Skip to Main content

Keywords

Co-authors

Researcher identifiers

Social networks

    Number of documents

    36

    Biography


    After a PhD in protein crystallography in Strasbourg in the laboratory of D. Moras, I was recruited in 1995 as an assistant professor at the University of Nancy, now University of Lorraine, France. I carry out my research work in the BioMod team at the CRM2 (UMR CNRS-UL 7036).
    I am currently involved in two main research projects.
    • The first one concerns glutathione transferases. Although the first structures were established about thirty years ago, the diversity of these proteins throughout living organisms reveals roles that are complex and still poorly known, particularly in plants and fungi. In collaboration with the team of Pr. E. Gelhaye (IAM laboratory, Nancy), we have more than 10 years of experience in the analysis of the structure of these proteins, especially in complex with specialized metabolites, in relation with their function.
    • My second research area concerns horizontal gene transfer via integrative and conjugative elements (ICE) in Streptococcus thermophilus, a Gram-positive bacterium. We analyze the structures of proteins involved in the early stage of conjugation and in the transfer through the type IV secretion system, in collaboration with Drs N. Soler and B. Douzi in the ICE-TeA team led by Pr. N. Leblond-Bourget (DynAMic laboratory in Nancy) who are long-time specialists in the field.
    • Previously, I worked for a long time on methionine sulfoxide reductases, which are protective proteins against oxidative stress.


