Skip to Main content
Number of documents

75

Frederic LEROUX


Frederic Leroux obtained a PhD in chemistry at the University of Konstanz (Germany), under the supervision of Prof. H. Fischer. In 1998, he moved to a postdoctoral position with Prof. M. Schlosser at the University of Lausanne (Switzerland) and accepted the same year a position of Assistant Professor. In 2001 he moved then to the Swiss Federal Institute of Technology in Lausanne (EPFL). He started his independent research career in 2003 as CNRS Research Associate at the University of Strasbourg (France). He obtained his habilitation in 2005 and was promoted CNRS Research Director in 2009. 

Frederic Leroux is presently the director of the molecular chemistry department “Laboratoire d’Innovation Moléculaire et Applications” UMR CNRS 7042-LIMA of the Université de Strasbourg, Université de Haute-Alsace and the CNRS (lima.unistra.fr) and director of the joint CNRS-Bayer-Université de Strasbourg laboratory on organofluorine chemistry.

His research (coha.unistra.fr) is published in >120 peer-reviewed publications, 18 patents, 11 books and book chapters and presented by invitation at >80 (inter)national conferences. He is Fellow of the Royal Society of Chemistry (FRSC) and member of the European Academy of Sciences and Arts. He is also a member of the International Scientific Committee of the Moissan Prize (Fluorine Chemistry), Director of the French Fluorine Network (http://www.reseau-fluor.fr) and President of the French-Japanese Society of Medicinal and Fine Chemistry (fjs.crihan.fr).

The philosophy of his research is based on a fruitful interplay of several objectives (a) the synthesis of biologically relevant molecules, (b) asymmetric methodologies using organic and organometallic chemistry, (c) organofluorine chemistry and (d) application of the objectives to industrial problems, which led to strong industrial collaborations. The discovery of new and mild methodologies to introduce fluorine atoms or emergent fluorinated groups (OCF3, CHF2, ...) onto heterocycles as well as their stereoselective introduction onto Csp3-centers is a key topic of his research and developed in close collaboration with industry.


