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Number of documents

49

Gildas Bertho


CV


Journal articles47 documents

  • Gildas Bertho, Imed Eddine Oumezziane, Cédric Caradeuc, Louis Guibout, Christine Balducci, et al.. Structural analysis of unstable norbixin isomers guided by pure shift nuclear magnetic resonance. Magnetic Resonance in Chemistry, Wiley, 2022, 60 (5), pp.504-514. ⟨10.1002/mrc.5252⟩. ⟨hal-03648920⟩
  • Gildas Bertho, Leonardo Lordello, Xi Chen, Covadonga Lucas-Torres, Imed Eddine Oumezziane, et al.. Ultrahigh-Resolution NMR with Water Signal Suppression for a Deeper Understanding of the Action of Antimetabolic Drugs on Diffuse Large B-Cell Lymphoma. Journal of Proteome Research, American Chemical Society, 2022, 21 (4), pp.1041-1051. ⟨10.1021/acs.jproteome.1c00914⟩. ⟨hal-03648893⟩
  • Mathilde Bourdon, Pietro Santulli, Fatiha Kateb, Khaled Pocate-Cheriet, Frederic Batteux, et al.. Adenomyosis is associated with specific proton nuclear magnetic resonance (1H-NMR) serum metabolic profiles. Fertility and Sterility, Elsevier, 2021, 116 (1), pp.243-254. ⟨10.1016/j.fertnstert.2021.02.031⟩. ⟨hal-03684698⟩
  • Raoul Manuel, Michelle de Souza Lima, Sébastien Dilly, Sylvain Daunay, Patricia Abbe, et al.. Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration. Antioxidants , MDPI, 2021, 10 (5), pp.723. ⟨10.3390/antiox10050723⟩. ⟨hal-03248720⟩
  • Christine Balducci, Laurence Dinan, Louis Guibout, Anne-Sophie Foucault, Christel Carbonne, et al.. The complex metabolism of poststerone in male rats. Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2021, 212, pp.105897. ⟨10.1016/j.jsbmb.2021.105897⟩. ⟨hal-03684677⟩
  • Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz Ribeiro, Hector Ardila-Osorio, et al.. Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases. PLoS Pathogens, Public Library of Science, 2021, 17 (10), pp.e1009991. ⟨10.1371/journal.ppat.1009991⟩. ⟨hal-03413478⟩
  • Alexis Gosset, Štěpánka Nováková Lachmanová, Sawsen Cherraben, Gildas Bertho, Jérémy Forté, et al.. On the Supra‐LUMO Interaction: Case Study of a Sudden Change of Electronic Structure as a Functional Emergence. Chemistry - A European Journal, Wiley-VCH Verlag, 2021, 27 (71), pp.17889-17899. ⟨10.1002/chem.202103136⟩. ⟨hal-03684619⟩
  • Chloé Maignien, Pietro Santulli, Fatiha Kateb, Cédric Caradeuc, Louis Marcellin, et al.. Endometriosis phenotypes are associated with specific serum metabolic profiles determined by proton-nuclear magnetic resonance. Reproductive BioMedicine Online, Elsevier, 2020, 41, pp.640 - 652. ⟨10.1016/j.rbmo.2020.06.019⟩. ⟨hal-03492022⟩
  • Khaled Pocate-Cheriet, Pietro Santulli, Fatiha Kateb, Mathilde Bourdon, Chloé Maignien, et al.. The follicular fluid metabolome differs according to the endometriosis phenotype. Reproductive BioMedicine Online, Elsevier, 2020, 41, pp.1023 - 1037. ⟨10.1016/j.rbmo.2020.09.002⟩. ⟨hal-03493619⟩
  • Margaux Luck, Caroline Schmitt, Neila Talbi, Laurent Gouya, Cédric Caradeuc, et al.. Urinary metabolic profiling of asymptomatic acute intermittent porphyria using a rule-mining-based algorithm. Metabolomics, Springer Verlag, 2018, 14 (1), pp.10. ⟨10.1007/s11306-017-1305-9⟩. ⟨hal-03684742⟩
  • Baptiste Fohlen, Quentin Tavernier, Thi-Mum Huynh, Cédric Caradeuc, Delphine Le Corre, et al.. Real-Time and Non-invasive Monitoring of the Activation of the IRE1α-XBP1 Pathway in Individuals with Hemodynamic Impairment. EBioMedicine, Elsevier, 2018, 27, pp.284-292. ⟨10.1016/j.ebiom.2017.12.023⟩. ⟨hal-03684748⟩
  • Maxime Melikian, Baptiste Eluard, Gildas Bertho, Véronique Baud, Nathalie Evrard-Todeschi. Model of the Interaction between the NF-κB Inhibitory Protein p100 and the E3 Ubiquitin Ligase β-TrCP based on NMR and Docking Experiments. Journal of Chemical Information and Modeling, American Chemical Society, 2017, 57 (2), pp.223-233. ⟨10.1021/acs.jcim.5b00409⟩. ⟨hal-03684765⟩