    Journal articles31 documents

    • Julien Cappele, Abbas Mohamad Ali, Nathalie N. Leblond-Bourget, Sandrine Mathiot, Tiphaine Dhalleine, et al.. Structural and Biochemical Analysis of OrfG: The VirB8-like Component of the Conjugative Type IV Secretion System of ICESt3 From Streptococcus thermophilus. Frontiers in Molecular Biosciences, Frontiers Media, 2021, 8, ⟨10.3389/fmolb.2021.642606⟩. ⟨hal-03196531⟩
    • Vedran Vuković, Theo Leduc, Zoe Jelić-Matošević, Claude Didierjean, Frédérique Favier, et al.. A rush to explore protein–ligand electrostatic interaction energy with Charger. Acta crystallographica Section D : Structural biology [1993-..], International Union of Crystallography, 2021, 77 (10), pp.1292-1304. ⟨10.1107/S2059798321008433⟩. ⟨hal-03361937⟩
    • Thomas Perrot, Mathieu Schwartz, Aurélie Deroy, Jean-Michel Girardet, Annegret Kohler, et al.. Diversity of Omega Glutathione Transferases in mushroom-forming fungi revealed by phylogenetic, transcriptomic, biochemical and structural approaches. Fungal Genetics and Biology, Elsevier, 2021, 148, pp.103506. ⟨10.1016/j.fgb.2020.103506⟩. ⟨hal-03143927⟩
    • Mathieu Schwartz, Thomas Perrot, Melanie Morel-Rouhier, Guillermo Mulliert, Éric Gelhaye, et al.. The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl-phenethylthiocarbamate reveals plasticity of its active site. Protein Science, Wiley, 2019, 28 (6), pp.1143-1150. ⟨10.1002/pro.3620⟩. ⟨hal-02311418⟩
    • Thomas Perrot, Mathieu Schwartz, Fanny Saiag, Guillaume Salzet, Stéphane Dumarcay, et al.. Fungal Glutathione Transferases as Tools to Explore the Chemical Diversity of Amazonian Wood Extractives. ACS Sustainable Chemistry & Engineering, American Chemical Society, 2018, 6 (10), pp.13078-13085. ⟨10.1021/acssuschemeng.8b02636⟩. ⟨hal-02492224⟩
    • Mathieu Schwartz, Thomas Perrot, Emmanuel Aubert, Stéphane Dumarçay, Frédérique Favier, et al.. Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor. Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.8472. ⟨10.1038/s41598-018-26601-3⟩. ⟨hal-01843732⟩
    • Mathieu Schwartz, Thomas Perrot, Aurélie Deroy, Thomas Roret, Melanie Morel-Rouhier, et al.. Trametes versicolor glutathione transferase Xi 3, a dual Cys-GST with catalytic specificities of both Xi and Omega classes. FEBS Letters, Wiley, 2018, 592 (18), pp.3163-3172. ⟨10.1002/1873-3468.13224⟩. ⟨hal-01959634⟩
    • Mathieu Schwartz, Claude Didierjean, Arnaud Hecker, Jean-Michel Girardet, Mélanie Morel-Rouhier, et al.. Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones. PLoS ONE, Public Library of Science, 2016, 11 (10), pp.e0164678. ⟨10.1371/journal.pone.0164678⟩. ⟨hal-01539425⟩
    • Claude Didierjean, Mathieu Schwartz, Thomas Perrot, Arnaud Hecker, Éric Gelhaye, et al.. Structural view of fungal glutathionyl-hydroquinone reductases. Acta Crystallographica Section A : Foundations and Advances [2014-..], International Union of Crystallography, 2016, 72 (a1), pp.s226 - s226. ⟨10.1107/S205327331609656X⟩. ⟨hal-01549101⟩
    • Thomas Roret, Anne Thuiier, Frederique Favier, Éric Gelhaye, Claude Didierjean, et al.. Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi. Fungal Genetics and Biology, Elsevier, 2015, 83, pp.103-112. ⟨10.1016/j.fgb.2015.09.002⟩. ⟨hal-01521792⟩
    • Pierre-Alexandre Lallement, Edgar Meux, José M. Gualberto, Stéphane Dumarcay, Frédérique Favier, et al.. Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones. FEBS Letters, Wiley, 2015, 589 (1), pp.37 - 44. ⟨10.1016/j.febslet.2014.11.021⟩. ⟨hal-01522015⟩
    • yann Mathieu, Pascalita Prosper, Frederique Favier, Luc Harvengt, Claude Didierjean, et al.. Diversification of Fungal Specific Class A Glutathione Transferases in Saprotrophic Fungi. PLoS ONE, Public Library of Science, 2013, 8 (11), ⟨10.1371/journal.pone.0080298⟩. ⟨hal-01520994⟩
    • Anne Thuillier, Thomas Roret, Frederique Favier, Éric Gelhaye, Jean-Pierre Jacquot, et al.. Atypical features of a Ure2p glutathione transferase from Phanerochaete chrysosporium. FEBS Letters, Wiley, 2013, 587 (14), pp.2125 - 2130. ⟨10.1016/j.febslet.2013.05.031⟩. ⟨hal-01268064⟩
    • yann Mathieu, Pascalita Prosper, Marc Buee, Stephane Dumarcay, Frederique Favier, et al.. Characterization of a Phanerochaete chrysosporium Glutathione Transferase Reveals a Novel Structural and Functional Class with Ligandin Properties. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (46), pp.39001 - 39011. ⟨10.1074/jbc.M112.402776⟩. ⟨hal-01268261⟩
    • Edgar Meux, Pascalita Prosper, Eiji Masai, Guillermo Mulliert, Stephane Dumarcay, et al.. Sphingobium sp SYK-6 LigG involved in lignin degradation is structurally and biochemically related to the glutathione transferase omega class. FEBS Letters, Wiley, 2012, 586 (22), pp.3944 - 3950. ⟨10.1016/j.febslet.2012.09.036⟩. ⟨hal-01268258⟩
