Nombre de documents

60

Resume


 

Dr. François PUEL

 

Professor,

 

Process Engineering and Materials Research Laboratory

 

Head, BioProcess & Chemical Engineering Education Department

 

CentraleSupélec, Université Paris-Saclay, France

 

 

 

Skills: Mass transfer, Crystallization, Filtration, Emulsification, Process scale-up and industrialization, modelling of particulate processes; Experimental investigation, Solid state transition, Process Analytical Technologies

 

Domains of application: crystallization and formulation of powders; purification of ingredients (pharmaceutics, cosmetics) and industrial products (nuclear fuel, crop science), bio-processes

 

Leadership: Head of a 15-people education group, member of the executive committee of IOCG (http://www.iocg.org) , Participation to national and international networks namely in the field of crystallization. Expert for French, Swiss and Belgian research agencies, Expertise and executive training for industry.

 

Resume

 

A graduate of the Chemical Engineering School of Lyon, he received his PhD in Chemical Engineering from the University of Lyon1 (UL1) in 1994. Then he joined the solid processing department at Rhône-Poulenc Research & Development Lab. in Decines, France for 8 years. He was engaged in the development of crystallization processes from laboratory to industrial scale as a senior scientist. He received the senior Moulton Medal in 1997 since he transferred a modelling framework from academy to industry. He joined UL1 in 2001 as an associate professor. He achieved in 2014 full professorship at the renowned Ecole Centrale Paris (now CentraleSupélec since January 2015). His major challenge is to develop an expertise in life science and biotechnologies at Ecole Centrale Paris both in teaching and research. In 2015, he was appointed head of the BioProcess & Chemical Engineering Education Department.

 

He cumulates a total of 44 papers in peer-review journals (WoS), 3 book chapters (international ed.), 4 patents and more than 110 contributions (oral and poster) at scientific conferences, including 5 keynotes. 0n 27 October 2015: 808 citations and h-factor = 16 (WoS – citation metrics at  http://www.researcherid.com/rid/G-2874-2014). 0n 27 October 2015: 1257 citations and h-factor = 19 (Google scholar).

 