Journal articles71 documents

  • Anthony Fernandes, Armen Panossian, Bastien Michelet, Agnès Martin-Mingot, Frédéric Leroux, et al.. CF -substituted carbocations: underexploited intermediates with great potential in modern synthetic chemistry. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2021, 17, pp.343-378. ⟨10.3762/bjoc.17.32⟩. ⟨hal-03154651⟩
  • David Augros, Corinne Comoy, Yves Fort, Frédéric Leroux, Armen Panossian. The winding road towards an atropo-enantioselective 'ARYNE coupling'. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2021, ⟨10.1002/ejoc.202100087⟩. ⟨hal-03170152⟩
  • Frédéric R. Leroux, Thomas Guérin, Nadiia Pikun, Ryutaro Morioka, Armen Panossian, et al.. Synthesis and Use of Trifluoromethylthiolated Ketenimines. Chemistry - A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.202002723⟩. ⟨hal-02990038⟩
  • Laura Santos, Armen Panossian, Morgan Donnard, Jean-Pierre Vors, Sergii Pazenok, et al.. Deprotonative Functionalization of the Difluoromethyl Group. Organic Letters, American Chemical Society, 2020, ⟨10.1021/acs.orglett.0c03380⟩. ⟨hal-02989088⟩
  • Tarak Saied, Catherine Demangeat, Armen Panossian, Frédéric Leroux, Yves Fort, et al.. Transition-Metal-Free Heterobiaryl Synthesis via Aryne Coupling. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 2019 (31-32), pp.5275-5284. ⟨10.1002/ejoc.201900130⟩. ⟨hal-02186792⟩
  • Catherine Demangeat, Tarak Saied, Romain Ramozzi, Francesca Ingrosso, Manuel Ruiz-Lopez, et al.. Transition-Metal-Free Approach for the Direct Arylation of Thiophene: Experimental and Theoretical Investigations towards the (Het)-Aryne Route. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 2019 (2-3), pp.547-556. ⟨10.1002/ejoc.201801173⟩. ⟨hal-02186820⟩
  • Chloé Batisse, Maria Cespedes Davila, Marco Castello, Amélia Messara, Bertrand Vivet, et al.. Efficient asymmetric synthesis of aryl difluoromethyl sulfoxides and their use to access enantiopure α-difluoromethyl alcohols. Tetrahedron, Elsevier, 2019, 75 (23), pp.3063-3079. ⟨10.1016/j.tet.2019.04.037⟩. ⟨hal-02400108⟩
  • Frédéric R. Leroux, Tarak Saied, Catherine Demangeat, Armen Panossian, Frédéric Leroux, et al.. Transition-Metal-Free Heterobiaryl Synthesis via Aryne Coupling. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 2019 (31-32), pp.5275-5284. ⟨10.1002/ejoc.201900130⟩. ⟨hal-02990047⟩
  • Chelliah Selvam, Isabelle Lemasson, Isabelle Brabet, Nadia Oueslati, Berin Karaman, et al.. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (5), pp.1969-1989. ⟨10.1021/acs.jmedchem.7b01438⟩. ⟨hal-02018007⟩
  • F. Aribi, A. Panossian, D. Jacquemin, J.-P. Vors, S. Pazenok, et al.. A physico-chemical investigation of fluorine-enriched quinolines. New Journal of Chemistry, Royal Society of Chemistry, 2018, 42 (12), pp.10036-10047. ⟨10.1039/c8nj00916c⟩. ⟨hal-02105499⟩
  • E. Schmitt, B. Commare, A. Panossian, J.-P. Vors, S. Pazenok, et al.. Synthesis of Mono- and Bis(fluoroalkyl)pyrimidines from FARs, Fluorinated Acetoacetates, and Malononitrile Provides Easy Access to Novel High-Value Pyrimidine Scaffolds. Chemistry - A European Journal, Wiley-VCH Verlag, 2018, 24 (6), pp.1311-1316. ⟨10.1002/chem.201703982⟩. ⟨hal-02105509⟩
  • ChloÉ Batisse, Armen Panossian, Gilles Hanquet, Frédéric Leroux. Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries. Chemical Communications, Royal Society of Chemistry, 2018, 54 (74), pp.10423-10426. ⟨10.1039/C8CC05571H⟩. ⟨hal-02150060⟩
