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Article dans une revue31 documents

  • Gerald F Späth, Joachim Clos. Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania.. Molecular Microbiology, Wiley, 2016, 100 (6), pp.923-927. <10.1111/mmi.13374>. <pasteur-01440873>
  • Emilie Durieu, Eric Prina, Olivier Leclercq, Nassima Oumata, Nicolas Gaboriaud-Kolar, et al.. From drug screening to target deconvolution: A target-based drug discovery pipeline using Leishmania casein kinase 1 isoform 2 to identify compounds with anti-leishmanial activity. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2016, <10.1128/AAC.00021-16>. <hal-01299756>
  • Gerald F Späth. Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids. Genome Biology and Evolution, Society for Molecular Biology and Evolution, 2016. <inserm-01342475>
  • Douglas de Souza Moreira, Pascale Pescher, Christine Laurent, Pascal Lenormand, Gerald F Späth, et al.. Phosphoproteomic analysis of wild-type and antimony-resistant Leishmania braziliensis lines by 2D-DIGE technology. Proteomics, Wiley-VCH Verlag, 2015, 15 (17), pp.2999-3019. <10.1002/pmic.201400611>. <pasteur-01433409>
  • Claire-Lise Forestier, Gerald F Späth, Eric Prina, Sreekanth Dasari. Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process. Microbial Pathogenesis, Elsevier, 2015, 88, pp.103-108. <10.1016/j.micpath.2014.10.012>. <pasteur-01433404>
  • Gerald F Späth, Sima Drini, Najma Rachidi. A touch of Zen: post-translational regulation of the Leishmania stress response. Cellular Microbiology, Wiley, 2015, 17 (5), pp.632-638. <10.1111/cmi.12440>. <pasteur-01433407>
  • Magali Casanova, I. J. Gonzalez, C. Sprissler, H. Zalila, Mariko Dacher, et al.. Implication of different domains of the Leishmania major metacaspase in cell death and autophagy. Cell Death and Disease , Nature Publishing Group, 2015, 6, pp.e1933. <10.1038/cddis.2015.288>. <pasteur-01433402>
  • Wai-Lok Yau, Pascale Pescher, Andrea Macdonald, Sonia Hem, Dorothea Zander, et al.. The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status.. Molecular Microbiology, Wiley, 2014, 93 (1), pp.80-97. <10.1111/mmi.12639>. <hal-01054664>
  • Mariko Dacher, Miguel A Morales, Pascale Pescher, Olivier Leclercq, Najma Rachidi, et al.. Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses. Molecular Microbiology, Wiley, 2014, 93, pp.146-166. <10.1111/mmi.12648>. <hal-01178772>
  • Najma Rachidi, Jean François Taly, Emilie Durieu, Olivier Leclercq, Nathalie Aulner, et al.. Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2014, 58 (3), pp.1501-1515. <10.1128/AAC.02022-13>. <pasteur-01433412>
  • Mathieu Cayla, Najma Rachidi, Olivier Leclercq, Dirk Schmidt-Arras, Heidi Rosenqvist, et al.. Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.. PLoS Pathogens, Public Library of Science, 2014, 10 (9), pp.e1004347. <10.1371/journal.ppat.1004347>. <pasteur-01109591>
  • Polina Tsigankov, Pier Federico Gherardini, Manuela Helmer-Citterich, Gerald F Späth, Peter J. Myler, et al.. Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends. Molecular and Cellular Proteomics (MCP Online), American Society for Biochemistry and Molecular Biology, 2014, 13 (7), pp.1787-1799. <10.1074/mcp.M114.037705>. <pasteur-01433413>
  • Aude L. Foucher, Najma Rachidi, Sarah Gharbi, Thierry Blisnick, Philippe Bastin, et al.. Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 57 (3), pp.1252-1261. <10.1128/AAC.01983-12>. <pasteur-01433417>
  • Polina Tsigankov, Pier Federico Gherardini, Manuela Helmer-Citterich, Gerald F Späth, Dan Zilberstein. Phosphoproteomic analysis of differentiating Leishmania parasites reveals a unique stage-specific phosphorylation motif. Journal of Proteome Research, American Chemical Society, 2013, 12 (7), pp.3405-3412. <10.1021/pr4002492>. <pasteur-01433421>
  • Andreas j. Müller, Salome Aeschlimann, Romain Olekhnovitch, Mariko Dacher, Gerald F Späth, et al.. Photoconvertible Pathogen Labeling Reveals Nitric Oxide Control of Leishmania major Infection In Vivo via Dampening of Parasite Metabolism. Cell host & microbe, 2013, 14 (4), pp.460 - 467. <10.1016/j.chom.2013.09.008>. <pasteur-01410262>
  • Hechmi Louzir, Karim Aoun, Gerald F Späth, Dhafer Laouini, Eric Prina, et al.. Les leishmanioses vues au travers du réseau international des Instituts Pasteur. médecine/sciences, EDP Sciences, 2013, 29 (12), pp.1151-60. <10.1051/medsci/20132912020>. <pasteur-01061043>
