Accéder directement au contenu

Florence Legendre

Ingénieur de Recherche biologiste en laboratoire, PhD, HDR
53
Documents
Affiliations actuelles
  • 1089273
  • 7127
Identifiants chercheurs
Contact

Présentation

Domaines de recherche

Sciences du Vivant [q-bio]

Compétences

Publications

Image document

Early castration in horses does not impact osteoarticular metabolism

Marion Rouge , Florence Legendre , Razan Elkhatib , Christelle Delalande , Juliette Cognie
International Journal of Molecular Sciences, 2023, 24 (23), pp.16778. ⟨10.3390/ijms242316778⟩
Article dans une revue hal-04312304v1
Image document

MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells

Clément Veys , Flavie Boulouard , Abderrahim Benmoussa , Manon Jammes , Emilie Brotin
Frontiers in Oncology, 2023, 13, ⟨10.3389/fonc.2023.1220459⟩
Article dans une revue hal-04216524v1
Image document

Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells

Clément Veys , Manon Jammes , Françoise Rédini , Laurent Poulain , Christophe Denoyelle
Pharmaceuticals, 2022, 15 (3), pp.362. ⟨10.3390/ph15030362⟩
Article dans une revue hal-03638646v1
Image document

Functionalized Nanogels with Endothelin-1 and Bradykinin Receptor Antagonist Peptides Decrease Inflammatory and Cartilage Degradation Markers of Osteoarthritis in a Horse Organoid Model of Cartilage

Aurélie Cullier , Frédéric Cassé , Seng Manivong , Romain Contentin , Florence Legendre
International Journal of Molecular Sciences, 2022, 23 (16), pp.8949. ⟨10.3390/ijms23168949⟩
Article dans une revue hal-03775355v1
Image document

Investigation of equine testis contribution to vitamin D bioactivation

Marion Rouge , Razan Elkhatib , Christelle Delalande , Juliette Cognié , Fabrice Reigner
Domestic Animal Endocrinology, 2022, 79, pp.1-9. ⟨10.1016/j.domaniend.2021.106691⟩
Article dans une revue hal-03478703v1
Image document

Marine Collagen Hydrolysates Downregulate the Synthesis of Pro-Catabolic and Pro-Inflammatory Markers of Osteoarthritis and Favor Collagen Production and Metabolic Activity in Equine Articular Chondrocyte Organoids

Bastien Bourdon , Romain Contentin , Frédéric Cassé , Chloé Maspimby , Sarah Oddoux
International Journal of Molecular Sciences, 2021, 22 (2), pp.580. ⟨10.3390/ijms22020580⟩
Article dans une revue hal-03114578v1
Image document

Tumor Suppressive Role of miR-342-5p in Human Chondrosarcoma Cells and 3D Organoids

Clément Veys , Abderrahim Benmoussa , Romain Contentin , Amandine Duchemin , Emilie Brotin
International Journal of Molecular Sciences, 2021, 22 (11), pp.5590. ⟨10.3390/ijms22115590⟩
Article dans une revue hal-03351650v1
Image document

Evaluation of Allogeneic Bone-Marrow-Derived and Umbilical Cord Blood-Derived Mesenchymal Stem Cells to Prevent the Development of Osteoarthritis in An Equine Model

Lélia Bertoni , Sandrine Jacquet , Thomas Branly , Mélanie Desancé , Florence Legendre
International Journal of Molecular Sciences, 2021, 22 (5), pp.2499. ⟨10.3390/ijms22052499⟩
Article dans une revue hal-03193164v1
Image document

An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization

Lélia Bertoni , Sandrine Jacquet , Thomas Branly , Florence Legendre , Mélanie Desancé
PLoS ONE, 2020, 15 (6), pp.e0235251. ⟨10.1371/journal.pone.0235251⟩
Article dans une revue hal-02935223v1
Image document

Regulation of extracellular matrix synthesis by shell extracts from the marine bivalve Pecten maximus in human articular chondrocytes - Application for cartilage engineering.