  • Frédéric Leroux, Kanhaiya Pandey, Riadh Rebhi, Frederic Chevy, Christian Miniatura, et al.. Non-Abelian adiabatic geometric transformations in a cold Strontium gas. Nature Communications, Nature Publishing Group, 2018, 9 (3580), ⟨10.1038/s41467-018-05865-3⟩. ⟨hal-01711814v2⟩
  • T. Naret, J. Bignon, G. Bernadat, M. Benchekroun, H. Levaique, et al.. A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. European Journal of Medicinal Chemistry, Elsevier, 2018, 143, pp.473-490. ⟨10.1016/j.ejmech.2017.11.055⟩. ⟨hal-02105508⟩
  • J. Bortoluzzi, V. Jha, G. Levitre, M. J. Fer, J. Berreur, et al.. Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen’s Reagent—Access to Highly Stereoenriched Transformable Biphenyls. Journal of Organic Chemistry, American Chemical Society, 2018, 83 (15), pp.7751-7761. ⟨10.1021/acs.joc.8b00648⟩. ⟨hal-02105503⟩
  • Giorgio Della Sala, Marina Sicignano, Rosaria Schettini, Francesco de Riccardis, Luigi Cavallo, et al.. Switchable Diastereoselectivity in the Fluoride-Promoted Vinylogous Mukaiyama–Michael Reaction of 2-[(Trimethylsilyl)oxy]furan Catalyzed by Crown Ethers. Journal of Organic Chemistry, American Chemical Society, 2017, 82 (13), pp.6629-6637. ⟨10.1021/acs.joc.7b00743⟩. ⟨hal-03054554⟩
  • Frédéric R. Leroux, Armen Panossian, David Augros. Control of axial chirality in absence of transition metals based on arynes. Comptes Rendus Chimie, Elsevier Masson, 2017, 20 (6), pp.682-692. ⟨10.1016/j.crci.2016.12.001⟩. ⟨hal-02105315⟩
  • David Augros, Boubacar Yalcouye, Sabine Choppin, Matthieu Chessé, Armen Panossian, et al.. Transition-Metal-Free Synthesis of a Known Intermediate in the Formal Synthesis of (-)-Steganacin. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2017, 2017 (3), pp.497-503. ⟨10.1002/ejoc.201601239⟩. ⟨hal-02105793⟩
  • Frédéric R. Leroux, Bruno Commare, Etienne Schmitt, Fallia Aribi, Armen Panossian, et al.. Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents. Molecules, MDPI, 2017, 22 (6), pp.977. ⟨10.3390/molecules22060977⟩. ⟨hal-02105792⟩
  • Frédéric R. Leroux, Giorgio Della Sala, Marina Sicignano, Rosaria Schettini, Francesco de Riccardis, et al.. Switchable Diastereoselectivity in the Fluoride-Promoted Vinylogous Mukaiyama–Michael Reaction of 2-[(Trimethylsilyl)oxy]furan Catalyzed by Crown Ethers. Journal of Organic Chemistry, American Chemical Society, 2017, 82 (13), pp.6629-6637. ⟨10.1021/acs.joc.7b00743⟩. ⟨hal-02105791⟩
  • Grégory Landelle, Etienne Schmitt, Armen Panossian, Jean-Pierre Vors, Sergiy Pazenok, et al.. Tri- and difluoromethoxylated N-based heterocycles − Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid. Journal of Fluorine Chemistry, Elsevier, 2017, 203, pp.155-165. ⟨10.1016/j.jfluchem.2017.08.006⟩. ⟨hal-02105310⟩
  • Etienne Schmitt, Sebastien Bouvet, Bruce Pegot, Armen Panossian, Jean-Pierre Vors, et al.. Fluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles. Organic Letters, American Chemical Society, 2017, 19 (18), pp.4960-4963. ⟨10.1021/acs.orglett.7b02444⟩. ⟨hal-02105321⟩
  • Guillaume Levitre, Audrey Dumoulin, Pascal Retailleau, Armen Panossian, Frederic R. Leroux, et al.. Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III). Journal of Organic Chemistry, American Chemical Society, 2017, 82 (22), pp.11877-11883. ⟨10.1021/acs.joc.7b01597⟩. ⟨hal-02105318⟩
  • Frédéric R. Leroux, Fallia Aribi, Etienne Schmitt, Armen Panossian, Jean-Pierre Vors, et al.. A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry. Organic Chemistry Frontiers, Royal Society of Chemistry, 2016, 3 (11), pp.1392-1415. ⟨10.1039/C6QO00319B⟩. ⟨hal-03004130⟩