  • Céline Desseille, Séverine Deforges, Olivier Biondi, Léo Houdebine, Domenico D’amico, et al.. Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice. Frontiers in Molecular Neuroscience, Frontiers Media, 2017, 10, ⟨10.3389/fnmol.2017.00332⟩. ⟨hal-03684756⟩
  • Manal Sarkis, Maria Miteva, Maria Chiara Dasso Lang, Maryse Jaouen, Marie-Agnès Sari, et al.. Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25. Proteins: Structure, Function, and Bioinformatics, 2017, 85 (4), pp.593-601. ⟨10.1002/prot.25236⟩. ⟨hal-03689998⟩
  • Manal Sarkis, Maria Miteva, Maria Chiara Dasso Lang, Maryse Jaouen, Marie-Agnès Sari, et al.. Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25. Proteins: Structure, Function, and Bioinformatics, 2017, 85 (4), pp.593-601. ⟨10.1002/prot.25236⟩. ⟨hal-03684762⟩
  • Margaux Luck, Gildas Bertho, Mathilde Bateson, Alexandre Karras, Anastasia Yartseva, et al.. Rule-Mining for the Early Prediction of Chronic Kidney Disease Based on Metabolomics and Multi-Source Data. PLoS ONE, Public Library of Science, 2016, 11 (11), pp.e0166905. ⟨10.1371/journal.pone.0166905⟩. ⟨hal-03684770⟩
  • J.W. Chiao, Maxime Melikian, Liying Han, Chengsen Xue, Allen Tsao, et al.. Interaction of a small molecule Natura-α and STAT3-SH2 domain to block Y705 phosphorylation and inhibit lupus nephritis. Biochemical Pharmacology, Elsevier, 2016, 99, pp.123-131. ⟨10.1016/j.bcp.2015.11.018⟩. ⟨hal-03684776⟩
  • Lionel Ducassou, Gabriella Jonasson, Laura Dhers, Nicolas Pietrancosta, Booma Ramassamy, et al.. Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.. BBA - Biochimica et Biophysica Acta, Elsevier, 2015, 1850 (7), pp.1426-37. ⟨10.1016/j.bbagen.2015.03.014⟩. ⟨hal-01449701⟩
  • Nicolas Pallet, Eric Thervet, Philippe Beaune, Alexandre Karras, Gildas Bertho. The urinary metabolome of chronic kidney disease. Kidney International, Nature Publishing Group, 2014, 85 (5), pp.1239-1240. ⟨10.1038/ki.2014.34⟩. ⟨hal-03684819⟩
  • Mickael Carichon, Nicolas Pallet, Caroline Schmitt, Thibaud Lefebvre, Laurent Gouya, et al.. Urinary Metabolic Fingerprint of Acute Intermittent Porphyria Analyzed by 1 H NMR Spectroscopy. Analytical Chemistry, American Chemical Society, 2014, 86 (4), pp.2166-2174. ⟨10.1021/ac403837r⟩. ⟨hal-03684829⟩
  • Stéphane Téletchéa, Verena Stresing, Soizic Hervouet, Marc Baud'Huin, Marie-Françoise Heymann, et al.. Novel RANK Antagonists for the Treatment of Bone-Resorptive Disease: Theoretical Predictions and Experimental Validation. Journal of Bone and Mineral Research, American Society for Bone and Mineral Research, 2014, 29 (6), pp.1466 - 1477. ⟨10.1002/jbmr.2170⟩. ⟨inserm-01644748⟩
  • Patrick Dansette, Dan Levent, Assia Hessani, Gildas Bertho, Daniel Mansuy. Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation. Chemical Research in Toxicology, American Chemical Society, 2013, 26 (5), pp.794-802. ⟨10.1021/tx400083b⟩. ⟨hal-03684856⟩
  • Christophe Decroos, Véronique Balland, Jean-Luc Boucher, Gildas Bertho, Yun Xu-Li, et al.. Toward Stable Electron Paramagnetic Resonance Oximetry Probes: Synthesis, Characterization, and Metabolic Evaluation of New Ester Derivatives of a Tris-( para -carboxyltetrathiaaryl)methyl (TAM) Radical. Chemical Research in Toxicology, American Chemical Society, 2013, 26 (10), pp.1561-1569. ⟨10.1021/tx400250a⟩. ⟨hal-03684842⟩
  • Cedric Charrier, Gildas Bertho, Olivier Petigny, Philippe Moneton, Robert Azerad. A new derivative detected in accelerated ageing of artesunate-amodiaquine fixed dose combination tablets. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2013, 81-82, pp.20-26. ⟨10.1016/j.jpba.2013.03.009⟩. ⟨hal-03684836⟩