Article dans une revue50 documents

  • Damien Bourcier, Yan Siong Kong, Jean-Pierre Feraud, Denis Ode, Didier Colson, et al.. Filtration Process Optimization: Rheological Behavior of a Filter Cake at Different Moisture Contents. Chemical Engineering and Technology, 2016, 39 (3), pp.515-521. <10.1002/ceat.201500426>. <hal-01279592>
  • Audrey Juban, Stéphanie Briançon, François Puel. Processing-induced-transformations (PITs) during direct compression: Impact of tablet composition and compression load on phase transition of caffeine. International Journal of Pharmaceutics, Elsevier, 2016, 501 (1-2), pp.253-264. <10.1016/j.ijpharm.2016.01.079>. <hal-01279575>
  • D. Bourcier, J.P. Féraud, D. Colson, K. Mandrick, D. Ode, et al.. Influence of particle size and shape properties on cake resistance and compressibility during pressure filtration. Chemical Engineering Science, Elsevier, 2016, 144, pp.176-187. <10.1016/j.ces.2016.01.023>. <hal-01279589>
  • A. Amokrane, S. Maass, F. Lamadie, François Puel, S. Charton. On droplets size distribution in a pulsed column. Part I: In-situ measurements and corresponding CFD–PBE simulations. Chemical Engineering Journal, Elsevier, 2016, 296, pp.366-376. <10.1016/j.cej.2016.03.089>. <hal-01301432>
  • Delphine Ach, Stéphanie Briançon, Guy Broze, François Puel, Alain Rivoire, et al.. Formation of microcapsules by complex coacervation. The Canadian Journal of Chemical EngineeringJournal of Chemical Engineering, 2015, 93 (2 (SI)), pp. 183-191. <10.1002/cjce.22086>. <hal-01273155>
  • Audrey Juban, Cécile Nouguier-Lehon, Stéphanie Briancon, Thierry Hoc, François Puel. Predictive model for tensile strength of pharmaceutical tablets based on local hardness measurements. International Journal of Pharmaceutics, Elsevier, 2015, 490 (1-2), pp. 438-445. <10.1016/j.ijpharm.2015.05.078>. <hal-01273157>
  • Marie-Alexandrine Bolzinger, Stephanie Briançon, Y. Chevalier, François Puel. Formulation des systèmes pâteux ou préparations semi-solides. Techniques de l'Ingenieur, Techniques de l'ingénieur, 2015, PHA2016. <hal-01273308>
  • Per Julian Becker, François Puel, Arend Dubbelboer, Jo Janssen, Nida Sheibat-Othman. Coupled population balance–CFD simulation of droplet breakup in a high pressure homogenizer. Computers and Chemical Engineering, 2014, 68, pp.140-150. <10.1016/j.compchemeng.2014.05.014>. <hal-01273154>
  • A. Ben Nasr, K. Walha, F. Puel, D. Mangin, R. Ben Amar, et al.. Precipitation and adsorption during fluoride removal from water by calcite in the presence of acetic acid. Desalination and Water Treatment, FHF, 2014, 52 (10-12), pp.2231-2240. <10.1080/19443994.2013.799441>. <hal-01273005>
  • A. Amokrane, S. Charton, F. Lamadie, J.F. Paisant, F. Puel. Single-phase flow in a pulsed column: Particle Image Velocimetry validation of a CFD based model. Chemical Engineering Science, Elsevier, 2014, 114, pp.40-50. <10.1016/j.ces.2014.04.003>. <hal-01273152>
  • Abdenour Amokrane, Sophie Charton, Nida Sheibat-Othman, Julian Becker, Jean P. Klein, et al.. Development of a CFD-PBE coupled model for the simulation of the drops behaviour in a pulsed column. The Canadian Journal of Chemical EngineeringJournal of Chemical Engineering, 2014, 92 (2), pp.220-233. <10.1002/cjce.21933>. <hal-01273007>
  • Per Julian Becker, François Puel, Hugo Atle Jakobsen, Nida Sheibat-Othman. Development of an improved breakage kernel for high dispersed viscosity phase emulsification. Chemical Engineering Science, Elsevier, 2014, 109, pp.326-338. <10.1016/j.ces.2014.02.008>. <hal-01273019>
  • Per Julian Becker, François Puel, Yves Chevalier, Nida Sheibat-Othman. Monitoring silicone oil droplets during emulsification in stirred vessel: Effect of dispersed phase concentration and viscosity. The Canadian Journal of Chemical EngineeringJournal of Chemical Engineering, 2014, 92 (2), pp.296-306. <10.1002/cjce.21885>. <hal-01273011>
  • Sophie Charton, Amine Kacem, Abdenour Amokrane, Gilles Borda, François Puel, et al.. Actinides oxalate precipitation in emulsion modeling: From the drop scale to the industrial process. Chemical Engineering Research and Design, Elsevier, 2013, 91 (4), pp.660-669. <10.1016/j.cherd.2013.02.001>. <hal-01271829>
  • J.P. Féraud, D. Bourcier, D. Ode, F. Puel. New filterability and compressibility test cell design for nuclear products. Nuclear Engineering and Design, Elsevier, 2013, 265, pp.288-293. <10.1016/j.nucengdes.2013.06.036>. <hal-01273000>
  • Abir Khalil, François Puel, Xavier Cosson, Olga Gorbatchev, Yves Chevalier, et al.. Crystallization-in-emulsion process of a melted organic compound: In situ optical monitoring and simultaneous droplet and particle size measurements. Journal of Crystal Growth, Elsevier, 2012, 342 (1), pp. 99-109. <10.1016/j.jcrysgro.2011.06.005>. <hal-01271819>