  • Frédéric R. Leroux, David Augros, Boubacar Yalcouye, Anaïs Berthelot-Bréhier, Matthieu Chessé, et al.. Atropo-diastereoselective coupling of aryllithiums and arynes — variations around the chiral auxiliary. Tetrahedron, Elsevier, 2016, 72 (34), pp.5208-5220. ⟨10.1016/j.tet.2016.01.047⟩. ⟨hal-03004140⟩
  • Frédéric R. Leroux, Armen Panossian, Frédéric Leroux. Lithium/Element Exchange as an Efficient Tool for Accessing Atropo-enriched Biaryls via Arynes. CHIMIA, Schweizerische Chemische Gesellschaft, 2016, 70 (1), pp.43-47. ⟨10.2533/chimia.2016.43⟩. ⟨hal-03004175⟩
  • Frédéric R. Leroux, Etienne Schmitt, Armen Panossian, Jean-Pierre Vors, Christian Funke, et al.. A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns. Chemistry - A European Journal, Wiley-VCH Verlag, 2016, 22 (32), pp.11239-11244. ⟨10.1002/chem.201601621⟩. ⟨hal-03004108⟩
  • Frédéric R. Leroux, Mickaël Fer, Joséphine Cinqualbre, Julien Bortoluzzi, Matthieu Chessé, et al.. When Chirality Meets “Buchwald-Type” Phosphines: Synthesis and Evaluation in Frustrated Lewis Pair-, Lewis Base- and Palladium-Promoted Asymmetric Catalysis. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2016, 2016 (26), pp.4545-4553. ⟨10.1002/ejoc.201600727⟩. ⟨hal-03004119⟩
  • Boubacar Yalcouye, Anaïs Brehier, David Augros, Armen Panossian, Sabine Choppin, et al.. Access to Atropisomerically Enriched Biaryls by the Coupling of Aryllithiums with Arynes under Control by Homochiral Oxazolines. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2016, 2016 (4), pp.725-732. ⟨10.1002/ejoc.201501503⟩. ⟨hal-02304102⟩
  • Bruno Commare, Delphine Rigault, Isabelle Lemasson, Patrick Deschamps, Alain Tomas, et al.. Determination of the absolute configuration of phosphinic analogues of glutamate. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2015, 13 (4), pp.1106-1112. ⟨10.1039/C4OB01960A⟩. ⟨hal-02268872⟩
  • Étienne Schmitt, Gregory Landelle, Jean-Pierre Vors, Norbert Lui, Sergiy Pazenok, et al.. A General Approach towards NH-Pyrazoles That Bear Diverse Fluoroalkyl Groups by Means of Fluorinated Iminium Salts. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, pp.6052-6060. ⟨10.1002/ejoc.201500920⟩. ⟨hal-02305226⟩
  • Renzo Ruzziconi, Frédéric Leroux. Tribute to Prof. Manfred Schlosser (1934-2013) Obituary. Journal of Fluorine Chemistry, Elsevier, 2015, 171, pp.2-3. ⟨10.1016/j.jfluchem.2014.09.014⟩. ⟨hal-02304109⟩
  • Anais Berthelot-Brehier, Armen Panossian, Francoise Colobert-Leuenberger, Frédéric Leroux. Atroposelective synthesis of axially chiral P,S-ligands based on arynes. Organic Chemistry Frontiers, Royal Society of Chemistry, 2015, 2 (6), pp.634-644. ⟨10.1039/C5QO00067J⟩. ⟨hal-02306240⟩
  • Joanna Wencel-Delord, Armen Panossian, Frédéric Leroux, Francoise Colobert-Leuenberger. Recent advances and new concepts for the synthesis of axially stereoenriched biaryls. Chemical Society Reviews, Royal Society of Chemistry, 2015, 44 (11), pp.3418-3430. ⟨10.1039/c5cs00012b⟩. ⟨hal-02305225⟩
  • F Mongin, C Curty, E Marzi, Frédéric Leroux, M Schlosser. Substituent effects on the relative rates and free energies of ortho-lithiation reactions: families of fluorobenzenes as the substrates. ARKIVOC - Online Journal of Organic Chemistry, Arkat USA Inc, 2015, 4, pp.48-65. ⟨10.3998/ark.5550190.p008.926⟩. ⟨hal-02304104⟩
  • R. Ballesteros-Garrido, B. Abarca, R. Ballesteros, F. Colobert, Frédéric R. Leroux, et al.. Unusual phosphine oxidation: new triazolopyridyl-quinolyl phosphine oxide fluorescent dyes. RSC Advances, Royal Society of Chemistry, 2015, 5 (38), pp.29809-29813. ⟨10.1039/C5RA04386G⟩. ⟨hal-03004215⟩
