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New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome
Pierre Conan
,
Alice Léon
,
Noéline Caroff
,
Claire Rollet
,
Loubna Chaïr
Article dans une revue
hal-04170617v1
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Identification of 8-Hydroxyquinoline Derivatives That Decrease Cystathionine Beta Synthase (CBS) Activity
Pierre Conan
,
Alice Léon
,
Mathilde Gourdel
,
Claire Rollet
,
Loubna Chaïr
Article dans une revue
hal-03701324v1
|
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In Situ Formation of Cationic π-Allylpalladium Precatalysts in Alcoholic Solvents: Application to C–N Bond Formation
Philippe Steinsoultz
,
Aurélien Bailly
,
Patrick Wagner
,
Estefania Oliva
,
Martine Schmitt
Article dans une revue
hal-03546107v1
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Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors
Jolien de Neve
,
Thomas M A Barlow
,
Dirk Tourwé
,
Frédéric Bihel
,
Frédéric Simonin
Article dans une revue
hal-03435229v1
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Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation
Aline Bamia
,
Maha Sinane
,
Rima Naït-Saïdi
,
Jamila Dhiab
,
Marc Keruzoré
Article dans une revue
hal-03158577v1
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Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model
Maud Bollenbach
,
Simona Nemska
,
Patrick Wagner
,
Guillaume Camelin
,
François Daubeuf
Article dans une revue
hal-03266504v1
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Identification of an N -acylated- D Arg-Leu-NH 2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia
Raphaëlle Quillet
,
Séverine Schneider
,
Valérie Utard
,
Armand Drieu La Rochelle
,
Khadija Elhabazi
Article dans une revue
hal-03363456v1
|
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Diastereoselective Synthesis of Nonplanar 3-Amino-1,2,4-oxadiazine Scaffold: Structure Revision of Alchornedine
Shuang-Qi Tang
,
Maeva Leloire
,
Severine Schneider
,
Julie Mohr
,
Jacques Bricard
Article dans une revue
hal-03021041v1
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From Electronic Waste to Suzuki−Miyaura Cross‐Coupling Reaction in Water: Direct Valuation of Recycled Palladium in Catalysis
Valentin Lacanau
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Françoise Bonnete
,
Patrick Wagner
,
Christiane Contino‐pépin
,
Martine Schmitt
Article dans une revue
hal-02999762v1
|
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Minimizing HCN in DIC/Oxyma mediated amide bond forming reactions
Marion Erny
,
Marika Lundqvist
,
Jon Rasmussen
,
Olivier Ludemann-Hombourger
,
Frédéric Bihel
Article dans une revue
hal-02997255v1
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Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model
Maud Bollenbach
,
Claire Lugnier
,
M Elanie Kremer
,
Eric Salvat
,
Salim Megat
Article dans une revue
hal-02322399v1
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POxAP Precatalysts and the Negishi Cross-Coupling Reaction
Shuang-Qi Tang
,
Martine Schmitt
,
Frédéric Bihel
Article dans une revue
hal-02997250v1
|
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Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
Amandine Grimm
,
Imane Lejri
,
François Hallé
,
Martine Schmitt
,
Jürgen Götz
Article dans une revue
hal-02368671v1
|
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Evolution of coumaroyl conjugate 3‐hydroxylases in land plants: lignin biosynthesis and defense
Annette Alber
,
Hugues Renault
,
Alexandra Basilio-Lopes
,
Jean-Etienne Bassard
,
Zhenhua Liu
Article dans une revue
hal-02437982v1
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Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP
Shuang-Qi Tang
,
Jacques Bricard
,
Martine Schmitt
,
Frédéric Bihel
Article dans une revue
hal-02323246v1
|
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TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
Imane Lejri
,
Amandine Grimm
,
François Hallé
,
Mustapha Abarghaz
,
Christian Klein
Article dans une revue
hal-02368657v1
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Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1
Irene Marginedas-Freixa
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Cora Lilia Alvarez
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Martina Moras
,
María Florencia Leal Denis
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Claude Hattab
Article dans une revue
hal-02368694v1
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A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects
Armand Drieu La Rochelle
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Karel Guillemyn
,
Maria Dumitrascuta
,
Charlotte Martin