Mouloud Bouyoucef , Rodolphe Rakic , Tangni Gómez-Leduc , Thomas Latire , Frédéric Marin
Marine Biotechnology, 2018, 20 (4), pp.436-450. ⟨10.1007/s10126-018-9807-7⟩
Article dans une revue hal-01861438v1
Image document

Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy

Mélanie Desancé , Romain Contentin , Lélia Bertoni , Tangni Gómez-Leduc , Thomas Branly
International Journal of Molecular Sciences, 2018, 19 (2), pp.537. ⟨10.3390/ijms19020537⟩
Article dans une revue hal-02186781v1

Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1

Thomas Branly , Lélia Bertoni , Romain Contentin , Rodolphe Rakic , Tangni Gómez-Leduc
Stem Cell Reviews and Reports, 2017, 13 (5), pp.611-630. ⟨10.1007/s12015-017-9748-y⟩
Article dans une revue hal-02186824v1
Image document

Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-β1, hypoxia, and COL1A1/HtrA1 siRNAs

Florence Legendre , David Ollitrault , Tangni Gómez-Leduc , Mouloud Bouyoucef , Magalie Hervieu
Scientific Reports, 2017, 7 (1), pp.3406. ⟨10.1038/s41598-017-03579-y⟩
Article dans une revue hal-02285453v1
Image document

Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges

Tangni Gómez-Leduc , Mélanie Desancé , Magalie Hervieu , Florence Legendre , David Ollitrault
International Journal of Molecular Sciences, 2017, 18 (9), pp.1933. ⟨10.3390/ijms18091933⟩
Article dans une revue hal-02186808v1

Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro

Thomas Latire , Florence Legendre , Mouloud Bouyoucef , Frédéric Marin , Franck Carreiras
Cytotechnology, 2017, 69 (5), pp.815-829. ⟨10.1007/s10616-017-0096-1⟩
Article dans une revue hal-01588926v1
Image document

RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation

Rodolphe Rakic , Bastien Bourdon , Magalie Hervieu , Thomas Branly , Florence Legendre
International Journal of Molecular Sciences, 2017, 18 (9), pp.1842. ⟨10.3390/ijms18091842⟩
Article dans une revue hal-02186507v1

Reduced NF- κ B activity is observed in dermal fibroblasts from black-skinned African individuals

Nicolas Bigot , Tangni Gómez-Leduc , Magalie Hervieu , Fanny Gallienne , Thierry Oddos
Experimental Dermatology, 2016, 25 (5), pp.392-394. ⟨10.1111/exd.12970⟩
Article dans une revue hal-02186862v1
Image document

Chondrogenic commitment of human umbilical cord blood-derived mesenchymal stem cells in collagen matrices for cartilage engineering

Tangni Gómez-Leduc , Magalie Hervieu , Florence Legendre , Mouloud Bouyoucef , Nicolas Gruchy
Scientific Reports, 2016, 6 (1), pp.32786. ⟨10.1038/srep32786⟩
Article dans une revue inserm-02304812v1
Image document

In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact

Dounia Hamdi , Sofia Barbieri , François Chevalier , Jean-Emmanuel Groetz , Florence Legendre
Article dans une revue hal-01315021v1

BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytes

D. Ollitrault , F. Legendre , C. Drougard , M. Briand , H. Benateau
Tissue Engineering Part C: Methods, 2015, 21 (2), pp.133-147. ⟨10.1089/ten.tec.2013.0724⟩
Article dans une revue hal-01804715v1
Image document

Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells

Séverine Cruet-Hennequart , Carole Drougard , Georgina Shaw , Florence Legendre , Magali Demoor
PLoS ONE, 2015, 10 (4), pp.e0119334. ⟨10.1371/journal.pone.0119334⟩
Article dans une revue hal-03156371v1

Cartilage tissue engineering: Molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction

Magali Demoor , David Ollitrault , Tangni Gómez-Leduc , Mouloud Bouyoucef , Magali Hervieu
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (8), pp.2414-2440. ⟨10.1016/j.bbagen.2014.02.030⟩
Article dans une revue hal-02132064v1
Image document

Shell Extracts from the Marine Bivalve Pecten maximus Regulate the Synthesis of Extracellular Matrix in Primary Cultured Human Skin Fibroblasts

Thomas Latire , Florence Legendre , Nicolas Bigot , Ludovic Carduner , Sabrina Kellouche
PLoS ONE, 2014, 9 (6), pp.e99931. ⟨10.1371/journal.pone.0099931⟩
Article dans une revue hal-01366292v1

Enhanced Hyaline Cartilage Matrix Synthesis in Collagen Sponge Scaffolds by Using siRNA to Stabilize Chondrocytes Phenotype Cultured with Bone Morphogenetic Protein-2 Under Hypoxia

Florence Legendre , David Ollitrault , Magalie Hervieu , Catherine Baugé , Laure Maneix
Tissue Engineering Part C: Methods, 2013, 19 (7), pp.550-567. ⟨10.1089/ten.TEC.2012.0508⟩
Article dans une revue hal-04199500v1

Deciphering chondrocyte behaviour in matrix-induced autologous chondrocyte implantation to undergo accurate cartilage repair with hyaline matrix

M. Demoor , L. Maneix , D. Ollitrault , F. Legendre , E. Duval
Pathologie Biologie, 2012, 60 (3), pp.199-207. ⟨10.1016/j.patbio.2012.03.003⟩
Article dans une revue hal-04202025v1

Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes

Emmanuelle Renard , Benoît Porée , Christos Chadjichristos , Magdalini Kypriotou , Laure Maneix
Journal of Molecular Medicine, 2012, 90 (6), pp.649-666. ⟨10.1007/s00109-011-0842-3⟩
Article dans une revue hal-03838419v1

Décryptage des signalisations moléculaires contrôlant la différenciation des chondrocytes : retombées pour l’ingénierie tissulaire du cartilage : le projet ANR-TecSan PROMOCART

S. Claus , E. Aubert-Foucher , E. Perrier-Groult , C. Bougault , M.-C. Ronzière
Innovation and Research in BioMedical engineering, 2011, 32 (2), pp.95-98. ⟨10.1016/j.irbm.2011.01.015⟩
Article dans une revue hal-04202120v1

Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis

F. Legendre , A. Heuze , K. Boukerrouche , S. Leclercq , K. Boumediene
Scandinavian Journal of Rheumatology, 2009, 38 (2), pp.104-111. ⟨10.1080/03009740802421996⟩
Article dans une revue hal-04200456v1

Interleukin-1 and Transforming Growth Factor-ß 1 as Crucial Factors in Osteoarthritic Cartilage Metabolism

Jean-Pierre Pujol , Christos Chadjichristos , Florence Legendre , Catherine Baugé , Gallic Beauchef
Connective Tissue Research, 2009, 49 (3-4), pp.293-297. ⟨10.1080/03008200802148355⟩
Article dans une revue hal-03838453v1

Evaluation of Adhesion, Proliferation, and Functional Differentiation of Dermal Fibroblasts on Glycosaminoglycan-Coated Polysulfone Membranes

Joan Attia , Florence Legendre , Quang Trong Nguyen , Catherine Baugé , Karim Boumediene
Tissue Engineering: Parts A, B, and C, 2008, 14 (10), pp.1687-1697. ⟨10.1089/ten.tea.2007.0057⟩
Article dans une revue hal-04200472v1

Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1β-stimulated chondrocytes – study in hypoxic alginate bead cultures

F. Legendre , C. Baugé , R. Roche , A.S. Saurel , J.P. Pujol
Osteoarthritis and Cartilage, 2008, 16 (1), pp.105-114. ⟨10.1016/j.joca.2007.05.020⟩
Article dans une revue hal-04200519v1
Image document