  • Frédéric R. Leroux, Julien Graff, Elżbieta Łastawiecka, Laure Guénée, Frédéric Leroux, et al.. Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2015, 357 (13), pp.2833-2839. ⟨10.1002/adsc.201500323⟩. ⟨hal-03004211⟩
  • Frédéric R. Leroux, Etienne Schmitt, Baptiste Rugeri, Armen Panossian, Jean-Pierre Vors, et al.. In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation. Organic Letters, American Chemical Society, 2015, 17 (18), pp.4510-4513. ⟨10.1021/acs.orglett.5b02184⟩. ⟨hal-03004193⟩
  • Kristína Plevová, Katarína Briestenská, Francoise Colobert-Leuenberger, Jela Mistríková, Viktor Milata, et al.. Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones. Tetrahedron Letters, 2015, 56 (36), pp.5112-5115. ⟨10.1016/j.tetlet.2015.07.031⟩. ⟨hal-02305222⟩
  • Chandani Singh, Jayant Rathod, Vishwajeet Jha, Armen Panossian, Pradeep Kumar, et al.. Modular Synthesis of Biaryl-Substituted Phosphine Ligands: Application in Microwave-Assisted Palladium-Catalyzed C-N Cross-Coupling Reactions. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, 2015 (29), pp.6515-6525. ⟨10.1002/ejoc.201500962⟩. ⟨hal-02304103⟩
  • Philippe Berdagué, Jose-Enrique Herbert-Pucheta, Vishwajeet Jha, Armen Panossian, Frédéric Leroux, et al.. Multi-nuclear NMR of axially chiral biaryls in polypeptide orienting solvents: spectral discriminations and enantiorecognition mechanisms. New Journal of Chemistry, Royal Society of Chemistry, 2015, 39 (12), pp.9504-9517. ⟨10.1039/c5nj01434d⟩. ⟨hal-02314357⟩
  • Frédéric Leroux, Mark Ford, Sergiy Pazenok. Fluorine Chemistry Special Feature. Organic Process Research and Development, American Chemical Society, 2014, 18 (8), ⟨10.1021/op500216s⟩. ⟨hal-02306238⟩
  • F Giornal, G Landelle, N Lui, J Vors, S Pazenok, et al.. A New Synthesis and Process Development of Bis(fluoroalkyl)pyrazoles As Novel Agrophores. Organic Process Research and Development, American Chemical Society, 2014, 18 (8), pp.1002-1009. ⟨10.1021/Op500102h⟩. ⟨hal-02342504⟩
  • Belen Abarca, Rafael Ballesteros, Rosa Adam, Rafael Ballesteros-Garrido, Frédéric Leroux, et al.. A theoretical and experimental study of the racemization process of hexaaza[5]helicenes. Tetrahedron, Elsevier, 2014, 70 (45), pp.8750-8757. ⟨10.1016/j.tet.2014.09.018⟩. ⟨hal-02307797⟩
  • Gregory Landelle, Armen Panossian, Frédéric Leroux. Trifluoromethyl Ethers and -Thioethers as Tools for Medicinal Chemistry and Drug Discovery. Current Topics in Medicinal Chemistry, Bentham Science Publishers, 2014, 14 (7), pp.941-951. ⟨hal-02306242⟩
  • Boubacar Yalcouye, Sabine Choppin, Armen Panossian, Frédéric Leroux, Francoise Colobert-Leuenberger. A concise atroposelective formal synthesis of (-)-steganone. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2014, 2014 (28), pp.6285-6294. ⟨10.1002/ejoc.201402761⟩. ⟨hal-02304105⟩
  • Abdelouahd Oukhrib, Laurence Bonnafoux, Armen Panossian, Sandrine Waifang, Duc Hanh Nguyen, et al.. Novel C1-symmetric dibenzophosphole ligands: application in hydroformylation reactions. Tetrahedron, Elsevier, 2014, 70 (7), pp.1431-1436. ⟨10.1016/j.tet.2014.01.003⟩. ⟨hal-00992450⟩
  • Thomas Wesch, Frédéric Leroux, Francoise Colobert-Leuenberger. Atropodiastereoselective C-H Olefination of Biphenyl p-Tolyl Sulfoxides with Acrylates. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2013, 355 (11-12), pp.2139-2144. ⟨10.1002/adsc.201300446⟩. ⟨hal-02304106⟩
