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Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.

 Mathieu Cayla , Najma Rachidi , Olivier Leclercq , Dirk Schmidt-Arras , Heidi Rosenqvist , et al.
PLoS Pathogens, 2014, 10 (9), pp.e1004347. ⟨10.1371/journal.ppat.1004347⟩
Article dans une revue pasteur-01109591v1
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Networking the Leishmania research community for the development of novel anti-leishmanial intervention strategies

 Gerald F Späth
Institut Pasteur International Network Annual Scientific Meeting, Nov 2010, Hong-Kong, Hong Kong SAR China. pp.L8, ⟨10.1186/1753-6561-5-S1-L8⟩
Communication dans un congrès inserm-00663865v1

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45−/− mice

 Gerald F Späth , Mary Ann Mcdowell , Stephen Beverley
Experimental Parasitology, 2008, 120 (3), pp.275-279. ⟨10.1016/j.exppara.2008.07.003⟩
Article dans une revue pasteur-03109079v1
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The Crystal Structure of the MAP Kinase LmaMPK10 from Leishmania Major Reveals Parasite-Specific Features and Regulatory Mechanisms.

 Sofía Horjales , Dirk Schmidt-Arras , Ramiro Rodriguez Limardo , Olivier Leclercq , Gonzalo Obal , et al.
Structure, 2012, epub ahead of print. ⟨10.1016/j.str.2012.07.005⟩
Article dans une revue pasteur-00727033v1

Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani

 Aude L. Foucher , Najma Rachidi , Sarah Gharbi , Thierry Blisnick , Philippe Bastin , et al.
Antimicrobial Agents and Chemotherapy, 2013, 57 (3), pp.1252-1261. ⟨10.1128/AAC.01983-12⟩
Article dans une revue pasteur-01433417v1
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Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability

 Wai-Lok Yau , Thierry Blisnick , Jean-François Taly , Manuela Helmer-Citterich , Cordelia Schiene-Fischer , et al.
PLoS Neglected Tropical Diseases, 2010, 4 (6), pp.e729. ⟨10.1371/journal.pntd.0000729⟩
Article dans une revue pasteur-01433566v1
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Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay

 Despina Smirlis , Florent Dingli , Valentin Sabatet , Aileen Roth , Uwe Knippschild , et al.
Frontiers in Cell and Developmental Biology, 2022, 9, pp.800098. ⟨10.3389/fcell.2021.800098⟩
Article dans une revue pasteur-03524218v1
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Post-transcriptional regulation of Leishmania fitness gain

 Laura Piel , K. Shanmugha Rajan , Giovanni Bussotti , Hugo Varet , Rachel Legendre , et al.
2021
Pré-publication, Document de travail pasteur-03210825v1

The role of phosphoglycans in Leishmania-sand fly interactions

 D. Sacks , G. Modi , E. Rowton , Gerald F Späth , L. Epstein , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (1), pp.406-411. ⟨10.1073/pnas.97.1.406⟩
Article dans une revue pasteur-03109433v1
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Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant

 Wai-Lok Yau , Ulrike Lambertz , Lucie Colineau , Pascale Pescher , Andrea Macdonald , et al.
Journal of Eukaryotic Microbiology, 2016, 63 (6), pp.823-833. ⟨10.1111/jeu.12329⟩
Article dans une revue pasteur-01451083v1

A Novel Role for Stat1 in Phagosome Acidification and Natural Host Resistance to Intracellular Infection by Leishmania major

 Gerald F Späth , Paul Schlesinger , Robert Schreiber , Stephen Beverley
PLoS Pathogens, 2009, 5 (4), pp.e1000381. ⟨10.1371/journal.ppat.1000381⟩
Article dans une revue pasteur-03109399v1

The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts

 Gerald F Späth , L. Garraway , S. Turco , S. Beverley , Department Of
Proceedings of the National Academy of Sciences of the United States of America, 2011, 100 (16), pp.9536-9541. ⟨10.1073/pnas.1530604100⟩
Article dans une revue pasteur-03109352v1
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Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania.

 Gerald F Späth , Joachim Clos
Molecular Microbiology, 2016, 100 (6), pp.923-927. ⟨10.1111/mmi.13374⟩
Article dans une revue pasteur-01440873v1
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The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?

