 2 (2), pp.69-74. ⟨hal-03504244⟩

G.D. Melo, M. Marcondes, R.O. Vasconcelos, G.F. Machado. Leukocyte entry into the CNS of Leishmania chagasi naturally infected dogs. Veterinary Parasitology, 2009, 162 (3-4), pp.248-256. ⟨10.1016/j.vetpar.2009.03.002⟩. ⟨hal-03503869⟩

Guilherme Dias de Melo, Perrine Parize, Grégory Jouvion, Laurent Dacheux, Fabrice Chrétien, et al.. Infections of the Central Nervous System - Chapter 13: Rabies. Fabrice Chrétien. Infections of the Central Nervous System: Pathology and Genetics, Wiley, 2020, 978-1-119-46774-8 (ebook). ⟨10.1002/9781119467748.ch13⟩. ⟨hal-03506122⟩

Rémy Robinot, Mathieu Hubert, Guilherme Dias de Melo, Françoise Lazarini, Timothée Bruel, et al.. SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance. 2021. ⟨pasteur-03244406⟩