,
Valérie Utard
Article dans une revue
hal-02368742v1
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Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation
Maud Bollenbach
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Eric Salvat
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Francois Daubeuf
,
Patrick Wagner
,
Ipek Yalcin
Article dans une revue
hal-02323729v1
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Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels
Omar Alijevic
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Hassan Hammoud
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Anand Vaithia
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Viktor Trendafilov
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Maud Bollenbach
Article dans une revue
hal-02368759v1
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Dioxygenation of styrenes with molecular oxygen in water
Shuang-Qi Tang
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An-Ping Wang
,
Martine Schmitt
,
Frédéric Bihel
Article dans une revue
hal-02326129v1
|
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Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands
Irene Marginedas-Freixa
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Cora L Alvarez
,
Martina Moras
,
Claude Hattab
,
Guillaume Bouyer
Article dans une revue
hal-01926983v1
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WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3– cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
Wanyin Chen
,
Leonel Nguekeu Zebaze
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Jihu Dong
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Laëtitia Chezeau
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Perrine Inquimbert
Article dans une revue
hal-02349611v1
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Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia
Hassan Hammoud
,
Khadija Elhabazi
,
Isabelle Bertin
,
Valeŕie Utard
,
Emilie Laboureyras
Article dans une revue
hal-02323065v1
|
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Development of a L-Tryptophan-Based Ligand for Regioselective Copper Catalyzed N 2 -Arylation of 1,2,3-Triazoles
Alexandra Basilio Lopes
,
Patrick Wagner
,
Arthur Eugen Kümmerle
,
Frédéric Bihel
,
Jean-Jacques Bourguignon
Article dans une revue
hal-02368798v1
|
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χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds
Olivier van Der Poorten
,
Robin van den Hauwe
,
Emilie Eiselt
,
Cecilia Betti
,
Karel Guillemyn
Article dans une revue
hal-02368778v1
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Efficient and Mild Ullmann-Type N-Arylation of Amides, Carbamates, and Azoles in Water
Maud Bollenbach
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Pedro Aquino
,
João Xavier De araújo-Júnior
,
Jean-Jacques Bourguignon
,
Frédéric Bihel
Article dans une revue
hal-02368823v1
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RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents
Khadija Elhabazi
,
Jean-Paul Humbert
,
Isabelle Bertin
,
Raphaelle Quillet
,
Valérie Utard
Article dans une revue
hal-01603852v1
|
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Discovery of Imidazoquinazolinone Derivatives as TSPO Ligands Modulating Neurosteroidogenesis and Cellular Bioenergetics in Neuroblastoma Cells Expressing Amyloid Precursor Protein
François Hallé
,
Imane Lejri
,
Mustapha Abarghaz
,
Amandine Grimm
,
Christian Klein
Article dans une revue
hal-02368811v1
|
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The translocator protein ligand XBD173 improves clinical symptoms and neuropathological markers in the SJL/J mouse model of multiple sclerosis
I. Marginedas-Freixa
,
C. Hattab
,
G. Bouyer
,
F. Halle
,
A. Chene
Article dans une revue
hal-02290250v1
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TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood
I Marginedas-Freixa
,
C Hattab
,
G Bouyer
,
F Halle
,
A Chene
Article dans une revue
hal-01369499v1
|
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Erratum to: "CMTX1 patients' cells present genomic instability corrected by CamKII inhibitors"
Saleh Mones
,
Burkhard Gess
,
Benoit Bordignon
,
Alexandre Altie
,
Peter Young
Article dans une revue
hal-02630248v1
|
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RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions
Raphaelle Quillet
,
Safia Ayachi
,
Frédéric Bihel
,
Khadija Elhabazi
,
Brigitte Ilien
Article dans une revue
hal-02368835v1
|
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Development of Dipeptidic hGPR54 Agonists
Christelle Doebelin
,
Isabelle I. Bertin
,