    • Edgar Meux, Pascalita Prosper, Andrew Ngadin, Claude Didierjean, Mélanie Morel, et al.. Glutathione transferases of Phanerochaete chrysosporium S-glutathionyl-p-hydroquinone reductase belongs to a new structural class. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (11), pp.9162-9173. ⟨10.1074/jbc.M110.194548⟩. ⟨hal-02648116⟩
    • Aik-Hong Teh, Jennifer Saito, Aida Baharuddin, Jason Tuckerman, James Newhouse, et al.. Hell's Gate globin I: An acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin. FEBS Letters, Wiley, 2011, 585 (20), pp.3250-3258. ⟨10.1016/j.febslet.2011.09.002⟩. ⟨hal-03576187⟩
    • Fanomezana Ranaivoson, Fabrice Neiers, Brice Kauffmann, Sandrine Boschi-Muller, Guy Branlant, et al.. Methionine Sulfoxide Reductase B Displays a High Level of Flexibility. Journal of Molecular Biology, Elsevier, 2009, 394 (1), pp.83 - 93. ⟨10.1016/j.jmb.2009.08.073⟩. ⟨hal-01690443⟩
    • Fanomezana Ranaivoson, Mathias Antoine, Brice Kauffmann, Sandrine Boschi-Muller, André Aubry, et al.. A Structural Analysis of the Catalytic Mechanism of Methionine Sulfoxide Reductase A from Neisseria meningitidis. Journal of Molecular Biology, Elsevier, 2008, 377 (1), pp.268 - 280. ⟨10.1016/j.jmb.2008.01.021⟩. ⟨hal-01690635⟩
    • Nicolas Rouhier, Cha San Koh, Éric Gelhaye, Catherine Corbier, Frederique Favier, et al.. Redox based anti-oxidant systems in plants: Biochemical and structural analyses. Biochimica et Biophysica Acta (BBA) - General Subjects, Elsevier, 2007, 1780 (11), pp.1249-1260. ⟨10.1016/j.bbagen.2007.12.007⟩. ⟨hal-02662632⟩
    • Nicolas Rouhier, Brice Kauffmann, Frédérique Tete-Favier, Pasquale Palladino, Pierre Gans, et al.. Functional and structural aspects of poplar cytosolic and plastidial type A methionine sulfoxide reductases. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (5), pp.3367-3378. ⟨10.1074/jbc.M605007200⟩. ⟨hal-02655515⟩
    • F.M. Ranaivoson, B. Kauffmann, F. Neiers, J. Wu, S. Boschi-Muller, et al.. The X-ray structure of the N-terminal domaine of PILB from Neissera meningitidis reveals a thioredoxin-fold. Journal of Molecular Biology, Elsevier, 2006, 358/2, pp.443-454. ⟨hal-00089617⟩
    • B. Kauffmann, A. Aubry, F. Favier. The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions. Review. BBA - Biochimica et Biophysica Acta, Elsevier, 2005, 1703 (Proteins & Proteomics), pp.249-260. ⟨10.1016/j.bbapap.2004.09.008⟩. ⟨hal-00022899⟩
    • Claude Didierjean, Catherine Corbier, Mustapha Fatih, Frederique Favier, Sandrine Boschi-Muller, et al.. Crystal Structure of Two Ternary Complexes of Phosphorylating Glyceraldehyde-3-phosphate Dehydrogenase from Bacillus stearothermophilus with NAD and d-Glyceraldehyde 3-Phosphate. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (15), pp.12968-12976. ⟨10.1074/jbc.M211040200⟩. ⟨hal-01690824⟩
    • Enrico Stura, Frédérique Tête-Favier, Sylviane Muller, André Aubry. Disulphide dimerised peptide creates a crystal contact in an anti-peptide antibody. Acta crystallographica Section D : Structural biology [1993-..], International Union of Crystallography, 2002, 58 (10), pp.1740-1743. ⟨10.1107/s0907444902012878⟩. ⟨hal-03576166⟩
    • Brice Kauffmann, Frederique Favier, Alexandre Olry, Sandrine Boschi-Muller, Philippe Carpentier, et al.. Crystallization and preliminary X-ray diffraction studies of the peptide methionine sulfoxide reductase B domain of Neisseria meningitidis PILB. Acta crystallographica Section D : Structural biology [1993-..], International Union of Crystallography, 2002, 58 (9), pp.1467 - 1469. ⟨10.1107/S0907444902010570⟩. ⟨hal-01690844⟩
    • S. Marchal, D. Cobessi, S. Rahuel-Clermont, F. Tête-Favier, A. Aubry, et al.. Chemical mechanism and substrate binding sites of NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.. Chemico-Biological Interactions, Elsevier, 2001, 130-132 (1-3), pp.15-28. ⟨hal-00151129⟩
    • F. Tête-Favier, D. Cobessi, G. A. Leonard, S. Azza, F. Talfournier, et al.. Crystallization and preliminary X-ray diffraction studies of the peptide methionine sulfoxide reductase from Escherichia coli.. Acta crystallographica Section D : Structural biology [1993-..], International Union of Crystallography, 2000, 56 (Pt 9), pp.1194-7. ⟨10.1107/s0907444903006814⟩. ⟨hal-00151126⟩
    • F. Tête-Favier, D. Cobessi, S. Boschi-Muller, S. Azza, G. Branlant, et al.. Crystal structure of the Escherichia coli peptide methionine sulphoxide reductase at 1.9 A resolution.. Structure / Struct Fold Des; Structure (Camb ), 2000, 8 (11), pp.1167-78. ⟨hal-00151127⟩
    • D. Cobessi, F. Tête-Favier, S. Marchal, G. Branlant, A. Aubry. Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.. Journal of Molecular Biology, Elsevier, 2000, 300 (1), pp.141-52. ⟨10.1006/jmbi.2000.3824⟩. ⟨hal-00151125⟩
    • D. Cobessi, F. Tête-Favier, S. Marchal, S. Azza, G. Branlant, et al.. Apo and holo crystal structures of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.. Journal of Molecular Biology, Elsevier, 1999, 290 (1), pp.161-73. ⟨10.1006/jmbi.1999.2853⟩. ⟨hal-00151107⟩

