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Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.
Mathieu Cayla
,
Najma Rachidi
,
Olivier Leclercq
,
Dirk Schmidt-Arras
,
Heidi Rosenqvist
,
et al.
Article dans une revue
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Networking the Leishmania research community for the development of novel anti-leishmanial intervention strategies
Gerald F Späth
Institut Pasteur International Network Annual Scientific Meeting, Nov 2010, Hong-Kong, Hong Kong SAR China. pp.L8, ⟨10.1186/1753-6561-5-S1-L8⟩
Communication dans un congrès
inserm-00663865v1
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Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45−/− mice
Gerald F Späth
,
Mary Ann Mcdowell
,
Stephen Beverley
Article dans une revue
pasteur-03109079v1
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The Crystal Structure of the MAP Kinase LmaMPK10 from Leishmania Major Reveals Parasite-Specific Features and Regulatory Mechanisms.
Sofía Horjales
,
Dirk Schmidt-Arras
,
Ramiro Rodriguez Limardo
,
Olivier Leclercq
,
Gonzalo Obal
,
et al.
Article dans une revue
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Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani
Aude L. Foucher
,
Najma Rachidi
,
Sarah Gharbi
,
Thierry Blisnick
,
Philippe Bastin
,
et al.
Article dans une revue
pasteur-01433417v1
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Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability
Wai-Lok Yau
,
Thierry Blisnick
,
Jean-François Taly
,
Manuela Helmer-Citterich
,
Cordelia Schiene-Fischer
,
et al.
Article dans une revue
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Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay
Despina Smirlis
,
Florent Dingli
,
Valentin Sabatet
,
Aileen Roth
,
Uwe Knippschild
,
et al.
Article dans une revue
pasteur-03524218v1
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Post-transcriptional regulation of Leishmania fitness gain
Laura Piel
,
K. Shanmugha Rajan
,
Giovanni Bussotti
,
Hugo Varet
,
Rachel Legendre
,
et al.
2021
Pré-publication, Document de travail
pasteur-03210825v1
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The role of phosphoglycans in Leishmania-sand fly interactions
D. Sacks
,
G. Modi
,
E. Rowton
,
Gerald F Späth
,
L. Epstein
,
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (1), pp.406-411. ⟨10.1073/pnas.97.1.406⟩
Article dans une revue
pasteur-03109433v1
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The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?
Brice Rotureau
,
Miguel Morales
,
Philippe Bastin
,
Gerald F Späth
Article dans une revue
pasteur-01849836v1
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Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant
Wai-Lok Yau
,
Ulrike Lambertz
,
Lucie Colineau
,
Pascale Pescher
,
Andrea Macdonald
,
et al.
Article dans une revue
pasteur-01451083v1
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A Novel Role for Stat1 in Phagosome Acidification and Natural Host Resistance to Intracellular Infection by Leishmania major
Gerald F Späth
,
Paul Schlesinger
,
Robert Schreiber
,
Stephen Beverley
Article dans une revue
pasteur-03109399v1
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The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts
Gerald F Späth
,
L. Garraway
,
S. Turco
,
S. Beverley
,
Department Of
Proceedings of the National Academy of Sciences of the United States of America, 2011, 100 (16), pp.9536-9541. ⟨10.1073/pnas.1530604100⟩
Article dans une revue
pasteur-03109352v1
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Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania.
Gerald F Späth
,
Joachim Clos
Article dans une revue
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Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation
Hervé Lecoeur
,
Thibault Rosazza
,
Kossiwa Kokou
,
Hugo Varet
,
Jean-Yves Coppée
,
et al.
Article dans une revue
pasteur-02861456v1
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Nuclear and mitochondrial genome sequencing of North-African Leishmania infantum isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype
Giovanni Bussotti
,
Alia Benkahla
,
Fakhri Jeddi
,
Oussama Souiaï
,
Karim Aoun
,
et al.
Article dans une revue
pasteur-03109058v1
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High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.
Nathalie Aulner
,
Anne Danckaert
,
Eline Rouault-Hardoin
,
Julie Desrivot
,
Olivier Helynck
,
et al.
Article dans une revue
pasteur-01433415v1
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Phosphoproteomic analysis ofLeishmania donovani pro- and amastigote stages
Miguel Morales
,
Reiko Watanabe
,
Christine Laurent
,
Pascal Lenormand
,
Jean-Claude Rousselle
,
et al.
Article dans une revue
istex
pasteur-03109403v1
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Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses
Benjamin Marsland
,
Timothy Soos
,
Gerald F Späth
,
Dan Littman
,
Manfred Kopf
Article dans une revue
pasteur-03109321v1
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Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion
Najma Rachidi
,
Uwe Knippschild
,
Gerald F Späth
Article dans une revue
pasteur-03402709v1
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Vaccination with Phosphoglycan-Deficient Leishmania major Protects Highly Susceptible Mice from Virulent Challenge without Inducing a Strong Th1 Response
Jude Uzonna
,
Gerald Späth
,
Stephen Beverley
,
Phillip Scott
Article dans une revue
pasteur-03109128v1
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Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines
Juvana Moreira Andrade
,
Leilane Oliveira Gonçalves
,
Daniel Barbosa Liarte
,
Davi Alvarenga Lima
,
Frederico Gonçalves Guimarães
,
et al.
Article dans une revue
pasteur-03109036v1
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Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening
Suzanne Lamotte
,
Nathalie Aulner
,
Gerald F Späth
,
Eric Prina
Article dans une revue
pasteur-02017484v1
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GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells
Gerald F Späth
,
Giovanni Bussotti
Article dans une revue
pasteur-03512652v1
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Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification
Giovanni Bussotti
,
Evi Gouzelou
,
Mariana Côrtes Boité
,
Ihcen Kherachi
,
Zoubir Harrat
,
et al.
Article dans une revue
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Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response
Hervé Lecoeur
,
Eric Prina
,
Thibault Rosazza
,
Kossiwa Kokou
,
Paya N'Diaye
,
et al.
Article dans une revue
pasteur-02562442v1
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Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania
T. Liburkin-Dan
,
D. Schlisselberg
,
R. Fischer-Weinberger
,
Pascale Pescher
,
E. Inbar
,
et al.
Article dans une revue
pasteur-01974297v1
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Inflammation recapitulates the ontogeny of lymphoid stromal cells.
Lucie Peduto
,
Sophie Dulauroy
,
Matthias Lochner
,
Gerald F Späth
,
Miguel A. Morales
,
et al.
Article dans une revue
pasteur-00429028v1
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Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas
Jean-Claude Dujardin
,
Dolores González-Pacanowska
,
Simon L. Croft
,
Ole F. Olesen
,
Gerald F Späth
Article dans une revue
istex
pasteur-01433565v1
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CD4+ T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation
Andreas j. Müller
,
Orchidée Filipe-Santos
,
Gerard Eberl
,
Toni Aebischer
,
Gerald F Späth
,
et al.
Article dans une revue
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