Séverine Schneider
,
Martine Schmitt
,
Jean-Jacques Bourguignon
Article dans une revue
hal-02368845v1
|
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d -Glucose: An Efficient Reducing Agent for a Copper(II)-Mediated Arylation of Primary Amines in Water
Maud Bollenbach
,
Patrick Wagner
,
Pedro Aquino
,
Jean-Jacques Bourguignon
,
Frédéric Bihel
Article dans une revue
hal-02368856v1
|
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CMTX Disorder and CamKinase
Frédéric Bihel
,
Burkhard Gess
,
Michel Fontés
Article dans une revue
hal-02630284v1
|
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The effect of neuropeptide FF in the amygdala kindling model
I. Buffel
,
A. Meurs
,
J. Portelli
,
R. Raedt
,
V. de Herdt
Article dans une revue
hal-02368848v1
|
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Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization
François Hallé
,
Olivier van Der Poorten
,
Christelle Doebelin
,
Marie Niederst
,
Séverine Schneider
Article dans une revue
hal-02290245v1
|
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Opioid adjuvant strategy: improving opioid effectiveness
Frédéric Bihel
Article dans une revue
hal-02368859v1
|
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Development of a Peptidomimetic Antagonist of Neuropeptide FF Receptors for the Prevention of Opioid-Induced Hyperalgesia
Frédéric Bihel
,
Jean-Paul Humbert
,
Severine Schneider
,
Isabelle Bertin
,
Patrick Wagner
Article dans une revue
hal-03198603v1
|
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Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103
Laurent Rouméas
,
Jean-Paul Humbert
,
Séverine Schneider
,
Christelle Doebelin
,
Isabelle Bertin
Article dans une revue
hal-02997151v1
|
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Neuropeptide FF receptors as novel targets for limbic seizure attenuation
Jeanelle Portelli
,
Alfred Meurs
,
Frederic Bihel
,
Hassan Hammoud
,
Martine Schmitt
Article dans une revue
hal-03005155v1
|
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Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors.
Ine Buffel
,
Alfred Meurs
,
Jeanelle Portelli
,
Robrecht Raedt
,
Veerle de Herdt
Article dans une revue
hal-03005167v1
|
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A Yeast/ Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency
Alexandra Seguin
,
Véronique Monnier
,
Amandine Palandri
,
Frédéric Bihel
,
Michael Rera
Article dans une revue
hal-03798926v1
|
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CMTX1 patients' cells present genomic instability corrected by CamKII inhibitors
Saleh Mones
,
Burkhardt Gess
,
Benoit Bordignon
,
Alexandre Altie
,
Peter Young
Article dans une revue
hal-02634560v1
|
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Design and validation of a homogeneous time-resolved fluorescence cell-based assay targeting the ligand-gated ion channel 5-HT3A
Emilie Blanc
,
Patrick Wagner
,
Fabrice Plaisier
,
M. Schmitt
,
Thierry Durroux
Article dans une revue
hal-02064366v1
|
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A Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency.
Alexandra Seguin
,
Véronique Monnier
,
Amandine Palandri
,
Frédéric Bihel
,
Michael Rera
Article dans une revue
hal-01267591v1
|
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Fully regiocontrolled polyarylation of pyridine.
C. Doebelin
,
P. Wagner
,
F. Bihel
,
N. Humbert
,
C.A. Kenfack
Journal of Organic Chemistry, 2014, 79, pp.908-918
Article dans une revue
hal-01065061v1
|
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Structure-activity relationship study around guanabenz identifies two derivatives retaining antiprion activity but having lost alpha 2-adrenergic receptor agonistic activity
- Phu Hai Nguyen
,
Hassan Hammoud
,
Sophie Halliez
,
Yanhong Pang
,
Justine Evrard
Article dans une revue
hal-02635473v1
|
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CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene
Saleh Mones
,
Benoit Bordignon
,
Franck Peiretti
,
Jean-Francois Landrier
,
Burkhardt Gess
Article dans une revue
hal-02639042v1
|
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Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors.
K. Elhabazi
,
J.P. Humbert
,
I. Bertin
,
M. Schmitt
,
F. Bihel
Neuropharmacology, 2013, 75, pp.164-171
Article dans une revue
hal-00860085v1
|
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Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists
Christelle Doebelin
,
Patrick Wagner
,
Isabelle Bertin
,
Frederic Simonin
,
Martine Schmitt
Article dans une revue
hal-03005205v1
|
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The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction.
