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59

Gladys Mirey, Team Leader, Genotoxicity & Signaling, Toxalim INRAE


Gladys Mirey currently works at the French National Institute for Agricultural Research (INRA), Toulouse-France. Gladys does research in Cell Biology, genotoxicology and current projects are linked to 'food toxicology.'


Journal articles36 documents

  • Benoît Pons, Aurélie Pettes-Duler, Claire Naylies, Frédéric Taieb, Catherine Bouchenot, et al.. Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response. Cellular and Molecular Life Sciences, Springer Verlag, 2021, ⟨10.1007/s00018-021-03902-x⟩. ⟨hal-03306242⟩
  • William Tremblay, Florence Mompart, Elisa Lopez, Muriel Quaranta, Valérie Bergoglio, et al.. Cytolethal Distending Toxin Promotes Replicative Stress Leading to Genetic Instability Transmitted to Daughter Cells. Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.1-15. ⟨10.3389/fcell.2021.656795⟩. ⟨hal-03248449⟩
  • Kevin Gillois, Charlotte Stoffels, Mathilde Lévêque, Isabelle Fourquaux, Justine Blesson, et al.. Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products. Science of the Total Environment, Elsevier, 2021, 754, ⟨10.1016/j.scitotenv.2020.142324⟩. ⟨hal-02945727⟩
  • Benoît Pons, Nicolas Loiseau, Saleha Hashim, Souria Tadrist, Gladys Mirey, et al.. Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B. Toxins, MDPI, 2020, 12 (9), pp.530. ⟨10.3390/toxins12090530⟩. ⟨hal-02927138⟩
  • Zhen He, Raad Z. Gharaibeh, Rachel C. Newsome, Jllian L. Pope, Michael W. Dougherty, et al.. Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin. Gut, BMJ Publishing Group, 2019, 68 (2), pp.289-300. ⟨10.1136/gutjnl-2018-317200⟩. ⟨hal-02627995⟩
  • Benoît Pons, Julien Vignard, Gladys Mirey. Cytolethal distending toxin subunit B: A review of structure–function relationship. Toxins, MDPI, 2019, 11 (10), 20 p. ⟨10.3390/toxins11100595⟩. ⟨hal-02618477⟩
  • Benoît Pons, Elisabeth Bezine, Mélissa Hanique, Valerie Guillet, Lionel Mourey, et al.. Cell transfection of purified cytolethal distending toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not. PLoS ONE, Public Library of Science, 2019, 14 (3), pp.e0214313. ⟨10.1371/journal.pone.0214313⟩. ⟨hal-02346660⟩
  • Anne Fernandez-Vidal, Liana C. Arnaud, Manon Maumus, Marianne Chevalier, Gladys Mirey, et al.. Exposure to the fungicide captan induces DNA base alterations and replicative stress in mammalian cells. Environmental and Molecular Mutagenesis, Wiley-Blackwell, 2019, 60 (3), pp.286-297. ⟨10.1002/em.22268⟩. ⟨hal-02620276⟩
  • Vanessa Graillot, Thibault Metenier, Odile Mondésert, Julien Vignard, Valérie Lobjois, et al.. Use of a reliable metabolically competent human rghep(+) hepatocyte model engineered with biological tracers for in vitro micronucleus test associating high-content imaging. Drug Metabolism and Pharmacokinetics, Japanese Society for the Study of Xenobiotics, 2018, 33 (1), pp.S59. ⟨10.1016/j.dmpk.2017.11.200⟩. ⟨hal-02618768⟩
  • Benjamin Kopp, Julien Vignard, Gladys Mirey, Valérie Fessard, Daniel Zalko, et al.. Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet. Environmental and Molecular Mutagenesis, Wiley-Blackwell, 2018, 59 (8), pp.1-13. ⟨10.1002/em.22214⟩. ⟨anses-01880114⟩
