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27

CV de François SICHEL


     SICHEL François

      Né le 14 novembre 1959 à Paris XIIème

      Marié, 2 enfants

      Nationalité française

      Adresse professionnelle : › ABTE, Bâtiment Recherche, Centre François Baclesse,

Av. du Général Harris, 14076 CAEN-Cedex 05

Tel 02 31 45 51 93  

francois.sichel@unicaen.fr

 

Professeur de Toxicologie, UFR Santé, Université de Caen-Normandie et CLCC François Baclesse

Directeur de l'EA4651 Aliments Bioprocédés Toxicologie Environnement.

Responsable du parcours de master Développement Clinique du Médicament.

Vice président de la Société Française de Toxicologie Génétique.

 

Cursus universitaire
  • D.E.A. "Structure et fonctionnement des systèmes biologiques intégrés", Université de Paris‑sud (Orsay), septembre 1987, mention bien.
  • Diplôme d'état de Docteur en Pharmacie : "Intérêt de la chromatographie liquide rapide par échange d'ions lors de l'analyse et de la purification des protéines" (Directeur de thèse Pr. Edith Bar), soutenue le 17 décembre 1987, mention très honorable avec les félicita­tions du jury.
  • Doctorat de l'Univer­sité de Caen, spécialité pharmacie : "Galactosyltransférase et cancer de l'ovaire : analyse clinique et étude d'un modèle expérimental humain" (Directeur de thèse Pr. Jean-Yves Le Talaër) soutenue le 20 juin 1991, mention très honorable avec les félicitations du jury.
  • Diplôme d'Habilitation à Diriger des Recherches, Université de Caen, 19 septembre 1996.

 


 