  • Florence Giornal, Lars Rodefeld, Norbert Lui, Jean-Pierre Vors, Frédéric Leroux. Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients. Journal of Fluorine Chemistry, Elsevier, 2013, 152, pp.2-11. ⟨10.1016/j.jfluchem.2012.11.008⟩. ⟨hal-02307799⟩
  • Stéphanie Toulot, Timo Heinrich, Frédéric Leroux. Convenient and Reliable Routes Towards 2-Aminothiazoles: Palladium-Catalyzed versus Copper-Catalyzed Aminations of Halothiazoles. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2013, 355 (16), pp.3263-3272. ⟨10.1002/adsc.201300591⟩. ⟨hal-02342506⟩
  • Thomas Wesch, Anaïs Brehier, Frédéric Leroux, Francoise Colobert-Leuenberger. Palladium-Catalyzed Intramolecular Direct Arylation of 2-Bromo-diaryl Sulfoxides via C-H Bond Activation. Organic Letters, American Chemical Society, 2013, 15 (10), pp.2490-2493. ⟨10.1021/ol400966q⟩. ⟨hal-02304107⟩
  • Rosa Adam, Rafael Ballesteros-Garrido, Oriol Vallcorba, Belen Abarca, Rafael Ballesteros, et al.. Synthesis and structural properties of hexaaza[5]helicene containing two [1,2,3]triazolo[1,5-a]pyridine moieties. Tetrahedron Letters, Elsevier, 2013, 54 (32), pp.4316-4319. ⟨10.1016/j.tetlet.2013.06.014⟩. ⟨hal-02306243⟩
  • Gregory Landelle, Armen Panossian, Sergiy Pazenok, Jean-Pierre Vors, Frédéric Leroux. Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2013, 9, pp.2476-2536. ⟨10.3762/bjoc.9.287⟩. ⟨hal-02304098⟩
  • Frédéric Leroux. Manfred Schlosser (1934-2013) Obituary. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (48), ⟨10.1002/anie.201308231⟩. ⟨hal-02307800⟩
  • Frédéric R. Leroux, Sergiy Pazenok, Florence Giornal, Grégory Landelle, Norbert Lui, et al.. A New Life for an Old Reagent: Fluoroalkyl Amino Reagents as Efficient Tools for the Synthesis of Diversely Fluorinated Pyrazoles. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2013, 2013 (20), pp.4249-4253. ⟨10.1002/ejoc.201300561⟩. ⟨hal-03004227⟩
  • Vincent Diemer, Anaïs Brehier, Jerome Bayardon, Sylvain Juge, Frédéric Leroux, et al.. Stereoselective Synthesis of P-Chirogenic Dibenzophosphole-Boranes via Aryne Intermediates. Journal of Organic Chemistry, American Chemical Society, 2012, 77 (14), pp.6117-6127. ⟨10.1021/jo3009098⟩. ⟨hal-02306244⟩
  • Frédéric R. Leroux, Jérôme Bayardon, Hugo Laureano, Vincent Diemer, Mathieu Dutartre, et al.. Stereoselective Synthesis of o -Bromo (or Iodo)aryl P-Chirogenic Phosphines Based on Aryne Chemistry. Journal of Organic Chemistry, American Chemical Society, 2012, 77 (13), pp.5759-5769. ⟨10.1021/jo300910w⟩. ⟨hal-03004233⟩
  • Vincent Diemer, Juan Garcia, Frédéric Leroux, Francoise Colobert-Leuenberger. Aryne-mediated fluorination: Synthesis of fluorinated biaryls via a sequential desilylation-halide elimination-fluoride addition process. Journal of Fluorine Chemistry, Elsevier, 2012, 134, pp.146-155. ⟨10.1016/j.jfluchem.2011.02.017⟩. ⟨hal-02306231⟩
  • Frédéric Leroux, Anaïs Brehier, Laurence Bonnafoux, Armen Panossian, Francoise Colobert-Leuenberger. Transition-Metal-Free Atropo-Selective Synthesis of Biaryl Compounds Based on Arynes. Chemistry - A European Journal, Wiley-VCH Verlag, 2012, 18 (45), pp.14232-14236. ⟨10.1002/chem.201202739⟩. ⟨hal-02306232⟩
  • Rafael Ballesteros-Garrido, Estefania Delgado-Pinar, Belen Abarca, Rafael Ballesteros, Frédéric Leroux, et al.. Triazolopyridines. Part 28. The ring-chain isomerization strategy: triazolopyridine- and triazoloquinoline-pyridine based fluorescence ligands. Tetrahedron, Elsevier, 2012, 68 (19), pp.3701-3707. ⟨10.1016/j.tet.2012.03.029⟩. ⟨hal-02306237⟩