  • Nadège Bossuet-Greif, Julien Vignard, Frederic Taieb, Gladys Mirey, Damien Dubois, et al.. The colibactin genotoxin generates DNA interstrand cross-links in infected cells. mBio, American Society for Microbiology, 2018, 9 (2), pp.e02393-17. ⟨10.1128/mBio.02393-17⟩. ⟨hal-02627565⟩
  • Anne Fernandez-Vidal, Julien Vignard, Gladys Mirey. Around and beyond 53BP1 nuclear bodies. International Journal of Molecular Sciences, MDPI, 2017, 18 (12), ⟨10.3390/ijms18122611⟩. ⟨hal-02619788⟩
  • Elisabeth Bezine, Yann Malaisé, Aurore Loeuillet, Marianne Chevalier, Elisa Boutet-Robinet, et al.. Cell resistance to the cytolethal distending toxin involves an association of DNA repair mechanisms. Scientific Reports, Nature Publishing Group, 2016, 6, pp.1-15. ⟨10.1038/srep36022⟩. ⟨hal-01602345⟩
  • Vanessa Graillot, Inge Dormoy, Jacques Dupuy, Jerry W. Shay, Laurence Huc, et al.. Genotoxicity of cytolethal distending toxin (cdt) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis. Frontiers in Cellular and Infection Microbiology, Frontiers, 2016, 6, pp.1-13. ⟨10.3389/fcimb.2016.00034⟩. ⟨hal-02635460⟩
  • Denis Jullien, Julien Vignard, Yoann Fedor, Nicolas Béry, Aurélien Olichon, et al.. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. Development (Cambridge, England), Company of Biologists, 2016, 143 (14), ⟨10.1242/dev.141804⟩. ⟨hal-01602858⟩
  • Denis Jullien, Julien Vignard, Yoann Fedor, Nicolas Béry, Aurélien Olichon, et al.. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. Journal of Cell Science, Company of Biologists, 2016, 129 (13), pp.2673-2683. ⟨10.1242/jcs.183103⟩. ⟨hal-01602848⟩
  • Vanessa Graillot, Odile Mondesert, Thibault Metenier, Julien Vignard, Valerie Lobjois, et al.. A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging. Toxicology Letters, Elsevier, 2016, 258, pp.S146. ⟨10.1016/j.toxlet.2016.06.1566⟩. ⟨hal-01602870⟩
  • Pierre Lebailly, Gladys Mirey, Fabrice Herin, Yannick Lecluse, Bernard Salles, et al.. DNA damage in B and T lymphocytes of farmers during onepesticide spraying season. International Archives of Occupational and Environmental Health, Springer Verlag, 2015, 88 (7), pp.963-972. ⟨10.1007/s00420-015-1024-3⟩. ⟨hal-01188319v2⟩
  • Elisabeth Bezine, Julien Vignard, Gladys Mirey. The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective.. Cells, MDPI, 2014, 3 (2), pp.592-615. ⟨10.3390/cells3020592⟩. ⟨hal-01192559⟩
  • Raghavendra A. Shamanna, Dharmendra Kumar Singh, Huiming Lu, Gladys Mirey, Guido Keijzers, et al.. RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex. Carcinogenesis, Oxford University Press (OUP), 2014, 35 (11), pp.2415 - 2424. ⟨10.1093/carcin/bgu137⟩. ⟨hal-02631395⟩
  • Laëtitia Trapp-Fragnet, Djihad Bencherit, Danièle Chabanne-Vautherot, Yves Le Vern, Sylvie Rémy, et al.. Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells. PLoS ONE, Public Library of Science, 2014, 9 (6), pp.1-14. ⟨10.1371/journal.pone.0100004⟩. ⟨hal-02641216⟩
  • Julien Vignard, Gladys Mirey, Bernard Salles. Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up. Radiotherapy and Oncology, Elsevier, 2013, 108 (3), pp.362-369. ⟨10.1016/j.radonc.2013.06.013⟩. ⟨hal-02648277⟩
