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Gabriel Markov

I investigate metabolic pathway evolution, integrating information about the evolution of single enzymes with the distribution of metabolites accross lineages. This led me to develop methods to tackle directly the evolution of pathways at that level of abstraction. I am strongly interested about eukaryotic metabolic pathways for which there is a significant amount of detailed biological knowledge, such as those producing signaling molecules.

Journal articles18 documents

  • Jean Girard, Goulven Lanneau, Ludovic Delage, Cédric Leroux, Arnaud Belcour, et al.. Semi-Quantitative Targeted Gas Chromatography-Mass Spectrometry Profiling Supports a Late Side-Chain Reductase Cycloartenol-to-Cholesterol Biosynthesis Pathway in Brown Algae. Frontiers in Plant Science, Frontiers, 2021, 12, pp.1-10. ⟨10.3389/fpls.2021.648426⟩. ⟨hal-03222505⟩
  • Arnaud Belcour, Jean Girard, Méziane Aite, Ludovic Delage, Camille Trottier, et al.. Inferring Biochemical Reactions and Metabolite Structures to Understand Metabolic Pathway Drift. iScience, Elsevier, 2020, 23 (2), pp.100849. ⟨10.1016/j.isci.2020.100849⟩. ⟨hal-01943880v2⟩
  • Simon M. Dittami, Erwan Corre, Loraine Brillet-Guéguen, Agnieszka Lipinska, Noé Pontoizeau, et al.. The genome of Ectocarpus subulatus – A highly stress-tolerant brown alga. Marine Genomics, Elsevier, 2020, 52, pp.100740. ⟨10.1016/j.margen.2020.100740⟩. ⟨hal-02866117⟩
  • Audrey Mat, Jozée Sarrazin, Gabriel Markov, Vincent Apremont, Christine Dubreuil, et al.. Biological rhythms in the deep-sea hydrothermal mussel Bathymodiolus azoricus. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17284-4⟩. ⟨hal-02907599⟩
  • Linhong Teng, Xiao Fan, David R. Nelson, Wentao Han, Xiao Zhang, et al.. Diversity and evolution of cytochromes P450 in stramenopiles. Planta, Springer Verlag, 2019, 249 (3), pp.647-661. ⟨10.1007/s00425-018-3028-1⟩. ⟨hal-02065007⟩
  • Delphine Nègre, Méziane Aite, Arnaud Belcour, Clémence Frioux, Loraine Brillet-Guéguen, et al.. Genome–Scale Metabolic Networks Shed Light on the Carotenoid Biosynthesis Pathway in the Brown Algae Saccharina japonica and Cladosiphon okamuranus. Antioxidants , MDPI, 2019, 8 (11), pp.564. ⟨10.3390/antiox8110564⟩. ⟨hal-02395080⟩
  • Konstantin Khalturin, Isabelle M.L. Billas, Yassmine Chebaro, Adam M. Reitzel, Ann M. Tarrant, et al.. NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding. Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2018, 184, pp.11-19. ⟨10.1016/j.jsbmb.2018.06.014⟩. ⟨hal-02017750⟩
  • Méziane Aite, Marie Chevallier, Clémence Frioux, Camille Trottier, Jeanne Got, et al.. Traceability, reproducibility and wiki-exploration for "à-la-carte" reconstructions of genome-scale metabolic models. PLoS Computational Biology, Public Library of Science, 2018, 14 (5), pp.e1006146. ⟨10.1371/journal.pcbi.1006146⟩. ⟨hal-01807842⟩
  • Gabriel V. Markov, Jean Girard, Vincent Laudet, Catherine Leblanc. Hormonally active phytochemicals from macroalgae: a largely untapped source of ligands to deorphanize nuclear receptors in emerging marine animal models. General and Comparative Endocrinology, Elsevier, 2018, 265, pp.41-45. ⟨10.1016/j.ygcen.2018.06.004⟩. ⟨hal-02393542⟩
