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Gabriel Markov

I investigate metabolic pathway evolution, integrating information about the evolution of single enzymes with the distribution of metabolites accross lineages. This led me to develop methods to tackle directly the evolution of pathways at that level of abstraction. I am strongly interested about eukaryotic metabolic pathways for which there is a significant amount of detailed biological knowledge, such as those producing signaling molecules.

Journal articles16 documents

  • Arnaud Belcour, Jean Girard, Méziane Aite, Ludovic Delage, Camille Trottier, et al.. Inferring Biochemical Reactions and Metabolite Structures to Understand Metabolic Pathway Drift. iScience, Elsevier, 2020, 23 (2), pp.100849. ⟨10.1016/j.isci.2020.100849⟩. ⟨hal-01943880v2⟩
  • Simon Dittami, Erwan Corre, Loraine Brillet-Guéguen, Agnieszka Lipinska, Noé Pontoizeau, et al.. The genome of Ectocarpus subulatus – A highly stress-tolerant brown alga. Marine Genomics, Elsevier, 2020, pp.1-24. ⟨10.1016/j.margen.2020.100740⟩. ⟨hal-02866117⟩
  • Linhong Teng, Xiao Fan, David R. Nelson, Wentao Han, Xiao Zhang, et al.. Diversity and evolution of cytochromes P450 in stramenopiles. Planta, Springer Verlag, 2019, 249 (3), pp.647-661. ⟨10.1007/s00425-018-3028-1⟩. ⟨hal-02065007⟩
  • Méziane Aite, Marie Chevallier, Clémence Frioux, Camille Trottier, Jeanne Got, et al.. Traceability, reproducibility and wiki-exploration for "à-la-carte" reconstructions of genome-scale metabolic models. PLoS Computational Biology, Public Library of Science, 2018, 14 (5), pp.e1006146. ⟨10.1371/journal.pcbi.1006146⟩. ⟨hal-01807842⟩
  • Gabriel Markov, Jean Girard, Vincent Laudet, Catherine Leblanc. Hormonally active phytochemicals from macroalgae: a largely untapped source of ligands to deorphanize nuclear receptors in emerging marine animal models. General and Comparative Endocrinology, Elsevier, 2018, 265, pp.41-45. ⟨10.1016/j.ygcen.2018.06.004⟩. ⟨hal-02393542⟩
  • Konstantin Khalturin, Isabelle M.L. Billas, Yassmine Chebaro, Adam Reitzel, Ann Tarrant, et al.. NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding. Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2018, 184, pp.11-19. ⟨10.1016/j.jsbmb.2018.06.014⟩. ⟨hal-02017750⟩
  • Gabriel Markov, Juliana Gutierrez-Mazariegos, Delphine Pitrat, Isabelle M. L. Billas, François Bonneton, et al.. Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen. Science Advances , American Association for the Advancement of Science (AAAS), 2017, 3 (3), pp.e1601778. ⟨10.1126/sciadv.1601778⟩. ⟨hal-01693173⟩
  • Pierluigi Scerbo, Gabriel Markov, Céline Vivien, Laurent Kodjabachian, Barbara Demeneix, et al.. On the origin and evolutionary history of NANOG. PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e85104. ⟨10.1371/journal.pone.0085104⟩. ⟨hal-01111124⟩
  • Pierluigi Scerbo, Fabrice Girardot, Céline Vivien, Gabriel V Markov, Guillaume Luxardi, et al.. Ventx factors function as Nanog-like guardians of developmental potential in Xenopus. PLoS ONE, Public Library of Science, 2012, 7 (5), pp.e36855. ⟨10.1371/journal.pone.0036855⟩. ⟨hal-00843463⟩
  • Eric Samarut, Ismail Amal, Gabriel Markov, Roland Stote, Annick Dejaegere, et al.. Evolution of Nuclear Retinoic Acid Receptor Alpha (RAR alpha) Phosphorylation Sites. Serine Gain Provides Fine-Tuned Regulation. Molecular Biology and Evolution, Oxford University Press (OUP), 2011, 28 (7), pp.2125 - 2137. ⟨10.1093/molbev/msr035⟩. ⟨hal-02645447⟩
  • Gabriel Markov, Vincent Laudet. Origin and evolution of the ligand-binding ability of nuclear receptors. Molecular and Cellular Endocrinology, Elsevier, 2011, 334 (1-2), pp.21 - 30. ⟨10.1016/j.mce.2010.10.017⟩. ⟨hal-02648059⟩
  • Gabriel V. Markov, Raquel Tavares, Chantal Dauphin-Villemant, Barbara A. Demeneix, Michael E. Baker, et al.. Independent elaboration of steroid hormone signaling pathways in metazoans. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2009, 106 (29), pp.11913-11918. ⟨10.1073/pnas.0812138106⟩. ⟨hal-02666864⟩
  • Pierre Abad, Jerome Gouzy, Jean-Marc Aury, Philippe Castagnone, Etienne Danchin, et al.. Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita. Nature Biotechnology, Nature Publishing Group, 2008, 26 (8), pp.909-915. ⟨10.1038/nbt.1482⟩. ⟨hal-01189285⟩
  • Mathilde Paris, Frédéric Brunet, Gabriel V. Markov, Michael Schubert, Vincent Laudet. The amphioxus genome enlightens the evolution of the thyroid hormone signaling pathway. Development Genes and Evolution, Springer Verlag, 2008, 218 (11-12), pp.667-680. ⟨10.1007/s00427-008-0255-7⟩. ⟨hal-02665062⟩
  • Gabriel V. Markov, Mathilde Paris, Stephanie Bertrand, Vincent Laudet. The evolution of the ligand/receptor couple: a long road from comparative endocrinology to comparative genomics. Molecular and Cellular Endocrinology, Elsevier, 2008, 293 (1-2), pp.5. ⟨10.1016/j.mce.2008.06.011⟩. ⟨hal-00532041⟩
  • Gabriel Markov, Guillaume Lecointre, Barbara Demeneix, Vincent Laudet. The "street light syndrome", or how protein taxonomy can bias experimental manipulations. BioEssays, Wiley-VCH Verlag, 2008, 30 (4), pp.349-357. ⟨10.1002/bies.20730⟩. ⟨hal-02662543⟩

Conference papers1 document

  • François Bonneton, A. Chaumot, T. Iwema, I. Billas, D. Moras, et al.. Evolution of nuclear receptors in insects. 18th International Ecdysone Workshop 2010, Jul 2010, Ceske Budejovice, Czech Republic. pp.1. ⟨hal-02593438⟩

Preprints, Working Papers, ...1 document

  • Simon M Dittami, Erwan Corre, Loraine Brillet-Guéguen, Agnieszka Lipinska, Méziane Aite, et al.. The genome of Ectocarpus subulatus -a highly stress-tolerant brown alga. 2019. ⟨hal-02333021⟩

Theses1 document