  • Yoann Fedor, Julien Vignard, Marie-Laure Travers, Elisa Boutet-Robinet, Claude Watrin, et al.. From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin. Cellular Microbiology, Wiley, 2013, 15 (1), pp.1 - 15. ⟨10.1111/cmi.12028⟩. ⟨hal-02647902⟩
  • Gladys Mirey, Isabelle Chartrain, Carine Froment, Muriel Quaranta, Jean-Pierre Bouché, et al.. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis.. Cell Cycle, Taylor & Francis, 2005, 4 (6), pp.806-11. ⟨hal-00317422⟩
  • Gladys Mirey, A. Soulard, C. Orange, S. Friant, B. Winsor. SH3 domain-containing proteins and the actin cytoskeleton in yeast.. Biochemical Society Transactions, Portland Press, 2005, 33 (Pt 6), pp.1247-9. ⟨10.1042/BST20051247⟩. ⟨hal-00153215⟩
  • A. Soulard, S. Friant, C. Fitterer, C. Orange, G. Kaneva, et al.. The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis.. PROTOPLASMA / Protoplasma (Wien); Protoplasma (Berl ); Protoplasma (D ), 2005, 226 (1-2), pp.89-101. ⟨10.1007/s00709-005-0108-4⟩. ⟨hal-00153221⟩
  • A. Soulard, S. Friant, C. Fitterer, C. Orange, G. Kaneva, et al.. The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis. Protoplasma, Springer Verlag, 2005, 226 (1-2), pp.89 - 101. ⟨10.1007/s00709-005-0108-4⟩. ⟨hal-01632653⟩
  • Young-Han Song, Gladys Mirey, Martha Betson, Daniel A Haber, Jeffrey Settleman. The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Current Biology - CB, Elsevier, 2004, 14 (15), pp.1354-1359. ⟨10.1016/j.cub.2004.06.064⟩. ⟨hal-02683413⟩
  • Stéphanie Dutertre, Martine Cazales, Muriel Quaranta, Christine Dozier, Gladys Mirey, et al.. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.. Journal of Cell Science, Company of Biologists, 2004, 117 (Pt 12), pp.2523-31. ⟨10.1242/jcs.01108⟩. ⟨hal-00317440⟩
  • Helen R Mott, Daniel Nietlispach, Louise J Hopkins, Gladys Mirey, Jacques H Camonis, et al.. Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (19), pp.17053-17059. ⟨10.1074/jbc.M300155200⟩. ⟨hal-02683415⟩
  • Gladys Mirey, Maria Balakireva, Sébastien l'Hoste, Carine Rossé, Stéphanie Voegeling, et al.. A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Molecular and Cellular Biology, American Society for Microbiology, 2003, 23 (3), pp.1112-1124. ⟨10.1128/MCB.23.3.1112-1124.2003⟩. ⟨hal-02681953⟩
  • Serge Moskalenko, Chao Tong, Carine Rossé, Gladys Mirey, Etienne Formstecher, et al.. Ral GTPases regulate exocyst assembly through dual subunit interactions. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (51), pp.51743-51748. ⟨10.1074/jbc.M308702200⟩. ⟨hal-02679145⟩
  • Ja Garcia-Ranea, Gladys Mirey, Jacques Camonis, Alfonso Valencia. p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. FEBS Letters, Wiley, 2002, 529 (2-3), pp.162-167. ⟨10.1038/ncb728⟩. ⟨hal-02683416⟩
  • Béatrice Vayssière, Gérard Zalcman, Yannick Mahe, Gladys Mirey, Tanja Ligensa, et al.. Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. FEBS Letters, Wiley, 2000, 467 (1), pp.91-96. ⟨10.1016/S0014-5793(99)01530-6⟩. ⟨hal-02695354⟩
  • Viviana Jullien-Flores, Yannick Mahe, Gladys Mirey, Corinne Leprince, Brigitte Meunier-Bisceuil, et al.. RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. Journal of Cell Science, Company of Biologists, 2000, 113 (16), pp.2837-2844. ⟨hal-02696179⟩