  • Claude Chopard, Gildas Bertho, Thierry Prangé. Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes. RSC Advances, Royal Society of Chemistry, 2012, 2 (2), pp.605-615. ⟨10.1039/C1RA00706H⟩. ⟨hal-03684941⟩
  • Sophie Fougeray, Iadh Mami, Gildas Bertho, Philippe Beaune, Eric Thervet, et al.. Tryptophan Depletion and the Kinase GCN2 Mediate IFN-γ–Induced Autophagy. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2012, 189 (6), pp.2954-2964. ⟨10.4049/jimmunol.1201214⟩. ⟨hal-03684891⟩
  • Gildas Bertho, Alexey Mantsyzov, Guillaume Bouvier, Nathalie Evrard-Todeschi. Contact-based ligand-clustering approach for the identification of active compounds in virtual screening. Advances and applications in bioinformatics and chemistry, Dove Medical Press Ltd., 2012, pp.61. ⟨10.2147/AABC.S30881⟩. ⟨hal-03684866⟩
  • Patricia Rada, Ana Rojo, Nathalie Evrard-Todeschi, Nadia Innamorato, Axelle Cotte, et al.. Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis. Molecular and Cellular Biology, American Society for Microbiology, 2012, 32 (17), pp.3486-3499. ⟨10.1128/MCB.00180-12⟩. ⟨hal-03684929⟩
  • Patrick Dansette, Julien Rosi, Justine Debernardi, Gildas Bertho, Daniel Mansuy. Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring. Chemical Research in Toxicology, American Chemical Society, 2012, 25 (5), pp.1058-1065. ⟨10.1021/tx3000279⟩. ⟨hal-03684932⟩
  • Patrick Dansette, Julien Rosi, Gildas Bertho, Daniel Mansuy. Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer. Chemical Research in Toxicology, American Chemical Society, 2012, 25 (2), pp.348-356. ⟨10.1021/tx2004085⟩. ⟨hal-03684944⟩
  • Patrick Dansette, Julien Rosi, Gildas Bertho, Daniel Mansuy. Paraoxonase-1 and clopidogrel efficacy. Nature Medicine, Nature Publishing Group, 2011, 17 (9), pp.1040-1041. ⟨10.1038/nm.2436⟩. ⟨hal-03684957⟩
  • Patrick Dansette, Stéphanie Thébault, Gildas Bertho, Daniel Mansuy. Formation and Fate of a Sulfenic Acid Intermediate in the Metabolic Activation of the Antithrombotic Prodrug Prasugrel. Chemical Research in Toxicology, American Chemical Society, 2010, 23 (7), pp.1268-1274. ⟨10.1021/tx1001332⟩. ⟨hal-03684983⟩
  • Guillaume Bouvier, Nathalie Evrard-Todeschi, Jean-Pierre Girault, Gildas Bertho. Automatic clustering of docking poses in virtual screening process using self-organizing map. Bioinformatics, Oxford University Press (OUP), 2010, 26 (1), pp.53-60. ⟨10.1093/bioinformatics/btp623⟩. ⟨hal-03684971⟩
  • Patrick Dansette, Julie Libraire, Gildas Bertho, Daniel Mansuy. Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel. Chemical Research in Toxicology, American Chemical Society, 2009, 22 (2), pp.369-373. ⟨10.1021/tx8004828⟩. ⟨hal-03684993⟩
  • Christophe Decroos, Yun Li, Gildas Bertho, Yves Frapart, Daniel Mansuy, et al.. Synthetic studies towards diazepanone scaffolds. Tetrahedron: Asymmetry, Elsevier, 2009, 20 (20), pp.2320-2330. ⟨10.1016/j.tetasy.2009.09.022⟩. ⟨hal-03685013⟩
  • Christophe Decroos, Yun Li, Gildas Bertho, Yves Frapart, Daniel Mansuy, et al.. Oxidative and Reductive Metabolism of Tris( p -carboxyltetrathiaaryl)methyl Radicals by Liver Microsomes. Chemical Research in Toxicology, American Chemical Society, 2009, 22 (7), pp.1342-1350. ⟨10.1021/tx9001379⟩. ⟨hal-03684990⟩
  • Christophe Decroos, Yun Li, Gildas Bertho, Yves Frapart, Daniel Mansuy, et al.. Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2˙−. Chemical Communications, Royal Society of Chemistry, 2009, pp.1416. ⟨10.1039/b819259f⟩. ⟨hal-02102841⟩