Interleukin-6 (IL-6) and/or Soluble IL-6 Receptor Down-regulation of Human Type II Collagen Gene Expression in Articular Chondrocytes Requires a Decrease of Sp1·Sp3 Ratio and of the Binding Activity of Both Factors to the COL2A1 Promoter

Benoît Porée , Magdalini Kypriotou , Christos Chadjichristos , Gallic Beauchef , Emmanuelle Renard
Journal of Biological Chemistry, 2008, 283 (8), pp.4850-4865. ⟨10.1074/jbc.M706387200⟩
Article dans une revue hal-03838464v1

Rhein, a diacerhein-derived metabolite, modulates the expression of matrix degrading enzymes and the cell proliferation of articular chondrocytes by inhibiting ERK and JNK-AP-1 dependent pathways.

F Legendre , P Bogdanowicz , G Martin , F Domagala , S Leclercq
Clinical and experimental rheumatology, 2007, 25 (4), pp.546-55
Article dans une revue hal-04200554v1

Interleukin-1β impairment of transforming growth factor β1 signaling by DOWN-REGULATION of transforming growth factor β receptor type II and up-regulation of Smad7 in human articular chondrocytes

C. Baugé , F. Legendre , S. Leclercq , J. Elissalde , J. Pujol
Arthritis and Rheumatism, 2007, 56 (9), pp.3020-3032. ⟨10.1002/art.22840⟩
Article dans une revue hal-04200583v1

Comparative effects of 2 antioxidants, selenomethionine and epigallocatechin-gallate, on catabolic and anabolic gene expression of articular chondrocytes.

Rina Andriamanalijaona , Madeleine Kypriotou , Catherine Baugé , Emmanuelle Renard , Florence Legendre
Journal of Rheumatology, 2005, 32 (10), pp.1958-67
Article dans une revue hal-04200629v1

Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular.

Florence Legendre , Patrick Bogdanowicz , Karim Boumediene , Jean-Pierre Pujol
Journal of Rheumatology, 2005, 32 (7), pp.1307-16
Article dans une revue hal-04201771v1
Image document

JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes

Florence Legendre , Jayesh Dudhia , Jean-Pierre Pujol , Patrick Bogdanowicz
Journal of Biological Chemistry, 2003, 278 (5), pp.2903-2912. ⟨10.1074/jbc.M110773200⟩
Article dans une revue hal-04201804v1

Study of therapeutic potential of new functionalized nanogels against osteoarthritis by using equine cartilage organoid cultures

Aurélie Cullier , Frédéric Cassé , Florence Legendre , Romain Contentin , Seng Manivong
Journée Normande de Recherche Biomédicale, Jun 2022, Rouen, France
Communication dans un congrès hal-03722806v1

Injection intra-articulaire d’un nanogel fonctionnalisé combinant des effets mécanique et biologique rémanents contre l’arthrose chez le cheval : étude de tolérance

A. Terlinden , Sandrine Jacquet , Aurélie Cullier , Frédéric Cassé , F. Legendre
50èmes Journées annuelles de l'AVEF, Nov 2022, Reims, France
Communication dans un congrès hal-04004349v1

Étude de l’impact des hormones testiculaires sur le métabolisme ostéo-articulaire chez l’espèce équine

Marion Rouge , Razan Elkhatib , Christelle Delalande , Juliette Cognie , Fabrice Reigner
eCongrès International de la Société d’Andrologie de Langue Française, Société d’Andrologie de Langue Française, Jan 2021, CAEN, France
Communication dans un congrès hal-04202823v1

Functionalized Nanohydrogels decrease Inflammatory and Cartilage Degradation Biomarkers in an organoid model of horse cartilage tissue

Aurélie Cullier , Romain Contentin , Frédéric Cassé , Florence Legendre , Seng Manivong
XXIIIèmes Journées de l'Ecole Doctorale Normande de Biologie Intégrative Santé et Environnement, May 2021, CAEN, France
Communication dans un congrès hal-03229755v1