  • Bettina Bauer, Gladys Mirey, Ingrid R Vetter, Ja García-Ranea, A Valencia, et al.. Effector recognition by the small GTP-binding proteins Ras and Ral. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1999, 274 (25), pp.17763-17770. ⟨10.1074/jbc.274.25.17763⟩. ⟨hal-02696131⟩

Patents1 document

  • Denis Jullien, Julien Vignard, Bernard Salles, Gladys Mirey. Anticorps monocaténaire à chaîne lourde de camelidae dirigé contre la chromatine et utilisations. France, N° de brevet: x. 2013. ⟨hal-02807167⟩

Conference papers22 documents

  • Gladys Mirey. HepaRG hep+ and biological tracers for a new in vitro micronucleus assay in living cells. AlterTox Academy, May 2018, Paris, France. ⟨hal-02790937⟩
  • Gladys Mirey. Biotraceur chromatinien pour l'étude de la génotoxicité dans des cellules hépatiques métaboliquement compétentes.. 32. Journée Chimie-Biologie-Santé, Apr 2018, Toulouse, France. ⟨hal-02787706⟩
  • Gladys Mirey. A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging. ANSES, Journée de la plateforme ASPiC, Nov 2017, Maisons-Alfort, France. ⟨hal-02787835⟩
  • Gladys Mirey. Chromatibody, a novel non-invasive biotracer to explore and manipulate chromatin in living cells. 7. Biosensor Group Meeting, Jun 2017, Toulouse, France. ⟨hal-01562312⟩
  • Gladys Mirey. HepaRG hep+ and biological tracers for a new in vitro micronucleus assay. CAAT Academy, Jun 2017, Rennes, France. ⟨hal-01601121⟩
  • Gladys Mirey. Contaminants alimentaires et cancers. 33. Journées Scientifiques de l’Association Française d’Etude et de Recherche sur l’Obésité (AFERO), Jan 2017, Toulouse, France. ⟨hal-01601087⟩
  • Gladys Mirey, Vanessa Graillot, Odile Mondésert, Thibault Metenier, Julien Vignard, et al.. In vitro micronucleus test in living cells associating biological tracers and high-content imaging. 53. Congress of the European-Societies-of-Toxicology (EUROTOX), Sep 2017, Bratislava, Slovakia. pp.1, ⟨10.1016/j.toxlet.2017.08.072⟩. ⟨hal-02735959⟩
  • Gladys Mirey. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. Les Avancées Scientifiques de la Recherche Biomedicale Toulousaine, Centre de la Recherche en Cancérologie. FRA., Nov 2016, Toulouse, France. ⟨hal-02792179⟩
  • Gladys Mirey, D.M. Steen, Vanessa Graillot. A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging. 47. Annual Meeting of the Environmental Mutagenesis and Genomics Society, Sep 2016, Kansas City, United States. ⟨hal-01603644⟩
  • Océane Martin, Marianne Chevalier, Sylviane Taché, Nathalie Naud, Bernard Salles, et al.. In vivo genotoxic effects of dietary heme iron on rat colon mucosa and ex vivo effects on colon cells monitored by an optimized alkaline comet assay. 11th International Comet Assay Workshop, Sep 2015, Antwerp, Belgium. ⟨hal-02792818⟩
  • Elisabeth Bezine, Julien Vignard, Marianne Chevalier, Elisa Boutet-Robinet, Bernard Salles, et al.. The bacterial cytolethal distending Toxin induces indirect double-strand breaks into eukaryotic cells. Journée de l’ecole Doctorale SEVAB, Mar 2015, Toulouse, France. ⟨hal-02796083⟩