  • Andreas j. Müller, Orchidée Filipe-Santos, Gerard Eberl, Toni Aebischer, Gerald F Späth, et al.. CD4+ T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation. Immunity, Elsevier, 2012, 37 (1), pp.147 - 157. <10.1016/j.immuni.2012.05.015>. <pasteur-01402724>
  • Sofía Horjales, Dirk Schmidt-Arras, Ramiro Rodriguez Limardo, Olivier Leclercq, Gonzalo Obal, et al.. The Crystal Structure of the MAP Kinase LmaMPK10 from Leishmania Major Reveals Parasite-Specific Features and Regulatory Mechanisms.. Structure, Elsevier (Cell Press), 2012, epub ahead of print. <10.1016/j.str.2012.07.005>. <pasteur-00727033>
  • Claire-Lise Forestier, Christophe Machu, Celine Loussert, Pascale Pescher, Gerald F Späth. Imaging host cell-Leishmania interaction dynamics implicates parasite motility, lysosome recruitment, and host cell wounding in the infection process. Cell Host and Microbe, Elsevier, 2011, 9 (4), pp.319-330. <10.1016/j.chom.2011.03.011>. <pasteur-01433561>
  • Jan Mani, Andreas Güttinger, Bernd Schimanski, Manfred Heller, Alvaro Acosta-Serrano, et al.. Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery. PLoS ONE, Public Library of Science, 2011, 6 (7), pp.e22463. <10.1371/journal.pone.0022463>. <pasteur-01433563>
  • Antonio Palmeri, Pier Federico Gherardini, Polina Tsigankov, Gabriele Ausiello, Gerald F Späth, et al.. PhosTryp: a phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae.. BMC Genomics, BioMed Central, 2011, 12 (1), pp.614. <10.1186/1471-2164-12-614>. <pasteur-00673514>
  • Pascale Pescher, Thierry Blisnick, Philippe Bastin, Gerald F Späth. Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation. Cellular Microbiology, Wiley, 2011, 13 (7), pp.978-991. <10.1111/j.1462-5822.2011.01593.x>. <pasteur-01433560>
  • Dirk Schmidt-Arras, Olivier Leclercq, Pier Federico Gherardini, Manuela Helmer-Citterich, Wolfgang Faigle, et al.. Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani. Journal of Proteomics, Elsevier, 2011, 74 (9), pp.1644-1651. <10.1016/j.jprot.2011.03.024>. <pasteur-01433562>
  • Sonia Hem, Pier Federico Gherardini, José Fortéa, Veronique Hourdel, Miguel A. Morales, et al.. Identification of Leishmania-specific protein phosphorylation sites by LC-ESI-MS/MS and comparative genomics analyses. Proteomics, Wiley-VCH Verlag, 2010, 10 (21), pp.3868-3883. <10.1002/pmic.201000305>. <pasteur-01433567>
  • Aude L. Foucher, Gerald F Späth, Iain K. Pemberton. Probing the dynamic nature of signalling pathways by IMAC and SELDI-tof MS. Archives of Physiology and Biochemistry, Informa Healthcare, 2010, 116 (4-5), pp.163-173. <10.3109/13813455.2010.495129>. <pasteur-01433568>
  • Miguel A Morales, Reiko Watanabe, Mariko Dacher, Philippe Chafey, José Osorio y Fortéa, et al.. Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2010, epub ahead of print. <10.1073/pnas.0914768107>. <pasteur-00476914>
  • Jean-Claude Dujardin, Dolores González-Pacanowska, Simon L. Croft, Ole F. Olesen, Gerald F Späth. Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas. Trends in Parasitology, Elsevier, 2010, 26 (8), pp.395-403. <10.1016/>. <pasteur-01433565>
  • Miguel A. Morales, Pascale Pescher, Gerald F Späth. Leishmania major MPK7 protein kinase activity inhibits intracellular growth of the pathogenic amastigote stage. Eukaryotic Cell, American Society for Microbiology, 2010, 9 (1), pp.22-30. <10.1128/EC.00196-09>. <pasteur-01433564>
  • Wai-Lok Yau, Thierry Blisnick, Jean-François Taly, Manuela Helmer-Citterich, Cordelia Schiene-Fischer, et al.. Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability. PLoS Neglected Tropical Diseases, Public Library of Science, 2010, 4 (6), pp.e729. <10.1371/journal.pntd.0000729>. <pasteur-01433566>
  • Lucie Peduto, Sophie Dulauroy, Matthias Lochner, Gerald F Späth, Miguel A. Morales, et al.. Inflammation recapitulates the ontogeny of lymphoid stromal cells.. Journal of Immunology, American Association of Immunologists, 2009, 182 (9), pp.5789-99. <10.4049/jimmunol.0803974>. <pasteur-00429028>
  • Orchidée Filipe-Santos, Pascale Pescher, Béatrice Breart, Christoph Lippuner, Toni Aebischer, et al.. A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection.. Cell Host and Microbe, Elsevier, 2009, 6 (1), pp.23-33. <10.1016/j.chom.2009.04.014>. <hal-00419292>

Communication dans un congrès1 document

  • Gerald F Späth. Networking the Leishmania research community for the development of novel anti-leishmanial intervention strategies. Institut Pasteur International Network Annual Scientific Meeting, Nov 2010, Hong-Kong, Hong Kong SAR China. BioMed Central, 5 (Suppl 1), pp.L8, 2011, BMC Proceedings. <10.1186/1753-6561-5-S1-L8>. <inserm-00663865>