Journal articles27 documents

  • Ahmed Karoui, Clément Crochemore, Najah Harouki, Cecile Corbiere, David Preterre, et al.. Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction. International Journal of Environmental Research and Public Health, MDPI, 2020, 17 (15), ⟨10.3390/ijerph17155526⟩. ⟨hal-02928488⟩
  • Valérie Lecureur, Christelle Monteil, Marie Jaguin, Fabrice Cazier, David Préterre, et al.. Comparative study on gene expression profile in rat lung after repeated exposure to diesel and biodiesel exhausts upstream and downstream of a particle filter. Environmental Pollution (Elsevier), 2020, 266 (Pt 2), pp.115264. ⟨10.1016/j.envpol.2020.115264⟩. ⟨hal-02930031⟩
  • Juliette Thariat, Samuel Valable, Carine Laurent, Siamak Haghdoost, Elodie Pérès, et al.. Hadrontherapy Interactions in Molecular and Cellular Biology. International Journal of Molecular Sciences, MDPI, 2020, 21 (1), pp.133. ⟨10.3390/ijms21010133⟩. ⟨hal-02429129⟩
  • F Lindenberg, François Sichel, Mathilde Lechevrel, R Respaud, Guillaume Saint-Lorant. Evaluation of Lung Cell Toxicity of Surfactants for Inhalation Route. Journal of Toxicology and Risk Assessment, ClinMed International Library, 2019, 5 (1), pp.133. ⟨10.23937/2572-4061.1510022⟩. ⟨hal-02448735⟩
  • Ahmed Karoui, Clément Crochemore, Paul Mulder, David Preterre, Fabrice Cazier, et al.. An integrated functional and transcriptomic analysis reveals that repeated exposure to diesel exhaust induces sustained mitochondrial and cardiac dysfunctions. Environmental Pollution, Elsevier, 2019, 246, pp.518-526. ⟨10.1016/j.envpol.2018.12.049⟩. ⟨hal-01978723⟩
  • Emmanuel Kammerer, Jennifer Le Guévelou, Sophie Jacob, Julien Geffrelot, Serge Danhier, et al.. Complications cardiaques de la radiothérapie mammaire. Bulletin du Cancer, John Libbey Eurotext, 2019, 106 (4), pp.379-388. ⟨10.1016/j.bulcan.2019.01.020⟩. ⟨hal-02160245⟩
  • Thierry Douki, Cécile Corbière, D. Preterre, P.J. Martin, V. Lecureur, et al.. Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats. Environmental Pollution, Elsevier, 2018, 235, pp.514-524. ⟨10.1016/j.envpol.2017.12.077⟩. ⟨hal-01711070⟩
  • Virginie Prevost, François Sichel, Ivannah Pottier, Alexandre Leduc, Stéphanie Lagadu, et al.. Production of early and late nuclear DNA damage and extracellular 8- oxodG in normal human skin fibroblasts after carbon ion irradiation compared to X-rays. Toxicology in Vitro, Elsevier, 2018, 52, pp.116-121. ⟨10.1016/j.tiv.2018.06.004⟩. ⟨inserm-02181592⟩
  • Bertrand Fougère, Yann Landkocz, Capucine Lepers, Perrine Martin, Lucie Armand, et al.. Influence of aging in the modulation of epigenetic biomarkers of carcinogenesis after exposure to air pollution. Experimental Gerontology, Elsevier, 2018, 110, pp.125-132. ⟨10.1016/j.exger.2018.05.018⟩. ⟨hal-02025021⟩
  • Sylvain Billet, Yann Landkocz, Perrine Martin, Anthony Verdin, Frédéric Ledoux, et al.. Chemical characterization of fine and ultrafine PM, direct and indirect genotoxicity of PM and their organic extracts on pulmonary cells. Journal of Environmental Sciences, Elsevier, 2018, 71, pp.168-178. ⟨10.1016/j.jes.2018.04.022⟩. ⟨hal-02025015⟩
  • François Sichel, Jean-Pierre Castillo, Pierre Noel, Alain Mayoux, Laurent Colombet. Répartition du mollusque gastéropode nudibranche Dendrodoris limbata (Cuvier, 1804) le long des côtes métropolitaines françaises : apport de l’outil de sciences participatives BioObs. Naturae, Publications scientifiques du Muséum, 2018, pp.57-62. ⟨10.5852/naturae2018a5⟩. ⟨hal-02492238⟩
  • Fatma Trabelsi, Rim Khlifi, Didier Goux, Marilyne Guillamin, Amel Hamza-Chaffai, et al.. Cytotoxicity and genotoxicity effects of arsenic trioxide on SQ20B human laryngeal carcinoma cells. Experimental and Toxicologic Pathology, Elsevier, 2017, 69 (6), pp.349-358. ⟨10.1016/j.etp.2017.02.003⟩. ⟨hal-02160250⟩
  • D. Lecomte Dumont, D. Stefan, F. Sichel, J.-L. Habrand, Carine Laurent. Résultats préliminaires de l’étude Paescart : prédiction de l’apparition d’effets secondaires cutanés tardifs après radiothérapie. Cancer Radiothérapie, Elsevier Masson, 2017, 21 (6-7), pp.712-713. ⟨10.1016/j.canrad.2017.08.077⟩. ⟨hal-02479011⟩
  • Claire Barraud, Cécile Corbière, I. Pottier, E. Estace, K. Blanchard, et al.. Impact of after-treatment devices and biofuels on diesel exhausts genotoxicity in A549 cells exposed at air-liquid interface. Toxicology in Vitro, Elsevier, 2017, 45 (Part 3), pp.426-433. ⟨10.1016/j.tiv.2017.04.025⟩. ⟨hal-02025402⟩