  • Elisabeth Bezine, Julien Vignard, Yann Malaisé, Aurore Loeuillet, Elisa Boutet-Robinet, et al.. L’analyse des voies de réparation nous renseigne sur les dommages à l’ADN induits par la toxine CDT. Journée des doctorants de l'INRA Toxalim, Jun 2015, Toulouse, France. ⟨hal-02800134⟩
  • Denis Jullien, Julien Vignard, Yoann Fedor, Aurélien Olichon, Michèle Crozatier, et al.. Nanobody-based universal histone binding domains for chromatin imaging and editing. 4. Biosensor Meeting of the Biosensor Group of the GDR 2588 Microscopie et Imagerie du Vivant, May 2014, Bordeaux, France. ⟨hal-02793548⟩
  • Denis Jullien, Julien Vignard, Yoann Fedor, Aurélien Olichon, Bernard Salles, et al.. VHH-based universal histone binding domains: novel tools for a different look on and manipulation of chromatin. FEBS EMBO 2014 Conférence, Aug 2014, Paris, France. 823 p. ⟨hal-02741249⟩
  • Laëtitia Trapp-Fragnet, Danièle Vautherot, Yves Le Vern, Sylvie Rémy, Elisa Boutet-Robinet, et al.. Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells. 4. ESVV Veterinary Herpesvirus Symposium, European Society for Veterinary Virology (ESVV)., Jan 2013, Zurich, Switzerland. ⟨hal-02749312⟩
  • Elisabeth Bezine, Yoann Fedor, Julien Vignard, Elisa Boutet-Robinet, Bernard Salles, et al.. Genotoxicity and repair: the cytolethal distending toxin model. 4? workshop "Genome, Structure and Functions", Hôpital Rangueil. FRA., Apr 2013, Toulouse, France. ⟨hal-02809832⟩
  • Laëtitia Trapp-Fragnet, Danièle Vautherot, Yves Le Vern, Sylvie Rémy, Elisa Boutet-Robinet, et al.. Cell cycle modulation by Marek's Disease Virus: the tegument protein VP22 trigers S Phase arrest and DNA damage in proliferating cells. 5. European Congress of Virology, European Society for Virology., Sep 2013, Lyon, France. 305 p. ⟨hal-02744756⟩
  • Laëtitia Trapp-Fragnet, Danièle Vautherot, Yves Le Vern, Sylvie Rémy, Jean-François Vautherot, et al.. Régulation du cycle cellulaire de la maladie de Marek : implication de la protéine de tégument VP22 dans l'arrêt prolifératif en phase-S.. Journée scientifique de l'Association HerPAS, Association Herpesvirus et Pathologies Associées (HerPAs). FRA., Mar 2012, Paris, France. 1 p. ⟨hal-02811446⟩
  • Laëtitia Trapp-Fragnet, Danièle Vautherot, Yves Le Vern, Sylvie Sylvie Rémy, Elisa Boutet-Robinet, et al.. Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells. 9. International Symposium on Marek's Disease and Avian Herpesviruses, Jun 2012, Berlin, Germany. pp.28. ⟨hal-02748181⟩
  • Denis Jullien, Julien Vignard, Gladys Mirey, Bernard Ducommun. Développement de nouveaux outils de détection non-invasive des cassures double brin de l’ADN. Réunion du groupe Biosenseur GDR2588, Groupe Biosenseur GDR2588., Mar 2012, Montpellier, France. ⟨hal-02807599⟩
  • Yoann Fedor, Aurélien Olichon, F. Favre, Bernard Ducommun, Bernard Salles, et al.. A diagnostic tool to assess genotoxic activity ex vivo. 47. Congress of the European Societies of Toxicology (EUROTOX), 2011, Paris, France. pp.S36-S36. ⟨hal-02745572⟩
  • Yoann Fedor, A. Olichon, G. Favre, B. Ducommun, Bernard Salles, et al.. Détection des cassures double brin en temps réel : un nouvel outil. 9e colloque des 3R, Ville service., May 2011, Giens, Belgique. ⟨hal-02806589⟩