Characterization and use of equine bone marrow mesenchymal stem cells in horse cartilage engineering

Thomas Branly , Magalie Hervieu , Sandrine Jacquet , Lélia Bertoni , Tangni Gómez-Leduc
World Congress of the Osteoarthritis-Research-Society-International, Osteoarthritis Research Society International (OARSI)., Apr 2014, Paris, France. pp.1, ⟨10.1016/j.joca.2014.02.937⟩
Communication dans un congrès hal-02740012v1

Intra-articular injection of a functionalized nanogel combining prolonged mechanical and biological effects as a treatment for osteoarthritis in the horse: a double-blinded, randomized tolerance study

A. Terlinden , Sandrine Jacquet , Aurélie Cullier , Frédéric Cassé , Florence Legendre
Journées Normandes de la Recherche Biomédicale, Jun 2022, Rouen, France
Poster de conférence hal-04003400v1

Functionalized Nanogels decrease Inflammatory and Cartilage Degradation markers of Osteoarthritis in a horse organoid model of cartilage

Aurélie Cullier , Romain Contentin , Frédéric Cassé , Florence Legendre , Seng Manivong
International Cartilage Regeneration & joint Preservation Society, Apr 2022, Berlin, Germany
Poster de conférence hal-03653007v1

Les hormones stéroïdiennes testiculaires contribuent-elles au métabolisme ostéo-articulaire chez l’espèce équine ?

Marion Rouge , Razan Elkhatib , Christelle Delalande , Juliette Cognie , Fabrice Reigner
37ème congrès de la Société Française d’Endocrinologie, Oct 2021, Le Havre, France
Poster de conférence hal-04202815v1

Caractérisation phénotypique des chondrocytes fœtaux humains

Manon Godin , Romain Contentin , Bastien Bourdon , Florence Legendre , Arnaud Molin
10èmes Assises de Génétique Humaine et Médicale, Jan 2020, Tours, France
Poster de conférence hal-02436461v1

Use of therapeutic miRNAs for the treatment of chondrosarcoma

Clément Veys , Abderrahim Benmoussa , Romain Contentin , Amandine Duchemin , Emilie Brotin
3rd International Conference on the Long and the Short of Non-Coding RNAs, Jun 2019, Chania, Greece
Poster de conférence hal-02188430v1
Image document

Improvement of the chondrocyte-specific phenotype upon equine bone marrow mesenchymal stem cell differentiation. Influence of TGF-ß1 or TGF-ß3, associated with BMP-2 and type I collagen siRNAs

Romain Contentin , Thomas Branly , Mélanie Desancé , Miranda Concari , Thibaud Jacquel
19èmes journées françaises de Biologie de Tissus Minéralisés (SFBTM 2017), 2017, Lyon, France
Poster de conférence hal-02294803v1
Image document

Caractérisation et différenciation des cellules souches mésenchymateuses (CSM) de la moelle osseuse équine et du sang de cordon ombilical pour des applications en ingénierie du cartilage

Thomas Branly , Mélanie Desancé , Lélia Bertoni , Romain Contentin , Rodolphe Rakic
AVEF, 2017, Paris, France
Poster de conférence hal-02294586v1

Characterization and differentiation of equine umbilical cord blood mesenchymal stem cells for cartilage tissue engineering

Mélanie Desancé , Lélia Bertoni , Romain Contentin , Thomas Branly , Tangni Gómez-Leduc
18èmes Journées Française de la Biologie des Tissus Minéralisés, 2016, Nancy, France
Poster de conférence hal-03957909v1
Image document

P046: Engineering of a 3D cartilage model: study of healthy cartilage exposition during hadrontherapy

François Chevalier , Dounia Hamdi , Yannick Saintigny , Florence Legendre , Magali Demoor
PTCOG 53 - Particle Therapy Co-Operative Group, Jun 2014, Shanghai, China.
Poster de conférence hal-04235720v1