    Conference papers4 documents

    • Julien Cappele, Badreddine Douzi, Abbas Mohamad Ali, Nathalie Leblond-Bourget, Sandrine Mathiot, et al.. Structure of a VirB8-like protein, one of the main components of the Type IV secretion system involved in horizontal gene transfer between bacteria. SFB-GEM Meeting 2021 - Biophysics of membranes and beyond., Sep 2021, Online, France. ⟨hal-03576846⟩
    • Mathieu Schwartz, Thomas Perrot, Emmanuel Aubert, Stephane Dumarcay, Frederique Favier, et al.. Interactions between wood polyphenols and detoxification enzymes of the white rot Trametes versicolor. 49th IRGWP Annual Meeting, Apr 2018, Johannesburg, South Africa. pp.IRG/WP 18-10906. ⟨hal-03127877⟩
    • F.M. Ranaivoson, M. Antoine, S. Boschi-Muller, G. Branlant, A. Aubry, et al.. Structure tridimensionnelle d'une méthionine sulfoxyde reductase de classe A en complexe avec un substrat. 14ème Réunion du Groupe Français des Peptides et des Protéines (GFPP), 2005, Aussois, France. ⟨hal-00089642⟩
    • F.M. Ranaivoson, F. Favier, C. Didierjean. The X-ray structure of the N-terminal domain of pilb from Neisseria meningitidis reveals a thioredoxin-fold. Regio Meeting, 2005, La Bresse, France. ⟨hal-00089656⟩

    Poster communications1 document

    • C. Didierjean, Mathieu Schwartz, Thomas Perrot, Arnaud Hecker, Éric Gelhaye, et al.. Structural view of fungal glutathionyl-hydroquinone reductases. 30. European Crystallographic Meeting, Aug 2016, Basel, Switzerland. Wiley-Blackwell, Acta crystallographica. Section A, Foundations of crystallography, A72, 1 p., 2016, ⟨10.1107/S205327331609656X⟩. ⟨hal-02743022⟩