  • E. Gagniere, F. Puel, D. Mangin, J.-P. Valour, A. Rivoire, et al.. In Situ Monitoring of Cocrystallization Processes - Complementary Use of Sensing Technologies. Chemical Engineering and Technology, 2012, 35 (SI) (6), pp.1039-1044. <10.1002/ceat.201100711>. <hal-01271824>
  • Sébastien Hubert, Stéphanie Briancon, Alain Hedoux, Yannick Guinet, Laurent Paccou, et al.. Process induced transformations during tablet manufacturing: Phase transition analysis of caffeine using DSC and low frequency micro-Raman spectroscopy. International Journal of Pharmaceutics, Elsevier, 2011, 420 (1), pp.76-83. <10.1016/j.ijpharm.2011.08.028>. <hal-01271810>
  • Nida Sheibat-Othman, Per Julian Becker, François E. Puel, Reynald Henry. Investigation of Discrete Population Balance Models and Breakage Kernels for Dilute Emulsification Systems. Industrial and engineering chemistry research, American Chemical Society, 2011, 50, pp.11358-11374. <10.1021/ie2006033>. <hal-00925079>
  • Abir Khalil, François Puel, Yves Chevalier, Jean-Marc Galvan, Alain Rivoire, et al.. Study of droplet size distribution during an emulsification process using in situ video probe coupled with an automatic image analysis. Journal Chemical Engineering, 2010, 165 (3), pp. 946-957. <10.1016/j.cej.2010.10.031>. <hal-01271793>
  • Catherine Charcosset, Roland Kieffer, Denis Mangin, François Puel. Coupling between Membrane Processes and Crystallization Operations. Industrial and engineering chemistry research, American Chemical Society, 2010, 49 (12), pp.5489-5495. <10.1021/ie901824x>. <hal-01271789>
  • Roland Kieffer, Denis Mangin, François Puel, Catherine Charcosset. Precipitation of barium sulphate in a hollow fiber membrane contactor, Part I: Investigation of particulate fouling. Chemical Engineering Science, Elsevier, 2009, 64 (8), pp.1759-1767. <10.1016/j.ces.2009.01.011>. <hal-01270944>
  • Emilie Gagnière, Denis Mangin, François Puel, Alain Rivoire, Olivier Monnier, et al.. Formation of co-crystals: Kinetic and thermodynamic aspects. Journal of Crystal Growth, Elsevier, 2009, 311 (9), pp.2689-2695. <10.1016/j.jcrysgro.2009.02.040 >. <hal-01270958>
  • D. Mangin, F. Puel, S. Veesler. Polymorphism in Processes of Crystallization in Solution: A Practical Review. Organic Process Research and Development, American Chemical Society, 2009, 13, pp.1241-1253. <hal-00440718>
  • Emilie Gagniere, Denis Mangin, François Puel, C. Bebon, Jean-Paul Klein, et al.. Cocrystal Formation in Solution: In Situ Solute Concentration Monitoring of the Two Components and Kinetic Pathways. Crystal Growth and Design, American Chemical Society, 2009, 9 (8), pp.3376-3383. <10.1021/cg801019d>. <hal-01271781>
  • Roland Kieffer, Denis Mangin, François Puel, Catherine Charcosset. Precipitation of barium sulphate in a hollow fiber membrane contactor: Part II The influence of process parameters. Chemical Engineering Science, Elsevier, 2009, 64 (8), pp.1885-1891. <10.1016/j.ces.2009.01.013>. <hal-01270948>
  • D. Mangin, F. Puel, S. Veesler. Polymorphisme et transition de phases solides en solution. Les Techniques de l'Ingenieur, Editions T.I., 2008, J2160, pp.1-10. <hal-00386832>
  • Roland Kieffer, Catherine Charcosset, François Puel, Denis Mangin. Numerical simulation of mass transfer in a liquid–liquid membrane contactor for laminar flow conditions. Computers and Chemical Engineering, 2008, 32 (6), pp.1325-1333. <10.1016/j.compchemeng.2007.06.013>. <hal-01270940>
  • Denis Mangin, François Puel, S. Veesler. Polymorphisme et transition de phases solides en solution. Techniques de l'Ingenieur, Techniques de l'ingénieur, 2008, pp.1-10. <hal-01273265>
  • F. Puel, E. Verdurand, P. Taulelle, C. Bebon, D. Colson, et al.. Crystallization mechanisms of acicular crystals. Journal of Crystal Growth, Elsevier, 2008, 310 (1), pp.110-115. <hal-00269963>
  • Alexandre Caillet, François Puel, Gilles Fevotte. Quantitative in situ monitoring of citric acid phase transition in water using Raman spectroscopy. Chemical Engineering and Processing: Process Intensification, Elsevier, 2008, 47 (3), pp.377-382. <10.1016/j.cep.2007.01.004>. <emse-00611868>
  • Manuel Henri, François E. Puel, Philippe D Perrichon, Caroline Wisniewski, Gilles Fevotte. Understanding and modelling of crystallization mechanisms by in-situ analytical technologies monitoring. International Journal of Chemical Reactor Engineering, De Gruyter, 2008, 6 (A3), pp.A3. <emse-00498786>
  • Manuel Henri, François E. Puel, Philippe D Perrichon, Caroline Wisniewski, Gilles Fevotte. Understanding and modelling of crystallization mechanisms by in-situ analytical technologies monitoring. International Journal of Chemical Reactor Engineering, De Gruyter, 2008, 6 (A3), pp.A3. <emse-00498120>