  • Timo Leermann, Pierre-Emmanuel Broutin, Frédéric Leroux, Francoise Colobert-Leuenberger. Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki-Miyaura coupling. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (20), pp.4095-4102. ⟨10.1039/c2ob25373a⟩. ⟨hal-02306241⟩
  • Vincent Diemer, Manon Begaud, Frédéric Leroux, Francoise Colobert-Leuenberger. Regioselectivity in the Aryne Cross-Coupling of Aryllithiums with Functionalized 1,2-Dibromobenzenes. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2011, pp.341-354. ⟨10.1002/ejoc.201001283⟩. ⟨hal-02306235⟩
  • Vincent Diemer, Frédéric Leroux, Francoise Colobert-Leuenberger. Efficient and Complementary Methods Offering Access to Synthetically Valuable 1,2-Dibromobenzenes. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2011, pp.327-340. ⟨10.1002/ejoc.201001217⟩. ⟨hal-02306234⟩
  • Laurence Bonnafoux, Ludger Ernst, Frédéric Leroux, Francoise Colobert-Leuenberger. Through-Space J(P,P) and J(P,F) Spin-Spin Coupling in C-1-Symmetric Biaryl Diphosphanes. European Journal of Inorganic Chemistry, Wiley-VCH Verlag, 2011, pp.3387-3397. ⟨10.1002/ejic.201100428⟩. ⟨hal-02306233⟩
  • Laurence Bonnafoux, Rafael Gramage-Doria, Francoise Colobert, Frederic R. Leroux. Catalytic Palladium Phosphination: Modular Synthesis of C1-Symmetric Biaryl-Based Diphosphines. Chemistry - A European Journal, Wiley-VCH Verlag, 2011, 17 (39), pp.11008-11016. ⟨10.1002/chem.201101529⟩. ⟨hal-01472931⟩
  • Laurence Bonnafoux, Frédéric Leroux, Francoise Colobert-Leuenberger. Bromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2011, 7, pp.1278-1287. ⟨10.3762/bjoc.7.148⟩. ⟨hal-02307798⟩
  • Timo Leermann, Frédéric Leroux, Francoise Colobert-Leuenberger. Highly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium Exchanges. Organic Letters, American Chemical Society, 2011, 13 (17), pp.4479-4481. ⟨10.1021/ol2016252⟩. ⟨hal-02305220⟩
  • Frédéric Leroux. Polar Organometallic Chemistry. Current Organic Chemistry, Bentham Science Publishers, 2011, 15 (13). ⟨hal-02305223⟩
  • Rafael Ballesteros-Garrido, Laurence Bonnafoux, Fernando Blanco, Rafael Ballesteros, Frédéric Leroux, et al.. [1,2,3]Triazolo[1,5-a]pyridyl phosphines reflecting the influence of phosphorus lone pair orientation on spectroscopic properties. Dalton Transactions, Royal Society of Chemistry, 2011, 40 (6), pp.1387-1395. ⟨10.1039/C0DT01183E⟩. ⟨hal-02306239⟩
  • Emmanuelle Remond, Arnaud Tessier, Frédéric Leroux, Jérome Bayardon, Sylvain Jugé. Efficient synthesis of quaternary and P-stereogenic phosphonium triflates. Organic Letters, American Chemical Society, 2010, 12 (7), pp.1568-1571. ⟨10.1021/ol100304c⟩. ⟨hal-00474388⟩
  • Frédéric Leroux. Villes musulmanes, villes arabes. Conceptions orientalistes et vues récentes. La Lettre de la Maison Française d'Oxford, Maison Française d'Oxford, 1996, 4, pp.137-141. ⟨hal-02626140⟩

Books2 documents

Book sections1 document

  • Chantal Andraud, Philippe Belmont, J.M. Campagne, Gaëlle Chouraqui, Emmanuel Gras, et al.. Rapport de Conjoncture du CoNRS 2014 (INC / Section 12). CNRS Editions, Paris,. Rapport de Conjoncture du CoNRS 2014, CNRS Editions, Paris,, pp.255-274, 2014, 978-2-271-08746-1. ⟨hal-02338362⟩

Theses1 document

  • Frédéric Leroux. Étude des traitements par plasma à pression atmosphérique : applications à l'industrie textile. Science des matériaux [cond-mat.mtrl-sci]. Université de Valenciennes et du Hainaut-Cambrésis, 2007. Français. ⟨NNT : 2007VALE0036⟩. ⟨tel-02998272⟩