Christian Klein
,
Christine Mensah-Nyagan
,
Omar Taleb
,
Jean-Jacques Bourguignon
,
Martine Schmitt
Article dans une revue
hal-02612146v1
|
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Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors
Khadija Elhabazi
,
Jean-Paul Humbert
,
Isabelle Bertin
,
Martine Schmitt
,
Frédéric Bihel
Article dans une revue
hal-02650252v1
|
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Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors
Ronan Gealageas
,
Severine Schneider
,
Jean-Paul Humbert
,
Isabelle Bertin
,
Martine Schmitt
Article dans une revue
hal-02993696v1
|
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New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam.
F.J.J. Bihel
,
H. Justiniano
,
M. Schmitt
,
M. Hellal
,
M.A. Ibrahim
Bioorganic and Medicinal Chemistry Letters, 2011, 21, pp.6567-6572
Article dans une revue
hal-00667395v1
|
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6-Endo-dig cyclization of heteroarylesters to alkynes promoted by Lewis acid catalyst in the presence of Bronsted acid
Hellal Malik
,
Bourguignon Jean-Jacques
,
Frédéric Bihel
Tetrahedron Letters, 2008, 49 (1), pp.62-65
Article dans une revue
hal-00195333v1
|
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Synthesis and reactivity of 2,3-dihydro-1H-2,3-benzodiazepine-1,4(5H)-dione
Frédéric Bihel
,
Hellal Malik
,
Bourguignon Jean-Jacques
Synthesis: Journal of Synthetic Organic Chemistry, 2007, 24, pp.3791-3796
Article dans une revue
hal-00195328v1
|
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Microwave-assisted cyclic amidine synthesis using TiCl4.
M. Hellal
,
F. Bihel
,
A. Mongeot
,
J.-J. Bourguignon
Organic & Biomolecular Chemistry, 2006, 4, pp.3142-3146
Article dans une revue
hal-00129884v1
|
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Photoactivatable helical peptide inhibitors of y-secretase covalently bind to presenilin at a site close to but distinct from the active site.
A.Y. Kornilova
,
F. Bihel
,
C. Das
,
M.S. Wolfe
Proceedings of the National Academy of Sciences of the United States of America, 2005, 102, pp.3230-5
Article dans une revue
hal-00159650v1
|
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substituded thiazolamide coupled to a redox delivery system : a new gamma-secretase inhibitor with enhanced pharmacokinetic profile
Y. Younes
,
G. Quelever
,
C. Garino
,
N. Pietrancosta
,
M. Shela
Organic & Biomolecular Chemistry, 2005, 21, pp.612-8
Article dans une revue
hal-00159607v1
|
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Substituted thiazolamide coupled to a redox delivery system: a new γ-secretase inhibitor with enhanced pharmacokinetic profile
Younes Laras
,
Gilles Quéléver
,
Cédrik Garino
,
Nicolas Pietrancosta
,
Mahmoud Sheha
Article dans une revue
hal-02351730v1
|
|
Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile
Y. Laras
,
G. Quelever
,
C. Garino
,
N. Pietrancosta
,
M. Sheha
Organic & Biomolecular Chemistry, 2005, 3, pp.612-618
Article dans une revue
hal-00118749v1
|
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New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties
Cédrik Garino
,
Frédéric Bihel
,
Nicolas Pietrancosta
,
Younes Laras
,
Gilles Quéléver
Article dans une revue
hal-02351737v1
|
|
New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties
C. Garino
,
F. Bihel
,
N. Pietrancosta
,
Y. Laras
,
G. Quelever
Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.135-138
Article dans une revue
hal-00117234v1
|
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N-acyl substituted 7-amino-4-chloroisocoumarin: a peptide degradation model via an imide mechanism