  • M. Oullion, F. Puel, G. Févotte, S. Righini, P. Carvin. Industrial batch crystallization of a plate-like organic product. In situ monitoring and 2D-CSD modelling: Part 1: Experimental study. Chemical Engineering Science, Elsevier, 2007, 62 (3), pp.820-832. <10.1016/j.ces.2006.08.077>. <hal-01270889>
  • M.A. Bolzinger, C. Cogne, L. Lafferrere, F. Salvatori, P. Ardaud, et al.. Effects of surfactants on crystallization of ethylene glycol distearate in oil-in-water emulsion. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2007, 299 (1-3), pp.93-100. <10.1016/j.colsurfa.2006.11.026>. <hal-01270892>
  • Alexandre Caillet, Alain Rivoire, Jean-Marc Galvan, François Puel, Gilles Fevotte. Crystallization of Monohydrate Citric Acid. 1. In Situ Monitoring through the Joint Use of Raman Spectroscopy and Image Analysis. Crystal Growth and Design, American Chemical Society, 2007, 7 (10), pp.2080-2087. <10.1021/cg060557b>. <hal-01270895>
  • M. Oullion, F. Puel, G. Févotte, S. Righini, P. Carvin. Industrial batch crystallization of a plate-like organic product. In situ monitoring and 2D-CSD modelling. Part 2: Kinetic modelling and identification. Chemical Engineering Science, Elsevier, 2007, 62 (3), pp.833-845. <10.1016/j.ces.2006.08.078>. <hal-01272260>
  • A. Caillet, F. Puel, G. Fevotte. In-line monitoring of partial and overall solid concentration during solvent-mediated phase transition using Raman spectroscopy. International Journal of Pharmaceutics, Elsevier, 2006, 307 (2), pp.201-208. <10.1016/j.ijpharm.2005.10.009>. <hal-01270880>
  • Sergio A. Galindo-Rodríguez, François Puel, Stephanie Briançon, Eric Allémann, Eric Doelker, et al.. Comparative scale-up of three methods for producing ibuprofen-loaded nanoparticles. European Journal of Pharmaceutical Sciences, Elsevier, 2005, 25 (4-5), pp.357-367. <10.1016/j.ejps.2005.03.013>. <hal-01270840>
  • S. Veesler, François Puel, Gilles Fevotte. Polymorphism in processes of crystallization in solution. STP Pharma Pratiques, 2005, 15 (1), pp.53-84. <hal-01270872>
  • François Puel, S. Veesler, Denis Mangin. Cristallisation : aspects théoriques. Techniques de l'Ingenieur, Techniques de l'ingénieur, 2005, pp.1-16. <hal-01273260>
  • Gilles Fevotte, J. Calas, François Puel, C. Hoff. Applications of NIR spectroscopy to monitoring and analyzing the solid state during industrial crystallization processes. International Journal of Pharmaceutics, Elsevier, 2004, 273 (1-2), pp.159-169. <10.1016/j.ijpharm.2004.01.003>. <hal-01270834>
  • M. Kohl, F. Puel, J.P. Klein, C. Hoff, O. Monnier. Investigation of the growth rate of β-cyclodextrin in water during both flow-cell and batch experiments. Journal of Crystal Growth, Elsevier, 2004, 270 (3-4), pp.633-645. <10.1016/j.jcrysgro.2004.07.023>. <hal-01270837>
  • F. Puel, G. Févotte, J.P. Klein. Simulation and analysis of industrial crystallization processes through multidimensional population balance equations. Part 2: a study of semi-batch crystallization. Chemical Engineering Science, Elsevier, 2003, 58 (16), pp.3729-3740. <10.1016/S0009-2509(03)00253-7>. <hal-01270743>
  • L Derdour, G Févotte, François Puel, P Carvin. Real-time evaluation of the concentration of impurities during organic solution crystallization. Powder Technology, Elsevier, 2003, 129 (1-3), pp.1-7. <10.1016/S0032-5910(02)00283-8>. <hal-01270735>
  • F. Puel, G. Févotte, J.P. Klein. Simulation and analysis of industrial crystallization processes through multidimensional population balance equations. Part 1: a resolution algorithm based on the method of classes. Chemical Engineering Science, Elsevier, 2003, 58 (16), pp.3715-3727. <10.1016/S0009-2509(03)00254-9>. <hal-01270738>
  • F. Lewiner, G. Févotte, J. P. Klein, F. Puel. An Online Strategy To Increase the Average Crystal Size during Organic Batch Cooling Crystallization. Industrial and engineering chemistry research, American Chemical Society, 2002, 41 (5), pp.1321-1328. <10.1021/ie000962e>. <hal-01270730>
  • F Lewiner, J.P Klein, François Puel, G Févotte. On-line ATR FTIR measurement of supersaturation during solution crystallization processes. Calibration and applications on three solute/solvent systems. Chemical Engineering Science, Elsevier, 2001, 56 (6), pp.2069-2084. <10.1016/S0009-2509(00)00508-X>. <hal-01270722>
  • F. Lewiner, G. Févotte, J.P. Klein, F. Puel. Improving batch cooling seeded crystallization of an organic weed-killer using on-line ATR FTIR measurement of supersaturation. Journal of Crystal Growth, Elsevier, 2001, 226 (2-3), pp.348-362. <10.1016/S0022-0248(01)01395-1>. <hal-01270726>
  • F. Puel, P. Marchal, J. Klein. Habit Transient Analysis in Industrial Crystallization Using Two Dimensional Crystal Sizing Technique. Chemical Engineering Research and Design, Elsevier, 1997, 75 (2), pp.193-205. <10.1205/026387697523444>. <hal-01270718>