  • Julien Pons, Nathalie Evrard-Todeschi, Gildas Bertho, Josyane Gharbi-Benarous, Valérie Tanchou, et al.. Transfer-NMR and Docking Studies Identify the Binding of the Peptide Derived from Activating Transcription Factor 4 to Protein Ubiquitin Ligase β-TrCP. Competition STD-NMR with β-Catenin. Biochemistry, American Chemical Society, 2008, 47 (1), pp.14-29. ⟨10.1021/bi7014212⟩. ⟨hal-03685028⟩
  • Gildas Bertho, Guillaume Bouvier, Gaston Hui Bon Hoa, Jean-Pierre Girault. The key-role of tyrosine 155 in the mechanism of prion transconformation as highlighted by a study of sheep mutant peptides. Peptides, Elsevier, 2008, 29 (7), pp.1073-1084. ⟨10.1016/j.peptides.2008.03.014⟩. ⟨hal-03685032⟩
  • Nathalie Evrard-Todeschi, Julien Pons, Josyane Gharbi-Benarous, Gildas Bertho, Richard Benarous, et al.. Structure of the Complex between Phosphorylated Substrates and the SCF β-TrCP Ubiquitin Ligase Receptor: A Combined NMR, Molecular Modeling, and Docking Approach. Journal of Chemical Information and Modeling, American Chemical Society, 2008, 48 (12), pp.2350-2361. ⟨10.1021/ci800248u⟩. ⟨hal-03685021⟩
  • Camille Levraud, Sandrine Calvet-Vitale, Gildas Bertho, Hamid Dhimane. Diastereoselective Additions to (3S)-3-Aminodehydrocaprolactams: Development of a Versatile Synthesis of New Substituted CyclicL-Lysines. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2008, 2008 (11), pp.1901-1909. ⟨10.1002/ejoc.200701004⟩. ⟨hal-03685043⟩
  • Olivier Monasson, Maryon Ginisty, Gildas Bertho, Christine Gravier-Pelletier, Yves Le Merrer. Efficient synthesis of polyfunctionalised enantiopure diazepanone scaffolds. Tetrahedron Letters, Elsevier, 2007, 48 (46), pp.8149-8152. ⟨10.1016/j.tetlet.2007.09.098⟩. ⟨hal-03685046⟩
  • Ulrich Darbost, Olivier Sénèque, Yun Li, Gildas Bertho, Jerome Marrot, et al.. Allosteric tuning of the intra-cavity binding properties of a calix[6]arene through external binding to a Zn(II) center coordinated to amino arms. Chemistry - A European Journal, Wiley-VCH Verlag, 2006, 13, pp.2078-2088. ⟨10.1002/chem.200601040⟩. ⟨hal-00391396⟩
  • Simon Megy, Gildas Bertho, Josyane Gharbi-Benarous, Françoise Baleux, Richard Benarous, et al.. STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody.. FEBS Letters, Wiley, 2006, 580 (22), pp.5411-22. ⟨10.1016/j.febslet.2006.08.084⟩. ⟨pasteur-00166653⟩
  • Patrick M. Dansette, Gildas Bertho, Daniel Mansuy. First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives. Biochemical and Biophysical Research Communications, Elsevier, 2005, 338, pp.450-455. ⟨10.1016/j.bbrc.2005.08.091⟩. ⟨hal-00068627⟩
  • Simon Megy, Gildas Bertho, Josyane Gharbi-Benarous, Françoise Baleux, Richard Benarous, et al.. Solution structure of a peptide derived from the oncogenic protein beta-Catenin in its phosphorylated and nonphosphorylated states.. Peptides / Peptides (Fayetteville), 2005, 26 (2), pp.227-41. ⟨10.1016/j.peptides.2004.09.021⟩. ⟨pasteur-00166821⟩
  • Simon Megy, Gildas Bertho, Serguey A. Kozin, Marie Pascale M. P. Debey, Gaston Hui Bon Hoa, et al.. Possible role of region 152-156 in structural duality of a peptide fragment from sheep prion protein. Protein Science, Wiley, 2004, 13 (12), pp.3151-3160. ⟨hal-02677622⟩

Conference papers1 document

  • M.M. Luck, A. Yartseva, Gildas Bertho, E. Thervet, Philippe Beaune, et al.. Metabolic Profiling of 1H NMR Spectra in Chronic Kidney Disease with Local Predictive Modeling. 2015 IEEE 14th International Conference on Machine Learning and Applications (ICMLA), Dec 2015, Miami, France. pp.176-181, ⟨10.1109/ICMLA.2015.155⟩. ⟨hal-03684787⟩

Poster communications1 document

  • Patrick M. Dansette, Shigeyuki Kitamura, Gildas Bertho, Daniel Mansuy. A NEW THIOPHENE METABOLITE: NADPH, O 2 AND THIOL DEPENDENT FORMATION OF A THIOPHENE HYDRATE FROM (S)-MTPPA BY CYP2C9. ISSX-JSSX joint symposium, Maui (Hawai) USA, novembre 2005, Nov 2005, Wailea, Maui, United States. ⟨hal-03515695⟩