C. Garino
,
F. Bihel
,
F. Souard
,
G. Quelever
,
J.L. Kraus
Bioorganic and Medicinal Chemistry Letters, 2004, 14, pp.1771-1774
Article dans une revue
hal-00305873v1
|
|
Novel synthesis of 3,4-dihydro-5-bromo[1,4]oxazin-2-one derivatives, new protease inhibitor scaffold
F. Bihel
,
J.L. Kraus
Organic & Biomolecular Chemistry, 2003, 1, pp.793-799
Article dans une revue
hal-00304322v1
|
|
New b-strand macrocyclic peptidomimetic analogues containing alpha-(O-, S- or NH-)aryl substituted glycine residues: synthesis, chemical and enzymatic properties
Gilles Quéléver
,
Frédéric Bihel
,
Jean-Louis Kraus
Organic & Biomolecular Chemistry, 2003, 1, pp.1676-1683
Article dans une revue
hal-00154124v1
|
|
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease
Agnès Petit-Paitel
,
Frédéric Bihel
,
Gilles Quéléver
,
Hugues Lelouard
,
Agnès Petit
Article dans une revue
hal-03016636v1
|
|
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new b-amyloid peptide production inhibitors and their activities on various classes of protease
Frédéric Bihel
,
Gilles Quéléver
,
Hugues Lelouard
,
Agnes Petit
,
Christine Alves da Costa
Bioorganic and Medicinal Chemistry, 2003, 11, pp.3141-3152
Article dans une revue
hal-00154122v1
|
|
Reactivity studies of 3-alkoxy-7-amino-4-chloroisocoumarins (beta-amyloid peptide inhibitors) versus different classes of amines
F. Bihel
,
R. Faure
,
J.L. Kraus
Organic & Biomolecular Chemistry, 2003, 1, pp.800-802
Article dans une revue
hal-00304324v1
|
|
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease
F. Bihel
,
G. Quelever
,
H. Lelouard
,
A. Petit
,
C. Alves da Costa
Bioorganic and Medicinal Chemistry, 2003, 11, pp.3141-3152
Article dans une revue
hal-00304333v1
|
|
Novel synthesis of 3,4-dihydro-5-bromo[1,4]oxazin-2-one derivatives, new protease inhibitor scaffold
Frédéric Bihel
,
Jean-Louis Kraus
Organic & Biomolecular Chemistry, 2003, 1, pp.793-799
Article dans une revue
hal-00154126v1
|
|
New beta-strand macrocyclic peptidomimetic analogues containing alpha-(O-, S- or NH-)aryl substituted glycine residues: synthesis, chemical and enzymatic properties
G. Quelever
,
F. Bihel
,
J.L. Kraus
Organic & Biomolecular Chemistry, 2003, 1, pp.1676-83
Article dans une revue
hal-00304318v1
|
|
Synthesis and antiviral activity of new Anti-HIV amprenavir bioisosteres
Luc Rocheblave
,
Frédéric Bihel
,
Céline de Michelis
,
Ghislaine Priem
,
Jérôme Courcambeck
Journal of Medicinal Chemistry, 2002, 45, pp.3321-3324
Article dans une revue
hal-00154120v1
|
|
Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres
L. Rocheblave
,
F. Bihel
,
C. de Michelis
,
G. Priem
,
J. Courcambeck
Journal of Medicinal Chemistry, 2002, 45, pp.3321-24
Article dans une revue
hal-00304305v1
|
|
New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: Synthesis and anti-HIV evaluation.
Patrick Vlieghe
,
Frédéric Bihel
,
Thierry Clerc
,
Christophe Pannecouque
,
Myriam Witvrouw
Journal of Medicinal Chemistry, 2001, 44, pp.777-786
Article dans une revue
hal-00154110v1
|
|
New protease inhibitors prevent gamma-secretase-mediated production of Ab40/42 without affecting Notch cleavage.
Frédéric Bihel
,
Agnes Petit
,
Christine Alves da Costa
,
Olivier Pourquié
,
Frédéric Checler
Nature Cell Biology, 2001, 3, pp.507-511
Article dans une revue
hal-00154118v1
|
|
Design of potential newHIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates.
Frédéric Bihel
,
Jérôme Courcambeck
,
Céline de Michelis
,
Gilles Quéléver
,
Jean-Louis Kraus
Journal of the Chemical Society Perkin Transactions 1, 2001, pp.1421-1430
Article dans une revue
hal-00154116v1
|