  • Simon Rodier, Guillaume Saint-Lorant, Jean-Marc Guilloit, Agnès Palix, Fabienne Divanon, et al.. Is hyperthermic intraperitoneal chemotherapy (HIPEC) safe for healthcare workers?. Surgical Oncology, Elsevier, 2017, 26 (3), pp.242-251. ⟨10.1016/j.suronc.2017.04.001⟩. ⟨hal-02025028⟩
  • Yann Landkocz, Frédéric Ledoux, Véronique André, Fabrice Cazier, Paul Genevray, et al.. Fine and ultrafine atmospheric particulate matter at a multi-influenced urban site: Physicochemical characterization, mutagenicity and cytotoxicity. Environmental Pollution, Elsevier, 2017, 221, pp.130-140. ⟨10.1016/j.envpol.2016.11.054⟩. ⟨hal-02025255⟩
  • Fatma Trabelsi, Rim Khlifi, Didier Goux, Marilyne Guillamin, Amel Hamza-Chaffai, et al.. Genotoxic effects of cadmium in human head and neck cell line SQ20B. Environmental Science and Pollution Research, Springer Verlag, 2016, 23 (16), pp.16127-16136. ⟨10.1007/s11356-016-6772-4⟩. ⟨hal-02025265⟩
  • V. Andre, Claire Barraud, David Capron, D. Preterre, V. Keravec, et al.. Comparative mutagenicity and genotoxicity of particles and aerosols emitted by the combustion of standard vs. rapeseed methyl ester supplemented bio-diesel fuels: Impact of after treatment devices: Oxidation catalyst and particulate filter. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Elsevier, 2015, 777, pp.33-42. ⟨10.1016/j.mrgentox.2014.11.007⟩. ⟨hal-02025276⟩
  • C. Lepers, M. Dergham, L. Armand, S. Billet, A. Verdin, et al.. Mutagenicity and clastogenicity of native airborne particulate matter samples collected under industrial, urban or rural influence. Toxicology in Vitro, Elsevier, 2014, 28 (5), pp.866-874. ⟨10.1016/j.tiv.2014.03.011⟩. ⟨hal-02186761⟩
  • Capucine Lepers, Veronique Andre, Mona Dergham, Sylvain Billet, Anthony Verdin, et al.. Xenobiotic metabolism induction and bulky DNA adducts generated by particulate matter pollution in BEAS-2B cell line: geographical and seasonal influence. Journal of Applied Toxicology, Wiley, 2014, 34 (6), pp.703-713. ⟨10.1002/jat.2931⟩. ⟨hal-02160269⟩
  • Imane Abbas, Guillaume Garçon, Françoise Saint-Georges, Veronique Andre, Pierre Gosset, et al.. Polycyclic aromatic hydrocarbons within airborne particulate matter (PM 2.5 ) produced DNA bulky stable adducts in a human lung cell coculture model. Journal of Applied Toxicology, Wiley, 2013, 33 (2), pp.109-119. ⟨10.1002/jat.1722⟩. ⟨hal-02186813⟩
  • Vincent Paget, Mathilde Lechevrel, Veronique Andre, Jérémie Le Goff, Didier Pottier, et al.. Benzo[a]pyrene, Aflatoxine B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology. PLoS ONE, Public Library of Science, 2012, 7 (2), pp.e30921. ⟨10.1371/journal.pone.0030921⟩. ⟨hal-02186767⟩
  • Véronique André, S. Billet, D. Pottier, J. Le Goff, I. Pottier, et al.. Mutagenicity and genotoxicity of PM2.5 issued from an urbano-industrialized area of Dunkerque (France). Journal of Applied Toxicology, Wiley, 2011, 31 (2), pp.131-138. ⟨10.1002/jat.1572⟩. ⟨hal-02186834⟩
  • Sylvain Billet, Vincent Paget, Guillaume Garçon, Natacha Heutte, Veronique Andre, et al.. Benzene-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the functional analysis of separated alleles in yeast, in human lung cells. Archives of Toxicology, Springer Verlag, 2010, 84 (2), pp.99-107. ⟨10.1007/s00204-009-0478-z⟩. ⟨hal-02186869⟩
  • Mathilde Lechevrel, François Sichel, Jean Breton, Didier Pottier, Rémy Couderc, et al.. 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker of oxidative damage in oesophageal cancer patients: lack of association with antioxidant vitamins and polymorphism of hOGG1 and GST. Journal of experimental & clinical cancer research : CR, 2010, 29 (1), pp.157. ⟨10.1186/1756-9966-29-157⟩. ⟨hal-02461268⟩
  • Stéphanie Lagadu, Ivannah Pottier, François Sichel, Carine Laurent, Jean-Louis Lefaix, et al.. Detection of extracellular 8-oxo-7,8-dihydro-2′-deoxyguanosine as a biomarker of oxidative damage in X-irradiated fibroblast cultures: optimization of analytical procedure. Biomarkers, Taylor & Francis, 2010, 15 (8), pp.707-714. ⟨10.3109/1354750X.2010.511269⟩. ⟨hal-02297398⟩
  • Sylvain Billet, Imane Abbas, Jérémie Le Goff, Anthony Verdin, Veronique Andre, et al.. Genotoxic potential of Polycyclic Aromatic Hydrocarbons-coated onto airborne Particulate Matter (PM2.5) in human lung epithelial A549 cells. Cancer Letters, Elsevier, 2008, 270 (1), pp.144-155. ⟨10.1016/j.canlet.2008.04.044⟩. ⟨hal-02186795⟩