 Brice Rotureau , Miguel Morales , Philippe Bastin , Gerald F Späth
Cellular Microbiology, 2009, 11 (5), pp.710 - 718. ⟨10.1111/j.1462-5822.2009.01295.x⟩
Article dans une revue pasteur-01849836v1
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Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation

 Hervé Lecoeur , Thibault Rosazza , Kossiwa Kokou , Hugo Varet , Jean-Yves Coppée , et al.
Frontiers in Immunology, 2020, 1, ⟨10.3389/fimmu.2020.01098⟩
Article dans une revue pasteur-02861456v1
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Nuclear and mitochondrial genome sequencing of North-African Leishmania infantum isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype

 Giovanni Bussotti , Alia Benkahla , Fakhri Jeddi , Oussama Souiaï , Karim Aoun , et al.
Microbial Genomics, 2020, 6 (10), ⟨10.1099/mgen.0.000444⟩
Article dans une revue pasteur-03109058v1
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High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

 Nathalie Aulner , Anne Danckaert , Eline Rouault-Hardoin , Julie Desrivot , Olivier Helynck , et al.
PLoS Neglected Tropical Diseases, 2013, 7 (4), pp.e2154. ⟨10.1371/journal.pntd.0002154⟩
Article dans une revue pasteur-01433415v1

Phosphoproteomic analysis ofLeishmania donovani pro- and amastigote stages

 Miguel Morales , Reiko Watanabe , Christine Laurent , Pascal Lenormand , Jean-Claude Rousselle , et al.
Proteomics, 2008, 8 (2), pp.350-363. ⟨10.1002/pmic.200700697⟩
Article dans une revue istex pasteur-03109403v1
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Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

 Giovanni Bussotti , Evi Gouzelou , Mariana Côrtes Boité , Ihcen Kherachi , Zoubir Harrat , et al.
mBio, 2018, 9 (6), pp.e01399-18. ⟨10.1128/mBio.01399-18⟩
Article dans une revue pasteur-01974308v1
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Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response

 Hervé Lecoeur , Eric Prina , Thibault Rosazza , Kossiwa Kokou , Paya N'Diaye , et al.
Cell Reports, 2020, 30 (6), pp.1870-1882.e4. ⟨10.1016/j.celrep.2020.01.030⟩
Article dans une revue pasteur-02562442v1

Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses

 Benjamin Marsland , Timothy Soos , Gerald F Späth , Dan Littman , Manfred Kopf
Journal of Experimental Medicine, 2004, 200 (2), pp.181-189. ⟨10.1084/jem.20032229⟩
Article dans une revue pasteur-03109321v1
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Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion

 Najma Rachidi , Uwe Knippschild , Gerald F Späth
Frontiers in Cellular and Infection Microbiology, 2021, 11, pp.655700. ⟨10.3389/fcimb.2021.655700⟩
Article dans une revue pasteur-03402709v1

Vaccination with Phosphoglycan-Deficient Leishmania major Protects Highly Susceptible Mice from Virulent Challenge without Inducing a Strong Th1 Response

 Jude Uzonna , Gerald Späth , Stephen Beverley , Phillip Scott
Journal of Immunology, 2004, 172 (6), pp.3793-3797. ⟨10.4049/jimmunol.172.6.3793⟩
Article dans une revue pasteur-03109128v1
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Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines

 Juvana Moreira Andrade , Leilane Oliveira Gonçalves , Daniel Barbosa Liarte , Davi Alvarenga Lima , Frederico Gonçalves Guimarães , et al.
Parasites & Vectors, 2020, 13 (1), pp.600. ⟨10.1186/s13071-020-04486-4⟩
Article dans une revue pasteur-03109036v1
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Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening

 Suzanne Lamotte , Nathalie Aulner , Gerald F Späth , Eric Prina
Scientific Reports, 2019, 9 (1), pp.438. ⟨10.1038/s41598-018-36944-6⟩
Article dans une revue pasteur-02017484v1
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GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells

 Gerald F Späth , Giovanni Bussotti
Nucleic Acids Research, 2021, ⟨10.1093/nar/gkab1237⟩
Article dans une revue pasteur-03512652v1

Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas

 Jean-Claude Dujardin , Dolores González-Pacanowska , Simon L. Croft , Ole F. Olesen , Gerald F Späth
Trends in Parasitology, 2010, 26 (8), pp.395-403. ⟨10.1016/j.pt.2010.04.012⟩
Article dans une revue istex pasteur-01433565v1
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Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania

 T. Liburkin-Dan , D. Schlisselberg , R. Fischer-Weinberger , Pascale Pescher , E. Inbar , et al.
Molecular and Biochemical Parasitology, 2018, 222, pp.1-5. ⟨10.1016/j.molbiopara.2018.04.002⟩
Article dans une revue pasteur-01974297v1

Inflammation recapitulates the ontogeny of lymphoid stromal cells.

 Lucie Peduto , Sophie Dulauroy , Matthias Lochner , Gerald F Späth , Miguel A. Morales , et al.
Journal of Immunology, 2009, 182 (9), pp.5789-99. ⟨10.4049/jimmunol.0803974⟩
Article dans une revue pasteur-00429028v1

CD4+ T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation

 Andreas j. Müller , Orchidée Filipe-Santos , Gerard Eberl , Toni Aebischer , Gerald F Späth , et al.
Immunity, 2012, 37 (1), pp.147 - 157. ⟨10.1016/j.immuni.2012.05.015⟩
Article dans une revue pasteur-01402724v1
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