  • Gabriel Markov, Juliana Gutierrez-Mazariegos, Delphine Pitrat, Isabelle M. L. Billas, François Bonneton, et al.. Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen. Science Advances , American Association for the Advancement of Science (AAAS), 2017, 3 (3), pp.e1601778. ⟨10.1126/sciadv.1601778⟩. ⟨hal-01693173⟩
  • Pierluigi Scerbo, Gabriel V Markov, Céline Vivien, Laurent Kodjabachian, Barbara Demeneix, et al.. On the origin and evolutionary history of NANOG. PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e85104. ⟨10.1371/journal.pone.0085104⟩. ⟨hal-01111124⟩
  • Pierluigi Scerbo, Fabrice Girardot, Céline Vivien, Gabriel V Markov, Guillaume Luxardi, et al.. Ventx factors function as Nanog-like guardians of developmental potential in Xenopus. PLoS ONE, Public Library of Science, 2012, 7 (5), pp.e36855. ⟨10.1371/journal.pone.0036855⟩. ⟨hal-00843463⟩
  • Gabriel Markov, Vincent Laudet. Origin and evolution of the ligand-binding ability of nuclear receptors. Molecular and Cellular Endocrinology, Elsevier, 2011, 334 (1-2), pp.21 - 30. ⟨10.1016/j.mce.2010.10.017⟩. ⟨hal-02648059⟩
  • Eric Samarut, Ismail Amal, Gabriel Markov, Roland Stote, Annick Dejaegere, et al.. Evolution of Nuclear Retinoic Acid Receptor Alpha (RAR alpha) Phosphorylation Sites. Serine Gain Provides Fine-Tuned Regulation. Molecular Biology and Evolution, Oxford University Press (OUP), 2011, 28 (7), pp.2125 - 2137. ⟨10.1093/molbev/msr035⟩. ⟨hal-02645447⟩
  • Gabriel V Markov, Raquel Tavares, Chantal Dauphin-Villemant, Barbara A. Demeneix, Michael E. Baker, et al.. Independent elaboration of steroid hormone signaling pathways in metazoans. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2009, 106 (29), pp.11913-11918. ⟨10.1073/pnas.0812138106⟩. ⟨hal-02666864⟩
  • Gabriel Markov, Guillaume Lecointre, Barbara Demeneix, Vincent Laudet. The "street light syndrome", or how protein taxonomy can bias experimental manipulations. BioEssays, Wiley-VCH Verlag, 2008, 30 (4), pp.349-357. ⟨10.1002/bies.20730⟩. ⟨hal-02662543⟩
  • Gabriel V Markov, Mathilde Paris, Stephanie Bertrand, Vincent Laudet. The evolution of the ligand/receptor couple: a long road from comparative endocrinology to comparative genomics. Molecular and Cellular Endocrinology, Elsevier, 2008, 293 (1-2), pp.5. ⟨10.1016/j.mce.2008.06.011⟩. ⟨hal-00532041⟩
  • Pierre Abad, Jerome Gouzy, Jean-Marc Aury, Philippe Castagnone, Etienne Danchin, et al.. Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita. Nature Biotechnology, Nature Publishing Group, 2008, 26 (8), pp.909-915. ⟨10.1038/nbt.1482⟩. ⟨hal-01189285⟩

Conference papers1 document

  • François Bonneton, Arnaud Chaumot, T. Iwema, I. Billas, D. Moras, et al.. Evolution of nuclear receptors in insects. 18th International Ecdysone Workshop 2010, Jul 2010, Ceske Budejovice, Czech Republic. pp.1. ⟨hal-02593438⟩

Preprints, Working Papers, ...2 documents

  • Arnaud Belcour, Jeanne Got, Méziane Aite, Ludovic Delage, Jonas Collen, et al.. AuCoMe: inferring and comparing metabolisms across heterogeneous sets of annotated genomes. 2022. ⟨hal-03778267⟩
  • Simon M. Dittami, Erwan Corre, Loraine Brillet-Guéguen, Agnieszka Lipinska, Méziane Aite, et al.. The genome of Ectocarpus subulatus -a highly stress-tolerant brown alga. 2019. ⟨hal-02333021⟩

Theses1 document