Communication dans un congrès6 documents

  • Abdenour Amokrane, Amine Kacem, Sophie Charton, François Puel, Jean-Paul Klein. Oxalate Precipitation in Emulsion: from the Drop Scale to the Industrial Process. Poinssot, C. International Conference on Nuclear Chemistry for Sustainable Fuel Cycles (ATALANTE), Sep 2012, Montpellier, France. ELSEVIER SCIENCE BV, Procedia Chemistry, 7, pp.456-459, 2012, ATALANTE 2012 INTERNATIONAL CONFERENCE ON NUCLEAR CHEMISTRY FOR SUSTAINABLE FUEL CYCLES. <10.1016/j.proche.2012.10.069>. <hal-01272092>
  • François Puel. Application des mécanismes fondamentaux de la cristallisation en solution : des succès, des avancées et des challenges.. Colloque CEA Journées Scientifiques de Marcoule 2012, Jun 2012, Marcoule, France. <hal-01275510>
  • François Puel. Application des mécanismes fondamentaux de la cristallisation à la cristallisation industrielle en solution. CRISTAL 6, CINaM, May 2010, Lyon, France. SFGP, pp.28, Récents Progrès en Génie des Procédés. <hal-01275500>
  • François Puel, Gilles Fevotte. Application de la spectroscopie moyen infra rouge in situ au développement et au contrôle des procédés de cristallisation en solution. Congrès CRISTAL 2, Nov 2003, Toulouse, France. <hal-01275499>
  • François Puel, Gilles Fevotte. Applications of infrared spectroscopy for the mastery of crystallization of organic materials. Workshop CGCOM6, Aug 2003, Glasgow, United Kingdom. <hal-01275496>
  • François Puel, J.P. Klein. Polymorphism in fine organic processes. Workshop Sympocrist CRMC2, Sep 2002, Marseille, France. <hal-01275492>

Chapitre d'ouvrage4 documents

  • Y. Chevalier, Marie-Alexandrine Bolzinger, François Puel. Emulsions. Anne-Marie PENSE-LHERITHIER. Conception des produits cosmétiques : La formulation , Lavoisier SA, pp.163-220, 2015. <hal-01273270>
  • S. Veesler, François Puel. Crystallization of Pharmaceutical Crystals. Tatau Nishinaga. Handbook of Crystal Growth, 1-A (Chapitre 21), Elsevier, pp.915-949, 2014, Fundamentals : Thermodynamics and Kinetics, 9780444563699. <10.1016/B978-0-444-56369-9.00021-6>. <hal-01273239>
  • Emilie Gagniere, Denis Mangin, S. Veesler, François Puel. Co-crystallization in solution and scale-up issues. Johan Wouters, Luc Quéré. Pharmaceutical salts and co-crystals, Royal Society of Chemistry, pp.188-211, 2012, RSC Drug Discovery Series, 978-1-84973-158-4. <10.1039/9781849733502-00188>. <hal-01273214>
  • François Puel, Stephanie Briançon, Hatem Fessi. Industrial technologies and scale up. S. Benita. Microencapsulation : methods and industrial applications , CRC Press Taylor & Francis group, pp.149-182, 2006, Drugs and Pharmaceutical Science, 978-0-8247-2317-0. <10.1201/9781420027990.fmatt>. <hal-01273208>